Congestive heart failure adherence redesign trial: a pilot study by Ashvarya Mangla, Rami Doukky, Lynda H Powell, Elizabeth Avery, DeJuran Richardson, James E Calvin

“…We hypothesised that providing individualised self-management support to patients and feedback on use of evidence-based HF therapies (EBT) to physicians could lead to improvements in care and decrease hospitalisations. …”
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Metastatic pancreatic cancer now in remission: a case report and literature review by Charles W. Shi, Thomas J. VanderMeer, Anita Pudusseri

“…Overall, barring clear availability for targeted therapies, a metastatic PDAC of the tail may be considered to have a better prognosis than previously considered. …”
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Integrated Management of Cardiovascular–Renal–Hepatic–Metabolic Syndrome: Expanding Roles of SGLT2is, GLP-1RAs, and GIP/GLP-1RAs by Nikolaos Theodorakis, Maria Nikolaou

“…By synthesizing evidence from landmark clinical trials, we highlight the paradigm-shifting potential of these therapies. SGLT2is, such as dapagliflozin and empagliflozin, have emerged as cornerstone guideline-directed treatments for heart failure (HF) and chronic kidney disease (CKD), providing benefits that extend beyond glycemic control and are independent of diabetes status. …”
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Assessment of the healing properties of Cichorium intybus L. extracts on wounds by Berivan Kaçmaz, Duygu Misirli, Seçil Erden Tayhan, Zafer Ömer Özdemir, Mahfuz Elmastaş

“…Further investigation into active chemicals and mechanisms contributing to its wound healing properties is needed, potentially leading to advancements in wound healing therapies.…”
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Ascitic Fluid in Ovarian Mass with Special Reference to Paired-box Gene 8 Immunoexpression: A Cross-sectional Analysis by Prabhat Mahato, Chhanda Das, Rama Saha, Ankita Pranab Mandal, Gourisankar Kamilya

“…Conclusion: An evaluation of PAX8 status in ascitic fluid cellblock study should be considered for high-grade ovarian cancers in patients who may benefit from targeted therapies. Patients with ovarian mass and ascites can be evaluated for PAX8 status in their ascitic fluid cytology study for the purpose of neoadjuvant chemotherapy.…”
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COVID-19 Infection Clinical Profile, Management, Outcome, and Antibody Response in Kidney Transplant Recipients: A Single Centre Experience by Sanjiv Jasuja, Gaurav Sagar, Anupam Bahl, Shalini Verma

“…Significant mortality (p<0.001) was observed in patients presenting with SpO2 <94 needing ICU care, ventilation, dialysis/acute kidney injury (AKI), and empirical therapies like convalescent plasma and remdesivir. …”
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Transitioning from wet lab to artificial intelligence: a systematic review of AI predictors in CRISPR by Ahtisham Fazeel Abbasi, Muhammad Nabeel Asim, Andreas Dengel

“…This groundbreaking technology holds immense potential for the development of targeted therapies for a wide range of diseases, including cancers, genetic disorders, and hereditary diseases. …”
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Learned phenotypes emerge during social stress modifying hippocampal orexin receptor gene expression by Jazmine D. W. Yaeger, Justin K. Achua, Clarissa D. Booth, Delan Khalid, Megan M. John, Leighton J. Ledesma, Trent L. Greschke, Ashley M. Potter, Chase B. Howe, Kevin T. Krupp, Justin P. Smith, Patrick J. Ronan, Cliff H. Summers

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From Night to Light: A Bibliometric Analysis of the Global Research Trajectory of Sleep Disorders in Parkinson&rsquo;s Disease by Shi L, Zhao X, Wu J, He C

