Rescue RM/CS-AKI by blocking strategy with one-dose anti-myoglobin RabMAb by Xinyue Wang, Ning Li, Lu Han, Ou Qiao, Xin Chen, Pengtao Wang, Lancao Zhang, Yingjie Hou, Fengjiao Bao, Herui Hao, Sania Saeed, Li Zhang, Zizheng Li, Xiaohong Duan, Shuquan Rao, Zichuan Liu, Yanhua Gong

“…The main goal of blocking the passage of free Mb through the glomerular filtration barrier has been achieved by using the anti-Mb RabMAb, which has a long-term stable therapeutic effect within 14 days and promotes phagocytosis of Mb. …”
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Neuregulin1 ameliorates metabolic dysfunction-associated fatty liver disease via the ERK/SIRT1 signaling pathways by Chengan Xu, Shouhao Wang, Di Meng, Mingshan Wang, Rong Yan, Yining Dai

“…The aforementioned therapeutic effect of NRG1 was lost after the intervention of PD98059. …”
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The Impact of Dermal Characteristics on Low-Level Laser Power Measurement in Postmortem Zoological Species by Faith Ramsey, Michelle Borsdorf, John Ladner, Anne White, Tara M. Harrison

“…This could necessitate adjustment of machine settings for therapeutic effect in different species, though further studies would be warranted to determine the extent to which this would be necessary. …”
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Ochratoxin A induces immunotoxicity by targeting Annexin A1 mediated neutrophil apoptosis in zebrafish by Yihong Zheng, Yinuo Liu, Jin Tian, Shuhong Liu, Gaowei Ma, Yupeng Xie, Chenhua Zheng, Zekai Wu

“…Additionally, the potential therapeutic effect of aesculetin was evaluated.ResultsOur results demonstrated that exposure to OTA inhibited embryonic development and induced malformations in a concentration-dependent manner. …”
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Electroacupuncture Alleviates Neuropathic Pain and Negative Emotion in Mice by Regulating Gut Microbiota by Feng C, Pan H, Zhang Y, Ye Z, Zhou Y, Zou H, Wang K

“…Following EA treatment, the relative abundance of Alistipes, A2, Roseburia, and Rikenella was decreased, whereas the relative abundance of Alloprevotella and Parabacteroides was increased in EA group when compared with the CCI group.Conclusion: These findings suggested that EA exerted a significant therapeutic effect on NP, potentially through modulation of the gut microbiota.Keywords: electroacupuncture, neuropathic pain, negative emotion, gut microbiota…”
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Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances by Jun Duan, Wanyuan Xia, Xuelei Li, Feng Zhang, Fan Wang, Mengwei Chen, Qian Chen, Bing Wang, Bing Li

“…Thus, MTBA can achieve satisfactory therapeutic effect in children with OSA and mandibular retrognathia with mandibular advancement.…”
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Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments by Beihui He, Zheng Chen, Yunmeng Nie, Minmin Luo, Sumei Xu, Junbin Yan, Zhiyun Chen

“…These results suggested that SQP could ameliorate NASH in rats, and that quercetin may be the critical active compound that exerts the therapeutic effect.…”
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Induced Pluripotent Stem Cells Reduce Progression of Experimental Chronic Kidney Disease but Develop Wilms’ Tumors by Heloisa Cristina Caldas, Fernando Henrique Lojudice, Cinthia Dias, Ida Maria Maximina Fernandes-Charpiot, Maria Alice Sperto Ferreira Baptista, Rosa Sayoko Kawasaki-Oyama, Mari Cleide Sogayar, Christina Maeda Takiya, Mario Abbud-Filho

“…The therapeutic effect of induced pluripotent stem cells (iPSs) on the progression of chronic kidney disease (CKD) has not yet been demonstrated. …”
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Dexmedetomidine pretreatment enhances protective effect efficacy of pericytes agaist acute lung injury in septic mice by LUO Xi, ZHANG Zisen, YANG Ao

“…What’s more， the therapeutic effect of Dex-PC cells was significantly better than that of the PC cells （P<0.05）. …”
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Anisodamine ameliorates crystalline silica-exposed pulmonary inflammation and fibrosis via the α7nAChR/JAK2/STAT3 signaling pathway by Meng Liu, Hui Liu, Hong Kang, Juan Wu, Puhua Xing, Xiaorui Ding, Yangyang Wei, Xiaomei Kong

“…Methyllycaconitine(MLA, α7nAChR inhibitor) and RO8191 (JAK2/STAT3 agonist) could reverse the therapeutic effect of ANI in silicosis and related molecular mechanisms. …”
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Exosomal miR-122 derived from M2 macrophages induces osteogenic differentiation of bone marrow mesenchymal stem cells in the treatment of alcoholic osteonecrosis of the femoral hea... by Guoping Le, Riyou Wen, Huaixi Fang, Zhifa Huang, Yong Wang, Hanwen Luo

