Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression by Zhenhua Liu, Mengke Wang, Lijun Meng, Yixiao Chen, Qiuyi Wang, Yan Zhang, Xuefeng Xi, Wenyi Kang

“…Patrinia scabiosaefolia, is used as wild vegetable in China for more than 2 000 years, with a variety of pharmacological activities, including anti-inflammatory, anti-tumor and hypoglycemic. …”
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Characterizing immune biomarkers and effector CD8+ T-cell exhaustion in pancreatic adenocarcinoma via single-cell RNA sequencing profiling by Rawaa AlChalabi, Raghda Makia, Semaa A. Shaban, Ahmed AbdulJabbar Suleiman

“…Drug repurposing of oxaprozin and celecoxib showed favorable binding interactions with both wild and mutant IL7R proteins. Conclusions: The K110N mutation, despite not causing significant structural changes, may impact T-cell and B-cell homeostasis and development. …”
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Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion by Lan Hailin, Chen Yiting, Wu Yue, Li Lijun, Zhang Renlu, Chen Yunhan, Zhu Yanyang, Zhang Qiuyu

“…Cell proliferation ability in vitro and the ability of growth and metastasis in mouse tumor models were compared between KO/OE and wild-type tumor cells. On day 7 after tumor implantation, tumor tissues were separated for flow cytometric assay, bulk RNA sequencing and single-cell RNA sequencing (ScRNA-seq). …”
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Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent by Jan Mersmann, Franziska Iskandar, Kathrina Latsch, Katharina Habeck, Vera Sprunck, René Zimmermann, Ralf R. Schumann, Kai Zacharowski, Alexander Koch

“…The objective of this study was to identify HMGB1 as an activator of TLR2 signalling during MI/R. C57BL/6 wild-type (WT) or TLR2−/−-mice were injected with vehicle, HMGB1, or HMGB1 BoxA one hour before myocardial ischemia (30 min) and reperfusion (24 hrs). …”
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Potential Involvement of IL-17F in Asthma by Kyoko Ota, Mio Kawaguchi, Satoshi Matsukura, Masatsugu Kurokawa, Fumio Kokubu, Junichi Fujita, Yuko Morishima, Shau-Ku Huang, Yukio Ishii, Hiroaki Satoh, Nobuyuki Hizawa

“…Moreover, this variant is a natural antagonist for the wild-type IL-17F. Moreover, IL-17F is involved in airway remodeling and steroid resistance. …”
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Fatty Acid Content and Profile in <i>Ulva lactuca</i> in Response to Exposure to Variable Growth Conditions in Indoor Photobioreactors by Nabeel Gnayem, Razan Unis, Rima Gnaim, Alexander Chemodanov, Álvaro Israel, Jallal Gnaim, Alexander Golberg

“…As such, there is great potential to reduce pressure on wild fish populations, helping to combat overfishing and its associated global impacts. …”
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Effect of KRAS mutation status on clinicopathological characteristics and overall survival in patients with rectal cancer by Shengbin Zheng, Zhijie You, Guodon Guo, Zhijing Lin, Siming Wang, Guohua Yang

“…The patients were categorized into two groups according to their KRAS status: wild-type KRAS (wKRAS) and mutant KRAS (mKRAS), with performing research on mKRAS G12D and mKRAS G13D mutation. …”
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Molecular identification of Leptospira spp. in urine samples from female water buffaloes. Preliminary results by Rosaura Pérez-Gil, Héctor Nava-Trujillo

“… Animal leptospirosis is a zoonotic disease that affects multiple domestic and wild species. It causes generalized vasculitis, which in pregnant females results in placentitis and triggers abortion. …”
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Heterogeneity in Seed Samples from Vineyards and Natural Habitats Along the Eurasian <i>Vitis vinifera</i> Range: Implications for Domestication and Hybridization by Diego Rivera, Javier Valera, David Maghradze, Maia Kikvadze, Anna Nebish, Rafael Ocete, Carlos Álvar Ocete, Claire Arnold, Emilio Laguna, Francisco Alcaraz, Diego José Rivera-Obón, Gianni Lovicu, Massimino Farci, Concepción Obón

“…In parallel, seeds with low domestication index values, found mainly in natural habitats, also displayed low entropy and are likely associated with <i>Vitis sylvestris</i> or other wild Vitaceae species. Intermediate domestication values pointed to hybrid swarms, highlighting the crucial role of hybridization in the development of modern grapevine cultivars. …”
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Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…We recently reported that the ethanol augmentation of GABAergic synaptic transmission in rat CeA involves CRF1 receptors, because both CRF and ethanol significantly enhanced the amplitude of evoked GABAergic inhibitory postsynaptic currents (IPSCs) in CeA neurons from wild-type (WT) and CRF2 knockout (KO) mice, but not in neurons of CRF1 KO mice. …”
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Evaluation of commercial traits in the accessions of Medicago sativa L. from Asia Minor by N. Yu. Malysheva, N. L. Isaeva, E. A. Gubanova, L. L. Malyshev

