Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review by Hasan Subhi, Nashwah Subhi, Salah Alhaidary, Mahmood S. Azeez, Abedelmalek Kalefh Tabnjh, Abedelmalek Kalefh Tabnjh, Abedelmalek Kalefh Tabnjh

“…IntroductionBiodentine is a well-known endodontic material that is applied in various endodontic therapies. Enterococcus faecalis (E. faecalis) is associated with endodontic failure and persistent periapical infection. …”
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Endogenous peptide CBDP1 inhibits clear cell renal cell carcinoma progression by targeting USP5/YTHDF2/TRPM5 axis by Yang Zhang, Wei Zhu, Ruijie Tao, Weijian Li, Chunming Jiang, Xiang Yan

“…Abstract Background: Clear cell renal cell carcinoma (ccRCC) has a high incidence rate and poor prognosis, and currently lacks effective therapies. Recently, peptide-based drugs have shown promise in cancer treatment. …”
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Modeling and simulation of distribution and drug resistance of major pathogens in patients with respiratory system infections by Li Yang, Ermin Liang, Yali Gao

“…Conclusion This study emphasizes the importance of regular monitoring of respiratory pathogen distribution and antimicrobial resistance patterns and the need for a comprehensive approach to managing RTIs, including implementation of antibiotic stewardship programs, infection control measures, and development of new therapies.…”
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Green Synthesis of Iron Oxide Nanoparticles and Their Antibacterial Efficacy against Carbapenem-resistant Klebsiella pneumoniae in Bloodstream Infections by Rahul Harikumar Lathakumari, Leela Kakithakara Vajravelu, Jayaprakash Thulukanam, Vishnupriya Panneerselvam, Poornima Baskar Vimala, Dakshina Manoj Nair, Sujith Sri Surya Ravi

“…These findings warrant further investigation into nanoparticle-based therapies for multidrug-resistant organisms.…”
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EVALUATION OF ADDING TWO TYPES OF ORGANIC CHROMIUM ON ENHANCING GROWTH AND CHEMICAL COMPOSITION CRITERIA OF COMMON CARP Cyprinus carpio L. by Alaa Alkhaledy, Mahmoud Mohammad

“…Results of the protein retention and protein productive value criteria showed that T2 and T3 were significantly superior to the remaining experimental therapies. At the same time, T4 and T7 were significantly superior to the remaining experimental treatments in the protein efficiency ratio. …”
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Three-Year Outcomes of Combined Autotransplantation and Regenerative Endodontic Treatment of an Immature Tooth: A Case Report by İdil Özden, Emrah Canbazoğlu, Hesna Sazak Öveçoğlu

“…The combination of autotransplantation and regenerative endodontic treatment can be considered as a long-termtreatment option for immature teeth.Keywords: Autotransplantation; Regeneration; Revascularisation; PRF; Vital pulp therapy…”
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Spinal presentations in children with type 1 spinal muscular atrophy on nusinersen treatment across the SMA-REACH UK network: a retrospective national observational study by Francesco Muntoni, Giovanni Baranello, Pinki Munot, Mariacristina Scoto, Adnan Manzur, Marion Main, Evelin Milev, Lianne Abbott, Victoria Selby, Amy Wolfe, Annemarie Rohwer, Catherine Rye, Sarah Gregson, Grainne NicFhirleinn, Rosanna Raab, Heather McMurchie, Angela Topping, Faye Mason, Jennie Sheehan, Felicity Vann, Steph Wadsworth, José Longatto, Lindsey Pallant, Nick Emery, Jenny Moustoukas, Sarah D’Urso, Kay White, Efthymia Panagiotopoulou

“…Background Prior to the introduction of disease-modifying treatments (DMTs), children with type 1 spinal muscular atrophy (SMA) typically did not survive beyond the age of 2 years; management was mainly palliative. Novel therapies have made this a treatable condition, resulting in increased life expectancy and more time spent upright. …”
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Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma by Ruilan Ma, Dian Yang, Peng Wang, Ziyi Zhang, Xuehong Zhang, Jialiang Song, Han Liu, Shuyan Liu, Yingqiu Zhang, Lijuan Zou

“…Therefore, further investigation on RIT1 will facilitate future development of targeted therapies. Our bioinformatic analysis revealed that RIT1 alterations in lung cancer predicted poor survivals but differed from its RAS paralogs by showing largely amplification and mutation. …”
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The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World by Peter C. Church, Jeffrey Hyams, Frank Ruemmele, Lissy de Ridder, Dan Turner, Anne M. Griffiths

