The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Our data confirmed the preservation of the genomic landscape from tumour tissue to GSCs, supporting the relevance of this cellular model to test in vitro new target therapies for GBM.…”
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Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

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The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial by Matthew Stephen Block, James Hugo Armstrong Clubb, Johanna Mäenpää, Santeri Pakola, Dafne Carolina Alves Quixabeira, Tatiana Kudling, Elise Jirovec, Lyna Haybout, Mirte van der Heijden, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Sini Raatikainen, Victor Arias, Saru Basnet, Nea Ojala, Teijo Pellinen, Annabrita Hemmes, Katja Välimäki, Annukka Pasanen, Tuomo Alanko, Daniel Adamo, Susan Ramadan, Jorma Sormunen, Juha Kononen, Julia Wanda Cohen, Michael Jon Chisamore, John Goldfinch, Suvi Sorsa, Riikka Havunen, Claudia Kistler, Aino Kalervo, Víctor Cervera-Carrascon, João Manuel dos Santos, Akseli Hemminki

“…Originally developed to improve efficacy of T-cell therapies such as immune checkpoint inhibitors and adoptive cell transfer, TILT-123 (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2) is a serotype chimeric oncolytic adenovirus encoding tumor necrosis factor alpha and interleukin-2. …”
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Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated pati... by Kai-Lin Yang, Mau-Shin Chi, Chung-Yu Hao, Hui-Ling Ko, Yi-Ying Huang, Ren-Hong Wu, Hung-Chih Lai, Ying-Chu Lin, Sheng-Po Hao, Kwan-Hwa Chi

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Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects by Massimo Mammucari, Enrica Maggiori, Domenico Russo, Chiara Giorgio, Gianpaolo Ronconi, Paola E Ferrara, Flora Canzona, Luciano Antonaci, Bartolomeo Violo, Renato Vellucci, Domenico Rocco Mediati, Alberto Migliore, Umberto Massafra, Barbara Bifarini, Fabio Gori, Massimo di Carlo, Stefano Brauneis, Teresa Paolucci, Piergiovanni Rocchi, Anna Cuguttu, Raffaele Di Marzo, Alessandro Bomprezzi, Stefania Santini, Manuela Giardini, Anna Rosa Catizzone, Fiammetta Troili, Dario Dorato, Alessandra Gallo, Costanza Guglielmo, Silvia Natoli

“…Intradermal therapy, known as mesotherapy, is a technique used to inject a drug into the surface layer of the skin. …”
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Extracorporeal Hemadsorption versus Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial by Gordana Taleska Stupica, Maja Sostaric, Marija Bozhinovska, Lea Rupert, Zoran Bosnic, Ales Jerin, Alojz Ihan, Tomislav Klokocovnik, Matej Podbregar

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PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting by Izabela Wojtkowska, Andrzej Tysarowski, Katarzyna Seliga, Janusz A. Siedlecki, Zbigniew Juraszyński, Milosz Marona, Lidia Greszata, Anna Skrobisz, Karol Kaminski, Robert Sawicki, Janina Stępińska

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Fas Ligand DNA Enhances a Vaccination Effect by Coadministered DNA Encoding a Tumor Antigen through Augmenting Production of Antibody against the Tumor Antigen by Boya Zhong, Guangyu Ma, Ayako Sato, Osamu Shimozato, Hongdan Liu, Quanhai Li, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa

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Availability in ECMO Reduces the Failure to Rescue in Patients With Pulmonary Embolism After Major Surgery: A Nationwide Analysis of 2.4 Million Cases by Johannes Diers, MD, Nikolas Baumann, MD, Philip Baum, MD, Konstantin L. Uttinger, MD, Johanna C. Wagner, MD, Peter Kranke, MD, Patrick Meybohm, MD, Christoph-Thomas Germer, MD, Armin Wiegering, MD

“…Postoperative pulmonary embolism (PE) is a rare but potentially life-threatening complication, which can be treated with extracorporeal membrane oxygenation (ECMO) therapy, a novel therapy option for acute cardiorespiratory failure. …”
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Design and Development of a Web‐Based Registry for Outpatient Rehabilitation: A Delphi Multi‐Disciplinary, Expert Consensus Study by Seyyedeh Fatemeh Mousavi Baigi, Masoumeh Sarbaz, Davood Sobhani‐Rad, Salman Nazary‐Moghadam, Javad Heravian Shandiz, Kosar Ghaddaripouri, Reyhane Norouzi Aval, Khalil Kimiafar

