The measurement of microplastics in surface water and their impact on histopathological structures in wading birds of district Lahore by Shaza Mehboob, Khalid Mahmood Anjum, Hamda Azmat, Muhammad Imran

“…Quantitative and qualitative histopathological analyses were performed to examine variations in prevalence percentage, frequency, and histological alteration indices (HAI) as a consequence of MPs exposure on the health of wild species. Tissue samples from the liver and kidneys of the Red-wattled lapwing were analyzed, and comparisons were made to assess the extent of damage and degree of alteration in bird organs. …”
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Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress... by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

“…Methods: In CRISPR/Cas9-induced aadat knockout (kat2-/-) mice, we examined the effects on emotion, memory, motor function, Trp and its metabolite levels, enzyme activities in the plasma and urine of 8-week-old males compared to wild-type mice. …”
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Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O) by Pia Gattinger, Luibov I. Kozlovskaya, Alexander S. Lunin, Olga S. Gancharova, Dina I. Sirazova, Dina I. Sirazova, Vasiliy D. Apolokhov, Egor S. Chekina, Ilya V. Gordeychuk, Ilya V. Gordeychuk, Alexander V. Karaulov, Alexander V. Karaulov, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Aydar A. Ishmukhametov, Aydar A. Ishmukhametov

“…The protein-based vaccine approach is exemplified solely in a proof of concept study by using W-PreS-O, a chimeric vaccine based on a single fusion protein (W-PreS-O), combining RBDs from Wuhan hu-1 wild-type and Omicron BA.1 with the hepatitis B virus (HBV)-derived PreS surface antigen adsorbed to aluminum hydroxide. …”
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Pathogenic potential of ornithogenic <i>Escherichia coli</i> strains detected in the Earth's polar regions by Batyrbek I. Aslanov, Daniil V. Azarov, Maria A. Makarova, Elizaveta G. Marysheva, Lyudmila A. Kraeva, Aleksey S. Mokhov, Ekaterina A. Lebedeva, Nikita E. Goncharov, Natalya V. Lebedeva, Dmitry A. Starikov, Victoria V. Kolodzhieva, Dmitry E. Polev, Artemy E. Goncharov

“…Pathogenic strains of Escherichia coli are an important object of surveillance within the One Health concept in the wild, agriculture and human society. Migratory bird colonies and high latitude avian colonies may be points of active intraspecies and interspecies contact between different animal species, accompanied by the spread of pathogens. …”
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Advancing poliovirus eradication: lessons learned from piloting direct molecular detection of polioviruses in high-risk and priority geographies by Paula L. Marcet, Brandon Short, Ashley Deas, Hong Sun, Chelsea Harrington, Shahzad Shaukat, Muhammad Masroor Alam, Marycelin Baba, Adedayo Faneye, Prossy Namuwulya, Lea Necitas Apostol, Tamer Elshaarawy, John Kofi Odoom, Peter Borus, Shelina Moonsamy, Yogolelo Riziki, Marie Claire Endegue Zanga, Mesfin Tefera, Anfumbom K. W. Kfutwah, Salmaan Sharif, Varja Grabovac, Cara C. Burns, Nancy Gerloff

“…A multi-laboratory demonstration project was conceived to field-test the DD-ITD method by GPLN laboratories from the WHO African, Western Pacific, and Eastern Mediterranean regions, where wild serotype 1 or vaccine-derived polioviruses still circulate. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…Methods: One-year-old female Sert-/- mice and their wild-type (WT) littermates were subjected to a control diet (CD) or the WD for a duration of three weeks. …”
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Development of a set of monosomic alien addition lines from Gossypium raimondii in Gossypium hirsutum toward breeding applications in cotton by Zhenzhen Xu, Xiaoxi Lu, Wenjie Ding, Wei Ji, Wuzhimu Ali, Heyang Wang, Shan Meng, Qi Guo, Peng Xu, Xianglong Chen, Liang Zhao, Huan Yu, Xinlian Shen

“…Abstract Background Gossypium raimondii Ulbr is a diploid wild cotton (2n = 26, D5D5) that originated in west-central Peru of South America and possesses desirable characteristics that are absent in the Upland cotton G. hirsutum. …”
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The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation by Guoli Huai, Yong Wang, Jiaxiang Du, Zhenhui Cheng, Yuxuan Xie, Jia Zhou, Hongmei Tang, Yanyan Jiang, Xiangyang Xing, Shaoping Deng, Dengke Pan, Dengke Pan, Dengke Pan