“…Subsequently, the effect of exosomal miR-122 on the osteogenic differentiation ability of BMSCs was detected, including cell proliferation, expression of osteogenic-related genes (RUNX2, BMP2, OPN, ALP), and calcium nodule formation. Finally, the therapeutic effect of M2-Exo was analyzed in a rat model of AIONFH, and bone repair and pathological damage were evaluated by Micro-CT, RT-qPCR, HE, Masson staining, and immunohistochemistry (COL I). …”
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Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline by Ge Gao, Ge Gao, Caipeng Lin, Caipeng Lin, Ruibo Li, Xi Xie, Hai-Bin Luo, Hai-Bin Luo

“…However, the research on OSF regarding EGCG is relatively limited.PurposeWe aimed to investigate the potential therapeutic effect of EGCG against OSF using an arecoline (ARE) -induced rat model and primary rat oral fibroblasts.MethodsPrimary rat oral mucosal fibroblasts (ROMF) were isolated and identified. …”
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Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome by Gao Y, Chen C, Huang X, Liu Y, Zhou Z, Pan Y

“…The somatic symptoms of IBS were determined by the 5-item IBS symptoms severity score (IBS-SSS), quality of life (QOL) by 34-item IBS-QOL questionnaire, and psychological disorders by Patient Health Questionnaire (PHQ-9), Hospital Anxiety and Depression Scale (HADS), Visceral Sensitivity Index (VSI). Therapeutic effect of omentin-1 for IBS was investigated in a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced IBS mouse model.Results: We found that serum levels of omentin-1 were significantly decreased in patients with the diarrhea-predominant IBS (IBS-D) subtype (not the constipation or alternating subtype) compared to those in healthy subjects. …”
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A novel cryopreservation solution for adipose tissue based on metformin by Yaping Deng, Xin Liu, Xichao Jian, Yan Zhang, Yinchi Hou, Suyun Hou, Fang Qi, Shune Xiao, Chengliang Deng

“…Young adipose tissue demonstrates a more pronounced therapeutic effect; thus, the cryopreservation of adipose tissue of young origin is particularly crucial. …”
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Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke by Kai Zhao, Rui Li, Changcong Gu, Long Liu, Yulong Jia, Xize Guo, Wanping Zhang, Chunying Pei, Linlu Tian, Bo Li, Jianrong Jia, Huakun Cheng, Hongwei Xu, Lixian Li

“…While the injection of ADSC leads to a relatively mild but prolonged therapeutic effect, the administration of ADSC-E results in a fast and pronounced clinical improvement which was associated with a unique change in the molecular signature suggesting that potential mechanisms underlying different therapeutic approach may be different. …”
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Injectable hydrogel regulates immune infiltration through physical and chemical synergy in the treatment of steroid-induced osteonecrosis of the femoral head by Zherui Fu, Yiwen Xu, Fangqi Xu, Haoyu Zhou, Na Lin, Ning Zhang, Feng Lin

“…Thus, the dual synergistic regulation of immune infiltration at the lesion site of SONFH enhanced the physiological activity and function of the stem cells, thereby improving the therapeutic effect of SONFH. This hydrogel system provides insight for the future development of multifactorial regulatory systems and provides a strategy for the treatment of SONFH.…”
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Study on the protective effect of naringin-regulated lncRNA GAS5 against mitochondrial apoptosis in osteoarthritic chondrocytes by LIN Qin, ZHU Yingkai, LIN Yanming, LAN Shujie, CHEN Changxing, FU Changlong

“…In addition, silencing lncRNA GAS5 will weaken the therapeutic effect of naringin on OA.ConclusionNaringin inhibits chondrocyte mitochondrial apoptosis and protects degraded cartilage tissues by down-regulating the expression of lncRNA GAS5, which has therapeutic value for OA diseases.…”
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Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study by Qing-jun Guo, Jing Shan, Yi-feng Xu, Yan-yan Hu, Cui-lan Huo, Jing-yun Song, Chao-qun Wang, Hui Zhou, Chao-qin Yu, Qin Huang

“…This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress. …”
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BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia by Xu Sang, Yongping Zhang, Fang Fang, Li Gao, Yanfang Tao, Xiaolu Li, Zimu Zhang, Jianwei Wang, Yuanyuan Tian, Zhiheng Li, Di Yao, Yumeng Wu, Xinran Chu, Kunlong Zhang, Li Ma, Lihui Lu, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Zhen Zhang, Jian Pan, Shaoyan Hu

“…This study is aimed at investigating the therapeutic effect of GNE-987 on AML and its underlying mechanism. …”
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The active roles of Rhodotorula mucilaginosa ZTHY2 in regulating antioxidant capacity and immune function of Leizhou black ducks by Jiang Wu, Yingxin Hu, Namula Zhao, Wei Yang, Zhibao Chen, Zhibao Chen

“…The serum levels of complement components C3 and C4, immunoglobulin IgG, and cytokines IFN-γ, IL-2, IL-4, IL-6, and TNF-α were significantly increased in Leizhou black ducks treated with ZTHY2 at 42-days post-treatment, with the therapeutic effect becoming more pronounced as the duration of the experiment prolonged. …”
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