“…ABSTRACT Background and Aims The goal of this research was to create a minimum data set (MDS) and design a web‐based registry for outpatient rehabilitation, focusing on four disciplines: speech therapy, audiology, optometry, and physical therapy. …”
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Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men by Feng-fei Li, Bing-li Liu, Hong-hong Zhu, Ting Li, Wen-li Zhang, Xiao-fei Su, Jin-dan Wu, Xue-qin Wang, Ning Xu, Wei-Nan Yu, Qun Yuan, Guan-cheng Qi, Lei Ye, Kok-Onn Lee, Jian-hua Ma

“…Each group was further divided into male and female patients. CSII therapy was maintained for 3 weeks after the glycemic target was reached. …”
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The “real life” efficacy of dupilumab is independent of initial polyp size and concomitant steroids in CRSwNP by Nicholas J. Campion, Jonas Brugger, Aldine Tu, Victoria Stanek, Faris F. Brkic, Tina J. Bartosik, David T. Liu, Bruna S. Hoehl, Katharina Gangl, Julia Eckl-Dorna, Sven Schneider

“…Finally the model showed that neither oral nor nasal steroids influenced the rate of response to dupilumab therapy. Conclusions Polyp size at the initiation of dupilumab therapy and whether patients continue to take steroid therapy does not appear to influence effectiveness of dupilumab treatment.…”
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Effect of Transcranial Direct-Current Stimulation and Task-Oriented Training on Electroencephalography-Based Motor Recovery Chronic Stroke: A Randomized Clinical Trial by Maryam Zolghadr, Shohreh Noorizadeh Dehkordi, Javad Sarrafzadeh, Saeed Talebian, Hassan Haddadzade Niri, Marzieh Yassin

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Injectable Tumoricidal Neural Stem Cell-Laden Hydrogel for Treatment of Glioblastoma Multiforme—An In Vivo Safety, Persistence, and Efficacy Study by Jasmine L. King, Alain Valdivia, Shawn D. Hingtgen, S. Rahima Benhabbour

“…Despite efforts to advance treatment, GBM remains treatment resistant and inevitably progresses after first-line therapy. Induced neural stem cell (iNSC) therapy is a promising, personalized cell therapy approach that has been explored to circumvent challenges associated with the current GBM treatment. …”
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Polyclonal Recipient nTregs Are Superior to Donor or Third-Party Tregs in the Induction of Transplantation Tolerance by Nina Pilat, Christoph Klaus, Karin Hock, Ulrike Baranyi, Lukas Unger, Benedikt Mahr, Andreas M. Farkas, Fritz Wrba, Thomas Wekerle

“…We have previously reported successful induction of chimerism and tolerance using cell therapy with recipient T regulatory cells (Tregs) to avoid cytotoxic recipient treatment. …”
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Does Gender Influence Physiological Tolerance in Resuscitators When Using Personal Protection Equipment against Biological Hazards? by Francisco Martín-Rodríguez, José Luis Martín Conty, Verónica Casado Vicente, Pedro Arnillas Gómez, Alicia Mohedano-Moriano, Miguel Ángel Castro Villamor

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Transcatheter Arterial Chemoembolization Based on Hepatic Hemodynamics for Hepatocellular Carcinoma by Satoru Murata, Takahiko Mine, Tatsuo Ueda, Ken Nakazawa, Shiro Onozawa, Daisuke Yasui, Shin-ichiro Kumita

“…Patients with intermediate-stage HCC benefit from transcatheter arterial chemoembolization (TACE), and those diagnosed at an advanced stage receive sorafenib, a multikinase inhibitor, or conservative therapy. Most patients receive palliative or conservative therapy only, and approximately 50% of patients with HCC are candidates for systemic therapy. …”
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Mesenchymal Stem Cells May Alleviate the Intervertebral Disc Degeneration by Reducing the Oxidative Stress in Nucleus Pulposus Cells by Yongzhao Zhao, Qian Xiang, Yunzhong Cheng, Jialiang Lin, Shuai Jiang, Weishi Li

“…Background. Stem cell therapy is a promising therapeutic modality for intervertebral disc degeneration (IDD). …”
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Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic rev... by Corliss Ann Elizabeth Best, Alexandra Elizabeth Quimby, Brittany Ann Barbara Best, Dean Fergusson, Hussain Alsaffar

“…Abstract Objective To systematically review the evidence to evaluate oncologic outcomes for patients with early stage buccal squamous cell carcinoma treated with surgery versus surgery and adjuvant radiation therapy. Data sources Ovid MedLine, EMBASE, Google Scholar, PubMed. …”
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Cardiac Effects of Thyrotropin Oversuppression with Levothyroxine in Young Women with Differentiated Thyroid Cancer by Kyung-Soon Hong, Jung-Woo Son, Ohk Hyun Ryu, Moon-Gi Choi, Ji Yeon Hong, Seong Jin Lee

“…This study shows that TSH suppression therapy in women with DTC may be safe with respect to cardiac functions and structures despite intermittent oversuppression of TSH during long-term suppressive therapy. …”
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