Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases by Eric Gomez, Martha Sanchez, Zonaira Gul, Carl Urban, Noriel Mariano, Robert H. K. Eng, David B. Huang, Tom Chiang

“…We report three cases of KPC-producing Klebsiella pneumoniae bacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. …”
Get full text

MOMENT registry: Patients with advanced non-small-cell lung cancer harboring MET exon 14 skipping treated with systemic therapy by Michael Thomas, Petros Christopoulos, Wade T Iams, Julien Mazieres, Alexis B Cortot, Nir Peled, Gabriele Minuti, Egbert F Smit, Francois Audhuy, Karin Berghoff, S Peter Eggleton, Frank Fries, Maike Hildenbrand, Peter Liu, Seyed Hamidreza Mahmoudpour, Christoph Menzel, Dina Oksen

Subjects:

Aloe-Emodin-Mediated Photodynamic Therapy Induces Apoptosis in Basal Cell Carcinoma Cells via Activation of ERK/JNK Signaling Pathway by Woodvine Otieno Odhiambo, Songmei Geng, Xiaopeng Wang, Xiaodong Chen, Mengting Qin, Meng Yuan, Yang Wang, Farooq Riaz, Chengcheng Liu, Yanhong Ji

“…Previous studies have reported the noninvasive, cost-effective, and localized photodynamic therapy (PDT) approach to BCC treatment. This study investigated the photodynamic effects of aloe-emodin (AE), a natural anthraquinone photosensitizer (PS), on proliferation and apoptosis of BCC TE 354.T cell line. …”
Get full text

Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study by Tesfay Mehari Atey, Helen Bitew, Solomon Weldegebreal Asgedom, Asrat Endrias, Derbew Fikadu Berhe

“…Early antiretroviral therapy (ART), isoniazid preventive therapy (IPT), and isoniazid-rifapentine (3HP) are effective strategies for preventing tuberculosis (TB) among people living with HIV (PLHIV). …”
Get full text

Propranolol in Use for Treatment of Complex Infant Hemangiomas: Literature Review Regarding Current Guidelines for Preassessment and Standards of Care before Initiation of Therapy by Andreas Fette

“…Thus, the aim of this communication is to evaluate the literature for current evidence regarding guidelines for preassessment and standards of care before initiation of therapy.…”
Get full text

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials by George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands

Get full text

Bowel Resection and Ileotransverse Anastomosis as Preferred Therapy for 15 Typhoid Ileal Perforations and Severe Peritoneal Contamination in a Very Elderly Patient by Benjamin Momo Kadia, Desmond Aroke, Martin Hongieh Abanda, Tsi Njim, Christian Akem Dimala

Get full text

Cardiovascular risk and mortality in men receiving testosterone replacement therapy for Klinefelter syndrome in Denmark: a retrospective cohort studyResearch in context by Simon Chang, Lars Pedersen, Anne Skakkebæk, Agnethe Berglund, Claus H. Gravholt

Subjects: “…Testosterone replacement therapy…”
Get full text

Red Blood Cell Transfusions and Iron Therapy for Patients Presenting with Acute Upper Gastrointestinal Bleeding: A Survey of Canadian Gastroenterologists and Hepatologists by Kyle J. Fortinsky, Myriam Martel, Roshan Razik, Gillian Spiegle, Zane R. Gallinger, Samir C. Grover, Katerina Pavenski, Adam V. Weizman, Lukasz Kwapisz, Sangeeta Mehta, Sarah Gray, Alan N. Barkun

Get full text

Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats by Doreen Enyang, Mubo A. Sonibare, Armelle D. Tchamgoue, Lauve R. Y. Tchokouaha, Fanta S. Yadang, Gael N. Nfor, Christelle W. Kom, Patrick D. H. Betote, Cedric F. Tchinda, Steveng S. K. Tiogo, Gabriel A. Agbor

“…Antiretroviral therapy (ART) has revolutionized the lives of people living with HIV/AIDS by overall improving their quality of life and increasing life expectancy. …”
Get full text