“…Background and Aims. Use of anti-TNF therapies varies internationally. As an initiative of the international Pediatric IBD Network (PIBDNet), we compared global pediatric IBD anti-TNF practice patterns. …”
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T14diLys/DOPE Liposomes: An Innovative Option for siRNA-Based Gene Knockdown? by Sophie Meinhard, Frank Erdmann, Henrike Lucas, Maria Krabbes, Stephanie Krüger, Christian Wölk, Karsten Mäder

“…Background/Objectives: Bringing small interfering RNA (siRNA) into the cell cytosol to achieve specific gene silencing is an attractive but also very challenging option for improved therapies. The first step for successful siRNA delivery is the complexation with a permanent cationic or ionizable compound. …”
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Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway by Zhihui Min, Jiebai Zhou, Ruolin Mao, Bo Cui, Yunfeng Cheng, Zhihong Chen

“…The current asthma therapies are inadequate for many patients with severe asthma. …”
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G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells by Chiao-Chun Liao, Yuqing Long, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Chia-Hwa Lee

“…Overall, the luminescence-based G-cleave LC3B biosensor presents a rapid and dependable avenue for determining autophagy activity, thereby facilitating high-throughput assessment of promising autophagy-associated anti-cancer therapies across diverse malignancies.…”
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Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction by Guoxing Li, Huilin Zhao, Zhe Cheng, Junjin Liu, Gang Li, Yongzheng Guo

“…Introduction: Despite the high morbidity and mortality, the effective therapies for heart failure with preserved fraction (HFpEF) are limited as the poor understand of its pathophysiological basis. …”
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Longitudinal pathways from emotional abuse to problematic gaming in adolescents: The role of psychoticism by Valeria Verrastro, Valeria Saladino, Fiorenza Giordano, Danilo Calaresi

“…Effective interventions might include emotional support programs and therapies targeting psychoticism traits. Combining these approaches could improve treatment outcomes for adolescents with PG.…”
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The effect of dienogest and gonadotropin-releasing hormone agonist on pelvic pain after laparoscopic surgery for endometriosis: An RCT by Fatemeh Davari Tanha, Azam Rasti, Hamideh Pakniat, Shohreh Salimi Setudeh

“…Currently, gonadotropin-releasing hormone (GnRH) agonists and dienogest are the most widely used medical therapies for endometriosis. Objective: This study aimed to investigate the efficacy of dienogest and GnRH agonists in improving pelvic pain after laparoscopic surgery for endometriosis. …”
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Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management by Bhargav Shreevatsa, Bhargav Shreevatsa, Abhigna Nagaraj, Chandan Dharmashekar, Anisha Jain, Bhavana Harendra, Siddesh V. Siddalingegowda, Haneen A. Al-Mazroua, Sheikh F. Ahmad, Shashanka K. Prasad, Chandrashekar Srinivasa, Chandan Shivamallu, Shiva Prasad Kollur

“…Precision ASO-based therapies could effectively manage MS by targeting the essential pathways involved in the disease. …”
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Lipidic folding pathway of α-Synuclein via a toxic oligomer by Vrinda Sant, Dirk Matthes, Hisham Mazal, Leif Antonschmidt, Franz Wieser, Kumar T. Movellan, Kai Xue, Evgeny Nimerovsky, Marianna Stampolaki, Magdeline Nathan, Dietmar Riedel, Stefan Becker, Vahid Sandoghdar, Bert L. de Groot, Christian Griesinger, Loren B. Andreas

“…These structural insights have implications for the development of therapies and biomarkers.…”
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Peptides as Versatile Regulators in Cancer Immunotherapy: Recent Advances, Challenges, and Future Prospects by Yu Lei, Jiacheng Liu, Yaowei Bai, Chuansheng Zheng, Dongyuan Wang

“…The emergence of effective immunotherapies has revolutionized therapies for many types of cancer. However, current immunotherapy has limited efficacy in certain patient populations and displays therapeutic resistance after a period of treatment. …”
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Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights by Mislav Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Andrea Gelemanović, Andrea Faour, Ivan Vlak, Josipa Radić

“…Overall, tetracyclines show promise as adjunct therapies in RA management due to their dual anti-inflammatory and immunomodulatory actions. …”
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Temperature and state-dependent electrical conductivity of soft biological tissue at hyperthermic temperatures by Junren Ran, Martin Ostoja-Starzewski

“…Objective: We present a physics-based, temperature and state-dependent electrical conductivity model for soft biological tissue under thermal therapies with a quantified damage parameter that represents the state of soft biological tissue (degree of denaturation). …”
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