Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity by Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui

“…Here, we studied CV1574-1 in a second mouse model, C57BL/6 wild-type mice treated with pegvisomant to induce GH resistance. …”
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Attributable risk factors for asymptomatic malaria and anaemia and their association with cognitive and psychomotor functions in schoolchildren of north-eastern Tanzania. by Geofrey Makenga, Vito Baraka, Filbert Francis, Daniel T R Minja, Samwel Gesase, Edna Kyaruzi, George Mtove, Swabra Nakato, Rashid Madebe, Sif R Søeborg, Kathrine H Langhoff, Helle S Hansson, Michael Alifrangis, John P A Lusingu, Jean-Pierre Van Geertruyden

“…Regarding the antimalarial drug resistance markers, the most prevalent Pfmdr1 86-184-1034-1042-1246 haplotypes were the NFSND in 47% (n = 88) and the NYSND in 52% (n = 98). The wild type Pfcrt haplotypes (codons 72-76, CVMNK) were found in 99.1% (n = 219) of the samples. …”
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A nonactivating ITGB3 mutation in the β3 cytoplasmic region causes macrothrombocytopenia with an impaired αIIbβ3/RhoA pathway by Keiichi Nakata, Keigo Akuta, Takaya Endo, Midori Koike, Daisuke Motooka, Daisuke Okuzaki, Hisashi Kato, Yoshiaki Tomiyama, Naoki Hosen, Hirokazu Kashiwagi

“…Macrothrombocytopenia was decreased to 76% and 40% of platelet counts in heterozygous (Hetero) and homozygous (Homo) KI mice, respectively, when compared with the wild-type mice. Platelet αIIbβ3 and GPVI expression were decreased in KI mice, and αIIbβ3 activation was not detected in nonstimulated KI platelets. …”
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Exploring the potential of underrated yet versatile crop Lunaria annua L.: New insights into honesty plant by Jovana Petrović, Daiana Almeida, Ângela Fernandes, Dejan Stojković, Dragana Robajac, Tayse F.F. da Silveira, Lillian Barros

“…Herein, we investigated nutritional value, phenolic profile, and bioactive properties of L. annua seeds collected in the wild. The results we obtained indicate that seeds of L. annua have high energy value (406.6 kcal/100 g dw), with high share of carbohydrates (65.2 g/100 g dw), followed by proteins (26.47 g/100 g dw) and fat (4.46 g/100 g dw). …”
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Unveiling the nutraceutical potential of indigenous and exotic eggplant for bioactive compounds and antioxidant activity as well as its suitability to the nutraceutical industry by Yvonne Angel Lyngdoh, Yvonne Angel Lyngdoh, Partha Saha, Partha Saha, Bhoopal Singh Tomar, Rakesh Bhardwaj, Laxman L. Nandi, Mohita Srivastava, Bishal Gurung, Jeetendra Kumar Ranjan, Paresh Chaukhande

“…., Pusa Krishna (G-32), G-5, Mayurbhanj Local, HABI-2, Solanum gilo, and Solanum sisymbrifolium, and cluster 3 had only three genotypes, namely, Solanum insanum, Solanum khasianum, and Solanum xanthocarpum. Furthermore, the wild species S. insanum, S. khasianum, and S. xanthocarpum can also be utilized as a donor line for carrying out the nutritional breeding program as they are the reservoir of many important biochemical genes.…”
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Automated and virus variant-programmable surrogate test qualitatively compares to the gold standard SARS-CoV-2 neutralization assay by Danielle W. Ali, Maggie L. Bartlett, Christopher D. Heger, Francisco Ramirez, Linwood Johnson, Kevin L. Schully, Eric D. Laing, Wei Wang, Carol D. Weiss, Emilie Goguet, Christopher C. Broder, Stephanie A. Richard, Nusrat J. Epsi, Brian Agan, David Tribble, Mark P. Simons, Timothy H. Burgess, Edward Mitre, Simon Pollett, Darci R. Smith

