Neuroprotective Effect of Melatonin Loaded in Human Serum Albumin Nanoparticles Applied Subconjunctivally in a Retinal Degeneration Animal Model by Sofia Mickaela Martinez, Ayelen Inda, Maximiliano Nicolás Ríos, Carolina del Valle Bessone, Abril Bruera Bossio, Mario Eduardo Guido, José Domingo Luna Pinto, Daniel Alberto Allemandi, Daniela Alejandra Quinteros

“…These findings highlight the synergistic potential of albumin and Mel in treating neurodegenerative ocular diseases, opening new perspectives for future therapies.…”
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Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis by Jianhao Bai, Zhongqi Wan, Wanru Zhou, Lijun Wang, Wei Lou, Yao Zhang, Haiying Jin

“…Keyword and co-citation analyses revealed a transition from early focus on BRAF mutations and MAPK pathway activation to recent emphasis on immunotherapy, combination therapies, and non-apoptotic cell death mechanisms like ferroptosis and pyroptosis. …”
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Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera) by Andrea Becchimanzi, Giovanna De Leva, Rosanna Mattossovich, Serena Camerini, Marialuisa Casella, Giovanni Jesu, Ilaria Di Lelio, Sabrina Di Giorgi, Joachim R. de Miranda, Anna Valenti, Silvia Gigliotti, Francesco Pennacchio

“…Our findings open novel perspectives on possible new therapies for DWV control by targeting specific host proteins.…”
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Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease – 2007 Update by Denis E O’Donnell, Shawn Aaron, Jean Bourbeau, Paul Hernandez, Darcy D Marciniuk, Meyer Balter, Gordon Ford, Andre Gervais, Roger Goldstein, Rick Hodder, Alan Kaplan, Sean Keenan, Yves Lacasse, Francois Maltais, Jeremy Road, Graeme Rocker, Don Sin, Tasmin Sinuff, Nha Voduc

“…Highlights of this update include new epidemiological information on mortality and prevalence of COPD, which charts its emergence as a major health problem for women; a new section on common comorbidities in COPD; an increased emphasis on the meaningful benefits of combined pharmacological and nonpharmacological therapies; and a new discussion on the prevention of acute exacerbations. …”
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Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation by M. Hidayat Budi Kusumo, Adi Prayitno, Soetrisno ., Abdurahman Laqif

“…Further research is warranted to fully elucidate the intricate mechanisms and optimize MSC-based therapies for clinical applications in hemorrhoidal disease management.…”
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Identification and validation of a metabolic-related gene risk model predicting the prognosis of lung, colon, and breast cancers by Jiyauddin Khan, Chanchal Bareja, Kountay Dwivedi, Ankit Mathur, Naveen Kumar, Daman Saluja

“…Our integrated approach combining bioinformatics analyses and experimental validations underscores the potential of MRGs as biomarkers for metabolic therapies, with machine learning models enhancing predictive capabilities for patient outcomes.…”
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Structural characterization of two γδ TCR/CD3 complexes by Mohammed Hoque, John Benji Grigg, Trudy Ramlall, Jennifer Jones, Luke L. McGoldrick, John C. Lin, William C. Olson, Eric Smith, Matthew C. Franklin, Tong Zhang, Kei Saotome

“…Collectively, these data shed light on γδ TCR/CD3 complex formation and may aid the design of γδ TCR-based therapies.…”
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Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach by Ronghua Bei, Justin Thomas, Shiven Kapur, Mahlet Woldeyes, Adam Rauk, Jason Robarge, Jiangyan Feng, Kaoutar Abbou Oucherif

“…Subcutaneous injections are an increasingly prevalent route of administration for delivering biological therapies including monoclonal antibodies (mAbs). Compared with intravenous delivery, subcutaneous injections reduce administration costs, shorten the administration time, and are strongly preferred from a patient experience point of view. …”
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Nomogram model and risk score predicting overall survival and guiding clinical decision in patients with Hodgkin’s lymphoma: an observational study using SEER population-based data... by Yue Yang, Shang Li, Xiao Zhu, Yi Kong, Mingtao Zhang, Xiangping Liang, Zherui Zhang, Shuzhen Tan, Yingqi Li, Yueyuan Zhong, Yingqi Shao, Jiayi Xu, Zesong Li

“…Patients with HL had good long-term outcomes but novel therapies are still in need for fewer complications.…”
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Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels by Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber, Gracjan Michlewski

