Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors by Jennifer Blaze, Viviana Dolores Evans, Jessica Abigail Feria Pliego, Petr Unichenko, Behnam Javidfar, Soeren Heissel, Hanan Alwaseem, Zachary Pennington, Denise Cai, Henrik Molina, Christian Henneberger, Schahram Akbarian

“…Background: The presence of treatment resistance in neuropsychiatric disease suggests that novel mechanism-based discoveries and therapies could benefit the field, with a viable candidate being transfer RNA (tRNA) epitranscriptomics. …”
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Measurable residual disease as predictor of post–day +100 relapses after allografting in adult AML by Naveed Ali, Megan Othus, Eduardo Rodríguez-Arbolí, Corentin Orvain, Filippo Milano, Brenda M. Sandmaier, Chris Davis, Ryan S. Basom, Frederick R. Appelbaum, Roland B. Walter

“…Thus, despite high MRD conversion rates, outcomes MRD positive/MRD negative (MRDneg) patients are inferior to those of MRDneg/MRDneg patients, suggesting all patients with pre-HCT MRD should be considered for preemptive therapies after allografting.…”
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Human umbilical cord derived-mesenchymal stem cells alleviate lipid metabolism disturbances of hepatocytes via mitochondrial transport by Jing Xue, Xiangnan Hu, Suying Xia, Pengfei Ren, Aihong Wang

“…Conclusion: UC-MSCs improve lipid metabolism in HepG2 cells through TNT mediated mitochondrial transport, indicating that mitochondria transfer-based therapies may be an innovative and promising therapeutic strategy for NAFLD.…”
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Expression of some circulating microRNAs as predictive biomarkers for prognosis and treatment response in glioblastoma by Elham Ali, Marwa Adel Ahmed, May A. Shawki, Lobna R. Ezz El Arab, Mohamed K. Khalifa, Menha Swellam

“…It is characterized by genetic heterogeneity, and an infiltrative nature, and GBM treatment is highly challenging. Despite multimodal therapies, clinicians lack efficient prognostic and predictive markers. …”
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Humoral and Cellular Immunity After Vaccination Against SARS-CoV-2 in Relapsing-Remitting Multiple Sclerosis Patients Treated with Interferon Beta and Dimethyl Fumarate by Marcin Bazylewicz, Monika Zajkowska, Monika Gudowska-Sawczuk, Rafał Kułakowski, Jan Mroczko, Dagmara Mirowska-Guzel, Joanna Kulikowska-Łoś, Agata Czarnowska, Barbara Mroczko, Jan Kochanowicz, Alina Kułakowska

“…Further clarification could help address medical concerns related to the use of immunosuppressive and immunomodulatory medications, known as disease-modifying therapies (DMTs), in PwMS, as well as ensure adequate protection against severe outcomes of COVID-19. …”
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HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007) by Raj Kalkeri, Junzhong Peng, Chunsheng Huang, Zhaohui Cai, Roger G. Ptak, Mark J. Suto

“…However, despite the availability of potent nucleoside/tide inhibitors, currently there are no curative therapies for chronic HBV infections. To identify potential new antiviral molecules, a select group of compounds previously evaluated in clinical studies were tested against 12 different viruses. …”
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Microvascular decompression: a contemporary update by Inibehe Ime Okon, Sidharth Sunil Menon, Mahmoud Osama, Maidan Aiman, Luis F. Fabrini Paleare, Don Lucero-Prisno Eliseo, Muhammad Danish Shafqat, Chizowa Okwuchukwu Ezeaku, Márcio Yuri Ferreira, Youssef Razouqi, Marianna Kapsetaki, Jovy Dia Remolino Saniel, Naneta M. Panit, Asad Gul Rao, Umer Iqbal, Daniel David Otobo, Ibraheem M. Alkhawaldeh, Felipe Salvagni Pereira, Imad Akbar, Omar Kasimieh, Bipin Chaurasia