“…Here we tested a prototype automated microfluidic cartridge-based sVNT platform using SARS-CoV-2 wild-type (WT) and B.1.617.2 (Delta) variant RBDs. …”
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The gene Sr38 for bread wheat breeding in Western Siberia by E. S. Skolotneva, V. N. Kelbin, V. P. Shamanin, N. I. Boyko, V. A. Aparina, E. A. Salina

“…The 2NS/2AS translocation has been introduced into the genome of the cultivated cereal Triticum aestivum from the wild relative T. ventricosum. It contains the Lr37, Yr17, and Sr38 genes, which support seedling resistance to the pathogens Puccinia triticina Eriks., P. striiformis West. f. sp. tritici, and P. graminis Pers. f. sp. tritici Eriks. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…Compared with that of wild-type mice, the fungal burden in the lung of TLR2-deficient mice was reduced and the knockout of TLR2 changed the expression of GSDMD, IL-1α, and IL-1β in A. fumigatus. …”
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A study of the influence of the T2DL.2DS-2SS translocation and the 5S(5D) substitution from <i>Aegilops speltoides</i> on breeding-valuable traits of common wheat by R. O. Davoyan, I. V. Bebykina, E. R. Davoyan, A. N. Zinchenko, Y. S. Zubanova, D. M. Boldakov, V. I. Basov, E. D. Badaeva, I. G. Adonina, E. A. Salina

“…The use of the gene pool of wild relatives for expanding the genetic diversity of common wheat is an important task of breeding programs. …”
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Otodectes cynotis (Acari: Psoroptidae) infestations in Southern pudus (Pudu puda): In situ and ex situ data of an unexpected host-parasite record by Caroline Wilhelm, Edwin Kniha, Pamela Muñoz, Ángelo Espinoza, Laura Platner, Saskia Dreyer, Lisa Grund, Zoë Tess Lara Lindhorst, Ulrich Gärtner, Julia Walochnik, Anja Taubert, Dominik Fischer, Stephan Hering-Hagenbeck, Carlos Hermosilla, David Ebmer

“…Otodectes cynotis (Acari: Psoroptidae) constitutes an obligate, non-burrowing ectoparasite and causes otodectic mange primarily in domestic and wild carnivores. Only few studies have described this parasite in herbivore hosts so far. …”
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Bayesian reinforcement learning models reveal how great-tailed grackles improve their behavioral flexibility in serial reversal learning experiments by Lukas, Dieter, McCune, Kelsey, Blaisdell, Aaron, Johnson-Ulrich, Zoe, MacPherson, Maggie, Seitz, Benjamin, Sevchik, August, Logan, Corina

“…We reanalyzed reversal learning data from 19 wild-caught great-tailed grackles (Quiscalus mexicanus), eight of whom participated in serial reversal learning experiment, and found that these predictions were supported. …”
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Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner by Wen Ge, Xiaohua Zhang, Jie Lin, Yangyang Wang, Xiao Zhang, Yu Duan, Xinchun Dai, Jiye Zhang, Yan Zhang, Mengyuan Jiang, Huanhuan Qiang, Zhijing Zhao, Xuebin Zhang, Dongdong Sun

“…The DIC model was established using wild-type, N-Tg, and Rnd3-Tg mice, with subsequent intraperitoneal injection of Dox for 4 weeks. …”
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Comparative analysis of ocular biometrics using spectral domain optical coherence tomography with Purkinje image and optic nerve head alignments in mice by Ying Hon Sze, Bing Zuo, Da Qian Lu, King Kit Li, Dennis Yan Yin Tse, Qian Zhao, Thomas Chuen Lam

“…Gaining an understanding of the implications of these methods in determining axial elongation in the normal growing eyes of wild-type C57BL/6J mice would offer valuable insight into their relevance for the experimental myopia model. …”
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Molecular Mechanisms of Synergistic Effect of PRIMA‐1met and Oxaliplatin in Colorectal Cancer With Different p53 Status by Xiao‐lan Li, Jianbiao Zhou, Nicole Xin‐Ning Tang, Yi Chai, Meng Zhou, Ai‐di Gao, Zhong‐kai Lu, Han Min

