The Therapeutic Effect of Nordic Walking on Freezing of Gait in Parkinson’s Disease: A Pilot Study by Agata Wróblewska, Agata Gajos, Urszula Smyczyńska, Andrzej Bogucki

“…The effectiveness of the currently utilized therapies for FoG is limited. Several studies demonstrated a beneficial impact of Nordic walking (NW) on several gait parameters in Parkinson’s disease, but only one paper reported reduction of freezing. …”
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Identification and mechanistic insights of cell senescence-related genes in psoriasis by Guiyan Deng, Cheng Xu, Dunchang Mo

“…Conclusions This study identified and validated key senescence-related genes involved in psoriasis, providing insights into their molecular mechanisms and potential therapeutic targets and offering a foundation for developing targeted therapies for psoriasis.…”
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Costs of Potential Medication Wastage Due to Switching Treatment Among People With Multiple Sclerosis by Darin T. Okuda, Achal Patel, Robert Schuldt, Ibraheem Abioye, Nicole G. Bonine

“…People with multiple sclerosis (PwMS) commonly switch disease-modifying therapies (DMTs), leading to medication wastage and substantial costs for insurers and patients. …”
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High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery. by Nathalie Aulner, Anne Danckaert, Eline Rouault-Hardoin, Julie Desrivot, Olivier Helynck, Pierre-Henri Commere, Hélène Munier-Lehmann, Gerald F Späth, Spencer L Shorte, Geneviève Milon, Eric Prina

“…No vaccine is available and numerous factors limit the use of current therapies. There is thus an urgent need for innovative initiatives to identify new chemotypes displaying selective activity against intracellular Leishmania amastigotes that develop and proliferate inside macrophages, thereby causing the pathology of leishmaniasis.…”
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Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation by Li Lu, Li Zhitao, Cui Nannan, Huang Mingzhu, Hu Xiaoping, Hong Dongsheng, Pan Zongfu, Lu Xiaoyang

“…Our data contribute to understanding diabetes pathogenesis and offer potential new targets for β cell regeneration therapies.…”
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Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution? by Zirintunda, Gerald, Biryomumaisho, Savino, Keneth Iceland, Kasozi, Batiha, Gaber El-Saber, Kateregga, John, Vudriko, Patrick, Nalule, Sarah, Olila, Deogracious, Mariam Kajoba, Mariam, Matama, Kevin, Kwizera, Mercy Rukundo, Ghoneim, Mohammed M., Abdelhamid, Mahmoud, Alshehri, Sultan, Abdelgawad, Mohamed A., Acai-Okwee, James, Zaghlool, Sameh S.

“…Pharmaceutical studies on plants as alternative therapies for the control of helminthparasites have not been fully explored especially in several developing countries. …”
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Rauwolfia vomitoria- a promising medical plant for benign prostatic hyperplasia management; yet with challenges by George Awuku Asare, Perpetua Dagadu, Samuel Adjei, Bernice Asiedu, Samkeliso Takaidza, Vivash Naidoo, Brodrick Amoah, Ifeoma Celestina Orabueze, Kwasi Bugyei

“…Although conventional allopathic treatments are widely used for managing BPH, they are frequently associated with adverse side effects, prompting a global shift toward natural and alternative therapies. This study aims to investigate the therapeutic effects of Rauwolfia vomitoria Aqueous Root Extract (RVARE) as a potential natural oral treatment for BPH. …”
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Denervation procedure of the lateral epicondyle for refractory lateral epicondylitis by Misty Suri, MD, MS, Arjun Verma, BS, Collyn O’Quin, MD, Gregory Parker, MD, Kareem Mohamed, MD, Hunter Starring, MD, Daniel Yoo, MD

“…Inclusion criteria for surgery were a minimum of 6 months symptom duration refractory to conservative therapies, a minimum of 2 years clinical follow-up, and significant (70-80%) pain relief from the nerve block test. …”
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Hematopoietic stem cell discovery: unveiling the historical and future perspective of colony-forming units assay by Nur Afizah Yusoff, Zariyantey Abd Hamid, Siti Balkis Budin, Izatus Shima Taib

“…Since then, HSCs have been studied and utilized in medical therapies and research for over several decades. Over time, more sophisticated tools have been developed to evaluate the behaviour of specifically purified subsets of hematopoietic cells that have the capacity to produce blood cells. …”
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Lipoprotein(a) and thromboembolism: current state of knowledge and unsolved issues by Małgorzata Konieczyńska, Joanna Natorska, Michał Ząbczyk, Anetta Undas

“…Targeted Lp(a) lowering therapies are currently being tested in randomized clinical trials and could potentially have clinically relevant antithrombotic effects, evidenced by the reduced risk of thromboembolism. …”
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Epidemiology and management of atopic dermatitis in England: an observational cohort study protocol by Simon de Lusignan, Carsten Flohr, John Dennis, Helen Alexander, Conor Broderick, Andrew McGovern, Claire Feeney

