Magnetic Resonance Thermometry of Focused Ultrasound Using a Preclinical Focused Ultrasound Robotic System at 3T by Antria Filippou, Nikolas Evripidou, Andreas Georgiou, Leonidas Georgiou, Antreas Chrysanthou, Cleanthis Ioannides, Christakis Damianou

“…Aim: Focused ultrasound (FUS) therapies are often performed within magnetic resonance imaging (MRI) systems providing thermometry-based temperature monitoring. …”
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The Role of Intraarterial Chemotherapy in the Management of Retinoblastoma by Aleksandra Pekacka

“…Future work should focus on conducting larger prospective studies with longer follow-up. Multiple novel therapies for the management of retinoblastoma are currently being tested, including angiogenic inhibitors and targeted agents. …”
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Prevalence and Associated Factors of Depressive Symptoms in Patients with Myasthenia Gravis: A Cross-Sectional Study of Two Tertiary Hospitals in Riyadh, Saudi Arabia by Mohammed H. Alanazy

“…Data were collected with a two-part standardized questionnaire: the first part included data on sociodemographic and clinical features of MG including disease type and duration, therapies, prednisolone dose, time of the last relapse, previous critical care unit admissions, MG status (controlled, partially controlled, or uncontrolled), and comorbid diseases; the second part included items from the previously validated Arabic version of the Patient Health Questionnaire-9 (PHQ-9). …”
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The Estimation of Cementoenamel Junction Crestal Bone Distance in Mandibular Anterior Teeth by Ahmed AS, Ali BJ, Hassan BK, Sabah Mohammad A

“…This data is essential for developing orthodontic, implant, and periodontal therapies.Keywords: alveolar bone crest, canines, cementoenamel junction, central incisors, cone-beam computed tomography, lateral incisors…”
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A multivalent binding model infers antibody Fc species from systems serology. by Armaan A Abraham, Zhixin Cyrillus Tan, Priyanka Shrestha, Emily R Bozich, Aaron S Meyer

“…Knowing these antibody features is important for both understanding how effector responses are naturally controlled through antibody Fc structure and designing antibody therapies with specific effector profiles. Here, we address this limitation by modeling the molecular interactions occurring in these assays and using this model to infer quantities of specific antibody Fc species among the antibodies being profiled. …”
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Intravenous thrombolysis prevents neurological deterioration in patients with acute pontine infarction by Zhenxiao Chai, Weili Chen, Yichan Ye, Mengwan Song, Lingling Lin, Dongdong Lin, Xuerong Huang, Lifen Chi, Ruyue Huang

“…Patients' clinical characteristics, laboratory findings, and outcomes were analyzed to determine the efficacy and safety of IVT.ResultsOf 211 study patients (median age, 67 years [interquartile range, 57–75 years]; 132 [62.6%] men), 74 received IVT; 137 patients did not receive IVT, but accepted other antithrombotic therapies, including antiplatelet or anticoagulant drugs. …”
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Outcome of spine surgery in the context of spinal metastatic disease: The National Surgical Quality Improvement Program by Salim M. Yakdan, Maya Herrera, Nour Wehbe, Monifa Al Akoum, Muhammad Irfan Kaleem, Miguel A. Ruiz-Cardozo, Karan Joseph, Nada Assaf, Hani Dimassi

“…Despite poor overall survival, recent advances in targeted therapies and minimally invasive surgical techniques have made surgery a more viable option for managing metastatic spine disease. …”
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Enhancement effect of urea toward electroporation-mediated plasmid transfection efficiency in the HEK-293 cell line by Mahshid Mowla, Gilar Gorji-Bahri, Hamid Reza Moghimi, Atieh Hashemi

“…Although many molecular tools have been created for cell-based gene therapies, it remains challenging to introduce external molecules into cells. …”
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A scoping review of the contralateral effects of unilateral peripheral stimulation on neuromuscular function. by Shi Zhou, Shuang-Shuang Zhang, Zachary J Crowley-McHattan

“…The findings suggest a need to enhance the awareness of cross-education caused by peripheral stimulation, to help improve the translation of theoretical concepts to clinical practice, and aid in developing well-designed clinical trials to determine the efficacy of cross-education therapies.…”
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High immunoproteasome and low constitutive proteasome subunit levels correlate with sensitivity to bortezomib-containing chemotherapy: update from the Children’s Oncology Group AAL... by Margot S. F. Roeten, Johan van Meerloo, Suzanne N. van Dijk, Zinia Kwidama, Gaye Jenkins, David T. Teachey, Meenakshi Devidas, Mignon L. Loh, Gertjan J. L. Kaspers, Sonja Zweegman, Gerrit Jansen, Terzah M. Horton, Jacqueline Cloos