“…Emerging trends involve comprehensive evaluations of sleep, early diagnosis and prevention of various sleep disorder subtypes in PD, and advancing research through animal models to develop effective therapies. Emerging keywords include machine learning, sleep quality, biomarkers, covid-19, and mouse model.Conclusion: This bibliometric analysis sheds light on the global landscape of PD-related sleep disorder research over the past two decades, highlighting key countries, institutions, authors, and journals driving advancements in the field. …”
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Endoplasmic reticulum protein TXNDC5 modulates thyroid eye disease TGF-β1-induced myofibroblast transdifferentiation by Albert Y Wu, Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai

“…Aim There remain limited therapies to treat thyroid eye disease (TED) orbital fibrosis, highlighting the urgency to develop novel targets. …”
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Phytomedicine nanoformulations for Parkinson's disease by Chinthu V. Saji, K P Mohanakumar, Rajesh A Shenoi

“…This highlights the need for disease-modifying therapies. In recent years, attentions of both clinicians and patients have shifted to herbal medicines that are rich source of bioactive compounds with therapeutic potential to target multiple pathways involved in PD pathology. …”
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Tools used to measure quality of life in adults with cystic fibrosis– a systematic review by Dorota Snop-Perkowska, Jakub Świtalski, Katarzyna Wnuk, Paweł Olszewski, Anna Augustynowicz

“…Abstract Background Measuring the quality of life in patients with cystic fibrosis is important, both in terms of assessing the implementation of new therapies and monitoring their effects, as well as the ongoing evaluation of patients’ condition. …”
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Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles by Yuqi Song, Fengrui Liang, Weikun Tian, Erin Rayhill, Liping Ye, Xinghan Tian

“…Despite the potential of MSC-EVs, this review also acknowledged the limitations of traditional MSC therapies and advocates for a strategic pivot towards exosome-based modalities to enhance therapeutic outcomes. …”
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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…Our results contribute new knowledge to the growing field focused on developing targeted therapies for diseases caused by epigene mutations, such as chromatinopathies and cancers.…”
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Role of controlled radial expansion balloon bronchoplasty in benign subglottic and tracheal stenosis by Jeetendra Kumar Patra, Chinmaya Sundar Ray, Manoranjan Pattnaik, Subrat Kumar Behera

“…It can serve as either a standalone treatment or an adjunct to other therapies for managing benign subglottic and tracheal stenosis.…”
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Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models by Luisa Maria Nieto Ramirez, Carolina Mehaffy, Karen Marie Dobos

“…Identifying early innate immune mediators and targetable pathways in the blood and affected tissues could identify biomarkers for immunization efficiency, disease progression, and potential synergistic therapies for ATB.…”
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Traditional Chinese medicine trade among RCEP countries: structural characteristics and determinants by Yue Fang, Yue Fang, Meng Xue Tang, Xu Liu

“…BackgroundWith the increasing global focus on health and the growing popularity of natural therapies, Traditional Chinese Medicine (TCM) products, including extracts, crude drugs, and herbal preparations, are widely utilized as both primary and complementary medicines worldwide. …”
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Lived experiences of people with chronic kidney disease on maintenance dialysis: a systematic review and thematic synthesis of qualitative studies by Maya Annie Elias, Wim Van Damme, Grace Marie V Ku, Mahesh Kadammanavar, Edwin Wouters

“…People with the most advanced stage of CKD require renal replacement therapies, either dialysis (the focus of this study) or a kidney transplant. …”
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NT5E (CD73) as a prognostic biomarker and therapeutic target associated with immune infiltration in lung adenocarcinoma by Leyan Chen, Tuoya Qi, Bishu Zhang, Xuelong Wang, Mingfeng Zheng

“…Additionally, drug sensitivity analysis highlights the potential of selumetinib and PD318088, both MEK1/2 inhibitors, to target NT5E in LUAD treatment, suggesting their use as single agents or in combination with other therapies. Collectively, these findings establish NT5E as a promising prognostic biomarker and therapeutic target in LUAD, particularly in the context of immune cell infiltration.…”
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Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction by Li T, Yang B, Liu X, Shi D, Wang Z, Chen Y, Shen C

“…Despite extensive research, no clinical therapies effectively target ferroptosis in IR injury. …”
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