Efficacy of non-surgical mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of peri-implantitis among patients undergoing chemotherapy by Asma Saleh Almeslet, Malak Mohammed ALOsaimi, Chitra Jhugroo, Abdullah Faraj Alshammari, Darshan Devang Divakar, Cristalle Soman

Subjects: “…Antimicrobial photodynamic therapy…”
Get full text

Microbial Changes in Subgingival Plaque and Polymicrobial Intracellular Flora in Buccal Cells after Fixed Orthodontic Appliance Therapy: A Preliminary Study by Caterina Montaldo, Matteo Erriu, Francesca Maria Giovanna Pili, Carla Peluffo, Annalisa Nucaro, Germano Orrù, Gloria Denotti

Get full text

Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review by Brian Hutton, Beverley Shea, Kimberly Corace, David Moher, Danielle B Rice, Becky Skidmore, Kednapa Thavorn, Sheena Taha, Dianna Wolfe, Fatemeh Yazdi, Beth A Sproule, Melanie Willows, Patricia Poulin, Gary Garber, Amy Porath, Leila Esmaeilisaraji

“…Current clinical guidelines recommend that individuals with persons with opioid use disorder (OUD) receive pharmacological (eg, opioid agonist therapy) and psychosocial (eg, cognitive behavioural therapy) therapy; however, the best combination of pharmacologic and psychosocial components is not known. …”
Get full text

Purpose built catheters for minimally invasive surfactant therapy: Experience from a Canadian tertiary level neonatal intensive care unit by Talib Al Harthy, Michael R Miller, Orlando daSilva, Soume Bhattacharya

“…Canadian Journal of Respiratory Therapy…”
Get full text

New Prospective for the Management of Low-Risk Pulmonary Embolism: Prognostic Assessment, Early Discharge, and Single-Drug Therapy with New Oral Anticoagulants by Alessandro Squizzato

“…Finally, the main characteristics of new oral anticoagulant drugs and the most recent published data on phase III trials on PE suggest that the single-drug therapy is a possible suitable option. Oral administration, predictable anticoagulant responses, and few drug-drug interactions of direct thrombin and factor Xa inhibitors may further simplify PE home therapy avoiding administration of low-molecular-weight heparin.…”
Get full text

Hydration with Mannitol and Dextrose May Promote Cisplatin-Induced Nephrotoxicity: Test of Five Protocols of Hydration during Cisplatin Therapy in Rat Models by Mohammad-Sedigh Khosravi, Alireza Samimiat, Bahar Mazaheri, Farzaneh Ashrafi, Ardeshir Talebi, Mehdi Nematbakhsh

“…Cisplatin (CP) still is a novel choice for solid tumor therapy, but it is accompanied with the side effect of nephrotoxicity. …”
Get full text

Postural Dysfunction During Standing and Walking in Children With Cerebral Palsy: What are the Underlying Problems and What New Therapies Might Improve Balance? by Marjorie Hines Woollacott, Anne Shumway-Cook

Get full text

Induction Versus Noninduction Antiviral Therapy for Chronic Hepatitis C Virus in Patients with Congenital Coagulation Disorders: A Canadian Multicentre Trial by A Chatterjee, MG Swain, SS Lee, VG Bain, K Peltekian, K Croitoru, PC Adams, K Kaita, J Teitel, EJ Heathcote

“…BACKGROUND: Patients with congenital coagulation disorders and chronic hepatitis C virus (HCV) infection have multiple risk factors (ie, infection predominantly with genotype-1 HCV, long duration of the disease, HIV coinfection and male sex) for poor response to antiviral therapy. The present study compared induction therapy with interferon-alpha (IFN-α)-2b with standard IFN-α2b therapy. …”
Get full text

How effective is the addition of specific exercise therapy for patients after anterior cruciate ligament surgery? A systematic review and meta-analysis by Hao Zhou, Jia Qian, Yu-Mei Xing, Long Cui, Yi-Feng Bu

Subjects: “…exercise therapy…”
Get full text

Risk Factors Analysis of Cutaneous Adverse Drug Reactions Caused by Targeted Therapy and Immunotherapy Drugs for Oncology and Establishment of a Prediction Model by Zimin Zhang, Mingyang Zhu, Weiwei Jiang

Subjects: Get full text