Chloroplast genome characteristics and phylogenetic analysis of Macropanax rosthornii (Harms) C.Y. Wu ex G. Hoo (Araliaceae) by Shuxin Du, Huiying Huang, Shuhui Yang, Tianyi Gu, Mengli Zhou, Ruihong Wang

“…M. rosthornii is a kind of high-quality wild ornamental plant resource and is also known for its effective medicinal treatment for fracture, rheumatoid arthritis, traumatic injury, infant malnutrition, etc. …”
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Simultaneous gains for negatively correlated traits of interest in plantain by Geferson Rocha Santos, Letícia Casseano de Souza Santos, Rafael Nunes de Almeida, Hércules dos Santos Pereira, Inês de Moura Trindade, Irany Rodrigues Pretti, Dimmy Herllen Silveira Gomes Barbosa, Edson Perito Amorim, Sávio da Silva Berilli, Ana Paula Candido Gabriel Berilli

“…The genotypes were divided into four groups, in which genotypes 13 (commercial) and 9 (wild) formed isolated groups. Positive correlations between yield and plant height, in addition to negative correlations between these two and the content of soluble solids (SS) were identified. …”
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Age-Related Changes in Female Murine Reproductive Mucosa with respect to γδ T Cell Presence by Katarzyna Skulska, Anna Ewa Kędzierska, Małgorzata Krzyżowska, Grzegorz Chodaczek

“…First, we analyzed γδ T cell presence in FRT in young (2 months) and old (18 months) wild-type (WT) C57BL/6 mice. We did not detect any changes in γδ T cell number nor distribution in the vaginas between the age groups, while in uteri, there was a twofold increase in γδ T cell number in aged mice. …”
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Altered Hepatic Lipid Metabolism Contributes to Nonalcoholic Fatty Liver Disease in Leptin-Deficient Ob/Ob Mice by James W. Perfield, Laura C. Ortinau, R. Taylor Pickering, Meghan L. Ruebel, Grace M. Meers, R. Scott Rector

“…Obese Ob/Ob mice had increased fasting glucose, insulin, and calculated HOMA-IR as compared with lean wild-type (WT) mice. Ob/Ob mice also had greater liver weights, hepatic triglyceride (TG) content, and markers of de novo lipogenesis, including increased hepatic gene expression and protein content of acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD-1), as well as elevated gene expression of PPARγ and SREBP-1c compared with WT mice. …”
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Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine by Marta Vicente-Rodríguez, Rosalía Fernández-Calle, Esther Gramage, Carmen Pérez-García, María P. Ramos, Gonzalo Herradón

“…To test this hypothesis, we studied astrogliosis and microglial response induced by amphetamine (10 mg/kg i.p. four times, every 2 h) in different brain areas of MK−/− mice and wild type (WT) mice. We found that amphetamine-induced microgliosis and astrocytosis are enhanced in the striatum of MK−/− mice in a region-specific manner. …”
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Cerebral blood flow and histological analysis for the accurate differentiation of infiltrating tumor and vasogenic edema in glioblastoma. by Hideki Kuroda, Yoshiko Okita, Atsuko Arisawa, Reina Utsugi, Koki Murakami, Ryuichi Hirayama, Noriyuki Kijima, Hideyuki Arita, Manabu Kinoshita, Yasunori Fujimoto, Hajime Nakamura, Naoki Kagawa, Noriyuki Tomiyama, Haruhiko Kishima

“…<h4>Methods</h4>Data were retrospectively collected from 48 patients with primary IDH-wild-type glioblastoma and 24 patients with meningiomas (Edemas-M). …”
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Different Angiogenic Potential in Low and High Grade Sporadic Clear Cell Renal Cell Carcinoma Is Not Related to Alterations in the von Hippel–Lindau Gene by Marcella M. Baldewijns, Iris J. H. van Vlodrop, Kim M. Smits, Peter B. Vermeulen, Gert G. Van den Eynden, Fiona Schot, Tania Roskams, Hein van Poppel, Manon van Engeland, Adriaan P. de Bruïne

