Combined delivery of IL12 and an IL18 mutant without IL18BP-binding activity by an adenoviral vector enhances tumor specific immunity by Yan Cheng, Renjie Luo, Erguang Li

“…We previously reported that adenovirus armed with an IL18 variant (DR18) that overcomes IL18BP neutralizing effect displayed powerful therapeutic effects in local and distant tumors when delivered intratumorally. …”
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Options of dyslipidemia treatment at non-alcoholic fatty liver disease by M. V. Mayevskaya, M. A. Morozova

“…Available clinical trials demonstrate high therapeutical effect of these agents at NAFLD. In the review results of the experimental studies investigating the role of SAM in NAFLD pathogenesis and disorders of lipid metabolism is presented. …”
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Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study by Monika M, Rudhra K, Vennila K, Elanchezhiyan, Sri Harini P, S. Shakeron

“…Given its comparable therapeutic effects and reduced side effect profile, VCO presents a viable alternative to chlorhexidine for managing chronic periodontitis.…”
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Occipital Nerve Blockade for the Treatment of Occipital Neuralgia-Like Acute Postcraniotomy Headache: A Retrospective Study by Shaoheng Wang, Xueye Han, Chunmei Zhao, Fang Luo

“…Objective. The therapeutic effectiveness and safety of occipital nerve blockade (ONB) on occipital neuralgia- (ON-) like acute postcraniotomy headache (ON-APCH) was evaluated. …”
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Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway by Yanqin Wu, Fusheng Sun, Yujin Guo, Yumao Zhang, Li Li, Ruili Dang, Pei Jiang

“…Our present study is aimed at investigating the antidepressant-like effects of curcumin (CUR) in a chronic unpredictable mild stress- (CUMS-) induced depression rat model and explore whether the PGC-1α/FNDC5/BDNF pathway is the major driving force behind the therapeutic effects of CUR. Methods. All rats were randomly divided into four groups, namely, control, CUMS, CUMS+CUR, and CUMS+CUR+SR18292 (PGC-1α inhibitor). …”
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Nanoparticles assisted drug delivery for effective management of Glioblastoma by Mansi Damani, Nagesh Nilawar, Munira Momin, Raghumani Singh Ningthoujham, Tabassum Khan

“…Standard treatments, including surgery, radiotherapy, and chemotherapy with temozolomide (TMZ), are often limited by the ability of the tumor to circumvent therapeutic effects and by the physiological barriers that restrict drug delivery to the brain parenchyma. …”
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Effects of Periodontal Endoscopy-Assisted Nonsurgical Treatment of Periodontitis: Four-Month Results of a Randomized Controlled Split-Mouth Pilot Study by Christian Graetz, Johanna Sentker, Miriam Cyris, Susanne Schorr, Claudia Springer, Karim M. Fawzy El-Sayed

“…Objective. Although the therapeutic effects of nonsurgical periodontal therapy (NSPT) are well established, the clinical benefits of the additional use of periodontal endoscopy (PE) remain controversial. …”
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Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression by Lili Hu, Na Wu, Jue Wang, Donghui Cai

“…This study aimed to explore the therapeutic effects of PHE on MDD through network pharmacology and experimental validation. …”
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Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment by Li G, He F, Feng J, Xu G, Wu C, Qiao Y, Liu Y, Chen H, Du P, Wang J

“…Current treatment methods primarily rely on analgesics or anti-inflammatory drugs to alleviate symptoms but fail to achieve the desired therapeutic outcome.Methods: To better realize therapeutic effects of OA, procyanidins (PAs), as a type of plant flavonoids with strong antioxidant and anti-inflammatory activities, were designed to self-assembly with well-dispersible Pluronic F127 (PF127) through the hydrogen-bond interaction to present an injectable, biocompatibility PA nanospheres.Results: These nanospheres significantly increased the cell viability in mouse L929 fibroblasts and ADTC5 chondrocytes compared with unassembled PAs. …”
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Mechanism of Radix Bupleuri and Hedysarum Multijugum Maxim drug pairs on liver fibrosis based on network pharmacology, bioinformatics and molecular dynamics simulation. by Lefei Yu, Pan Yu, Yongchang Cao, Weiya Cao

