Screening and Treatment of Immigrants and Refugees to Canada for Tuberculosis: Implications of the Experience of Canada and other Industrialized Countries by Roger E Thomas, Brian Gushulak

“…Objective: To assess the incidence of tuberculosis in immigrants and refugees in Canada and other industrialized countries; the effectiveness of the screening process; the incidence of drug resistance; recommendations for prophylaxis and therapy; and indications for and effectiveness of directly observed therapy.…”
Get full text

piR-26441 inhibits mitochondrial oxidative phosphorylation and tumorigenesis in ovarian cancer through m6A modification by interacting with YTHDC1 by Jing Yuan, Bu-Min Xie, Yu-Meng Ji, Hai-Juan Bao, Jie-Lin Wang, Jia-Chen Cheng, Xiang-Chun Huang, Yang Zhao, Shuo Chen

Get full text

Determining the Language Measurements in a Turkish-Persian Bilingual Child Suspected of Language Impairment: A Case Report by Galavizh Karimi Javan, Mahsa Mehdizadeh Behtash, Nahid Jalilehvand, Amirsalar Tozihi

Get full text

The Effectiveness of a Nondiet Multidisciplinary Weight Reduction Program for Severe Overweight Patients with Psychological Comorbidities by Bettina Bannert, Wolfgang Schobersberger, Ulrich Tran, Andreas Remmel

“…For successful sustainable weight reduction, a multimodal program including behaviour therapy is needed. Lifestyle modification is mostly used for obesity BMI <40 kg/m2. …”
Get full text

Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis by Hongmei Chen, Wei Ouyang, Christopher Martoni, Satya Prakash

Get full text

Management of Nonsteroidal Anti-Inflammatory Drug-Induced Gastroduodenal Disease by Acid Suppression by R Lad, D Armstrong

“…Subsequent studies reported that higher dose H2 receptor antagonist therapy can protect against both gastric and duodenal ulcers during continued NSAID therapy. …”
Get full text

Severe Diltiazem Poisoning Treated with Hyperinsulinaemia-Euglycaemia and Lipid Emulsion by Nadine Monteiro, Joana Silvestre, João Gonçalves-Pereira, Camila Tapadinhas, Vitor Mendes, Pedro Póvoa

“…The patient developed symptoms of refractory shock to conventional therapy and required mechanical ventilation, a temporary pacemaker, and renal replacement therapy. …”
Get full text

Parental perception of treatment options for mucopolysaccharidosis: a survey to bridge the gap for personalized medicine by Anna-Maria Wiesinger, Florian B. Lagler

“…Results Most likely parents would choose an approach to repurposed treatments for their child (neuronopathic: 82%, 14/17 and non-neuronopathic: 94%, 16/17), followed by enzyme replacement therapy (ERT, both 88%, 15/17), hematopoietic stem cell therapy (HSCT, 70%, 12/17 and 76%, 13/17), and finally gene therapy (GT, 58%, 10/17 and 53%, 9/17). …”
Get full text

Effects of the Multidimensional Treatment on Pain, Disability, and Sitting Posture in Patients with Low Back Pain: A Randomized Controlled Trial by Tae-Sung In, Jin-Hwa Jung, Kyoung-Sim Jung, Hwi-Young Cho

Get full text

Sudden Vision Loss Secondary to Optic Nerve Infiltration as a Presenting Symptom of Metastatic Lung Adenocarcinoma by M. M. Shamim, M. Whaley, H. Rana, S. K. Jeffus, S. Bhatti, A. B. Sallam

“…We treated him with local radiation therapy to the left eye and systemic osimertinib (EGFR-TKI). …”
Get full text

Recent advances in the management of knee osteoarthritis: a narrative review by Viktor Shtroblia, Pavlo Petakh, Iryna Kamyshna, Iryna Halabitska, Oleksandr Kamyshnyi

“…Topical treatments, such as NSAIDs and capsaicin, offer significant pain relief with minimal systemic side effects and are suitable for initial therapy, together with nonpharmacologic interventions like exercise and, when relevant, weight loss. …”
Get full text

Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells by Geng Yin, Ying Wang, Xiao-min Cen, Min Yang, Yan Liang, Qi-bing Xie

