Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug by S. A. Bulgakov

“…Article presents results of use of hexapeptide, algorithm and guideline on its application are analyzed, possible mechanisms of action are discussed. The therapeutic effect of dalargin at various gastro-intestinal diseases is determined by its bioregulator properties maintaining body homeostasis up to standard. …”
Get full text

Anticonvulsant Effects of Synthetic <i>N</i>-(3-Methoxybenzyl)oleamide and <i>N</i>-(3-Methoxybenzyl)linoleamide Macamides: An In Silico and In Vivo Study by Karin Jannet Vera-López, Jorge Alberto Aguilar-Pineda, Rodrigo Martín Moscoso-Palacios, Gonzalo Davila-Del-Carpio, José Luis Manrique-Murillo, Badhin Gómez, Minerva González-Melchor, Rita Nieto-Montesinos

“…In this work, we used in silico and in vivo techniques to analyze the potential therapeutic effect of three synthetic macamides in the treatment of epilepsy: <i>N</i>-3-methoxybenzyl-oleamide (3-MBO), <i>N</i>-3-methoxybenzyl-linoleamide (3-MBL), and <i>N</i>-3-methoxybenzyl-linolenamide (3-MBN). …”
Get full text

Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases by Xian Zhang, Jun Yang, Hong Hu, Yong Wang, Zhenfeng Zhang, Jinhao lv, Junping Li

“…Therefore, the aim of this study is to conduct a longitudinal MRI evaluation of the therapeutic effect of non-enhanced lung cancer BM, thereby enabling improved efficacy prediction and more personalized treatment plans. …”
Get full text

Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study by Li-Qiong Chen, Yong-Can Zhou, Fang Ning, Ming-Jin Zhu

“…BackgroundTraditional Chinese medicine has a good clinical therapeutic effect on perimenopausal insomnia, Jiawei Suanzaoren Tang (JW-SZRT) has a significant therapeutic effect on people with yin deficiency and fire excess type insomnia.MethodFirstly, 80 cases of perimenopausal yin deficiency and fire excess type insomnia were included in the study. …”
Get full text

The Auto/biographical Nature of Ukrainian Women’s Literature on the War in Donbas by Anna Gaidash

“…In the close reading of Natal’ya Vorozhbit’s drama Bad Roads (2017), Yevgeniya Podobna’s book of stories and memoirs titled Girls Cutting Their Locks (2018), and Tamara Duda’s novel Daughter (2019), the author of the article examines the relations between subject and object of the Donbas war texts in the framework of their creation, auto/biographic nature, gender optics, and therapeutic effect. The goal of the study is to analyze how auto/biographical narratives employ actualization of life, leading to the fictionalization of drama and prose texts, which results in heterobiography or synthesis of auto/biographical narratives with heterobiographies. …”
Get full text

Current Status of New Anticoagulants in the Management of Venous Thromboembolism by Roberto C. Montoya, Ajeet Gajra

“…Despite their broad use, these agents have important limitations that have led to the development of new drugs in a bid to overcome the disadvantages of the old ones without decreasing their therapeutic effect. These novel medications, some approved and others in different stages of development, include direct thrombin inhibitors like dabigatran etexilate, and direct activated factor X inhibitors like rivaroxaban. …”
Get full text

The Influence of Intervertebral Disc Microenvironment on the Biological Behavior of Engrafted Mesenchymal Stem Cells by Jing Zhang, Wentao Zhang, Tianze Sun, Jinzuo Wang, Ying Li, Jing Liu, Zhonghai Li

“…However, due to the harsh and complex internal microenvironment of the intervertebral disc, it will affect the biological behaviors of the implanted mesenchymal stem cells, such as viability, proliferation, migration, and chondrogenic differentiation, thereby affecting the therapeutic effect. This review is aimed at summarizing the influence of each intervertebral disc microenvironmental factor on the biological behavior of mesenchymal stem cells, so as to provide new ideas for using tissue engineering technology to assist stem cells to overcome the influence of the microenvironment in the future.…”
Get full text

Clinical Application of Partial Splenic Embolization by Yong-Song Guan, Ying Hu

“…Indicators of the therapeutic effect evaluation of PSE comprise blood routine test, changes in hemodynamics and in splenic volume. …”
Get full text

PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response by Tian L, Wang Z, Lei T, Feng L, Li Y, Wang K, Zhang Y, Zhang C, Liu J, Xing H, Ren W

“…A full-thickness burn wound injury model in 12 SD rats was established, and the therapeutic effect of PLL-g-HPA hydrogel combined with hUC-MSCs was detected by healing time/Histology/inflammation factor expression level.Results: The findings from SEM, FTIR, and HFF analyses demonstrated the successful synthesis of PLL-g-HPA hydrogels. …”
Get full text

