Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study by Ana Molina, Nagore Ambrosio, María Molina, Eduardo Montero, Leire Virto, David Herrera, Elena Figuero, Mariano Sanz

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Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients: Role of Individual Genetic Background by Marzia Rigolli, Mariantonietta Cicoira, Corinna Bergamini, Andrea Chiampan, Andrea Rossi, Corrado Vassanelli

“…Due to interindividual heterogeneity in the benefits of therapy, it may be hypothesized that polymorphisms of neurohormonal systems may affect left ventricular (LV) remodelling and systolic function. …”
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Thulium laser enucleation of the prostate plus thulium fiber laser therapy for benign prostatic hyperplasia combined with bladder stones by Chen Wang, Yuanwei Li, Yongjun Yang, Junjie Chen, Zhuo Li, Guangqing Song, Jia Chen, Liu Zhe, Yili Teng, Qiang Lu

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Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation by Shushu Xue, Junrong Jiao, Si Miao, Lijun Wang, Yang Liu, Qingjie Zhang, Qiyue Wang, Yu Xi, Yuanyuan Zhang

“…Abstract Lung metastatic breast cancer (LMBC) leads to a large number of deaths in women with breast cancer, and radiotherapy has been considered the common assay for tumour therapy except for surgery. However, radiotherapy still faces problems of low efficiency due to resistance and easily induced side effects. …”
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Examining alternative approaches to antibiotic utilisation: A critical evaluation of phage therapy and antimicrobial peptides combination as potential alternatives by Chibuzo Vincent Alisigwe, Chibuzor Stanley Ikpa, Uchenna Joseph Otuonye

“…However, concerns about phage evolution potentially eliciting human immune responses necessitate additional investigation to enhance phage therapy. The issue of safety also extends to the recommended purification of AMPs when used in conjunction with bacteriophages to prevent adverse immune reactions in patients. …”
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Early detection of myocarditis caused by immune checkpoint inhibitor therapy with nivolumab and ipilimumab for advanced recurrent renal cell carcinoma by Maki Todo, Yodo Gatate, Shintaro Nakano, Go Kaneko, Masayuki Hagiwara, Takayuki Takahashi, Yuta Umezawa, Genji Ueda, Shiho Ishikawa, Yoshinori Makino, Masafumi Oyama, Suguru Shirotake

“…Abstract Combination therapy with nivolumab and ipilimumab for advanced renal cell carcinoma (RCC) may cause immune-related myocarditis; however, its incidence in this cancer type and regimen remains unknown. …”
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Short-term Effectiveness of High-intensity Laser Therapy in De Quervain Tenosynovitis: A Prospective, Randomized, Controlled Study by Emine DUNDAR AHI, Hulya SIRZAI2

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Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis by Yiming Zhao, Qifan Luo, Xiao Zhang, Yafei Qin, Jingpeng Hao, Dejun Kong, Hongda Wang, Guangming Li, Xiangying Gu, Hao Wang

“…Current treatment was still limited, and stem cell-based therapy has been proposed as a novel strategy for management of AS. …”
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18F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns by Sanjay Chandrasekaran, Andrew Hollander, Xiangsheng Xu, Joseph L. Benci, James J. Davis, Jay F. Dorsey, Gary Kao

“…These studies were undertaken to investigate the effectiveness of 18F-FLT-PET in a GBM mouse model, especially after radiation therapy (RT), and its correlation with useful biomarkers, including proliferation and DNA damage. …”
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Combined Therapy of Catheter Ablation and Left Atrial Appendage Closure for Patients with Atrial Fibrillation: A Case-Control Study by Bin-Feng Mo, Jian Sun, Peng-Pai Zhang, Wei Li, Mu Chen, Jia-Li Yuan, Yi Yu, Qun-Shan Wang, Yi-Gang Li

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Investigating the significance of SPECT/CT-SUV for monitoring 177Lu-PSMA-targeted radionuclide therapy: a systematic review by Tahani O. Alkahtani

Subjects: “…Targeted radionuclide therapy…”
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Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials by Tyler Pitre, Daniel Lupas, Jasmine Mah, Matthew Stanbrook, Alina Blazer, Dena Zeraatkar, Terence Ho

“…However, in the subgroup of patients with blood eosinophils ≥300/mcL, both tezepelumab (MD 0.15 [95% CI 0.05 to 0.26]) and dupilumab (MD 0.13 [95% CI 0.06 to 0.19]) probably improved FEV1 above the MCID.Conclusion Dupilumab is effective at improving patient-relevant outcomes in COPD with higher eosinophil levels. Other biological therapies, including tezepelumab, have no important effect on patient-relevant outcomes.…”
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Cost-effectiveness of oral versus injectable disease modifying therapies in relapsing multiple sclerosis: a systematic review analysis by Mehdi Rezaee, Ramin Ravangard, Seyyed Morteza Mojtabaeian, Abdosaleh Jafari

“…Results Thirty studies that had conducted the economic analysis of oral versus injectable therapies in MS patients were included in this review. …”
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Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy by Peter Gee, Huaigeng Xu, Akitsu Hotta

“…In this review, we highlight recent advances made using the CRISPR Cas9 system to correct genetic mutations and discuss how emerging CRISPR technologies and iPSCs in a combined platform can play a role in bringing a therapy for DMD closer to the clinic.…”
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Applying Focal Therapy to Lesions Detected via Magnetic Resonance Imaging: Delivering Cancer Ablation Beyond the Visibility Phenomenon by Clement Orczyk, Teresa Marsden, Francesco Giganti, Joseph M. Norris, Santosh Waigankar, Louise Dickinson, Shonit Punwani, Alex Kirkham, Alex Freeman, Aiman Haider, Caroline M. Moore, Arnauld Villers, Clare Allen, Mark Emberton

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Abdominal obesity as a predictor for response to anti-vascular endothelial growth factor therapy in patients with diabetic macular edema by Tamer E. Wasfy, Shaimaa S. Soliman, Nehad Hawash, Elham A. Gad

“…Anti-vascular endothelial growth factor (anti-VEGF) therapy has been widely used to treat DME. Obesity is associated with higher levels of circulating VEGF, which may worsen diabetic retinopathy and hinder the response to anti-VEGF therapy. …”
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Oral probiotic extracellular vesicle therapy mitigates Influenza A Virus infection via blunting IL-17 signaling by Hongxia Zhou, Wenbo Huang, Jieting Li, Peier Chen, Lihan Shen, Wenjing Huang, Kailin Mai, Heyan Zou, Xueqin Shi, Yunceng Weng, Yuhua Liu, Zifeng Yang, Caiwen Ou

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Hereditary vitamin D resistant rickets (HVDRR) case series: phenotype, genotype, conventional treatment, and adjunctive cinacalcet therapy by Noman Ahmad, Sundus A. Ansari, Nabil A. Aleysae, Emily L.G. Heaphy, Mrouge M. Sobaihi, Balgees A. Alghamdi, Ali S. Alzahrani

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Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy by Qian Luo, Honghu Li, Wei Shan, Cong Wei, Yan Long, Shuyang Cai, Xiangjun Zeng, Xue Li, Yulin Xu, Xiaoxiao Xu, Yi Luo, Pengxu Qian, He Huang

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Role of Traditional Cardiovascular Risk Factors after Initiation of Statin Therapy: A PharmLines Inception Cohort Study by Dennis Steenhuis, Stijn de Vos, Jens Bos, Eelko Hak

“…Nowadays, millions receive such therapy for the primary prevention of cardiovascular events (CVE). …”
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