“…Conclusions These findings uncover novel posttranscriptional mechanisms governed by HuR and its inhibitor, elucidating pathways relevant to HuR-mediated regulation and molecular therapies aimed at targeting this protein.…”
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FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma by Jian Chen, Cheng Zhu, Yan He, Liping Huang, Weizhuo Wang, Shuaishuai Huang

“…Immunogenic cell death (ICD) has the potential to activate anti-tumor immunity, presenting a promising avenue for ccRCC therapies. Methods We analyzed data from GSE29609, TCGA-KIRC, and GSE159115 to identify ICD-related prognostic genes in ccRCC. …”
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Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…This suggests that targeting this protein could restore liver function without compromising the immune system, thereby decreasing sepsis mortality and supporting the recent paradigm that the liver is a hub for the host response to infection that might, in the future, result in novel host-directed therapies supporting the current state-of-the-art intensive care medicine in patients with sepsis-associated liver failure.…”
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Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems by Vitale Miceli, Mariangela Pampalone, Serena Vella, Anna Paola Carreca, Giandomenico Amico, Pier Giulio Conaldi

“…This work reveals the placenta as an important source of MSCs that can be used for eventual clinical applications as cell-free therapies.…”
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Initial Experience with Sildenafil, Bosentan, and Nitric Oxide for Pediatric Cardiomyopathy Patients with Elevated Pulmonary Vascular Resistance before and after Orthotopic Heart T... by Babak Daftari, Juan Carlos Alejos, Gregory Perens

“…All pulmonary vasodilator therapies used are described as well as outcomes during the first year posttransplant. …”
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Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model by Joaquín López-Carrillo, Johanna Bernáldez-Sarabia, Tushar J. Pawar, Samanta Jiménez, Salvador Dueñas, Andrea Figueroa-Montiel, José L. Olivares-Romero, Vinicio Granados-Soto, Alexei F. Licea-Navarro, Alexei F. Licea-Navarro, Nadia L. Caram-Salas, Nadia L. Caram-Salas

“…Structural analyses revealed notable differences between O1_cal6.4b and O1_cal6.4d, suggesting unique functional properties.DiscussionThe findings indicate that O1_cal6.4b exhibits a promising analgesic profile with advantages over traditional opioid-based therapies. These results underscore the molecular diversity of conotoxins and highlight their potential as innovative analgesic treatments. …”
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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone by Xiongxiong Liu, Tong Zheng, Yanyu Bao, Ping Li, Ting Zhao, Yan Liu, Hui Wang, Chao Sun

“…Future research should focus on dosage optimization and administration, the exploration of combination therapies, and long-term clinical trials to establish genistein benefits in clinical settings. …”
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DICER1: The Argonaute Endonuclease Family Member and Its Role in Pediatric and Youth Pathology by Consolato M. Sergi, Fabrizio Minervini

“…The ubiquity of this enzyme in the human body makes it an exquisite target for nanotechnology-supported therapies and repurposing drug approaches.…”
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College of American Pathologists (CAP)/American College of Medical Genetics and Genomics (ACMG) proficiency testing for urinary glycosaminoglycan analysis: A summary of performance by Kristina Cusmano-Ozog, Dietrich Matern, Thomas Long, Nicola Longo, Sarah Young

“…The decline of laboratories participating in PT is concerning because MPS are increasingly included in newborn screening programs and urinary GAGs can be used to monitor the effectiveness of new therapies.…”
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Burden of Coronary Artery Disease and Peripheral Artery Disease: A Literature Review by Rupert Bauersachs, Uwe Zeymer, Jean-Baptiste Brière, Caroline Marre, Kevin Bowrin, Maria Huelsebeck

“…Use of medication to control modifiable CV risk factors was variable by country (lower in France than in Canada); statins and aspirin were the most widely used therapies in patients with chronic disease. Survival rates have improved with medical advancements, but there is an additional need to improve the humanistic burden of disease (i.e., associated disability and quality of life). …”
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Omega-3 fatty acids: molecular weapons against chemoresistance in breast cancer by Vittoria Marchio, Giuseppina Augimeri, Catia Morelli, Adele Vivacqua, Cinzia Giordano, Stefania Catalano, Diego Sisci, Ines Barone, Daniela Bonofiglio

“…Abstract Breast cancer is the most commonly diagnosed type of cancer and the leading cause of cancer-related death in women worldwide. Highly targeted therapies have been developed for different subtypes of breast cancer, including hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-positive breast cancer. …”
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