Genetic variations and clinical significance in young-onset nasopharyngeal cancer: Analysis of EBV interaction with cellular receptor variants and viral glycoproteins by Sulistyo Emantoko Dwi Putra, Farizky Martriano Humardani, Hikmawan Wahyu Sulistomo, Yulanda Antonius, Jonathan Jonathan, Riyan Charlie Milyantono, Artika Uthary, Risma Ikawaty

“…Molecular docking suggested that this variant enhances interaction more than the wild-type. RT-qPCR validation of EBV showed lower levels in subject one (mutant-NRP1) compared to subject two (wild-type-NRP1). …”
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Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway by Adam Šafanda, Nikola Hájková, Michaela Kendall Bártů, Marián Švajdler, Radoslav Matěj, Jitka Hausnerová, Tomáš Zima, Pavel Dundr, Kristýna Němejcová

“…All tumors showed the wild-type pattern of p53 expression. Regarding predictive markers, all tumors were HER2 negative and did not express PD-L1. …”
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Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations by Hannah Schmieg, Hermann Ferling, Karina Annika Bucher, Stefanie Jacob, Julia Regnery, Hannah Schrader, Julia Schwaiger, Anton Friesen

“…Widespread exposure of terrestrial and avian non-target species is well-known and recently hepatic anticoagulant rodenticide residues have been detected in wild fish. However, no sufficient data exist to interpret the effects of these findings on fish health. …”
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Using the synthetic form RS5 to obtain new introgressive lines of common wheat by R. O. Davoyan, I. V. Bebyakina, E. R. Davoyan, Y. S. Zubanova, D. M. Boldakov, D. S. Mikov, V. A. Bibishev, A. N. Zinchenko, E. D. Badaeva

“…The use of the gene pool of wild relatives, which have a significant reserve of genetic diversity, is of immediate interest for breeding common wheat. …”
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CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations] by Ivana Purnama Dewi, Irawan Yusuf, Agussalim Bukhari, Muzakkir Amir, Vitriyaturrida ., Yusra Pintaningrum, Idar Mappangara, Hendy Bhaskara Perdana Putra

“…Two hundred and six patients had wild-type genotypes, while 78 patients had the LOF genotype. …”
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Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration by Shouhong Wang, Liezhen Fu, Bin Wang, Yanmei Cai, Jianping Jiang, Yun-Bo Shi

“…Finally, T3 treatment at stage 56, while not inducing any measurable tail resorption, inhibited tail regeneration in the wild type but not TRDKO tadpoles. Conclusions Our study suggests that TR-mediated, T3-induced gene regulation changed the permissive environment during the initial period of regeneration and affected the subsequent patterning/outgrowth period of the regeneration process. …”
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Development of SacB-based counterselection for efficient allelic exchange in Fusobacterium nucleatum by Peng Zhou, Bibek G C, Bo Hu, Chenggang Wu

“…Our application of the sacB-based methodology successfully yielded a tonB in-frame deletion mutant and a luciferase gene knock-in at the precise chromosomal location in the wild-type background. The new method augments the existing toolkit for F. nucleatum research and has far-reaching implications due to the easy accessibility to the counterselection compound sucrose. …”
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Mobilization of plant genetic resources from the territory of India by N. P. Loskutova, T. M. Ozerskaya

“…Vitkovsky collected and studied wild and cultivated forms of fruit crops, subtropical plants and grapevines. …”
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The Relationship Between LRP-5 and LRP-6 Gene Mutations and Postmenopausal Type 2 Diabetes and Obesity by Jun Li, Ya Li, Yunqiu Lu, Siyuan Li, Yecheng Zhu, Chuanbing Sun, Partab Rai, Xuehai Jia

“…OB was identified as a risk factor for T2DM in individuals with the wild-type at locus rs1181334, and the interaction between wild-type and mutant was significant ( P  < .05). 3. …”
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The Polymorphism of Voltage-Gated Sodium Channel Gene in Culex Mosquitoes in Banyuwangi District, Indonesia by Yasmin Azzahra Arifin, Hanifah Dzakiyah, Catherine Canina Charunita, Sakura Alya Ashari, Winna Putri Veliarta, Muhammad Akbar Panjinegara, Francesca Giovanetti, Carlo Montagna, Wojciech Jankowski, Muhammad Fathoni, Binarri Augustya, Lynda Rossyanti, Suhintam Pusarawati, Sukmawati Basuki

“…A total of 62 Culex mosquitoes were analyzed. The wild type Culex mosquitoes were found predominant (77%, 48/62). …”
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Current Status, Challenges, and Perspectives in the Conservation of Native Honeybees and Beekeeping in Cambodia by Eric Guerin, Chhouk Chheang, Chainarong Sinpoo, Korrawat Attasopa, Nuttapol Noirungsee, Huoqing Zheng, Tial C. Ling, Patcharin Phokasem, Terd Disayathanoowat

