A novel therapeutic multiepitope vaccine based on oncoprotein E6 and E7 of HPV 16 and 18: An in silico approach by Sari Eka Pratiwi, Ysrafil Ysrafil, Mardhia Mardhia, Mahyarudin Mahyarudin, Muhammad Inam Ilmiawan, Heru Fajar Trianto, Delima Fajar Liana, Yuri Amia

“…Introduction: The current vaccine strategies to prevent cervical cancer are effective only for individuals unexposed to HPV, lacking therapeutic effects against pre-existing infections. Multiepitope vaccines, using an immunoinformatic approach, are promising against tumors and viral infections because of their high specificity, safety, and stability, as well as the cheap cost of development. …”
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MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing by Xiaoning He, Zhiwei Dong, Yina Cao, Han Wang, Shiyu Liu, Li Liao, Yan Jin, Lin Yuan, Bei Li

“…Numerous studies have shown that the therapeutic effects of MSCT appear to be mediated by paracrine signaling. …”
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Immunotherapy and Antivascular Targeted Therapy in Patients’ Treatment with Concurrent Malignant Tumors after Organ Transplantation: Opportunity or Challenge by Bairu Shen, Zi Guo, Peng Huang, Minghua Tan, Xiaoshen Zhang, Siyao Lin, Changshan Song, Jiaqing Wang, Minqian Huang

“…To analyze the therapeutic effects and organ rejection of anti-PD-1 immunotherapy or antivascular targeting therapy on patients with combined malignancies after organ transplantation. …”
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Bioactivity of plants used traditionally in the treatment and management of men’s sexual health by Tsumbedzo Nemandalali, Monde A. Nyila, Thilivhali E. Tshikalange

“…Contribution: The investigated plants have potential therapeutic effects and can be used as leads in the development of new pharmaceuticals to manage men’s sexual disorders.…”
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Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin by Michał Biernacki, Elżbieta Skrzydlewska

“…Therefore, it is believed that dysregulation of eicosanoid levels may contribute to the development of skin diseases, such as psoriasis or atopic dermatitis, which in turn suggests that targeted control of the generation of specific eicosanoids may have diagnostic significance and beneficial therapeutic effects. This review is the first systemic and very detailed approach presenting both the causes and consequences of changes in phospholipid metabolism leading to the generation of eicosanoids, changes in the level of which result in specific metabolic disorders in skin cells leading to the development of various diseases. …”
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A review of leishmaniasis: current knowledge and future directions of heterocyclic molecules by Tejaswini Masne, Dileep Kumar, Deepali Bansode

“…This review article provides: (1) a comprehensive analysis of current knowledge and the evolving landscape of heterocyclic drug therapies for leishmanial diseases; (2) focusing on the mechanism of drug action; (3) therapeutic effects; (4) side effects; (5) potential future directions. …”
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Etoricoxib–NLC Mitigates Radiation-Induced Ovarian Damage in Rats: Insights into Pro-Inflammatory Cytokines, Antioxidant Activity, and Hormonal Responses by Sahar Khateeb

“…The findings indicate that ETO-NLC has the potential to ameliorate the harmful effects of ovarian damage induced by γ-radiation. These therapeutic effects were achieved through the modulation of oxidative stress, inflammation, augmentation of antioxidant defenses (including <i>Nrf2</i> activation), support for cell survival pathways (via PI3K/Akt signaling), regulation of MAPK, mitigation of fibrosis (<i>TGF-β</i>), and preservation of ovarian reserve (as evidenced by AMH, FSH/LH, and estrogen levels). …”
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Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts by Yi Wang, Guihua Chen, Deng Li

“…Abstract Clinically, phosphodiesterase type 5 inhibitors (PDE5-Is) remain the first-line therapy for erectile dysfunction (ED) patients; however, approximately 35% of these patients are still failing to respond to the therapeutic effects. So, urgent needs are required to identify novel therapeutic targets for ED. …”
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Efficacy of Cabbage Leaf versus Cooling Gel Pad or Diclofenac Gel for Patients with Knee Osteoarthritis: A Randomized Open-Labeled Controlled Clinical Trial by Thanapon Chobpenthai, Patcharapol Arunwatthanangkul, Wiriya Mahikul