Advances and prospects of cell-penetrating peptides in tumor immunotherapy by Di Yang, Baorui Liu, Huizi Sha

“…Abstract Cell-penetrating peptides (CPPs) have been shown to have superior material transport ability because poor infiltration of activated lymphocytes into tumors is one of the crucial factors limiting the therapeutic effect of tumor immunotherapy. Numerous studies have investigated the potential application of CPPs in tumor immunotherapy. …”
Get full text

The Anticancer Perspective of Tangeretin: A Small Review by Yuan Xu, Xi Yan, Junpeng Zhuang, Haijun Hao

“…Tangeretin can also work with other chemotherapy drugs, such as cisplatin, to reduce the drug resistance of cancer cells and improve the therapeutic effect of chemotherapy drugs. This review summarizes the effects of tangeretin on various cancers.…”
Get full text

Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein by Pooja Gogia, Yiqing Xu

“…We discuss a few potential mechanisms of action and propose further studies to elucidate the therapeutic effect of COVID-19 mAb in ITP.…”
Get full text

6-Octadecenoic and Oleic Acid in Liquid Smoke Rice Husk Showed COVID-19 Inhibitor Properties by Ira Arundina, Neni Frimayanti, Meircurius Dwi Condro Surboyo, Theresia Indah Budhy, Benni Iskandar

“…The phenol, 6-octadecenoic acid, oleic acid, and 9-octadecanoic acid were responsible for their therapeutic effect. The LSRH also demonstrated their potential for infectious diseases such as coronavirus disease (COVID-19). …”
Get full text

Cupriavidus gilardii infection following heart failure: a case report and literature review by Yanwen Liu, Jianxin Gao, Jingyun Ye, Hui Han, Haiyan Zhu

“…Conclusion Meropenem has a limited therapeutic effect on this bacterium. Monitoring heart function and selecting effective antibiotics are crucial for improving the prognosis of patients suffered from heart disease and Cupriavidus gilardii infection.…”
Get full text

Visual Outcome after Vitrectomy with Subretinal tPA Injection to Treat Submacular Hemorrhage Secondary to Age-Related Macular Degeneration or Macroaneurysm by Yasmin Ali Said, Evelien Dewilde, Peter Stalmans

“…Larger multicenter randomized controlled studies are warranted to determine the therapeutic effect of this surgical approach.…”
Get full text

Use of Hyaluronic Acid as Adjuvant in Periodontal Therapy and Healing: a Bibliographic Review by Marcelo Fernando Armijos Briones, Cinthya Lisbeth Sinchiguano Moreano, Coralia de los Ángeles Ortega Medina

“…Perform a synthesis of information on the properties of hyaluronic acid and its use as an adjuvant in the therapy of gingivitis, chronic periodontitis and periodontal healing to verify its therapeutic effect and benefits in the field of dentistry. …”
Get full text

Immunosuppressive therapy of patients with pemphigus with ineffectiveness of systemic corticosteroids by Vadim V. Chikin, Arfenya E. Karamova

“…Nevertheless, comparative studies show an increase in the effectiveness of therapy in patients with pemphigus and a faster achievement of therapeutic effect when prescribing cyclophosphamide, but not azathioprine, dapsone, methotrexate, mycophenolate mofetil or cyclosporine. …”
Get full text

Research Progress on Tumor Treatment Strategies Targeting TGF-β by Jian ZHANG, Binyue LYU, Xiao ZHAO

“…Based on current evidence, the therapeutic effect of TGF-β monotherapy on advanced solid tumors is limited. …”
Get full text

Efficacy and Safety of Tripterygium Wilfordii Glycoside Tablets Combined with Acitretin Capsules in the Treatment of Moderate to Severe Plaque Psoriasis: A Randomized Controlled Tr... by Qinghui Fu, Yunjie Zhu, Yiqi Fang, Changbo Dai

“…TWGs combined with acitretin had better therapeutic effects and higher safety in the treatment of MSPP.…”
Get full text

Baricitinib Successfully Treated a Teenager with Refractory Livedoid Vasculopathy: A Case Report and Literature Review by Liu C, Jin YY, Han X, Huang H, Bao S, Xu X, Wang L, Jin Y

“…However, the symptoms improved significantly 2 weeks after treatment with baricitinib, and remission was maintained during its gradual reduction.Conclusion: Successful treatment of this refractory patient with baricitinib provides another evidence for the potential therapeutic effect of JAK1/JAK2 inhibitors in LV, and also offers a reference for the dosage tapering regime of baricitinib in LV.Keywords: livedoid vasculopathy, refractory, baricitinib…”
Get full text