“…We will describe contemporary treatment by estimating prescribing rates across medication classes used in AD (emollients, topical corticosteroids by potency, topical calcineurin inhibitors, topical antimicrobials, antihistamines, oral corticosteroids and systemic immunomodulatory therapies) overall, and by age and sociodemographic groupings. …”
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Variational Approaches for Drug-Disease-Gene Links in Periodontal Inflammation by Pradeep Kumar Yadalam, Prabhu Manickam Natarajan, Musab Hamed Saeed, Carlos M. Ardila

“…This could lead to more targeted therapies for oral diseases like periodontitis, improving patient outcomes and advancing personalized treatment strategies in clinical practice.…”
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Engineering aortic valves via transdifferentiating fibroblasts into valvular endothelial cells without using viruses or iPS cells by Peng Tang, Fuxiang Wei, Weihua Qiao, Xing Chen, Chenyang Ji, Wanzhi Yang, Xinyu Zhang, Sihan Chen, Yanyan Wu, Mingxing Jiang, Chenyu Ma, Weiqiang Shen, Qi Dong, Hong Cao, Minghui Xie, Ziwen Cai, Li Xu, Jiawei Shi, Nianguo Dong, Junwei Chen, Ning Wang

“…This approach provides possibilities for cell replacement therapies and drug screening, but the potential risk of tumorigenesis hampers its further development and in vivo application. …”
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Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver DiseasesSummary by Lan Zhou, Min Yan, Qin Luo, Wen Qiu, Yu-Ru Guo, Xiao-Qing Guo, Hong-Bin Yu, Jing-Ru Huo, Yan-Lin Feng, De-Ping Wang, Teng Sun, Kai-Fang Wang, Jian-Yun Shi, Xuan Shang, Mei-Na Wu, Lin Wang, Ji-Min Cao

“…This study explores the mechanisms underlying CRSDs in CLDs and novel therapies. Methods: We monitored the sleep of patients with CLD using actigraphic watch and established male mouse cholemia models by feeding with BA or bile duct ligation. …”
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Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation by Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng

“…These findings offer insights for developing novel PAH therapies and diagnostics.…”
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Relationship between muscle activation and sagittal knee joint biomechanics in patients with patellofemoral pain syndrome: a cross-sectional study by Byung Sun Choi, Soon Bin Kwon, Sehyeon Jeon, Myeongjun Kim, Yunseo Ku, Du Hyun Ro, Hyuk-Soo Han

“…These results highlight altered neuromuscular adaptations in PFPS, suggesting targeted therapies may help improve functional outcomes. Level of evidence III, cross-sectional study…”
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Evaluating implementation of a hospital‐based cancer registry to improve childhood cancer care in low‐ and middle‐income countries by Melissa R. Maas, Allison Yang, Michele A. Muir, James B. Collins IV, Courtney Canter, Gevorg Tamamyan, Inam Chitsike, Francine Kouya, Kim Hoa Nguyen, Alia Ahmad, Ana Patricia Alcasabas, Yi‐Jin Gao, Kimberly J. Johnson, Gia Ferrara, Nickhill Bhakta, Benyam Muluneh

“…While treatable with modern therapies, children living in low‐ and middle‐income countries (LMICs) have limited access to care and lower survival rates. …”
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Canadian healthcare capacity gaps for disease-modifying treatment in Huntington’s disease: a survey of current practice and modelling of future needs by Sylvain Chouinard, Blair R Leavitt, Angèle Bénard, Nathalie Budd, Jennifer W Wu, Kerrie Schoffer

“…Objectives Disease-modifying therapies in development for Huntington’s disease (HD) may require specialised administration and additional resource capacity. …”
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Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study by Antonio Romanelli, Renato Gammaldi, Alessandro Calicchio, Salvatore Palmese, Antonio Siglioccolo

“…Further studies are needed to clarify the relationship between Quantra parameters and laboratory tests in the critical care setting and the role of sonorheometry in guiding targeted therapies and improving outcomes.…”
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EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8+ T cell dysfunction in neuroblastoma by Di Li, Meng Li, Zhenjian Zhuo, Huiqin Guo, Weixin Zhang, Yile Xu, Hai-Yun Wang, Jiabin Liu, Huimin Xia, Huiran Lin, Jue Tang, Jing He, Lei Miao

“…Modulating NB-associated GD3 levels through metabolic intervention is beneficial for tuning the depth and duration of responses to current NB therapies. The integration of transcriptomic and lipidomic data offers a more comprehensive understanding of the interaction between LacCer metabolites and the immune status in NB. …”
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