Lessons learnt from measures taken to prevent rabies introduction and spread into a long rabies free territory (case study of the Irkutsk Oblast) by I. V. Meltsov, A. M. Ablov, E. N. Shkolnikova, M. E. Koplik, P. A. Minchenko, T. V. Desyatova, I. D. Zarva, A. D. Botvinkin, A. Ye. Metlin

“…The paper demonstrates cartograms of fox and wolf population density along with designation of sites, where oral vaccination of wild carnivores was performed.…”
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« Mon seul Shakespeare » by Jacques Nichet

“…So, some sort of counter-plan is progressively put in place which looks as if it chimed in with the tragic course of events only to better deceive the wild beast named Angelo! To each measure of tragedy a measure of comedy is being added! …”
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Preparation and evaluation of Brucella T4SS recombinant proteins in serodiagnosis of human brucellosis based on TMT-based proteomics technology by Qi Wu, Chen Sun, Liping Guo, Yujia Xie, Jinpeng Zhang, Jinpeng Zhang, Dehui Yin, Dehui Yin

“…VirB proteins, components of the Type IV secretion system (T4SS) in Brucella, play a pivotal role in bacterial virulence and pathogenesis but have been understudied for their diagnostic potential.MethodsTandem Mass Tag (TMT) proteomics technology was utilized to identify highly expressed VirB proteins from wild-type Brucella strains. Recombinant T4SS proteins were prepared, and an indirect ELISA method was established for serological diagnosis of human brucellosis.ResultsSeven T4SS proteins (rVirB3, rVirB4, rVirB9, rBMEII0036, rVirB8, rVirB11, and rVirB10) were expressed used to construct the indirect ELISA method which showed high diagnostic accuracy. …”
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HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…The HACE1 knockout group exhibited higher levels of malondialdehyde (MDA), greater mitochondrial fission, and dissipation of mitochondrial membrane potential (MMP), leading to more apoptosis and severe cardiac dysfunction compared to the wild-type I/R group(P < 0.05). On the other hand, HACE1 knockout further reduced superoxide dismutase (SOD) activity in the myocardium(P < 0.05), further supporting the findings. …”
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Bloodstream infections at a tertiary hospital in the Gambia - a one-year retrospective study by Paul Rahden, Ebrima Barrow, Haddy Bah, Sheikh Omar Bittaye, David Nygren, Abdoulie Badjan

“…Acquired antibiotic resistance, beyond wild-type, was reported in 17/20 (85%) of Pseudomonas spp. and 16/19 (84%) of Acinetobacter spp. …”
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Proton motive force generated by microbial rhodopsin promotes extracellular electron transfer by Wenqi Ding, Tong Lin, Yun Yang, Wen-Wei Li, Shaoan Cheng, Hao Song

“…Among these, the recombinant strain expressing rhodopsin cR-1 exhibited the highest output power density of 0.87 W/m2, 3.49-fold increase over the wild-type S. oneidensis MR-1. Our further transcriptomics analyses of the energy and materials metabolism of strain cR-1 showed that the underlying mechanism of enhanced EET efficiency was resulted from heterologous expression of the light-driven proton pump. …”
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Neutralization of omicron subvariants and antigenic cartography following multiple COVID 19 vaccinations and repeated omicron non JN.1 or JN.1 infections by Nungruthai Suntronwong, Sitthichai Kanokudom, Thaneeya Duangchinda, Warangkana Chantima, Pattarakul Pakchotanon, Sirapa Klinfueng, Jiratchaya Puenpa, Thaksaporn Thatsanathorn, Nasamon Wanlapakorn, Yong Poovorawan

“…A single omicron PVI elicited lower neutralization titers to all variants compared to wild-type (WT), indicating immunological imprinting. …”
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The gut microbiota predicts and time-restricted feeding delays experimental colitis by Hannah K. Ruple, Eva Haasis, Anna Bettenburg, Carina Maier, Carolin Fritz, Laura Schüle, Sarah Löcker, Yvonne Soltow, Lynn Schintgen, Nina S. Schmidt, Celine Schneider, Axel Lorentz, W. Florian Fricke

“…We show that while altered light/dark cycles disrupted the intestinal clock in wild type (WT) mice, IL-10-/- mice were characterized by altered microbiota composition, impaired intestinal clock, and microbiota rhythmicity irrespective of external clock disruption, which had no consistent colitis-promoting effect on IL-10-/- mice. …”
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Novel primers improve species delimitation in Cercospora by Mounes Bakhshi, Mahdi Arzanlou, Asadollah Babai-ahari, Johannes Z. Groenewald, Pedro W. Crous

“…Abstract The genus Cercospora includes many important plant pathogens that are commonly associated with leaf spot diseases on a wide range of cultivated and wild plant species. Due to the lack of useful morphological features and high levels of intraspecific variation, host plant association has long been a decisive criterion for species delimitation in Cercospora. …”
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Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens by Zhuliang Yang, Yongcui Liu, Jintang Luo, Cong Xiao, Hong Yuan, Wenya Du, Xiurong Yang