“…Conclusions In summary, our research reveals the differential molecular mechanisms of combined PRIMA‐1met and L‐OHP in CRC with wild type p53 and mutant p53. Our data not only demonstrate that this combined regimen exerts synergistic anti‐CRC effect in vitro and in vivo, but also suggest the benefit of PRIMA‐1met on prevention of L‐OHP‐related side effects. …”
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Three-dimensional structure of entire hydrated murine hearts at histological resolution by Jasper Frohn, Frederik Böddeker, Marius Reichardt, Hendrik Bruns, Titus Czajka, Amara Khan, Ludovic Broche, Michael Krisch, Alberto Bravin, Frauke Alves, Jana Zschüntzsch, Tim Salditt

“…We have used XPCT at two beamlines of the extremely brilliant source (EBS) at the European Synchrotron Radiation Facility (ESRF) to scan wild-type murine hearts at high resolution, as well as a series of murine hearts of different pathological models, at reduced resolution and higher throughput. …”
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Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice by Ryan Brown, Donna M. Small, Declan F. Doherty, Leslie Holsinger, Robert Booth, Richard Williams, Rebecca J. Ingram, J. Stuart Elborn, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon

“…Methods. βENaC-Tg mice and wild-type (WT) littermates were treated with a CatS inhibitor from 4 to 6 weeks of age, and CatS-/-βENaC-Tg mice were analysed at 6 weeks of age. …”
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Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice by Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

“…Moreover, it significantly lowered serum cholesterol and triglyceride levels while increasing LDL-R level without causing hepatotoxicity in wild-type mice. Additionally, it decreased PCSK9 expression and elevated low-density lipoprotein receptor expression in Apolipoprotein E-deficient mice, leading to early changes in lipid profiles but lacking a sustained impact on circulating lipids. …”
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TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner by Arun Chhetri, Channy Park, Hyunsoo Kim, Laxman Manandhar, Chagtsalmaa Chuluunbaatar, Jaetaek Hwang, Xiaofan Wei, Gyuho Jang, Batching Chinbold, Hyug Moo Kwon, Sang-wook Lee, Raekil Park

“…TMEM135 knockout (TMEM135KO) and wild type (WT) mice were fed a high-fat diet (HFD) to induce hepatic steatosis. …”
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The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells by Friederike Behler-Janbeck, Anke Baranowsky, Timur A. Yorgan, Michelle Y. Jaeckstein, Anna Worthmann, Marceline M. Fuh, Karthikeyan Gunasekaran, Gisa Tiegs, Michael Amling, Thorsten Schinke, Joerg Heeren

“…For this purpose, we analyzed the skeletal phenotype of wild type controls (WT) and Gpr41/43 double knockout (Gpr41/43 dKO) mice fed either a chow or an inulin-enriched diet. …”
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PET imaging of HIV-1 envelope protein gp120 using 18F-labeled nanobodies by Neysha Martinez-Orengo, Swati Shah, Jianhao Lai, Falguni Basuli, Anna Lyndaker, Mitchell L. Turner, Morteza Peiravi, Suman Sourabh, Kevon Sampson, Peng Zhang, Rolf E. Swenson, Paolo Lusso, Frank Maldarelli, Avindra Nath, Chuen-Yen Lau, Dima A. Hammoud

“…In this study, three nanobodies (J3, 3E3, B9) chosen based on their binding properties to the conserved CD4-binding site of gp120 were labeled with fluorine-18 and used for PET imaging in mice bearing wild-type (WT) and/or gp120-expressing (Env+) tumors. [18F]J3 and [18F]3E3 selectively targeted Env+ tumors and not WT tumors, with minimal background signal. …”
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