Fatigue in Parkinson’s disease—A narrative review by Baikuntha Panigrahi, Kanchana S. Pillai, Divya M. Radhakrishnan, Roopa Rajan, Achal K. Srivastava

“…Fatigue in PD is treated using pharmacological therapies (such as dopaminergic agents, antidepressants, methylphenidate, and modafinil) and non-pharmacological interventions (such as exercise). …”
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Papular Acantholytic Dyskeratosis of the Vulva: A Case Report and Literature Review by Sakpuwadol N, Suchonwanit P

“…However, various treatment modalities have been reported for symptomatic patients, including topical and systemic therapies, and procedural interventions. We present a case of a 21-year-old Thai woman with asymptomatic perivulvar papules with typical histopathological features of PAD. …”
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Inflammatory Response Mechanisms Exacerbating Hypoxemia in Coexistent Pulmonary Fibrosis and Sleep Apnea by Ayodeji Adegunsoye, Jay Balachandran

“…Increased understanding of the inflammatory mechanisms driving hypoxemia in pulmonary fibrosis and obstructive sleep apnea may potentiate the identification of appropriate therapeutic targets for developing effective therapies.…”
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Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery. by Mohammed Alrouji, Sabina Yasmin, Mohammed S Alshammari, Fahad A Alhumaydhi, Sharaf E Sharaf, Moyad Shahwan, Anas Shamsi

“…Cathepsin B (CatB) is a cysteine protease that plays a pivotal role in this process, making it a potential target for the development of anti-Alzheimer's therapies. Apart from AD, CatB is implicated in various physiological and pathological processes, including cancer. …”
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A methodological scoping review on EMG processing and synergy-based results in muscle synergy studies in Parkinson’s disease by Valentina Lanzani, Cristina Brambilla, Alessandro Scano

“…We detailed the features of the screened papers by reporting the clinical findings, a detailed report of EMG processing choices and synergy-based results.ResultsWe found that synergistic control is in general altered in patients with Parkinson’s Disease, but it can improve if patients are subjected to pharmacological and rehabilitation therapies. Moreover, a further understanding of synergistic control in Parkinson’s patients is needed.DiscussionWe discuss the future developments in the field with a detailed assessment of the topic on the view of physicians, including the most promising lines of research for clinical practice and from the perspective of engineers, for methodological application of synergistic approaches.…”
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Halp Score: A Simple and Easily Accessible Index for Predicting Prognosis in Colorectal Cancer Patients by Zeynep Güç

“…Objective: Colorectal cancer is the fourth most common malignant tumor in the world, and survival times are seen to increase together with the increase in the options for targeted therapies, local ablative applications, and supportive care. …”
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Cost-effectiveness of lazertinib as first-line treatment in patients with -mutated advanced lung cancer by Li-Jung Elizabeth Ku, Jui-Hung Tsai, Li-Jun Chen, Szu-Chun Yang

“…The model inputs were derived from the trials (survival outcomes, incidence of adverse events (AEs), and subsequent therapies), National Health Insurance payments (costs of drugs and AEs), and hospital cohorts (utility values). …”
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Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression by Soo Jung Park, Kyung Won Kim, Eun Jeong Lee

“…Given the accessibility of the gut to both dietary and pharmacological interventions, targeting gut-localized α-synuclein represents a promising avenue for developing effective Parkinson’s disease therapies.…”
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Yinzhihuang injection induces apoptosis and suppresses tumor growth in acute myeloid leukemia cells. by Zhe Huang, Yunfu Shen, Xianming Fan, Qulian Guo, Wenzhe Ma

“…<h4>Background</h4>The unmet needs in treating acute myeloid leukemia(AML) promote us to look for more effective and less toxic therapies. In this study, we discovered that Yinzhihuang injection(YZHI), a traditional Chinese patent medicine for hepatitis treatment, suppressed the growth of AML cells.…”
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Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy by Saima Khatoon, Nida Kalam

“…It is a challenge to develop new therapies that can reduce seizures by modulating the underlying mechanisms with no adverse effects. …”
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Advancing Insights into Large-Artery Stiffening in Humans Through the Application of Multi-omics by Marie-Joe Dib