“…Feathered foot is a trait observed in domestic and wild chickens, resulting from the partial or complete transformation of scales on the tarsus, shanks, and toes into feathers. …”
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Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model by Catarina Raposo, Ana Karolina de Santana Nunes, Rayana Leal de Almeida Luna, Shyrlene Meiry da Rocha Araújo, Maria Alice da Cruz-Höfling, Christina Alves Peixoto

“…We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice. Herein, the understandings of the neuroprotective effect of sildenafil and the mediation of iNOS/NO system on inflammatory demyelination induced by cuprizone were investigated. …”
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Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets. by Natalia A Ilyushina, Jon P Seiler, Jerold E Rehg, Robert G Webster, Elena A Govorkova

“…However, H5N1 viruses carrying the E119A or the N294S NA mutation were lethal to 1 of 3 inoculated animals and were associated with significantly higher virus titers (P<0.01) and inflammation in the lungs compared to the wild-type virus. Our results suggest that highly pathogenic H5N1 variants carrying mutations within the NA active site that decrease susceptibility to NA inhibitors may possess increased virulence in mammalian hosts compared to drug-sensitive viruses. …”
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Quarantine nematode species and pathotypes potentially dangerous for domestic potato production: populations diversity and the genetics of potato resistance by N. V. Mironenko, T. A. Gavrilenko, A. V. Khiutti, O. S. Afanasenko

“…The review provides data on sources of potato resistance to parasitic nematodes identified in collections of wild and cultivated species. Data on identified R-gens and QTL of resistance that have been introduced into breeding varieties using different methods and approaches are analyzed. …”
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USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

“…In vitro experiments demonstrated that USP25−/− CD4+ T lymphocytes had a higher proportion for Th17 cell differentiation and exhibited higher RORγt levels upon stimulation. Wild-type mice with anti-GBM GN showed higher USP25 levels compared to healthy mice, and a positive correlation was observed between USP25 levels and Th17 cell counts. …”
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Antiviral Activity of Pistacia atlantica subsp. Kurdica Extract Against Herpes Simplex Virus Type 1 by Shahin Gavanji, Hojjat Baghshahi, Azizollah Bakhtari, Ali Mohamadi, Zahra Hamami Chamgordani, Mojtaba Khandan, Javaher Sinaei

“…Objective: Most research on the therapeutic effects of wild pistachio species has focused on bacteria and fungi. …”
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Complete mitochondrial genome sequence analysis revealed double matrilineal components in Indian Ghoongroo pigs by Pranab Jyoti Das, Satish Kumar, Manasee Choudhury, Seema Rani Pegu, K. Meera, Rajib Deb, Sunil Kumar, Santanu Banik, Vivek Kumar Gupta

“…The phylogenetic study using complete mitogenome also indicated that GH pigs were originated locally from Indian wild boar independently from Asian and European pig population. …”
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Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization by Yushuo Gao, Yisheng Zhong, Yanji Zhu, Anna M. Demetriades, Yujuan Cai, Jikui Shen, Qing Lu, Xi Shen, Bing Xie

“…Flow cytometry analysis demonstrated that Flt3 deficiency shifted Mphi polarization towards an M2 phenotype during RNV with significant reduction in M1 cytokine expression when compared to the wild-type controls (P<0.05). Based on the above findings, we concluded that Flt3 inhibition alleviated ocular NV by promoting a Mphi polarization shift towards the M2 phenotype. …”
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Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma by Giuseppina De Filpo, Elisa Contini, Viola Serio, Andrea Valeri, Massimiliano Chetta, Daniele Guasti, Daniele Bani, Massimo Mannelli, Elena Rapizzi, Michaela Luconi, Mario Maggi, Tonino Ercolino, Letizia Canu

“…This mutation was also associated with an increased number of mitochondria through the electron microscopy compared with wild-type tissues as suggestive for mitochondria neoformation compensatory to the mitochondrial autophagic figures observed. …”
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The Fatty Acid Content, Health Lipid Indices, and Instrumental, Histological, and Sensory Quality of Hare Meat (<i>Lepus europaeus</i> Pallas) by Gabriela Frunză, Marius-Mihai Ciobanu, Otilia Cristina Murariu, Răzvan-Mihail Radu-Rusu, Paul-Corneliu Boișteanu

“…Hare meat is an appreciated resource for consumers in terms of its sensory, instrumental, and nutritional values, and it has a higher value than that obtained from livestock species or other wild animals (more valuable proteins, lower fat content, and better health lipid indices).…”
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Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease by Maria Victoria Legorreta-Haquet, Rocio Flores-Fernández, Francisco Blanco-Favela, Ezequiel M Fuentes-Pananá, Luis Chávez-Sánchez, Rafael Hernández-González, Emiliano Tesoro-Cruz, Lourdes Arriaga-Pizano, Adriana Karina Chávez-Rueda

“…We observed that the PRL-receptor is expressed in early bone-marrow B-cell; the expression in lupus-prone mice, which had the highest level of expression in pro-B cells and immature cells, differed from that in wild-type mice. These expression levels did not significantly change in response to hyperprolactinemia; however, populations of pro-B and immature cells from lupus-prone strains showed a decrease in the absolute numbers of cells with high PRL-receptor expression in response to PRL. …”
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