“…A number of studies demonstrate the therapeutic effectiveness of Radix Bupleuri (RB) and Hedysarum Multijugum Maxim (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear. …”
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Discussion on the Mechanism of Gandoufumu Decoction Attenuates Liver Damage of Wilson’s Disease by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway Based on Network Pharmacol... by Lulu Tang, Chenling Zhao, Jing Zhang, Ting Dong, Huaizhen Chen, Taohua Wei, Jiuxiang Wang, Wenming Yang

“…GDFMD imparted therapeutic effects on WD through autophagy suppression by acting through the PI3K/Akt/mTOR pathway.…”
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Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation by Qiongqiong Gao, Zhentao Gao, Minzhi Su, Yong Huang, Chi Zhang, Cuiping Li, Hailun Zhan, Bolong Liu, Xiangfu Zhou

“…This study aimed to test the therapeutic effects of hUMSCs overexpressing HO-1 on cyclophosphamide-induced cystitis rat model. …”
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Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure by Zhuoran Wang, Jun Ling, Shaoli You, Bing Zhu

“…Abstract Background Exosomes derived from pre-stimulated mesenchymal stem cells (MSCs) have improved therapeutic effects in disease-associated microenvironments. …”
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Clinical Efficacy Evaluation of Sirolimus in Congenital Hyperinsulinism by Somayyeh Hashemian, Reza Jafarzadeh Esfehani, Siroos Karimdadi, Rahim Vakili, Daniel Zamanfar, Amirhossein Sahebkar

“…This study aimed to evaluate the potential therapeutic effects of sirolimus in CHI patients with mutations in the ABCC8 and KCNJ11 genes. …”
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Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review by Shangwu Liu, Runhong Zhang, Jamal Hallajzadeh

“…The altered ncRNA profiles may contribute to the neuroprotective and therapeutic effects observed with exercise interventions. …”
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Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy by Chunhuan Jin, Xinyu Zhou, Minhui Xu, Hiroki Okanishi, Ryuichi Ohgaki, Yoshikatsu Kanai

“…Nanvuranlat exhibited a sustained inhibitory effect on LAT1 even after its removal, indicating the potential for prolonged therapeutic effects. Both compounds showed comparable dissociation rates, suggesting that N-acetylation does not affect the interaction responsible for slow dissociation. …”
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Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis by Xiaobao Chen, Li Liu, Weidan Wang, Yuan Yuan, Wei Wang

“…Our objective was to evaluate the capability of complex coacervation to mitigate the adverse effects of PME while preserving its antibacterial potency and therapeutic effectiveness. <b>Methods:</b> Three negatively charged polyions: potassium sucrose octasulfate, polytamic acid, and sodium hyaluronate, were used for formulation. …”
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Endometrial Regenerative Cell-Derived Conditioned Medium Alleviates Experimental Colitis by Chenglu Sun, Jingpeng Hao, Hong Qin, Yanglin Zhu, Xiang Li, Baoren Zhang, Yafei Qin, Guangming Li, Hongda Wang, Hao Wang

“…The results suggest that ERC-CM can exert similar therapeutic effects as ERCs and could be explored for future application of cell-free therapy in the treatment of colitis.…”
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Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective by Wenhao Liao, Jing Wang, Yuchen Li

“…In contrast to existing work, we hope to uncover NPs with sequential therapeutic effects on multiple phases of GC development, providing new ideas for gastric cancer prevention, treatment, and drug development.…”
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Upregulation of TCPTP in Macrophages Is Involved in IL-35 Mediated Attenuation of Experimental Colitis by Baoren Zhang, Chenglu Sun, Yanglin Zhu, Hong Qin, Dejun Kong, Jingyi Zhang, Bo Shao, Xiang Li, Shaohua Ren, Hongda Wang, Jingpeng Hao, Hao Wang

“…Interleukin-35 (IL-35), as a cytokine with immunomodulatory function, has been shown to have therapeutic effects on UC, but its mechanism is not yet clear. …”
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