“…Emerging innovations such as robotic-assisted MVD and gene therapies for cranial nerve disorders, including TN and GPN, promise even greater efficacy and precision. …”
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Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults by Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu, Eiji Funayama, Yuki Maruyama, Toshiaki Tsurui, Kohei Tajima, Aya Sasaki, Yoshitaka Yamazaki, Ryota Nakano, Yutaka Sano, Atsushi Ishida, Tatsuya Nakanishi, Seiji Mochizuki, Yuri Yoshizawa, Sumito Kumagai, Sakiko Yasuhara, Kakei Ryu, Tatsunori Oguchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takehiko Sambe, Sei Kobayashi, Naoki Uchida

“…This study revealed a genome–microbiome interaction within the resident microbiota of the external auditory canal that may help to elucidate the pathogenesis of ear diseases and develop novel therapies.IMPORTANCEThe ABCC11 gene polymorphism, which determines earwax characteristics, regulates the composition of the ear canal microbiota and its metabolic pathways. …”
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Advances and Pitfalls of Specialized Pain Care through Public and Private Health Care Providers in Catalonia and the Balearic Islands: A Physician’s Survey by Javier Medel, Ancor Serrano, Carme Batet, Lluis Lorente, Susana Bella, Marta Ferrandiz, María-del-Mar Monerris, Sergi Boada, Jesus Villoria, Maria-Victoria Ribera, Antonio Montes, Sebastian Videla

“…They offered a wide range of pharmacological and interventional therapies, although psychotherapy and the most sophisticated procedures were only available in ≤50% of sites. …”
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Peripheral blood age-sensitive immune markers in multiple sclerosis: relation to sex, cytomegalovirus status, and treatmentResearch in context by Haritha Desu, Renaud Balthazard, Audrey Daigneault, Sandra Da Cal, Wendy Klément, Jennifer Yu, Marie-Laure Clénet, Clara Margarido, Annie Levert, Canisius Fantodji, Olivier Tastet, Jean-Marc Girard, Pierre Duquette, Alexandre Prat, Gabrielle Macaron, Marie-Claude Rousseau, Nathalie Arbour, Catherine Larochelle

“…How MS and disease-modifying therapies (DMTs) impact age-sensitive immune biomarkers is only partially understood. …”
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ERBB3-related gene PBX1 is associated with prognosis in patients with HER2-positive breast cancer by Shufen Mo, Haiming Zhong, Weiping Dai, Yuanyuan Li, Bin Qi, Taidong Li, Yongguang Cai

“…Increased ERBB3 expression has been implicated as a potential cause of resistance to other HER-targeted therapies. Our study aimed to screen and validate prognostic markers associated with ERBB3 expression by bioinformatics and affecting the prognosis of HER2 staging. …”
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Management of Inflammatory Bowel Disease during Pregnancy and Breastfeeding Varies Widely: A Need for Further Education by Vivian Wai-Mei Huang, Hsiu-Ju Chang, Karen Ivy Kroeker, Karen Jean Goodman, Kathleen M. Hegadoren, Levinus Albert Dieleman, Richard Neil Fedorak

“…Women with IBD require maintenance therapies during pregnancy and breastfeeding. However, physician management of IBD during pregnancy and breastfeeding has not been well characterized. …”
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Deletion of cyclin dependent kinase inhibitor 2a gene as a marker of oropharyngeal carcinomas non-associated with human papillomavirus and its prognostic value by I.S. Shponka, Bondarenko O.O. Bondarenko ч, O.V. Kovtunenko, V.V. Rakhmanov

“…However, prognostic evaluation for non-papillomavirus-associated oropharyngeal squamous cell carcinoma remains a problem that could be solved through the molecular mechanisms of squamous cell carcinoma for the purpose of further development of target therapies. Detection of cyclin dependent kinase inhibitor 2a gene deletion in oropharyngeal squamous cell carcinomas can have clinical significance as it may serve as a prognostic marker and potentially guide treatment decisions. …”
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Healthcare Futures: Opportunities, Challenges and Risks in a Blockchain-Driven Environment by Robert Goldberg, Peter J. Pitts, Jennifer Hinkel