“…Background: von Hippel–Lindau (VHL) inactivation is common in sporadic clear cell renal cell carcinomas (ccRCC). pVHL is part of the ubiquitin ligase complex that targets the alpha subunits of hypoxia-inducible transcription factor (HIF) for degradation under well-oxygenated conditions. In the absence of wild-type pVHL, as observed in VHL patients and most sporadic ccRCCs, constitutive upregulation of HIF results in transcriptional activation of angiogenesis-related genes, such as VEGF. …”
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The Sequence of Prostaglandin-Endoperoxide Synthase 2 Gene in Women with Cervicitis by Maha A. Ahlial, Nazar Sh. Mohammed, Maysara S. Khalaf

“…The mutation occurrence in analysis of rs20417 NSP of PTGS2 gene with wild CC GG and the variation C>G G>C. …”
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Siglec-E augments adipose tissue inflammation by modulating TRAF3 signaling and monocytic myeloid-derived suppressor cells during obesity by Ahmed Rakib, Mousumi Mandal, Md Abdullah Al Mamun, Sonia Kiran, Nelufar Yasmen, Lexiao Li, Daniel M. Collier, Jianxiong Jiang, Frank Park, Udai P. Singh

“…RNA-Seq analysis of AT immune cells isolated from mice fed a high-fat diet (HFD) versus normal fat diet (ND) identified a panel of genes that were markedly downregulated, including sialic acid-binding Ig-like lectin E (siglec-E), in HFD compared to ND mice.MethodsA series of experiments in wild-type (WT) and siglec-E knockout (siglec-E KO) mice was designed to investigate the effect of HFD on the functional role of siglec-E in the regulation of AT inflammation and adipogenesis. …”
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Applying reproductive technologies and genome resource banking to laboratory animals by S. Ya. Amstislavsky, E. Yu. Brusentsev, T. O. Abramova, D. S. Ragaeva, I. N. Rozhkova, T. N. Igonina, E. A. Kizilova, V. A. Naprimerov, N. Yu. Feoktistoiva

“…This is the world’s first reported successful freezing of semen of this wild felid (Prionailurus bengalensis euptilurus). …”
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Cellular Localization and Biochemical Characterization of a Chimeric Fluorescent Protein Fusion of Arabidopsis Cellulose Synthase-Like A2 Inserted into Golgi Membrane by Monica De Caroli, Marcello S. Lenucci, Gian-Pietro Di Sansebastiano, Michela Tunno, Anna Montefusco, Giuseppe Dalessandro, Gabriella Piro

“…The enzyme specific activity is increased by approximately 38% in the transformed protoplasts with respect to wild-type. Preliminary tests with proteinase K, biochemical data, and TM domain predictions suggest that the catalytic site of AtCslA2 faces the Golgi lumen.…”
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Adiponectin Deficiency Blunts Hypoxia-Induced Mobilization and Homing of Circulating Angiogenic Cells by Bert R. Everaert, Vincent J. Nijenhuis, Florence C. M. Reith, Vicky Y. Hoymans, Jean-Pierre Timmermans, Christiaan J. Vrints

“…Methods & Results. AMI was induced in wild-type (WT) (n=10) and adiponectin knockout (Adipoq−/−) mice (n=7). …”
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Geranylgeranyl Transferase-I Knockout Inhibits Oxidative Injury of Vascular Smooth Muscle Cells and Attenuates Diabetes-Accelerated Atherosclerosis by Guo-Ping Chen, Jian Yang, Guo-Feng Qian, Wei-Wei Xu, Xiao-Qin Zhang