“…With the advent of novel highly effective therapies for atherosclerosis, and the likely decline of other causes of death in the next few decades, prevention and treatment of increased LAS may be one of the most relevant strategies for preventing multimorbidity in aging populations in upcoming decades. …”
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Multimodal Imaging of Neural Progenitor Cell Fate in Rodents by Yannic Waerzeggers, Markus Klein, Hrvoje Miletic, Uwe Himmelreich, Hongfeng Li, Parisa Monfared, Ulrich Herrlinger, Mathias Hoehn, Heinrich Hubert Coenen, Michael Weller, Alexandra Winkeler, Andreas Hans Jacobs

“…For clinical application of stem cell–based therapies, noninvasive detection of applied stem cells is of high importance. …”
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Sex differences in slow-wave electroencephalographic activity (SWA) in adolescent depression by Robert Hoffmann, Roseanne Armitage, Graham Emslie, Jorge Lopez

“…These results underscore the need to develop sex-specific therapies to enhance and restore SWA in depressed adolescents…”
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Identification of key regulators in pancreatic ductal adenocarcinoma using network theoretical approach. by Kankana Bhattacharjee, Aryya Ghosh

“…Pancreatic Ductal Adenocarcinoma (PDAC) is a devastating disease with poor clinical outcomes, which is mainly because of delayed disease detection, resistance to chemotherapy, and lack of specific targeted therapies. The disease's development involves complex interactions among immunological, genetic, and environmental factors, yet its molecular mechanism remains elusive. …”
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Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics. by Kate Summer, Qi Guo, Lei Liu, Bronwyn Barkla, Sarah Giles, Kirsten Benkendorff

“…Antimicrobial proteins and peptides (AMPPs) are considered among the most promising antibiotic alternatives and complementary therapies. Here, we build upon previous work investigating the antibacterial activity of a semi-purified hemolymph protein extract (HPE) of the Australian oyster Saccostrea glomerata. …”
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Clinical Guidelines for Diagnosis and Treatment of Knee Osteoarthritis(Xibibing)in Orthopedics and Traumatology of Traditional Chinese Medicine by Working Group on Setting up Guidelines for Diagnosis and Treatment of Knee Osteoarthritis (Xibibing) in Orthopedics Section of China Association of Chinese Medicine

“…Non-drug treatment mainly includes health education, skill training, manipulation, acupuncture and moxibustion, acupotomology, physiotherapy and other therapies. In the drug treatment part, it is discussed from the aspects of external medicine, injection medicine, syndrome differentiation and internal treatment of traditional Chinese medicine, Chinese patent medicine, oral medicine for symptom control, diseases modifying osteoarthritis drugs(DMOAD)and cartilage protectant. …”
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Persistent Hyperinsulinemic Hypoglycemia in Iraqi Pediatric Population: A Single Tertiary Center Experience by Munib Ahmed Al-Zubaidi, Wasnaa Hadi Abdullah, Khalid Hatem Kareem

“…Background: Congenital hyperinsulinism (CHI) is an inappropriate insulin secretion by the pancreatic cells. When medical therapies are ineffective, surgical treatment is required. …”
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Mechanistic Insights into the Inhibition of Colorectal Cancer by BuShenFang through Adenomatous Polyposis Coli Expression and Wnt/β-catenin Pathway Regulation by Khang Wen Goh, Jie Ji, Hiu Ching Phang, Xian Gu, Rajesh Sreedharan Nair, Xiaohui Wei, Mohammed Tahir Ansari, Kai Bin Liew

“…Despite advances in chemotherapy and radiotherapy, significant side effects persist, prompting the exploration of alternative therapies such as traditional Chinese medicine (TCM). …”
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A systematic review of proaporphine alkaloids and a pharmacological update by Christian Bailly

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The Role of Gut Microbiota in Hypertension Management - A Review by Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej

“…Summary: This review underscores the promise of microbiota-targeted therapies in managing hypertension and calls for further research to elucidate precise mechanisms and develop personalized medicine approaches. …”
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