“…In vitro, 6GE pAECs showed significantly reduced binding of human IgM and IgG compared to wild-type pAECs (IgG p&lt;0.01, IgM p&lt;0.0001). …”
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The transcriptional regulator Lrp activates the expression of genes involved in the biosynthesis of tilimycin and tilivalline enterotoxins in Klebsiella oxytoca by Miguel A. De la Cruz, Hilda A. Valdez-Salazar, Diana Rodríguez-Valverde, Santa Mejia-Ventura, Nayely Robles-Leyva, Tania Siqueiros-Cendón, Quintín Rascón-Cruz, Nancy León-Montes, Jorge Soria-Bustos, Fernando Chimal-Cázares, Roberto Rosales-Reyes, María L. Cedillo, Jorge A. Yañez-Santos, J. Antonio Ibarra, Javier Torres, Jorge A. Girón, James G. Fox, Miguel A. Ares

“…We determined the transcriptional expression of aroX and npsA, the first genes of each tilimycin (TM)/tilivalline (TV) biosynthetic operon in K. oxytoca MIT 09-7231 wild-type and its derivatives Δlrp mutant and complemented strains. …”
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Clinical features and predictors of atrial fibrillation in patients with light‐chain or transthyretin cardiac amyloidosis by Maria Papathanasiou, Aiste‐Monika Jakstaite, Sara Oubari, Johannes Siebermair, Reza Wakili, Julia Hoffmann, Alexander Carpinteiro, Tim Hagenacker, Andreas Thimm, Christoph Rischpler, Lukas Kessler, Tienush Rassaf, Peter Luedike

“…The study included 133 patients [53% AL, 41% wild‐type (wt) ATTR‐CA, & 6% hereditary ATTR‐CA]. …”
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PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis by Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim

“…Notably, several inhibitors of the IRE1-JNK pathway dramatically inhibited HBV replication and inflammation induced by 21Del-HBV but not by the wild-type HBV in infected hepatocytes. Furthermore, IL6 blockade significantly reduced HCC tumor load induced by 21Del-HBV. …”
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Association between METTL14 gene polymorphisms and risk of ovarian endometriosis by Zijun Zhou, Zijun Zhou, Youkun Jie, Xianyue Hu, Xianyue Hu, Guange Chen, Yanjing Bao, Yanjing Bao, Zhenbo OuYang, Liangzhi Wu, Tianyang Gao, Qiushi Zhang, Qiushi Zhang, Wenfeng Hua, Wenfeng Hua

“…Haplotype analysis showed that individuals with the GATAA haplotype were at higher risk of ovarian endometriosis (AOR = 5.54, 95% CI = 1.63–18.87, P = 0.006), whereas the AGTTG haplotype exhibited protective effects (AOR = 0.55, 95% CI = 0.31–0.97, P = 0.039) compared with wild-type GACAG haplotype carriers. Additionally, Bayesian false discovery probability and false positive report probability analysis confirmed the robustness of the significant findings. …”
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Vingt années de recherches à Oedenburg (Biesheim et Kunheim, Haut-Rhin) : un bilan by Michel Reddé

“…Faunal studies revealed the role of wild species (birds and fish) in the meat diet, which are rarely brought to light without wet sieving.The departure of the troop, during the conquest of the “Agri decimates”, at the beginning of the reign of Vespasian, did not mark the end of the civil agglomeration. …”
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European distribution and intramuscular pathogenicity of divergent lyssaviruses West Caucasian bat virus and Lleida bat lyssavirus by Stefania Leopardi, Laurent Dacheux, Jordi Serra-Cobo, Ágota Ábrahám, Branka Bajić, Hervé Bourhy, Szilárd-Lehel Bücs, Ivana Budinski, Martina Castellan, Petra Drzewniokova, Heliana Dundarova, Francesca Festa, Lauriane Kergoat, Maxime Leuchtmann, Marc López-Roig, Dominique Pontier, Maria Francesca Priore, Emmanuelle Robardet, Dino Scaravelli, Barbara Zecchin, Zsófia Lanszki, Tamás Görföl, Gábor Kemenesi, Paola De Benedictis

