Pharmacist prescriber in Italy and possible changes to current legislation: survey of attitudes among pharmacists, family doctors and users by Francesca Baratta, Irene Pignata, Lorenzo Ravetto Enri, Paola Brusa

“…Background In many countries in Europe and in the world, pharmacists are allowed to prescribe or modify therapies. In Italy, the only healthcare professions authorised to prescribe are medical doctors and veterinary surgeons. …”
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Identification of MYC and STAT3 for early diagnosis based on the long noncoding RNA-mRNA network and bioinformatics in colorectal cancer by Kunhou Yao, Hao Fan, Tiancheng Yang, Can Yang, Guibin Wang, Xingwang Li, Xin-Ying Ji, Qun Wang, Shaojiang Lv, Shihao Guo

“…Validation through the HPA database further supported these findings, confirming the potential of MYC and STAT3 as diagnostic biomarkers for CRC.ConclusionOur results suggest that MYC and STAT3 are promising diagnostic biomarkers for CRC, offering new insights into its pathophysiology and potential for targeted therapies.…”
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Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC by Chenxuan Li, En-di Zhang, Rui Yu, Bo Yuan, Yunxin Yang, Zhong Zeng, Hanfei Huang

“…It holds promise as a diagnostic and prognostic biomarker for cancer, and offers potential in immunomodulatory and targeted therapies.…”
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Resolving Covid-19 with Blockchain and AI by Suyogita Singh, Satya Bhushan Verma

“…AI also offered smart forms of diagnosing coronavirus therapies and supported the development of pharmaceuticals. …”
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Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives by Domenica Lucia D’Antonio, Anna Zenoniani, Samia Umme, Adriano Piattelli, Maria Cristina Curia

“…It is thought that given the role of <i>Fn</i> in tumor formation and metastasis processes via its FadA, FapA, Fap2, and RadD, new therapies for tumor treatment targeting <i>Fn</i> will be developed.…”
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Effects of transcutaneous electric nerve stimulation on pain after episiotomy. A systematic review and meta-analysis by Elisa López-Campos, Mercedes Soto-González, Alejandra Alonso-Calvete, Iria Da Cuña-Carrera

“…There are different reasons that lead to an episiotomy; however, it is recommended to be performed occasionally and not systematically, since it may produce negative effects such as pain. Different therapies have been described to reduce this pain, including transcutaneous electrical nerve stimulation (TENS). …”
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Mathematics achievement emotions: Global trend, emotional treatment, and directions for future research by Suparman Suparman, Dadang Juandi

“…Conclusion: This implies that the stability of mathematics achievement emotions of students in doing mathematics activities has to be generated to promote students’ mathematics achievement in which a few of emotional treatments, such as psychological therapies and web-based learning can be applied to stabilize students’ mathematics achievement emotions.…”
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Molecularly redefining small bowel adenocarcinoma to accelerate precision patient care – protocol of a multicenter observational cohort biomarker study by Rasmus Haunstrup Døssing, Julia Johanna Almer Broman, Colm J. O’Rourke, Elizaveta Mitkina Tabaksblat, Jesper Bøje Andersen, Carsten Palnæs Hansen, Tim Svenstrup Poulsen, Estrid V. S. Høgdall, Jakob Hagen Vasehus Schou, Dan Høgdall

“…However, its findings will have the potential to substantially impact future clinical practices and guide targeted therapies for SBA patients. Trial registration ClinicalTrials.gov NCT06234306.…”
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Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study by Xing-kang He, Wenrui Wu, Yu-e Ding, Yue Li, Lei-min Sun, Jianmin Si

“…However, the relationship between location and prognosis was varied by subgroups defined by age, year at diagnosis, stage, and therapies. Conclusions. We demonstrated that LCC was associated with better prognosis, especially for patients with distant metastasis. …”
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G Protein-Coupled Receptor 17 Inhibits Glucagon-like Peptide-1 Secretion via a Gi/o-Dependent Mechanism in Enteroendocrine Cells by Jason M. Conley, Alexander Jochim, Carmella Evans-Molina, Val J. Watts, Hongxia Ren

“…Gut peptides, including glucagon-like peptide-1 (GLP-1), regulate metabolic homeostasis and have emerged as the basis for multiple state-of-the-art diabetes and obesity therapies. We previously showed that G protein-coupled receptor 17 (GPR17) is expressed in intestinal enteroendocrine cells (EECs) and modulates nutrient-induced GLP-1 secretion. …”
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Protective effects of small RNAs encapsulated in Artemisia Capillaris-derived exosomes against non-alcoholic fatty liver disease by Min Xu, Longjun Ma, Hongwei Liang, Wei Tang, Shouyong Gu

