Prediction of the Binding to the Nuclear Factor NF-Kappa-B by Constituents from <i>Teucrium polium</i> L. Essential Oil by Renilson Castro de Barros, Renato Araújo da Costa, Nesrine Guenane, Boulanouar Bakchiche, Farouk Benaceur, Omer Elkiran, Suelem Daniella Pinho Farias, Vanessa Regina Silva Mota, Maria Fani Dolabela

“…Based on the docking and molecular dynamics results, these molecules have potential as anti-inflammatory and antitumor therapies, with further in vitro and in vivo studies needed to evaluate their activity and toxicity.…”
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Prion Diseases and the Gastrointestinal Tract by Gwynivere A Davies, Adam R Bryant, John D Reynolds, Frank R Jirik, Keith A Sharkey

“…Further research is required to understand how the cellular components of the gut wall interact to propagate and transmit infectious prions to develop potential therapies that may prevent the progression of transmissible spongiform encephalopathies.…”
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Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67 by Vandana Puri, Manjula Jain, Shaji Thomas

“…Hence CD10 expression correlated strongly with well-established negative prognostic markers, that is, HER2-neu and ki67 positivity, ER/PR negativity, and higher tumour grade, thus indicating that CD10 can be used as independent marker indicating poor prognosis and can be used as target for the development of novel therapies.…”
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Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…Androgen signaling plays a significant role, with alterations in the AR pathway contributing to resistance to antiandrogen therapies. In ovarian cancer, high-grade serous carcinomas are characterized by mutations in TP53, BRCA1/2, and homologous recombination repair genes. …”
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Integrating traditional machine learning with qPCR validation to identify solid drug targets in pancreatic cancer: a 5-gene signature study by Xiaoyan Wang, Pengcheng Yu, Wei Jia, Bingbing Wan, Zhougui Ling, Yangyang Tang

“…These findings lay a foundation for developing diagnostic tests and targeted therapies, potentially offering a pathway toward improved outcomes in pancreatic cancer management.…”
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Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis by Hang Han, Guojiang Zhang, Yuanyuan Yang, Chenxi Li, Xiandeng Li, Ling Zhong, Zan Chen, Jianxia Xiong, Tao Cai, Lingjuan Zhang, Xiao Zhang, Qinjian Zhao

“…Current treatments for psoriasis, such as topical agents, systemic therapies and phototherapy, frequently fail to achieve complete remission in clinical settings. …”
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Total Body Irradiation without Chemotherapy as Conditioning for an Allogeneic Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia by Sultan Altouri, Mitchell Sabloff, David Allan, Harry Atkins, Lothar Huebsch, Dawn Maze, Rajiv Samant, Christopher Bredeson

“…Current therapies for acute myeloid leukemia (AML), failing induction, are rarely effective. …”
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Highly Sensitive In Vivo Imaging of Bacterial Infections with a Hydrophilicity‐Switching, Self‐Immobilizing, Near‐Infrared Fluorogenic β‐Lactamase Probe Enriched within Bacteria... by Fangfang Chen, Yuyao Li, Yan Peng, Yifan Zhu, Gao He, Zhengwei Zhang, Hexin Xie

“…The discovery of effective therapies against antibiotic‐resistant pathogens has become an urgent need, necessitating innovative approaches to accelerate the identification and development of novel antibacterial agents. …”
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Ketamine-Induced Cystitis: A Comprehensive Review of the Urologic Effects of This Psychoactive Drug by Danyon J. Anderson, Jessica Zhou, David Cao, Matthew McDonald, Maya Guenther, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“…Empirical treatment options for KIC are available and consist of ketamine cessation, noninvasive therapies, and surgery, and should be decided upon based on the time course and severity of the disease. …”
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Laser Ablation for Small Hepatocellular Carcinoma by Claudio Maurizio Pacella, Giampiero Francica, Giovanni Giuseppe Di Costanzo

“…For these cases, curative therapies such as resection, liver transplantation, or percutaneous ablation have been proposed. …”
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A computational approach to drug design for multiple sclerosis via QSPR modeling, chemical graph theory, and multi-criteria decision analysis by Fozia Bashir Farooq, Nazeran Idrees, Esha Noor, Nouf Abdulrahman Alqahtani, Muhammad Imran

“…While disease-modifying therapies can slow progression, there is a need for more effective treatments. …”
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Targeting the B-Cell Pathway in Lupus Nephritis: Current Evidence and Future Perspectives by Panagiotis Pateinakis, Athina Pyrpasopoulou

“…In an effort to accurately evaluate the potential of these therapies in lupus nephritis, several issues have been raised mainly in terms of patient selection criteria and trial duration. …”
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Looking outside the box with a pathology aware AI approach for analyzing OCT retinal images in Stargardt disease by Parisa Khateri, Tiana Koottungal, Damon Wong, Rupert W. Strauss, Lucas Janeschitz-Kriegl, Maximilian Pfau, Leopold Schmetterer, Hendrik P. N. Scholl

“…The development of effective therapies faces the challenge of identifying appropriate outcome measures that accurately reflect treatment benefits. …”
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Primary intracranial malignant melanoma in an adolescent: case report and literature review by Nyoman Golden, I Gusti Ketut Agung Surya Kencana, Christopher Lauren, Angky Saputra, Denny Japardi

“…Additionally, the findings underscore the critical role of complete surgical resection in improving outcomes, with adjuvant therapies potentially enhancing long-term management and surveillance. …”
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Otomycosis by Yan Edward, Dolly Irfandy

“…<br />Keywords: Otomycosis, Aspergillus sp,Therapy…”
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AVP-GPT2: A Transformer-Powered Platform for De Novo Generation, Screening, and Explanation of Antiviral Peptides by Huajian Zhao, Gengshen Song

“…Despite extensive research, effective antiviral therapies are still limited. To address this urgent need, we present AVP-GPT2, a deep-learning model that significantly outperforms its predecessor, AVP-GPT, in designing and screening antiviral peptides. …”
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Effect of γ-ethyl-γ-phenyl-butyrolactone (EFBL), anticonvulsant and hypnotic drug, on mouse brain catecholamine levels by Rasgado Lourdes A. Vega, Villanueva Iván, Díaz Fernando Vega

“…The results support the role of DA and NA in regulating seizure activity in the brain and indicate that EFBL offers a potential treatment for refractory epilepsy without complementary drugs and Parkinson’s disease, without the drawbacks of oral therapies.…”
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Expert Opinion on Fixed Dose Combination of Dapagliflozin Plus Sitagliptin for Unmet Cardiovascular Benefits in Type 2 Diabetes Mellitus by Soumitra Ray, J Ezhilan, Rajiv Karnik, Ashish Prasad, Rajashree Dhar

“…Based on CV risk, including HF, the combination of SGLT2i and DPP4i may be preferred over other conventional therapies (those with no CV benefit) in cases of established CV disease and/or HF risk. …”
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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations by Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

“…Personalized treatments tailored to tumor molecular profiles, along with identifying biomarkers predictive of resistance to VSV oncolysis, will enhance patient selection and enable more effective, individualized VSV-based therapies.…”
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Physical Exercise as a Diagnostic, Rehabilitation, and Preventive Tool: Influence on Neuroplasticity and Motor Recovery after Stroke by Caroline Pin-Barre, Jérôme Laurin

“…Stroke remains a leading cause of adult motor disabilities in the world and accounts for the greatest number of hospitalizations for neurological disease. Stroke treatments/therapies need to promote neuroplasticity to improve motor function. …”
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