Phytomedicine nanoformulations for Parkinson's disease by Chinthu V. Saji, K P Mohanakumar, Rajesh A Shenoi

“…Conclusions: Phytomedicines formulated using nanoliposomes, nanoemlusions, polymeric nanoparticles, nanocrystals and metal nanoparticles have shown promise in improving the drug bioavailability and BBB penetration, resulting in better therapeutic effect in PD cellular and animal models. However, challenges such as scalability, regulatory compliance, and concerns over long term safety of these nanoformulations have to be considered for them to be clinically viable. …”
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The Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats by An Y, Zhang J, Ren Q, Liu J, Liu Z, Cao K

“…It also reduces the levels of inflammatory cytokines, thereby mitigating neurogenic inflammation and improving central sensitization.Conclusion: Acupuncture exerts its therapeutic effect on migraine by regulating neurotransmitter release, inhibiting inflammatory responses, modulating central analgesic mechanisms, and suppressing glial cell activation. …”
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Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency by Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers

“…As clinically applied hyperthermia enhances the therapeutic effect of photon irradiation by, among other factors, inducing homologous recombination deficiency, our results suggests that hyperthermia could be more effective in combination with proton irradiation than photon irradiation.…”
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Platelet Rich Plasma in the Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw: Personal Experience and Review of the Literature by F. Longo, A. Guida, C. Aversa, E. Pavone, G. Di Costanzo, L. Ramaglia, F. Ionna

“…In our study, we considered 72 patients with BRONJ with nonsurgical therapy, surgical therapy, and surgical therapy with platelet rich plasma (PRP) gel to evaluate its therapeutic effect in promoting ONJ wounds healing. Good results showed by PRP in improving wound healing give away to case-control randomized studies that could give definitive evidence of its effectiveness.…”
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Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Lear... by Zhilu Zou, Yin Chen, Qinqin Shen, Xiaoyan Guo, Yuxuan Zhang, Gang Chen

“…Here, we investigated the therapeutic effect of repeated low dose of Yueju in the animal model mimicking clinical long-term depression condition and the role of neural plasticity associated with PKA- (protein kinase A-) CREB (cAMP response element binding protein) and NMDA (N-methyl-D-aspartate) signaling. …”
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<i>Aspergillus oryzae</i> Fermented <i>Plumula Nelumbinis</i> Against Atopic Dermatitis Through AKT/mTOR and Jun Pathways by Fengfeng Chen, Jing Liu, Xinwei Yu, Honglei Jia, Cheng Yang, Bingtian Zhao

“…<b>Methods:</b> The potential targets of FPN for AD were preliminarily screened using network pharmacology, and then PCR and WB were used to prove the therapeutic effect of FPN in AD. <b>Results:</b> Network pharmacology indicated that mTOR and Jun were key targets for AD. …”
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The Transcription Factor SOX18 Inhibitor Small Molecule 4 Is a Potential Treatment of Cancer‐Induced Lymphatic Metastasis and Lymphangiosarcoma by Katja K. Koll, Martin M. Zimmermann, Patrick A. Will, Ulrich Kneser, Christoph Hirche

“…Aims In this in vitro study, we investigated the potential therapeutic effect of a small molecule called Sm4, which inhibits SOX18, on lymphatic endothelial and lymphangiosarcoma cells in vitro. …”
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A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma by Josefina Navarrete-Solís, Juan Pablo Castanedo-Cázares, Bertha Torres-µlvarez, Cuauhtemoc Oros-Ovalle, Cornelia Fuentes-Ahumada, Francisco Javier González, Juan David Martínez-Ramírez, Benjamin Moncada

“…To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients. …”
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Effects of high-power pain threshold ultrasound technique in patients with knee osteoarthritis: A single-blind randomized controlled trial by Yomna F. Ahmed, Rania M. Tawfik, Ahmed M. Tawfick, Shimaa T. Abu El Kasem

“…The current study aimed at evaluating the therapeutic effect of the high-power pain-threshold ultrasound technique (HPPTUS) in comparison with conventional ultrasound (US) techniques in patients with knee osteoarthritis (KOA). …”
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Early prevention of carrageenan-induced peripheral/spinal inflammation suppresses microglial hyperreactivity in the trigeminal spinal subnucleus caudalis and alleviates chronic fac... by Toru Yamamoto, Mitsuhiro Yoshida, Yuhei Koyama, Yatendra Mulpuri, Eiji Imado, Kana Oue, Mitsuru Doi, Yoshitaka Shimizu, Naotaka Kishimoto, Hiroshi Hanamoto, Kenji Seo

“…In this study, we investigated the mechanisms underlying carrageenan-induced chronic pain and the therapeutic effect of the anti-inflammatory drug meloxicam. …”
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Relieving Effect of <i>Artemisia ordosica Krasch</i> Extract on DSS-Induced Colitis by Regulating Immunity, Antioxidant Function, Gut Microbiota, and Bile Acid Metabolism in Mice by Min Jiang, Xuekai Zhang, Xiao Jin, Binlin Shi, Yuanqing Xu, Zheqi Wang