“…Moreover, after a 16-week duration of diabetes, Pggt1bΔ/Δ mice exhibited lower α-smooth muscle actin (α-SMA) and nitrotyrosine level, Rac1 activity, p47phox and NOXO1 expression, and phospho-ERK1/2 and phosphor-JNK content than wild-type mice. Meanwhile, the same changes were found in Pggt1bΔ/Δ VSMCs cultured with high glucose (22.2 mM) in vitro. …”
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Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model by Rui Dang, Mridul Dalmia, Ziyuan Ma, Mengmeng Jin, Kushal Aluru, Vincent R. Mirabella, Ava V. Papetti, Li Cai, Peng Jiang

“…Interestingly, our RNA sequencing data suggest that these mutant astroglia significantly upregulate pathways that support neural functions when compared to isogenic wild-type astroglia. Our findings establish a novel astroglia-enriched organoid model, offering a valuable platform for probing the roles of human astroglia in brain development and related disorders.…”
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Comparative lipidome and transcriptome provide novel insights into zero-valent iron nanoparticle-treated Fremyella diplosiphon by Yavuz S. Yalcin, Samson Gichuki, Huan Chen, Anithachristy Sigamani Arumanayagam, Shyama Malika Malwalage, Viji Sitther

“…In the present study, total fatty acid methyl esters (FAMEs) in the wild-type (B481-WT) and transformant (B481-SD) Fremyella diplosiphon strains treated with nanoscale zero-valent iron nanoparticles (nZVIs) were characterized, and transcriptome changes analyzed. …”
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The box tree moth Cydalima perspectalis: a review of biology, invasiveness, management practices and future perspectives of control strategy in Europe by Marta Budziszewska, Paweł Krystian Bereś

“…Since its initial detection in Europe in 2006, C. perspectalis has spread rapidly, causing widespread damage to both ornamental and wild boxwood populations. Although extensive investigations have been conducted on its biology, reproduction, ecology, and phenology, achieving fully sustainable control strategies in Europe remains challenging, even with numerous studies and pest management efforts documented in the literature. …”
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Exogenous Janus Kinase 617 Codon Influences Small Noncoding RNAs and Gene Expression in Ba/F3 Cells by Yi-Yang Chen, Ying-Hsuan Wang, Chih-Cheng Chen, Cih-En Huang, Chia-Chen Hsu, Shu-Huei Hsiao, Yu-Wei Leu

“…Patients with MPN have been shown to have dysregulation of noncoding RNAs, such as microRNA (miRNA) and PIWI-interacting RNA (piRNA), although there is not any concrete proof that JAK2V617F alone is responsible for the aberrant regulation of miRNA and piRNA. Human wild type versus V617F-mutated JAK2 are expressed in mouse Ba/F3 cells, and the expressed small and total RNAs were subjected to next generation sequencing analysis to determine the direct induction. …”
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The current state of the problem of in vitrogene pool preservation in poultry by Y. L. Silyukova, O. I. Stanishevskaya, N. V. Dementieva

“…The freeze-drying of reproductive cells, as a technology for cheaper access to the genetic material of wild and domestic animals, compared to cryopreservation, attracts the attention of scientists in Japan, Israel, Egypt, Spain, and France. …”
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Biodiversity conservation and threat reduction in Kibale and Queen Elizabeth conservation areas, Uganda by Joseph Katswera, Norah M. Mutekanga, Charles K.Twesigye

“…The conservation areas are threatened by habitat transition/changes, wild fires, human-wildlife conflicts, armed poaching and illegal wildlife trade/trafficking in game meat and game products, increasing human population pressure, and boundary encroachment. …”
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Morphological change in an isolated population of red squirrels (Sciurus vulgaris) in Britain by Kim E. Chandler, Eloy Gálvez-López, Stuart Black, Andrew C. Kitchener, Kat Hamill, Bethan Roberts, Sean Doherty, Philip G. Cox

“…This could be an example of diet-induced plastic changes to the skeleton in non-muroid wild mammals, although further research is needed to exclude other driving factors such as genetics.…”
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