Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan by Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed

“…Homozygous mutant (CC) was 53% in both NAFLD and T2DM subjects, while heterozygous mutant (CT) was 15.53% in NAFLD and 22% in T2DM subjects. Wild-type allele (TT) was 31.06% in NAFLD and 25% in T2DM subjects. …”
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Enhanced Antitumor Immune Response in 2′-5′ Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy by Chan Kyu Sim, Jung Hoon Lee, In-Jeoung Baek, Sang-Wook Lee, Myeong Sup Lee

“…Thus, OASL1-deficient (Oasl1−/−) mice were more resistant to implanted tumor growth than wild-type (WT) mice. In this study, we investigated whether targeting or suppressing OASL1 could show synergistic effects on tumor clearance with conventional cancer therapies (such as chemotherapy and radiotherapy) using Oasl1−/− mice and a transplantable lung metastatic tumor cell model. …”
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Evaluating antibacterial and antioxidant properties of sericin recovered from cocoons of Bombyx mori, Gonometa postica and Samia ricini in Kenya. by Mwangi G Kanyora, Timothy M Kegode, Justus Kurgat, Harrison Kibogo, George Asudi, Chrysantus M Tanga, Workneh Ayalew, Subramanian Sevgan, Nelly Ndungu

“…Therefore, this work focus on evaluating antibacterial and antioxidant capacity of sericin recovered from cocoons of domesticated (Bombyx mori, Samia ricini) and wild (Gonometa postica) silkworms in Kenya. Sericin recovery was achieved using high temperature-high pressure method. …”
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Stochastic processes govern gut bacterial community assembly in a Schistosoma mansoni-transmitting snail, Biomphalaria straminea. by Zhanhong Yuan, Jinni Hong, Jehangir Khan, Jinghuang Lu, Benjamin Sanogo, Zhongdao Wu, Xi Sun, Datao Lin

“…The assembly of gut bacterial communities in both laboratory and wild samples is predominantly influenced by stochastic processes rather than deterministic processes, as evidenced by the neutral community model (NCM). …”
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ATP-Binding Cassette Genes Genotype and Expression: A Potential Association with Pancreatic Cancer Development and Chemoresistance? by Li Pang, Beverly Word, Joshua Xu, Honggang Wang, George Hammons, Shiew-Mei Huang, Beverly Lyn-Cook

“…Moreover, the expression of ABCB1 in 2677TT and 3435TT carriers was lower compared to the wild-type homozygotes and heterozygotes. A cell viability assay, using standard pancreatic cancer cell lines, revealed that the ABCB1 2677TT-3455TT haplotype was more sensitive than the other haplotypes to gemcitabine. …”
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Polymorphism of microsattelite loci within the grape germplasm collection maintained at the Dagestan Experiment Station of VIR by M. M. Agakhanov, V. A. Volkov, P. S. Ulianich, K. M. Abdullaev, E. N. Kislin

“…Ampelographical collection of the VIR experiment station in Dagestan comprises 320 accessions of grape cultivars and 25 ecotypes of wild grape species, that are highly polymorphic in their morphological traits. …”
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Portable optical spectroscopy and machine learning techniques for quantification of the biochemical content of raw food materials by Cosimo Ricci, Agata Gadaleta, Annamaria Gerardino, Angelo Didonna, Giuseppe Ferrara, Francesca Romana Bertani

“…Methods Two species of wheat were evaluated in this study: durum wheat, Triticum turgidum var. durum, and Tritordeum (durum wheat × wild barley) together with pomegranate fruits of the variety Wonderful. …”
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Genome-wide identification and comparative analysis of the AP2/ERF gene family in Prunus dulcis and Prunus tenella: expression of PdAP2/ERF genes under freezing stress during dorma... by Dongdong Zhang, Bin Zeng, Yawen He, Jiangui Li, Zhenfan Yu

“…This study identified 114 and 116 AP2/ERF genes in the genomes of 'Wanfeng' almond (Prunus dulcis) and 'Yumin' wild dwarf almond (Prunus tenella), respectively. …”
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Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. by Lance D Eckerle, Michelle M Becker, Rebecca A Halpin, Kelvin Li, Eli Venter, Xiaotao Lu, Sana Scherbakova, Rachel L Graham, Ralph S Baric, Timothy B Stockwell, David J Spiro, Mark R Denison

“…Using novel bioinformatic tools and deep sequencing across the full-length genome following 10 population passages in vitro, we demonstrate retention of ExoN mutations and continued increased diversity and mutational load compared to wild-type SARS-CoV. The results define a novel genetic and bioinformatics model for introduction and identification of multi-allelic mutations in replication competent viruses that will be powerful tools for testing the effects of decreased fidelity and increased quasispecies diversity on viral replication, pathogenesis, and evolution.…”
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INFORMATIONAL RESOURCES ON POTATO GERMPLASM COLLECTIONS by D. A. Afonnikov, I. V. Totsky, Z. Stasevski