“…However, it remains underdeveloped compared to neighboring countries, with wild honey collection continuing to play a significant role. …”
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VdPAT1 encoding a pantothenate transporter protein is required for fungal growth, mycelial penetration and pathogenicity of Verticillium dahliae by Stephen Mwangi Kamau, Yongtai Li, Tiange Sun, Feng Liu, Qian-Hao Zhu, Xinyu Zhang, Jie Sun, Yanjun Li

“…Comparative transcriptome analysis of wild-type and mutant strain cultivated on sterilized carboxymethyl cellophane membranes found that the amino sugar and nucleotide sugar metabolism pathway, which was related to chitin synthesis and degradation as well as UDP-glucose synthesis, was the most significantly down-regulated pathway in VdPAT1 deletion mutant. …”
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Enhanced membrane protein production in HEK293T cells via ATF4 gene knockout: A CRISPR-Cas9 mediated approach by Byung-Jo Choi, Ba Reum Kim, Ho Joong Choi, Ok-Hee Kim, Say-June Kim

“…Genome sequencing and membrane protein productivity of ATF4-KO cells were compared to wild-type cells using next-generation sequencing (NGS) and a membrane protein isolation kit, respectively. …”
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Mechanism of Action of Decitabine in the Treatment of Acute Myeloid Leukemia by Regulating LINC00599 by Fan Du, Ting Jin, Li Wang

“…The regulatory relationship between miR-135a-5p and LINC00599 was verified by constructing miR-135a-5p mimics, miR-135a-5p inhibit, wild type LINC00599 3′-untranslated region (UTR), and mutant LINC00599 3′-UTR. …”
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Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells: A Nondirected Metabolomic Study by Anabel García-Heredia, Judit Marsillach, Anna Rull, Iris Triguero, Isabel Fort, Bharti Mackness, Michael Mackness, Diana M. Shih, Jorge Joven, Jordi Camps

“…HUVEC cells were incubated with native LDL, oxidized LDL, oxidized LDL plus HDL from wild type mice, and oxidized LDL plus HDL from PON1-deficient mice. …”
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Safeguarding and using global banana diversity: a holistic approach by Ines Van den houwe, Rachel Chase, Julie Sardos, Max Ruas, Els Kempenaers, Valentin Guignon, Sebastien Massart, Sebastien Carpentier, Bart Panis, Mathieu Rouard, Nicolas Roux

“…Genomic and bioinformatic studies of several banana wild relatives greatly enhance our understanding of Musa genetic diversity, links to important phenotypic traits and bring new methods for management of the collection. …”
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Inhibition of NLRP3 enhances pro-apoptotic effects of FLT3 inhibition in AML by Helene Sieberer, Michela Luciano, Diana Amend, Constantin Blöchl, Anna Eglseer, Alina Steinkellner, Sebastian Rieser, Ancuela Andosch, Philip Steiner, Laura Hummer, Peter W. Krenn, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Theresa Neuper, Jutta Horejs-Hoeck

“…In contrast, NLRP3 inhibition selectively induced apoptosis in FLT3 mutant AML cell lines, but not in FLT3 wild-type AML cells. Moreover, we show that NLRP3 inhibition impairs FLT3 signaling by reducing both FLT3 expression as well as downstream signaling in FLT3 mutant cells. …”
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Effects of Clinicopathological Characteristics on the Survival of Patients Treated with PD-1/PD-L1 Inhibitor Monotherapy or Combination Therapy for Advanced Cancer: A Systemic Revi... by Yuhan Wei, Yongfu Li, Qi Du, Xinyi Peng, Jiangtao Jin, Hong Guo, Yongyan Li, Qin Li

“…KRAS wild-type patients had no survival benefit from monotherapy (HR, 0.89; P=0.49). …”
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A suite of wildlife crossing structures facilitates mammal movement across tropical forest fragments in a city by Li Si Tay, Ruisheng Choo, Max D. Y. Khoo, Eunice Kong, Yi Xiang Chan, Wivian H. Y. Neo, Sebastian Ow, Yuet Hsin Toh, Han Ling, Malcolm C. K. Soh, Benjamin P. Y.‐H. Lee, Adrian H. B. Loo, Kenneth B. H. Er

“…Fourteen mammal species were detected across all crossing types, with wild boar (Sus scrofa) being the most prevalent species (68.2%). …”
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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…The functional impact of wild-type and mutated CXCR4 variants was evaluated through molecular docking with its natural ligand CXCR4-modulator 1, using the PyRx tool. …”
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