The Antiangiogenic Effects of a Vascular Endothelial Growth Factor Decoy Receptor Can Be Monitored in Vivo Using Contrast-Enhanced Ultrasound Imaging by Flemming Forsberg, Raymond J. Ro, Andrew Marshall, Ji-Bin Liu, See-Ying Chiou, Daniel A. Merton, Priscilla Machado, Adam P. Dicker, Levon N. Nazarian

“…The development of antiangiogenic therapies has stimulated interest in noninvasive imaging methods to monitor response. …”
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Bioinformatics analysis of miRNAs germacrone protection on diabetic nephropathy by Binqi Wang, Wenfang He, Zhixuan Xie, Jinshi Zhang, Yan Ren, Qiang He, Juan Jin

“…Despite the recent developments in germacrone-based therapies for DN, the underlying mechanisms of germacrone in DN remain poorly understood. …”
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Potential involvement of cuproptosis induced by m6A-modified autophagy gene ATG10 in KICH by Qingyun Zhu, Daiquan Fu, Zhaohui Zhu, Jian Wu, Chenxi Li, Jiajun Chen, Chuan Chen, Yanxiang Li, Yuehui Guo, Xiangqi Li

“…The identification of B cells and CD8 + T cells as key immune components, along with specific amino acids, suggests that a combination of targeted immune therapies and dietary interventions could provide a multifaceted approach to KICH treatment. …”
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RNA N4‐acetylcytidine modification and its role in health and diseases by Qiang Wang, Yixiao Yuan, Qiang Zhou, YingDong Jia, Jing Liu, GuangJun Xiao, Chunhong Li, Xiulin Jiang

“…In summary, this review clarifies the multifaceted roles of ac4C modification in both health and disease and explores NAT10‐targeted therapies with the aim of advancing cancer research and improving patient outcomes.…”
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Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications by Mehdi Karasu, Hasan Ata Bolayır, İbrahim Aktaş

“…These findings suggest a novel avenue for understanding and mitigating no-reflow in STEMI, paving the way for targeted therapies. Early identification of high-risk patients could inform tailored interventions, ultimately improving STEMI outcomes. …”
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Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Zhihan Zhao, Huan Lan, Ibrahim El-Battrawy, Xin Li, Fanis Buljubasic, Katherine Sattler, Gökhan Yücel, Siegfried Lang, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Lukas Cyganek, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, Ibrahim Akin

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are providing new possibilities for the biological study, cell therapies, and drug discovery. However, the ion channel expression and functions as well as regulations in hiPSC-CMs still need to be fully characterized. …”
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Accurate assembly of full-length consensus for viral quasispecies by Jia Tian, Ziyu Gao, Minghao Li, Ergude Bao, Jin Zhao

“…Reconstructing a robust consensus representation for these diverse mutant strains is essential for recognizing the genetic variations among strains and delving into aspects like virulence, pathogenesis, and selecting therapies. Virus genomes are typically small, often composed of only a few thousand to several hundred thousand nucleotides. …”
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Leveraging computational approaches in identifying novel HER-2 + breast cancer potential therapeutics: integrating virtual screening and molecular dynamics simulation by Olawale Quadri Bolaji, Temitope Isaac Adelusi, Taiwo Ooreoluwa Ojo, Ibrahim Damilare Boyenle, Abdul-Quddus Kehinde Oyedele, Taiwo Temitope Ogunjobi, Adegboye Oyewole Oyaronbi, Sukurat Oluwatoyin Ayoola, Abdeen Tunde Ogunlana

“…While immensely promising, further optimization and pre-clinical investigation are imperative to validate this compound as a viable alternative to existing therapies for HER-2 positive breast cancer. Graphical abstract…”
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Computational and GC-MS screening of bioactive compounds from Thymus Vulgaris targeting mycolactone protein associated with Buruli ulcer by Muhammad Naveed, Imran Ali, Tariq Aziz, Ayesha Saleem, Zeerwah Rajpoot, Sameera Khaleel, Ayaz Ali Khan, Mitub Al-harbi, Thamer H. Albekairi

“…This work aims to address these challenges by employing computational methods to identify therapeutic candidates from organic compounds, which may be developed into more effective therapies for Buruli ulcer. The Gas-Chromatography Mass Spectrometry (GCMS) analysis of the Thymus Vulgaris identified the 29 bioactive compounds as potential drug candidates having different medicinal properties. …”
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Case report: Tocilizumab for hypersensitivity reaction after oxaliplatin in a patient with NK/T-cell lymphoma by Juanyan Liao, Ming Jiang