“…Potato cultivars are characterized by low genetic diversity, which reduces their potential to produce varieties with improved properties. Wild potato relatives retain a high degree of genetic diversity, which can be used to find the superior alleles and for their further transfer to cultural genotypes. …”
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Patterns of nucleotide diversity for different domains of centromeric histone H3 (CENH3) gene in Secale L. by S. S. Gatzkaya, E. V. Evtushenko

“…The mean values of nucleotide diversity in the NTT and HFD of wild cross- and self-pollinating taxa are close in αCENH3: πtot = 0.0176–0.0090 and 0.0136–0. 0052, respectively. …”
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Anthocyanin profiles and color properties of red wines made from Vitis davidii and Vitis vinifera grapes by Yanlun Ju, La Yang, Xiaofeng Yue, Yunkui Li, Rui He, Shenglin Deng, Xin Yang, Yulin Fang

“…Spine grape (Vitis davidii Foex.) is an important wild grape species native to China. Fifteen red spine grape clones and three red Vitis vinifera grape varieties were used to evaluate the differences in the anthocyanin profiles and color properties of wines made from V. davidii and V. vinifera grapes. …”
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Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity by Jiaqi Ma, Cory M. Ayres, Chad A. Brambley, Smita S. Chandran, Tatiana J. Rosales, W. W. J. Gihan Perera, Bassant Eldaly, William T. Murray, Steven A. Corcelli, Evgenii L. Kovrigin, Christopher A. Klebanoff, Brian M. Baker

“…Here we show that TCR discrimination between an HLA-A*03:01 (HLA-A3)-restricted public neoantigen and its wild-type (WT) counterpart emerges from distinct motions within the HLA-A3 peptide binding groove that vary with the identity of the peptide’s first primary anchor. …”
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FeLV-induced feline leukemia as a natural model for leukemia pathophysiology study (review) by T. V. Tabakaeva, A. V. Tsybulsky, K. A. Baranchugova, I. V. Galkina, M. Yu. Shchelkanov

“…There view focuses on feline leukemia, a common disease of domestic and wild felids (Carnivora, Felidae), being one of the main causes of their deaths. …”
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ClaPEPCK4: target gene for breeding innovative watermelon germplasm with low malic acid and high sweetness by Congji Yang, Jiale Shi, Yuanyuan Qin, ShengQi Hua, Jiancheng Bao, Xueyan Liu, Yuqi Peng, Yige Gu, Wei Dong

“…In the knockout transgenic watermelon plants, two SNP mutations and one base deletion occurred in the ClaPEPCK4 gene, with the malic acid content in the leaves increasing considerably and the PEPCK enzyme activity reduced to half of the wild-type. It is interesting that the ClaPEPCK4 gene triggered the closure of leaf stomata under dark conditions in the knockout transgenic plants, which indicated its involvement in stomatal movement. …”
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Effects of IGF-1 on IK and IK1 Channels via PI3K/Akt Signaling in Neonatal Cardiac Myocytes by Richard M. Millis, Zikiar V. Alvin, Aiqiu Zhao, Georges E. Haddad

“…We compared the delayed outward rectifier (IK) and the inward rectifier (IK) current densities resulting from IGF-1 treatments to those resulting from simulation of PI3K/Akt signaling using adenoviral (Ad) BD110 and wild-type Akt and to those resulting from inhibition of PI3K signaling by LY294002. …”
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Variation of some physical and chemical quality traits of Moroccan domesticated tetraploid oat lines of <i>Avena murphyi</i> Ladiz. by R. Manzali, M. Bouksaim, A. Douaik, G. Ladizinsky, N. Saidi

“…A sequence-based diversity study was conducted on ten tetraploid oat lines of A. murphyi to shed light not only on the importance of domesticating wild oat species for crop improvement but also to highlight the nutritional traits of those oat lines. …”
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Orphan nuclear receptor NR2E3 is a new molecular vulnerability in solid tumors by activating p53 by Yidan Wang, Todd G. Kroll, Linhui Hao, Zhi Wen

“…Here, we demonstrate that the full-length protein isoform of NR2E3 instead of its short isoform activates wild-type p53 and is capable of rescuing certain p53 mutations in various cancer cell lines. …”
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Habitat sharing and interspecies interactions in caves used by bats in the Republic of Congo by Morgane Labadie, Serge Morand, Mathieu Bourgarel, Fabien Roch Niama, Guytrich Franel Nguilili, N’Kaya Tobi, Alexandre Caron, Helene De Nys

“…We investigated the temporal variation in the use of caves and the potential interactions between humans, wild animals and bat colonies. Our study contributes to the understanding of the interface and interactions, for the first time quantified, between cave-dwelling animal species, including humans. …”
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RAISE OF HIGH FROST-RESISTANT AGROPYRON–TRITICUM HYBRIDS by E. P. Razmakhnin, T. M. Razmakhnina, V. E. Kozlov, E. I. Gordeeva, N. P. Goncharov, G. Y. Galitsyn, S. G. Veprev, V. M. Chekurov

“…One way of obtaining high-frost-resistant varieties of winter wheat is a wide hybridization with wild relatives, in particular, certain species of wheatgrass. …”
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