The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis by Nazar Trotsko, Agnieszka Głogowska, Barbara Kaproń, Katarzyna Kozieł, Ewa Augustynowicz-Kopeć, Agata Paneth

“…The TZD-based hybrids with the thiosemicarbazone or the pyridinecarbohydrazone moiety were synthesised and their antimycobacterial activity was investigated against the reference H37Rv and two wild Mycobacterium tuberculosis (Mtb) strains. In further studies, a two-drug interaction analysis was also performed for assessing their synergism with the current first-line drugs used for the treatment of TB. …”
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Chloramphenicol and gentamicin reduce the evolution of resistance to phage ΦX174 by suppressing a subset of E. coli LPS mutants. by Lavisha Parab, Jordan Romeyer Dherbey, Norma Rivera, Michael Schwarz, Jenna Gallie, Frederic Bertels

“…Growth of the bacterial strains with the deep rough phenotype is inhibited at low concentrations of chloramphenicol and, to a much lesser degree, gentamicin. Treating E. coli C wild type with ΦX174 and chloramphenicol eliminates the emergence of mutants with the deep rough phenotype, and thereby slows the evolution of resistance to phage infection. …”
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Great ape infants’ face touching and its role in social engagement by Beatriz Felicio, Kim A. Bard

“…In this work, we document chimpanzee infants and human infants’ touching of other’s faces, a behavior already described in wild capuchin monkey infants, and investigate possible functions of infants’ social touch. …”
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Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

“…Patients converting from BRAF V600E mutant to a BRAF V600 wild‐type status (36%, N = 18) had a superior PFS (8.6 vs 2.3 months; P = 0.0002) and OS (17.4 vs 5.1 months; P < 0.0001) compared to patients with stable or increased mutational allele frequency (12%, N = 6). …”
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Deep application of controlled-release urea increases the yield and saponin content of Panax notoginseng by regulating soil nitrate distribution by Yun-xia Su, Yun-xia Su, Yun-xia Su, Ping Zhao, Li-jie Jia, Li-jie Jia, Li-jie Jia, Yuan-feng Cao, Guan-ze Liu, Guan-ze Liu, Jun-wen Chen, Jun-wen Chen, Sheng-chao Yang, Sheng-chao Yang, Yan-li Zhou, Guang-qiang Long, Guang-qiang Long, Guang-qiang Long

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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…Results: The half maximal inhibitory concentration (IC50) for gemcitabine was significantly higher in the gemcitabine-resistant cell strain (Mia GR) than in the wild-type cell line (Mia WT) (258.10 μmol/L vs 0.18 μmol/L), with a resistance index (RI) of 1 443.9. …”
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Annexin A8 deficiency delays atherosclerosis progression by Carmen Gutiérrez‐Muñoz, Rafael Blázquez‐Serra, Irene San Sebastian‐Jaraba, Sandra Sanz‐Andrea, Maria J. Fernández‐Gómez, Gonzalo Nuñez‐Moreno, Pablo Mínguez, Joan Carles Escolá‐Gil, Paula Nogales, Veronique Ollivier, Jose L. Martín‐Ventura, Benoit Ho‐Tin Noe, Ursula Rescher, Nerea Méndez‐Barbero, Luis M. Blanco‐Colio

“…Methods RNA‐Seq analysis was performed on aortas from ApoE−/− and wild‐type mice. AnxA8 expression was assessed in human and mice atherosclerotic tissue and healthy aorta. …”
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From ocean to cage: evaluating the culture feasibility of Black-spotted croaker (Protonibea diacanthus) by Shubhadeep Ghosh, Gyanaranjan Dash, Biswajit Dash, Rajesh Kumar Pradhan, Sekar Megarajan, Pralaya Ranjan Behera, Ritesh Ranjan, Swatipriyanka Sen, Madhumita Das, Vettath Raghavan Suresh, Achamveetil Gopalakrishnan, Joykrushna Jena

“…The study aims to determine growth performance, feed efficiency, and the potential of P. diacanthus as a candidate species for polyculture.MethodsWild-caught P. diacanthus were reared in six high-density polyethylene sea cages (Inner Diameter: 6 m; Outer Diameter: 7 m; Depth: 4.5 m; Area: 28.29 m²; Volume: 127.29 m³). …”
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Regulation of Expression of Oxacillin-Inducible Methionine Sulfoxide Reductases in Staphylococcus aureus by Kyle R. Baum, Zulfiqar Ahmad, Vineet K. Singh

“…To understand the regulation of this locus, reporter strains were constructed by integrating a DNA fragment consisting of the msrA1/msrB promoter in front of a promoterless lacZ gene in the chromosome of wild-type and MsrA1-, MsrB-, MsrA1/MsrB-, and SigB-deficient methicillin-sensitive S. aureus strain SH1000 and methicillin-resistant S. aureus strain COL. …”
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Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction by Sarah K. Macklin, Katelyn A. Bruno, Charitha Vadlamudi, Haytham Helmi, Ayesha Samreen, Ahmed N. Mohammad, Stephanie Hines, Paldeep S. Atwal, Thomas R. Caulfield