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Viral and Nonviral Engineering of Natural Killer Cells as Emerging Adoptive Cancer Immunotherapies by Sandro Matosevic

“…As effectors of cancer immunotherapy, NK cells are attractive as they do not attack healthy self-tissues nor do they induce T cell-driven inflammatory cytokine storm, enabling their use as allogeneic adoptive cellular therapies. Clinical responses to adoptive NK-based immunotherapy have been thwarted, however, by the profound immunosuppression induced by the tumor microenvironment, particularly severe in the context of solid tumors. …”
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Growth Characteristics of Sheep-Derived <i>Bacteroides fragilis</i> and Preliminary Research on Effects in Mice and Lambs by Cheng Cheng, Jinye Du, Jianping Tao, Darong Cheng

“…Traditional antibiotic treatments often disrupt the Intestinal microbiota, induce antibiotic resistance, and cause adverse side effects, highlighting the urgent need to develop alternative therapies. <i>Bacteroides fragilis</i>, a candidate next-generation probiotic, has been closely associated with intestinal health. …”
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Competitive Sports Anxiety, Healing Imagery and Achievement Goal; Mediating Role of Coaching Feedback in Young Pakistani Athletes by Yumna Ali, Syeda Farhana Kazmi

“…Providing sports students and active players with regular sports psychological workshops and access to the latest therapies is essential. Exploring the motivational climate is integral for future studies. …”
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Il-6 and MSH3 in colorectal carcinoma: Expression, relationship, and prognostic significance in 171 colorectal carcinoma cases by Elif Kolay Bayram, Betul Ogut, Mehmet Arda Inan, Ayse Dursun

“…The use of IHC to identify patients who may benefit from anti-IL-6 therapies in CRC in the future may be critical.…”
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A Predicted Helix-Turn-Helix Core Is Critical for Bacteriophage Kil Peptide to Disrupt <i>Escherichia coli</i> Cell Division by Arindam Naha, Todd A. Cameron, William Margolin

“…<b>Conclusions</b>: Understanding the structure and function of Kil and similar peptides can potentially reveal additional ways to target FtsZ for antimicrobial therapies and elucidate how FtsZ functions in bacterial cell division.…”
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Metabolic Reprograming of Macrophages: A New Direction in Traditional Chinese Medicine for Treating Liver Failure by Junli Zhang, Na Li, Xiaoyu Hu

“…This review aimed to provide valuable insights that could contribute to the development of new therapies or drugs for ALF.…”
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Cell Differentiation Trajectory Predicts Prognosis and Immunotherapeutic Response in Clear Cell Renal Cell Carcinoma by Jin Xu, Xi Chen, Yinyu Chen, Qiushuang Wang, Yingliang Jin, Huashuo Zhao

“…In the study of immune checkpoints, we found that patients in the high-risk group had a disposition to get worse prognosis and better effects of immune checkpoint blocking therapies. Finally, we found the expression level of model DRGs was associated with a tumor-immune microenvironment (TIME) pattern and the response of 83 compounds or inhibitors was significantly different in the two risk groups. …”
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Enfortumab vedotin plus pembrolizumab for previously untreated locally advanced or metastatic urothelial carcinoma: a cost-effectiveness analysis by Youwen Zhu, Kun Liu, Hong Zhu, Shan Li, Dan Yuan

“…Cost-effectiveness is necessary to consider whether the increased efficacy of the two therapies will lead to higher prices for first-line treatment of previously untreated la/mUC. …”
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Multiple machine learning-based integrations of multi-omics data to identify molecular subtypes and construct a prognostic model for HNSCC by Xiaoqin Luo, Chao Li, Gang Qin

“…., Cisplatin, 5-Fluorouracil), while low-risk patients responded better to immunotherapy and targeted therapies. Conclusion Our study delineates two molecular subtypes of HNSCC and establishes a robust prognostic model using multi-omics data and machine learning. …”
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Cabozantinib Resolves Bone Scans in Tumor-Naïve Mice Harboring Skeletal Injuries by Michael G. Doran, Daniel E. Spratt, John Wongvipat, David Ulmert, Brett S. Carver, Charles L. Sawyers, Michael J. Evans

“…Among malignancies with tropism for the bone (prostate, breast), one striking feature of early clinical reports about this drug has been the rapid and complete resolution of bone scans, a phenomenon almost never observed even among therapies already shown to confer survival benefit. …”
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