“…Traditional financial mechanisms struggle to capture the downstream savings generated by new therapies, particularly as insurers and health systems face the challenge of managing short-term costs while realizing long-term health benefits. …”
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Achieving Medication‐Free Remission in Patients With Juvenile Dermatomyositis by Ilaria Maccora, Hermine I. Brunner, Amy Cassedy, Mekibib Altaye, Megan Quinlan‐Waters, Daniel J. Lovell, Alexei Grom, Sheila T. Angeles‐Han

“…MFR was defined as inactive JDM after discontinuation of all systemic immunosuppressives for ≥6 months, in line with international consensus guidelines for trials of therapies in idiopathic inflammatory myopathies. A two‐sided P < 0.05 was considered statistically significant. …”
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Therapeutic Effect of Traditional Chinese Medicine on a Rat Model of Branch Retinal Vein Occlusion by Pan Long, Weiming Yan, Jianwen Liu, Manhong Li, Tao Chen, Zuoming Zhang, Jing An

“…Currently, the general strategies for BRVO are symptomatic therapies. Cardiovascular aspects are essential risk factors for BRVO. …”
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A qualitative systematic review of umbilical cord care practices in Nigeria by Precious Ebube Anyakorah, Florence Chinelo Aguna, David Chinaecherem Innocent, Anthony Chinonso Uwandu-Uzoma, Uzochukwu Godswill Ekeleme, Chidera Chisom Obasi, Stanley Chinedu Eneh, Chidinma Peace Ahunam, Ihuoma Chimdimma Dike, Vivian Chidimma Maduekwe, Oluwaseunayo Deborah Ayando, Chinazaekpere Oguguo Duruji, Rejoicing Chijindum Innocent, Princess Chidiebube Uwaezuoke, Oluwafunmilayo Opeyemi Adenuga, Chiagoziem Ogazirilem Emerole

“…Infections continue to be a problem, highlighting the significance of appropriate therapies. Conclusion This systematic review offers a comprehensive perspective of Nigerian umbilical cord care practices, emphasizing the importance of culturally responsive educational interventions, enhanced healthcare infrastructure, and targeted legislative measures. …”
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Transcriptional signature of CD56bright NK cells predicts favourable prognosis in bladder cancer by Md Abdullah Al Kamran Khan, Alexander James Sedgwick, Yuhan Sun, Julian P. Vivian, Julian P. Vivian, Julian P. Vivian, Alexandra J. Corbett, Riccardo Dolcetti, Riccardo Dolcetti, Riccardo Dolcetti, Theo Mantamadiotis, Theo Mantamadiotis, Stefano Mangiola, Stefano Mangiola, Stefano Mangiola, Alexander David Barrow

“…Our findings facilitate a better understanding of the NK cell anti-tumour responses that may ultimately lead to the development of promising NK and T cell-based therapies for BLCA.…”
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The role of Latin America medicinal plants in wound healing by Mariana Sánchez-Ramos, Andrea Ruiz-Betancourt, Stephany Abigail Tadeo-Cuenca, Angélica Román-Guerrero, María Crystal Columba-Palomares, Araceli Guerrero-Alonso, Antonio Bernabé-Antonio, Deyanira Ojeda-Ramírez, Francisco Cruz-Sosa

“…At a biological level, wound healing involves a complex mechanism in which the immune system and cellular biochemical cascades intervene in a coordinated manner, whose development occurs in stages such as inflammation, proliferation, and remodeling. Therefore, therapies have been developed to accelerate wound healing and have proven effective. …”
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Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context by Podjanee Jittamala, Simon Boyd, William H.K. Schilling, James A. Watson, Thundon Ngamprasertchai, Tanaya Siripoon, Viravarn Luvira, Elizabeth M. Batty, Phrutsamon Wongnak, Lisia M. Esper, Pedro J. Almeida, Cintia Cruz, Fernando R. Ascencao, Renato S. Aguiar, Najia K. Ghanchi, James J. Callery, Shivani Singh, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, Borimas Hanboonkunupakarn, Kittiyod Poovorawan, Manus Potaporn, Attasit Srisubat, Bootsakorn Loharjun, Walter R.J. Taylor, Farah Qamar, Abdul Momin Kazi, M. Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P.J. Day, Mauro M. Teixeira, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White

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