Efficacy of Antibiotic Versus Probiotics as Adjuncts to Mechanical Debridement for the Treatment of Peri-Implant Mucositis by Sindhu Sudhakar Kumararama, Manali Patil, Bhavna Jha Kukreja, Manjiri Salkar, Shikha Verma, Naina Pattnaik, Lalit Patil

“…The efficacy of adjunctive therapies, such as antibiotics and probiotics, in enhancing treatment outcomes remains a topic of interest. …”
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Evaluating the Treatment of Diabetic Macular Edema with Aflibercept Based on a Regional Network of Ophthalmologic Care Givers by Haidar Khalil, Siegfried Mariacher, Rupert Strauss, Dominika Podkowinski, Klemens Waser, Matthias Bolz

“…In Austria, anti-VEGF therapies are reimbursed only in clinical settings. …”
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Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson’s disease by Yong Hui Nies, Wei Ling Lim, Norwahidah Abd Karim, Mohamad Fairuz Yahaya, Seong Lin Teoh

“…IntroductionParkinson’s disease (PD) is a common neurodegenerative disorder primarily affecting motor function due to progressive loss of dopaminergic neurons in the substantia nigra. Current therapies offer symptomatic relief but fail to halt disease progression, highlighting the need for novel therapeutic strategies. …”
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Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights by Bantayehu Addis Tegegne, Tesfa Begashaw, Wubetu Yihunie Belay, Mengistie Kassahun Tariku, Tirsit Ketsela Zeleke, Mohammed Jemal, Mamaru Getinet, Agumas Alemu Alehegn, Abebe Dagne

“…This study seeks to inspire researchers to quickly discover and isolate the key active metabolites found in Kleinia taxa, thereby promoting the development of novel, safe, and effective therapies for a variety of illnesses. To this end, we performed a thorough search of English-language publications from PubMed, Scopus, ScienceDirect, Web of Science, Google Scholar, and ResearchGate. …”
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Thermal performance and MHD peristaltic flow of hybrid nanofluid (Au-Ta/Blood) in an asymmetric conduit with electro-osmosis and shape factor effects by K. Thirunavukarasan, G. Sucharitha

“…The current research aims to create a mathematical model for targeted drug delivery systems, applicable in areas like cancer treatment, genetic disorder therapies, and infection management. Considering that, the study examines the magnetohydrodynamic peristaltic transport of Ree-Eyring hybrid nanofluid (Au-Ta/Blood) in an asymmetric channel. …”
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Reducing Hospital Readmissions in Chronic Obstructive Pulmonary Disease Patients: Current Treatments and Preventive Strategies by Claudia Di Chiara, Giulia Sartori, Alberto Fantin, Nadia Castaldo, Ernesto Crisafulli

“…Over the years, new effective therapies have been proposed. However, the burden of COPD is still conditioned by frequent acute events defined as exacerbations (exacerbation of COPD-ECOPD), which have a significant impact not only on the patient’s quality of life but also on the progression of the disease, morbidity, and mortality. …”
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Mechanistic modelling of allergen-induced airways disease in early life by Hannah J. Pybus, Prakrati Dangarh, Man Yin Melanie Ng, Clare M. Lloyd, Sejal Saglani, Reiko J. Tanaka

“…We hypothesised that altered epithelial function following allergen exposure determines the onset of airway remodelling and abnormal lung function, which are irreversible with current asthma therapies. We calibrated the in silico model using age appropriate in vivo data from neonatal and adult mice. …”
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Female Sex as a Thromboembolic Risk Factor in the Era of Nonvitamin K Antagonist Oral Anticoagulants by Mariacarla Gallù, Giulia Marrone, Jacopo Maria Legramante, Antonino De Lorenzo, Nicola Di Daniele, Annalisa Noce

“…These differences can also impact on the effects of CV therapies. Female sex is recognized as an independent predictor of thromboembolic risk, particularly in older patients. …”
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Exploring the Therapeutic Potential of Cannabidiol in U87MG Cells: Effects on Autophagy and NRF2 Pathway by Laura Giannotti, Benedetta Di Chiara Stanca, Francesco Spedicato, Daniele Vergara, Eleonora Stanca, Fabrizio Damiano, Luisa Siculella

“…These properties allow CBD to influence oxidative stress responses and potentially enhance the efficacy of antitumor therapies. In this study, we treated U87MG glioma cells with low dose (1 μM) CBD and evaluated its molecular effects. …”
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To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics by Tingting Xu, Tianying Zhang, Yan Sun, Sijia Wu

“…By facilitating the development of targeted therapies and personalized treatment strategies, these results hold promise for improving clinical outcomes in gastric cancer patients.…”
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Senegalin-2: A Novel Hexadecapeptide from <i>Kassina senegalensis</i> with Antibacterial and Muscle Relaxant Activities, and Its Derivative Senegalin-2BK as a Bradykinin Antagonist by Yueyang Lu, Yanguo Zhu, Chengbang Ma, Lei Wang, Mei Zhou, Tianbao Chen, Xiaonan Ma, Xu Zhang, Zhimin Fan