“…The aim of this experiment was to investigate the therapeutic effect of <i>Artemisia ordosica Krasch</i> extraction (AOE) in treating colitis induced by dextran sulfate sodium (DSS) in mice. …”
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Research status quo of Traditional Chinese Medicine hot ironing therapy in the treatment of spleen and stomach diseases (中医热熨疗法治疗脾胃疾病的研究现状分析) by TIAN Xiaodong (田小冬), HUANG Yanping (黄砚萍), WANG Wenqing (王文清), WANG Ting (王婷)

“…By searching ancient books and literature, this paper summarized the development history of Traditional Chinese Medicine hot ironing therapy and its treatment methods, therapeutic effects and application progress in spleen and stomach diseases, and to understand the research status of Traditional Chinese Medicine hot ironing therapy in the treatment of spleen and stomach diseases. …”
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Capecitabine enhances sensitivity to oxaliplatin in advanced gastric cancer and the effects on patients’ FOXP1 and GGT levels by Xinyu Guo, Yi Liu

“…Conclusion Capecitabine effectively enhanced the sensitivity of intermediate and advanced gastric cancer to oxaliplatin, improved the therapeutic effect and ameliorated the prognosis of patients. …”
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Local electrical stimulation: introduction to the problem by Lev G. Agasarov, Maxim Yu. Yakovlev, Tatyana V. Konchugova, Larisa A. Marchenkova, Victor A. Drobyshev, Tatyana V. Apkhanova, Tatyana E. Belousova, Tatyana V. Marfina, Nadezhda V. Gushchina, Valeria A. Vasileva, Anastasia A. Mukhina, Irina A. Grishechkina, Tatyana K. Chernyavskaya, Elena P. Ivanova

“…The paper reveals the mechanisms underlying the therapeutic effect of these methods, and puts forward an assumption about the prevailing biological significance of low-intensity stimuli. …”
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PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPα/SYK/FcγR signalings in tumor associated macrophages by Deyou Kong, Yongzhen Chen, Yajuan Yin, Zhikun Liu, Fang Yang, Xiaohong Li, Dongxing Shen, Jun Zhang

“…Both cGAMP content measurement and Masson staining results indicated that PD-L1 mAb had a therapeutic effect on mice with breast cancer and MI, improving the infarct condition and slowing tumor progression. …”
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Investigating the Effect of Olfactory Stimulation in Preterm Infants: A Review Study by Hashem Lashgari Kalat, Mohammad Hasan Mohammadi, Shahabaddin Sorouri, Hossein Ali Kharazmi, Zahra Ramazanian Bafghi, Masumeh Ghazanfarpour, Najmeh Soltani Nejad

“…Rosa damascenes odor had a therapeutic effect on apnea attacks, but not breast milk odor. …”
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Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway by Katyakyini Muniandy, Sivapragasam Gothai, Khaleel M. H. Badran, S. Suresh Kumar, Norhaizan Mohd Esa, Palanisamy Arulselvan

“…Inflammation over a short period of time is essential for its therapeutic effect. However, prolonged inflammation can be detrimental as it is related to many chronic diseases such as delayed wound healing, cardiovascular disease, arthritis, and autoimmune disorders. …”
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Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows by L. I. Drozdova, A. S. Barkova, M. N. Isakova, L. P. Larionov, V. V. Permikin, N. M. Starikov, T. G. Khonina

“…The production tests conducted inhigh producing dairy cows have demonstrated good therapeutic effect of the Si-Zn-B gel for teat-end hyperkeratosis and confirmed its long-term effect that helps to longer maintain the results achieved during treatment. …”
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Comparative analysis of lactaptin activity when produced in bacterial or eukaryotic expression systems by O. A. Koval, O. Y. Volkova, A. A. Gorchakov, S. V. Kulemzin, A. V. Tkachenko, A. A. Nushtaeva, E. V. Kuligina, V. A. Richter, A. V. Taranin

“…In the present study, we demonstrate that the combination of RL2 and cyclophosphamide treatments has an additive therapeutic effect against hepatoma tumor in immunocompetent mice. …”
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Preparation and In Vitro Evaluation of Alginate Microparticles Containing Amphotericin B for the Treatment of Candida Infections by Merlis P. Alvarez-Berrios, Lisa M. Aponte-Reyes, Lourdes Diaz-Figueroa, Juan Vivero-Escoto, Alexis Johnston, David Sanchez-Rodriguez

“…In the last decades, alginate has gained significant interest in drug delivery applications as a cost-effective strategy to improve the safety and therapeutic effect of toxic drugs. In this work, the clinically relevant drug AmB was encapsulated into alginate microparticles using the emulsification/external gelation method. …”
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