“…We also provide the electrostatics calculations from the wild type and mutant variant. Through a combined multiomic approach of clinical, functional, and protein informatics, we arrive at a data fusion for determination of pathogenicity embedded within the genetic code for this particular genetic variant, which, as a platform, continues to broaden its scope across the field of variants of uncertain significance classification.…”
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ASSESSMENT OF EFFICACY AND SAFETY OF INACTIVATED RABIES VACCINES BASED ON “ARRIAH” STRAIN AND FORMULATED WITH DIFFERENT ADJUVANTS IN CATTLE by A. N. Balashov, D. A. Lozovoy, A. V. Borisov, D. V. Mikhalishin, M. I. Doronin

“…Rabies cases are still reported in various mammal species in the Russian Federation. Wild carnivores contacting with domestic and farm animals and transmitting the pathogen to them are the main source and natural reservoirs of rabies. …”
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The <i>Pelvicachromis pulcher</i>: A Local Aquarium Species by A.T. Ibim, G.C. Eziefule

“…This is as a result of certain constraints such as the absence of its Aquaculture, as very little is known about it and its economic importance where it occurs naturally, collection of fish from the wild for stocking tanks which is associated with risks in their area of occurrence. …”
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Abundance, Species Diversity, and Distribution of Diurnal Mammals in Humbo Community-Based Forest Area, Southern Ethiopia by Adanech Lemma, Wondimagegnehu Tekalign

“…Though the forest is the living place for various wild mammalian species, the conservation measures of the local community should also consider those species in line with the efforts that have been done on forest management practices.…”
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Getting Real: A Naturalistic Methodology for Using Smartphones to Collect Mediated Communications by Chad C. Tossell, Philip Kortum, Clayton W. Shepard, Ahmad Rahmati, Lin Zhong

“…This paper contributes an intentionally naturalistic methodology using smartphone logging technology to study communications in the wild. Smartphone logging can provide tremendous access to communications data from real environments. …”
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ABIOTIC STRESS RESPONSE-ASSOCIATED PROTEINS IN A SALT TOLERANT STRAIN OF THE CYANOBACTERIUM FREMYELLA DIPLOSIPHON: A POTENTIAL BIOFUEL AGENT by Behnam TABATABAI, Viji SITTHER

“…In this study, protein expression in wild type and halotolerant mutant F. diplosiphon strains was compared using two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization time of flight mass spectrometry. …”
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Identification and Characterization of a Novel Rat MAVS Variant Modulating NFκB Signaling by Ihsan Nalkiran, Hatice Sevim Nalkiran

“…In this study, we identified and characterized a novel rat MAVS variant (MAVS500) with a twenty-one-nucleotide deletion, resulting in a protein seven amino acids shorter than the wild-type (WT) rat MAVS. The MAVS500 was cloned from the rat bladder cancer cell line, NBT-II, using specific primers, and subsequently sequenced. …”
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The Canis tangle: a systematics overview and taxonomic recommendations by V. Dinets

“…Analysis of available data shows that Dog should be classified as a full species with four subspecies, since its origin from a common ancestor with modern Gray Wolf has likely predated its domestication (contrary to the most popular view), and interbreeding between Dog and Gray Wolf in the wild is limited. It is possible that never-domesticated Dog populations have survived in southeastern Asia until very recently, or even exist today.…”
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Evaluation of Proteins Released to Medium in Yeast-Bacteria Co-culture System by Çağatay Tarhan, Ayşegül Yanık

“…In addition, co-culture systems are also used in industrial, environmental and medical studies. In this study, the wild strain of Schizosaccharomyces pombe and the DH5α strain of Escherichia coli were grown in their own specific media, then cultured for 48 hours and 72 hours by cultivating in media containing 0,1% glucose with different cell number, and finally the differentiation in the proteins released by the cells into the medium was observed in SDS polyacrylamide gels. …”
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Automatic Adaptive Algorithm for Delineation of Cerebral-Spinal Fluid Regions for Non-contrast Magnetic Resonance Imaging Volumetry and Cisternography in Mice by Ryszard Gomolka

“…It allowed revealing subtle differences in CSF volumes between aquaporin-4-null and wild-type littermate mice, showing robustness and reliability. …”
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Seaweed and its antioxidant content at Batu Layar beach, Senggigi, West Lombok Regency by Nunik Cokrowati, Fisma Apriliyanti, Nuryatin Nuryatin, Jayusri Jayusri, Muhammad Junaidi, Yuliana Asri

“…It can be concluded that there are 12 types of seaweed that grow wild consisting of four species each of green, brown, and red alga. …”
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