“…As a synthetically derived bradykinin antagonist and myotropic peptide with antibacterial properties, Senegalin-2BK shows promise in effective therapies for relieving pain, inflammation, and addressing muscular disorders such as urinary retention, constipation, and infections.…”
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Clinical Characteristics and Management of Hypercalcemic Crisis in 155 Patients: A Single Center Retrospective Study by Yuqing Qu, Yang Liu, Xianling Wang, Qinghua Guo, Jin Du, Yu Pei, Jianming Ba, Weijun Gu, Jingtao Dou, Zhaohui Lv, Yiming Mu

“…These 155 patients with hypercalcemic crisis got effective therapies that included simultaneous administration of intravenous injection (IV) isotonic saline, subcutaneous calcitonin, bisphosphonate, or hemodialysis in serious cases. …”
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The Role of IL-6 and TNF-Alpha Biomarkers in Predicting Disability Outcomes in Acute Ischemic Stroke Patients by Ciprian-Ionuț Băcilă, Maria-Gabriela Vlădoiu, Mădălina Văleanu, Doru-Florian-Cornel Moga, Pia-Manuela Pumnea

“…Further research into anti-inflammatory therapies targeting these cytokines may improve stroke rehabilitation and outcomes.…”
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Transcriptomic and proteomic profiling identifies feline fibrosarcoma as clinically amenable model for aggressive sarcoma subtypes by Mikiyo Weber, Daniel Fuchs, Amiskwia Pöschel, Erin Beebe, Zuzana Garajova, Armin Jarosch, Laura Kunz, Witold Wolski, Lennart Opitz, Franco Guscetti, Mirja C. Nolff, Enni Markkanen

“…Interestingly, aggressive FSA occur more frequently in domestic cats, hence potentially representing a clinically amenable model to assess novel therapies such as targeted imaging or theranostics. …”
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Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends by Prateek Uttreja, Indrajeet Karnik, Ahmed Adel Ali Youssef, Nagarjuna Narala, Rasha M. Elkanayati, Srikanth Baisa, Nouf D. Alshammari, Srikanth Banda, Sateesh Kumar Vemula, Michael A. Repka

“…SEDDS have revolutionized drug delivery by improving bioavailability and enabling precise, patient-centric therapies. While challenges such as scalability and excipient toxicity persist, emerging technologies and multidisciplinary collaborations are paving the way for next-generation SEDDS. …”
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Controlled ovarian hyperstimulation with or without letrozole for fertility preservation in breast cancer patients: study protocol for a randomised controlled trial by Ping Li, Kun Wang, Qi Fan, Peng Sun, Yuhua Shi, Yanqiu Xie, Weifen Deng, Jiajing Kang

“…Introduction Multimodal anticancer therapies greatly damage the fertility of breast cancer patients, which raises urgent demand for fertility preservation. …”
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Clinical outcomes and adverse events of Hedgehog pathway inhibitors for advanced basal cell carcinoma patients: A systematic review and meta-analysis by Suvijak Untaaveesup, Wichapol Dendumrongsup, Pornteera Srichana, Chanamon Pongphaew, Gynna Techataweewan, Kanmanee Viratkapan, Nichanant Nampipat, Ben Ponvilawan, Chayanis Kositamongkol, Walaiorn Pratchyapruit, Pochamana Phisalprapa

“…Treatment options include surgery, radiotherapy, and systemic therapies, but tumor location and prior interventions can limit these methods. …”
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The length of price&reimbursement negotiation procedures in Italy in the period 2021-2023 was independent from the price of medicines by Raffaella Cocciolo, Paola Turella, Daniela Pilunni, Pierluigi Navarra

“…Biosimilars, generics, gene therapies, Sars-Cov-2 vaccines and medicines with no negotiated price at the datalock of December 2023 were excluded from the analysis. …”
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Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages by Laura Hyväri, Miina Ojansivu, Miia Juntunen, Kimmo Kartasalo, Susanna Miettinen, Sari Vanhatupa

“…Adipose tissue is an attractive stem cell source for soft and bone tissue engineering applications and stem cell therapies. The adipose-derived stromal/stem cells (ASCs) have a multilineage differentiation capacity that is regulated through extracellular signals. …”
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Sustained response off treatment after fostamatinib in refractory immune thrombocytopenia: A series of four case reports by Waleed Ghanima, Francisco Javier Lucas Boronat, Valentina Carrai, Stefan Rackwitz

“…SROT was observed for more than ten months (in remission to date).Discussion: These cases emphasize that SROT is achievable with fostamatinib in complex ITP cases unresponsive to multiple previous therapies. Additional research is needed to identify the magnitude of the underlying mechanisms, and the clinical factors associated with, and potentially predictive of, SROT.…”
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