“…Oxaliplatin-induced hypersensitivity reactions (HSRs) are commonly encountered in first-line therapies for various malignancies. Recent research indicates that these reactions can include cytokine release reactions (CRRs), which are characterized by a marked increase in interleukin-6 (IL-6) levels, sometimes rising as much as 40-fold. …”
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Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples by Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Vladimir Lyadov, Vladimir Lyadov, Vladimir Lyadov, Maria Suntsova, Marat Garipov, Anna Semenova, Natalia Popova, Egor Guguchkin, Rustam Heydarov, Marianna Zolotovskaia, Xiaowen Zhao, Qing Yan, Ye Wang, Evgeny Karpulevich, Anton Buzdin, Anton Buzdin, Anton Buzdin, Anton Buzdin

“…Gene fusion events result in chimeric proteins that are frequently found in human cancers. Specific targeted therapies are available for several types of cancer fusions including receptor tyrosine kinase gene moieties. …”
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Tumor organoids in cancer medicine: from model systems to natural compound screening by Rong Cong, Can Lu, Xinying Li, Zhijie Xu, Yaqin Wang, Shusen Sun

“…These self-assembled 3D cell clusters closely replicate the histopathological, genetic, and phenotypic characteristics of primary tissues, making them invaluable tools in cancer research and drug screening.Objective This review addresses the challenges in developing in vitro models that accurately reflect tumor heterogeneity and explores the application of tumor organoids in cancer research, with a specific focus on the screening of natural products for antitumor therapies.Methods This review synthesizes information from major databases, including Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, ScienceDirect, Google Scholar, Scopus, PubMed and Springer Link. …”
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Modulation of Apoptosis and ER Stress Markers in Hepatocellular Carcinoma Cells by Irinotecan, Hesperidin, and Piperine by Serkan Sen, Kardelen Kocaman Kalkan, Canan Yilmaz, Sefa Celik

“…These findings highlight complex interactions between chemotherapeutic agents and natural compounds, warranting further exploration in combination therapies.…”
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The mediating effect of intrusive rumination on the relationship between illness uncertainty and fear of cancer recurrence in breast cancer survivors by Alper Türkel, Nur Nihal Türkel, Ahmet Kadıoğlu, Mutlu Doğan, İrem Ekmekçi Ertek

“…In addition, metacognitive therapies that can functionalize the ruminative thinking style can also effectively intervene in FCR.…”
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Clinical Significance of the Relationship between Progression-Free Survival or Postprogression Survival and Overall Survival in Patients with Extensive Disease-Small-Cell Lung Canc... by Hisao Imai, Keita Mori, Nodoka Watase, Sakae Fujimoto, Kyoichi Kaira, Masanobu Yamada, Koichi Minato

“…The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with small-cell lung cancer (SCLC). …”
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Interleukin-12p70 Expression by Dendritic Cells of HIV-1-Infected Patients Fails to Stimulate gag-Specific Immune Responses by Ellen Van Gulck, Nathalie Cools, Derek Atkinson, Lotte Bracke, Katleen Vereecken, Marc Vekemans, Viggo F. I. Van Tendeloo, Zwi N. Berneman, Guido Vanham

“…A variety of immune-based therapies has been developed in order to boost or induce protective CD8+ T cell responses in order to control HIV replication. …”
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MONet: cancer driver gene identification algorithm based on integrated analysis of multi-omics data and network models by Yingzan Ren, Tiantian Zhang, Jian Liu, Fubin Ma, Jiaxin Chen, Ponian Li, Guodong Xiao, Chuanqi Sun, Yusen Zhang

“…Identifying cancer driver genes is crucial for elucidating the molecular mechanisms of cancer, advancing targeted therapies, and uncovering novel biomarkers. Based on integrated analysis of Multi-Omics data and Network models, we present MONet, a novel cancer driver gene identification algorithm. …”
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Individual variability in cortical representations of tonic pain by Bettina Deak, Anne Stankewitz, Astrid Mayr, Viktor Witkovsky, Pauline Jahn, Enrico Schulz

“…They do not inform us how pain is processed in the brain as none of the participants exhibited the processing pattern of the group statistics. Therapies to relieve pain that rely on the modulation of brain regions will fail unless they are adapted to an individual's unique pain processing characteristics.…”
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Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents by null Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani

“…As we delve deeper into understanding the intricate mechanisms underlying hypertension, LBDDS offers a pathway to develop next-generation antihypertensive therapies that are safer, more effective, and tailored to individual patient needs.…”
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Sealless Production Ultracentrifuge and Its Magnetically Self-Bearing Openable Motors for Purification in Viral Nanotechnology by Emanuel J. Hubmann, Daniel Steinert, Thomas Nussbaumer, Johann W. Kolar

“…Viral nanotechnology enables new possibilities for gene therapies and vaccines. However, the manufacturing of viral vectors lacks a satisfactory production capable method for purification of full capsids. …”
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