“…The present study involved 65 local varieties and wild accessions of alfalfa from Turkey preserved in the VIR collection. …”
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Novel Inhibitors for MDM2-MDM4 E3 Ligase Potently Induce p53-Indepedent Apoptosis in Drug-Resistant Leukemic Cells by Rati Lama, Joseph M. Fose, Diana Martín, Inés G. Muñoz, Eunice S. Wang, Pamela J. Sung, Sherry R. Chemler, Xinjiang Wang

“…Inhibitors disrupting p53 interaction with MDM2/MDM4 are in clinical trials in patients bearing wild-type p53 cancers. However, these inhibitors are not designed to work for p53-null/mutant cancer cells. …”
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Annual cycle variations in the gut microbiota of migratory black-necked cranes by Yujia Zhang, Ruifeng Ma, Suolangduoerji, Shujuan Ma, Shujuan Ma, Akebota Nuertai, Ke He, Hongyi Liu, Ying Zhu

“…These results enhance our understanding of the gut microbiota of wild migratory birds and support further research on black-necked cranes.…”
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HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model by Yi-fu He, Xi-min Hu, Md. Asaduzzaman Khan, Bo-yao Yu, Yi-cun Sheng, Xian-zhong Xiao, Xin-xing Wan, Si-pin Tan, Kun Xiong

“…In this study, we used wild-type mice and hsf1-/- mice for in vivo research and PC12 cells for in vitro research. …”
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Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts by Atsuki Fukada, Yasunori Enomoto, Ryo Horiguchi, Yoichiro Aoshima, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Takafumi Suda, Toshihide Iwashita

“…Methods and results Using cell surface markers applicable even into wild-type mouse lungs, we could classify PDGFRα+ total lung resident fibroblasts into at least two major distinct subpopulations: integrin α8 (ITGA8)+ and SCA-1+ fibroblasts. …”
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Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy by Danielle Sidsworth, Noah Tregobov, Noah Tregobov, Colin Jamieson, Jennifer Reutens-Hernandez, Joshua Yoon, Geoffrey W. Payne, Geoffrey W. Payne, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers

“…This pilot study used intravital microscopy to assess differences in responsiveness of gluteal muscle arterioles between a transgenic AD mouse model (APP/PS1; Tg) and wild-type (C57BL/6; WT) mice to further elucidate the role of vascular dysfunction in AD. …”
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Abyssinian pea (Lathyrus schaeferi Kosterin nom. nov. pro Pisum abyssinicum A. Br.) is a problematic taxon by O. E. Kosterin

“…The continuously reproduced notion of its possible spontaneous occurrence in the wild ascends to suppositions made in the XIX century and is not based on any actual data. …”
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Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A by Mingliang Zhang, Xiaomin Nie, Yeqing Yuan, Yansu Wang, Xiaojing Ma, Jun Yin, Yuqian Bao

“…Consistent with previous studies, uncarboxylated osteocalcin significantly protected high-fat diet-fed wild-type mice from obesity and NAFLD, while it did not protect high-fat diet-fed GPRC6ALKO mice from NAFLD. …”
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Molecular characteristics and pathogenicity analysis of infectious laryngotracheitis virus isolated in China from 2015 to 2019 by Xuehui Zhang, Lihua Tang, Linqing Duan, Ruihua Yang, Kangchengyin Liu, Jing Zhao, Ye Zhao, Guozhong Zhang

“…Phylogenetic analysis showed that six isolates (SD2015, GD2017, SYB2018, HB201812, HB201806, and TJ2019) were classified together with CEO vaccine strains, while only one isolates LN2018 belonged to the wild-type cluster. Recombination analysis revealed compelling evidence of probable recombination events existing in SD2015, HB201806, and LN2018. …”
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Affecting of Glyphosate Tolerance and Metabolite Content in Transgenic <i>Arabidopsis thaliana</i> Overexpressing <i>EPSPS</i> Gene from <i>Eleusine indica</i> by Jingchao Chen, Zhiling Li, Haiyan Yu, Hailan Cui, Xiangju Li

“…The results showed that the average resistance index of the transgenic lines was 4.7 and the exogenous <i>E. indica EPSPS</i> expression levels were 265.3- to 532.0-fold higher than those in the wild-type (WT) line. The EPSPS protein ranged from 148.5 to 286.2 μg g⁻¹, which was substantially higher than that in the WT line (9.1 μg g⁻¹). 103 metabolites associated with flavone and flavonol biosynthesis, the metabolism of aromatic amino acids, energy metabolism, and auxin synthesis were significantly higher in the transgenic glyphosate-resistant individuals (R) than in the WT individuals. …”
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