“…This study clinically demonstrated that cabbage leaf application and cooling gel pad application showed similar improvements in reducing OA symptoms in terms of the overall NRS score and Oxford Knee Score. Their therapeutic effectiveness was better than that of diclofenac gel.…”
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Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment by Lu Y, Wang Y, Li Y, Li Y, Jiang YW, Li J

“…This match of therapeutic agents and inhibitors not only achieves good therapeutic effects but also minimizes side effects as much as possible, which may provide an effective way for PTT-based treatment of atherosclerosis.Keywords: gold nanorods, photothermal therapy, NO, activated macrophages, atherosclerosis…”
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Quercetin Inhibits Pyroptosis in Diabetic Cardiomyopathy through the Nrf2 Pathway by Zhang Wei, Zhou Jing, Kang Pinfang, Shi Chao, Qian Shaohuan

“…We found that quercetin promoted the nuclear translocation of Nrf2 in cardiac cells of diabetic rats, increased the expression of the antioxidant proteins HO-1, GCLC, and SOD, reduced the accumulation of ROS and the degree of cardiomyocyte apoptosis, and alleviated diabetes-induced cardiac fibrosis. The therapeutic effects of quercetin were further validated in H9C2 cardiomyocytes. …”
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Development and Validation of a Stability-Indicating HPLC Method for the Simultaneous Determination of trans-Resveratrol and cis-Resveratrol in an Injectable Solution by Esmeralda Mota-Lugo, Mariana Dolores-Hernández, Elvia A. Morales-Hipólito, Iris A. Blanco-Alcántara, Hugo Cuatecontzi-Flores, Raquel López-Arellano

“…trans-Resveratrol, a phytochemical compound with antioxidant power and various therapeutic effects, such as cardioprotective, chemopreventive, and neuroprotective, among others, has disadvantages of poor solubility and limited stability, creating difficulties for the development of new strategies for its quantification. …”
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Stimuli-responsive hydrogel dressing for wound healing by Wei Zhang, Jun Hu, Hao Wu, Xiufei Lin, Limei Cai

“…Traditional wound dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during wound healing and repair processes because they cannot respond to the dynamic wound microenvironment changes over the long-term. …”
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Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics by Xiaomin Xu, Donghua Yu, Yu Wang, Xin Jiang, Fang Lu, Shumin Liu

“…In addition, non-targeted metabolomics techniques were combined to further investigate the mechanism of Res in treating GA.ResultsThe results of network pharmacology showed that Res may exert its therapeutic effects through the NF-κB signaling pathway. …”
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Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis by Yajie Sun, Zhuo Sun, Yukai Chen, Guohua Deng

“…To analyze the therapeutic effects of corneal debridement combined with intrastromal voriconazole in recalcitrant fungal keratitis. …”
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The perfect molecule for hormonal contraception: Estetrol benefits. A review by Elena A. Gorbunova, Inna A. Apolikhina

“…Further research is needed on the impact of COCs with E4 on the psycho-emotional state and quality of women's sexual life, as well as the possible therapeutic effects of E4-based COCs, which will individualize the approach to contraception and provide women with safer and more effective options.…”
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Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…Negative regulation of MAPK3 expression using miRNAs has led to therapeutic effects in cancer. Objectives. The present study performed molecular docking and dynamics simulation to identify potential MAPK3 inhibitors from natural flavonoids, possibly leading to drug development in cancer therapy. …”
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Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice by Yanyan Zhang, Yaxi Du, Hong Yu, Yongchun Zhou, Feng Ge

“…Treatment with a high dose of OL had more positive therapeutic effects on ARF than using a low dose of OL. …”
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The Effect of P-Cymene on Glucose, Insulin, Antioxidant Power, and the Level of AKT Gene mRNA in Streptozotocin-Induced Diabetes Model in Male Wistar Rats by Maryam Arabloei Sani, Zahra Hajebrahimi, Parichehreh Yaghmaei, Nasim Hayati Roodbari

“…In the present study, the therapeutic effects of p-cymene on blood glucose and insulin levels, the antioxidant power of serum (FRAP assay) and the expression of AKT mRNAs in streptozotocin-induced diabetic rats were investigated. …”
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Design and Optimization of the Circulatory Cell-Driven Drug Delivery Platform by Pengyu Gao, Dan Zou, Ansha Zhao, Ping Yang

“…These cells possess extended circulation times and innate chemomigration ability and can activate an immune response that exerts therapeutic effects. However, new challenges have emerged, such as payloads, cell function change, cargo leakage, and in situ release. …”
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