“…High throughput sequencing further identified a distinct small RNA profile in ACDEs, indicating the potential involvement in interspecies physiological regulation.DiscussionIn conclusion, this study provides evidence for the therapeutic potential of ACDEs in NAFLD and offers a novel perspective for the development of Artemisia capillaris-based therapies for NAFLD, related metabolic disorders, and hepatitis.…”
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Comparative efficacy of chemical peels and laser treatments in melasma: a meta-analysis of randomized controlled trials by Ingyu Lee, SeoWon Kang, JinHan Lee, Hyungin Cho, Ki Won Lee, Dongkeun Lim

“…Chemical peels, though slower, are safer for patients prone to adverse effects. Combination therapies and maintenance strategies may improve long-term outcomes in melasma…”
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Development of [F]FPy-WL12 as a PD-L1 Specific PET Imaging Peptide by Wojciech G. Lesniak PhD, Ronnie C. Mease PhD, Samit Chatterjee PhD, Dhiraj Kumar PhD, Ala Lisok MA, Bryan Wharram MS, Venkateswara Rao Kalagadda PhD, Leisha A. Emens MD, PhD, Martin G. Pomper MD, PhD, Sridhar Nimmagadda PhD

“…Expression of programmed cell death ligand 1 (PD-L1) within tumors is an important biomarker for guiding immune checkpoint therapies; however, immunohistochemistry-based methods of detection fail to provide a comprehensive picture of PD-L1 levels in an entire patient. …”
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Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies by Ray Wagiu Basrowi, Ray Wagiu Basrowi, Ray Wagiu Basrowi, Tonny Sundjaya, Tonny Sundjaya, Dessy Pratiwi, Nurlinah Amalia, Nurlinah Amalia, Nurlinah Amalia, Yosi Yohanes Putra Tandi, Muhammad Yasir Syafa’atulloh, Garuda Nusantara Putra Utomo, Muhammad Abdir Rahman Albarok, Fahrul Nurkolis

“…These miRNA-protein interactions suggest targeted therapies such as protein-based miRNA modulators could optimize erythropoiesis, advancing IDA management. …”
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Ultrasound and 3D Skin Imaging: Methods to Evaluate Efficacy of Striae Distensae Treatment by Mariella Bleve, Priscilla Capra, Franca Pavanetto, Paola Perugini

“…In order to evaluate the effectiveness of these therapies, objective measurement tools are necessary. …”
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Challenges and Novelties in the Treatment of Obesity in Adults. A review by Karolina Kuczapska, Marek Kurowski, Anna Gliwa, Monika Ryglewicz, Dariusz Fabian, Elżbieta Leszczyńska-Knaga, Natalia Jakubczyk, Weronika Rutkowska-Kawalec, Paweł Moczydłowski, Karolina Michalczuk

“…Personalized treatment, referring to different obesity phenotypes, has shown improvement in the therapeutic outcomes. Some new therapies are studied including triple agonists (retatrutide), non-peptide GLP-1 receptor agonists, and drugs reaching other receptors. …”
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Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment by Giulia Gerini, Alice Traversa, Fabrizio Cece, Matteo Cassandri, Paola Pontecorvi, Simona Camero, Giulia Nannini, Enrico Romano, Francesco Marampon, Mary Anna Venneri, Simona Ceccarelli, Antonio Angeloni, Amedeo Amedei, Cinzia Marchese, Francesca Megiorni

“…Furthermore, this study underscores the potential of epigenetic drugs like RG108 to enhance ASC properties, paving the way for more effective and personalized cell-based therapies for bone regeneration.…”
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The Multifaceted Roles of MicroRNA-181 in Stem Cell Differentiation and Cancer Stem Cell Plasticity by Chun Yang, Rui Wang, Pierre Hardy

“…Additionally, we discuss challenges in miRNA-based therapies and targeted delivery with nanotechnology-based systems.…”
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pACP-HybDeep: predicting anticancer peptides using binary tree growth based transformer and structural feature encoding with deep-hybrid learning by Shahid, Maqsood Hayat, Wajdi Alghamdi, Shahid Akbar, Ali Raza, Rabiah Abdul Kadir, Mahidur R. Sarker

“…Despite numerous traditional therapies and wet-laboratory methods for treating cancer-affected cells, these approaches often face limitations, including high costs and substantial side effects. …”
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Operationalizing goal setting as an outcome measure in trials involving patients with frailty, multimorbidity or complexity by Emma Tenison, Katherine Lloyd, Yoav Ben-Shlomo, Emily J. Henderson

“…Background/aims: In the absence of disease-modifying therapies for Parkinson's disease, much research focuses on improving quality of life, health and wellbeing. …”
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