“…However, some of the targeted therapies for inflammation reactions do not display significant clinical improvement after initiation of therapy. …”
Get full text

Optimal Molecular Methods in Detecting p190BCR-ABL Fusion Variants in Hematologic Malignancies: A Case Report and Review of the Literature by Rebecca J. Sonu, Brian A. Jonas, Denis M. Dwyre, Jeffrey P. Gregg, Hooman H. Rashidi

“…Patients with BCR-ABL1 positive hematologic malignancies and Philadelphia-like B-lymphoblastic leukemia (B-ALL) are potential candidates for targeted therapy with tyrosine kinase inhibitors (TKI). Before TKIs, patients with B-ALL had a much worse prognosis and current treatments with targeted TKI therapy have improved outcomes. …”
Get full text

Prospects of Using Microbiota Correction Methods in the Treatment of Inflammatory Bowel Disease by A. I. Akinshina, D. V. Smirnova, A. V. Zagainova, V. V. Makarov, S. M. Yudin

“…The present article examines key methods of microbiota correction (antibiotic therapy; pro-, pre- and metabiotic therapy; faecal microbiota transplantation) used in treating inflammatory bowel disease, as well as compares the clinical trial results of these methods.Key findings. …”
Get full text

Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes by Gry Høst Dørflinger, Charlotte Brink Holt, Steffen Thiel, Jakob Appel Østergaard, Troels Krarup Hansen

“…We measured MBL, fructosamine, and HbA1cat baseline and after 6 weeks in 52 type 1 diabetic patients following the change from conventional insulin therapy to insulin pump therapy. Results. After initiation of insulin pump therapy, the total daily insulin dose was significantly reduced (from 51 ± 18 IE/day to 39 ± 13 IE/day, P<0.0001). …”
Get full text

Severe Diverticulitis Associated to <i>Clostridioides difficile</i> Infection in a 91 Year Old Patient (Clinical Case) by A. A. Makushina, L.  N. Androsova, K. B. Puzakov, A. V. Okhlobystin, M. A. Tatarkina, O. S. Shifrin

“…Combined therapy of exacerbation of diverticular disease and C. difficile-associated disease made it possible to achieve a steady improvement of the condition.Conclusion. …”
Get full text

Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review by Rui Bergantim, Juliana Bastos, Maria José Soares, Bruno Carvalho, Pedro Soares, Cristina Marques, Jennifer Costa, José Eduardo Guimarães, Fernanda Trigo

“…There is no standard therapy for this extramedullary relapse, and a tailored and multiple therapy should be promptly started—intrathecal therapy, radiotherapy, and systemic therapy, including an immunomodulator.…”
Get full text

Early Poststroke Rehabilitation Using a Robotic Tilt-Table Stepper and Functional Electrical Stimulation by Alexey N. Kuznetsov, Natalia V. Rybalko, Vadim D. Daminov, Andreas R. Luft

“…Hemiparetic ischemic stroke survivors (age years, days after stroke) were assigned to 30 days of ROBO-FES (), ROBO (), or control () in addition to conventional physical therapy. Impedance cardiography and transcranial doppler sonography were performed before, during, and after training. …”
Get full text

Treatment of Extensive Plaque Psoriasis and Psoriatic Arthropathy using Methotrexate in a Patient with High Serum Alkaline Phosphatase by Suad HH, Muna Mohammed El Amin, Gad Allah Modawe, Osman Elbasheer

“…Recommendations: Methotrexate is recommended for the treatment of severe morbid forms of psoriasis. The biologic therapy for severe forms of psoriasis is now available and can be a good alternative for the treatment of severe forms of psoriasis in good centers and for patients who can afford and in patients with absolute contraindications to methotrexate therapy.…”
Get full text

Granulocyte-Monocyte Apheresis in Steroid-Dependent, Azathioprine-Intolerant/Resistant Moderate Ulcerative Colitis: A Prospective Multicenter Study by Gianni Imperiali, Arnaldo Amato, Maria Maddalena Terpin, Ivo Beverina, Aurora Bortoli, Massimo Devani, Chiara Viganò, Study Group on IBD (GSMII)

“…Apheresis might represent an alternative to biologic therapy or surgery in this specific subgroup of patients. …”
Get full text