“…We evaluated the intramuscular lethality of wild type isolates in Syrian hamsters. WCBV induced 100% lethality and a clinical disease compatible with furious rabies. …”
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Genome-Wide Approach Identifies Natural Large-Fragment Deletion in ASFV Strains Circulating in Italy During 2023 by Claudia Torresi, Roberta Biccheri, Cesare Cammà, Carmina Gallardo, Maurilia Marcacci, Simona Zoppi, Barbara Secondini, Caterina Riverso, Alejandro Soler, Cristina Casciari, Michela Pela, Elisabetta Rossi, Claudia Pellegrini, Carmen Iscaro, Francesco Feliziani, Monica Giammarioli

“…In vivo characterization of the deleted strain 22489.4_2312/RC/2023 revealed identical disease progression to the wild-type strain, with severe ASF symptoms in inoculated pigs. …”
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Genetic status assessment and future development forecast for an isolated giant panda population by Jiabin Liu, Jiaojiao Yu, Wenlei Bi, Mingxia Fu, Xiang Yu, Rong Hou, Xinqiang Song, Rui Ma, Yanshan Zhou, Zusheng Li, Hong Yang, Wei Wu, Jiang Gu, Chong Huang, Long Zhang, Xiaodong Gu, Haijun Gu, Daode Yang, Dunwu Qi

“…Releasing the existing three female wild-training giant pandas can slightly boost the current genetic diversity, but the long-term survival probability is low (42.9 %). …”
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Preparedness, prevention and control related to zoonotic avian influenza by EFSA Panel on Animal Health and Animal Welfare (AHAW), ECDC, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Claire Brugerolles, Thorsten Wolff, Anna Parys, Erika Lindh, Neus Latorre‐Margalef, Marie‐Anne Rameix Welti, Ralf Dürrwald, Ramona Trebbien, Sylvie Van der Werf, Magnus Gisslén, Isabella Monne, Alice Fusaro, Claire Guinat, Alessio Bortolami, Leonidas Alexakis, Theresa Enkirch, Olov Svartstrom, Katriina Willgert, Francesca Baldinelli, Ludovica Preite, Malin Grant, Alessandro Broglia, Angeliki Melidou

“…The main drivers of mammalian adaptation include virus and host characteristics, and external factors increasing AIV exposure of mammals and humans to wild and domestic birds (e.g. human activities and ecological factors). …”
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CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct t... by Mercedes Zubiaur, Laura C. Terrón-Camero, Fernando Gordillo-González, Eduardo Andrés-León, Alicia Barroso-del Jesús, Luz María Canet-Antequera, María M. Pérez Sánchez-Cañete, África Martínez-Blanco, Marilú Domínguez-Pantoja, María Botia-Sánchez, Sonia Pérez-Cabrera, Nerea Bello-Iglesias, Antonio Alcina, Ana-Clara Abadía-Molina, Fuencisla Matesanz, Esther Zumaquero, Ramón Merino, Jaime Sancho

“…This study aimed to elucidate the transcriptomic signatures and dysregulated pathways associated with the autoimmune response in Cd38-/- mice compared to wild-type (WT) mice within the bm12 chronic graft-versus-host disease (cGVHD) lupus model. …”
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Effect of Tiaoxin Recipe on Memory Learning and Synaptic Plasticity in APP/PS1 Double Transgenic Alzheimer's Disease Mice based on αCaMKⅡ-CREB-BDNF Signal Pathway by Xiaowen WANG, Hong QIAN, Chunjuan SHEN, Yanjun LI, Haixin YUAN, Jian WANG

“…Another 18 C57/BL6 male wild type mice of the same age and the same strain were set as the normal group. …”
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Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis by Virginie Carrière, Muhammad Imran Arshad, Jacques Le Seyec, Benjamin Lefevre, Muhammad Farooq, Aurélien Jan, Christelle Manuel, Laurence Touami-Bernard, Catherine Lucas-Clerc, Valentine Genet, Hugues Gascan, Jean-Philippe Girard, Frédéric Chalmel, Lucie Lamontagne, Claire Piquet-Pellorce, Michel Samson

“…We aimed to decipher its function by infecting IL-33-deficient mice (IL-33 KO) and their wild-type (WT) littermates with pathogenic mouse hepatitis virus (L2-MHV3). …”
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