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2161
Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone
Published 2025-01-01“…Abalone is an economically important mollusk, whose slow growth has impeded the recovery of its wild populations and development of aquaculture. …”
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2162
The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death
Published 2025-01-01“…In THP-1 monocytes ΔROP55 infection increased NF-κB p65 nuclear translocation, IL-1β production, and GSDMD cleavage compared to wild type or complemented parasites. ΔROP55 infection also induced RIPK3-dependent necroptosis in human and mouse primary macrophages. …”
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2163
Regulation of MAP2, GFAP, and calcium in the CA3 Region Following Kainic Acid Exposure to organotypic hippocampal slice culture [version 3; peer review: 2 approved]
Published 2025-01-01“…Methods OHSC was obtained from three healthy wild type Wistar rats aged P10. Healthy culture slices were obtained and lasted up to 10 days in vitro (DIV 10). …”
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2164
How, why, where and when people feed birds?—Spatio‐temporal changes in bird‐feeding in Finland
Published 2025-02-01“…Policy implications: Our results highlight that provisioning food to wild animals involves complex decision‐making depending on habitat, geography and economic factors. …”
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2165
Distal protein-protein interactions contribute to nirmatrelvir resistance
Published 2025-02-01“…To probe the role of the non-active site mutations in fitness rescue, here we use an Mpro triple mutant (L50F/E166A/L167F) that confers nirmatrelvir drug resistance with a viral fitness level similar to the wild-type. By comparing peptide and full-length Mpro protein as substrates, we demonstrate that the binding of Mpro substrate involves more than residues in the active site. …”
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2166
Cytogenetic features of intergeneric amphydiploids and genome-substituted forms of wheat
Published 2024-11-01“…Synthetic intergeneric amphydiploids and genome-substituted wheat forms are an important source for transferring agronomically valuable genes from wild species into the common wheat (Triticum aestivum L.) genome. …”
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2167
IL-17 Is a Key Regulator of Mucin-Galectin-3 Interactions in Asthma
Published 2021-01-01“…We previously showed that the absence of tissue inhibitor of metalloproteinase 1 (TIMP-1) enhances lung inflammation, airway hyperreactivity, and lung remodeling in asthma in an ovalbumin (OVA) asthma model of TIMP-1 knockout (TIMPKO) mice as compared to wild-type (WT) controls and mediated by increased galectin-3 (Gal-3) levels. …”
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2168
The RNA-binding protein Puf5 and the HMGB protein Ixr1 regulate cell cycle-specific expression of CLB1 and CLB2 in Saccharomyces cerevisiae.
Published 2025-01-01“…On the contrary, CLB2 expression was unchanged between wild-type strain and puf5Δ mutant in unsynchronized cultures, and the puf5Δ clb1Δ double mutant did not show growth retardation. …”
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2169
Correlation Between <i>Cryptococcus</i> Infection and the Nasal Mycobiota in a Population of Free-Ranging Koalas (<i>Phascolarctos cinereus</i>) in New South Wales, Australia
Published 2025-01-01“…This study represents the first investigation of the nasal mycobiota of wild koalas. Further studies involving koalas with clinical disease are necessary to determine the role of the nasal mycobiota in the development of cryptococcosis.…”
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2170
Mesenchymal stem cell‐derived exosomes mitigate amyloid β‐induced retinal toxicity: Insights from rat model and cellular studies
Published 2025-01-01“…Through intravitreal injections in wild‐type rats and RPE‐like cell culture experiments, we examined the protective effects of AT‐MSC‐Exosomes against Aβ42 retinotoxicity. …”
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2171
Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas
Published 2025-01-01“…Increased IGFBP2 expression in gliomas significantly correlated with isocitrate dehydrogenase mutation-wild type. GSEA results revealed that five differential pathways involved in collagen binding, collagen-containing extracellular matrix, collagen metabolic process, collagen trimer, and extracellular structure organization were significantly enriched in patients with glioma with high IGFBP2 expression.Conclusion: Our study is the first to show that overexpression IGFBP2 could be an independent glioma biomarker. …”
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2172
Activity of the mammalian DNA transposon piggyBat from Myotis lucifugus is restricted by its own transposon ends
Published 2025-01-01“…Here we show that structure-based rational re-engineering of the transposase through the removal of putative phosphorylation sites and a changed domain organization - in combination with truncated transposon ends - results in a transposition system that is at least 100-fold more active than wild-type piggyBat.…”
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2173
Stem cutting, rooting, and shoot growth potentials of some hedge plant species as influenced by number of nodes
Published 2024-11-01“…., Boungainvillea glabra Wild., and Alternanthra dentata Scheygr. Stem cuttings of each of the ten species with 2, 3 and 5 nodes constituted the treatments arranged in Completely Randomized Design with three replicates. …”
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2174
Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS
Published 2025-02-01“…The expression level of variant c.3175 C > T(p.Q1059X) in podocytes showed a significant decrease compared to that of the wild-type (P < 0.05), whereas variant c.694 C > T(p.Q232X) was markedly upregulated (P < 0.01). …”
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2175
Prevalence and Molecular Characterization of Cysticercus tenuicollis Isolated from Some Intermediate Host in Kurdistan-Iraq
Published 2018-09-01“…Cysticercus tenuicollis (C. tenuicollis) is the larval stage infection of Taenia hydatigena, a common tapeworm of dogs and other Canidae, which has a wide range of intermediate hosts including sheep, goat, cattle, deer, camel, horse, human and other wild ruminants, the disease spreads through a contaminated water, soil and food with feces of infected dogs or other carnivores, T. hydatigena lives in the intestinal of the definitive host (carnivores) and excretes a huge number of eggs with feces daily. …”
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2176
MICROSATELLITES-BASED EVALUATION OF THE PEAR CULTIVARS SELECTED FROM NIKITSKY BOTANICAL GARDENS GERMPLASM BY THEIR ECONOMICALLY VALUABLE CHARACTERISTICS
Published 2018-03-01“…Mobilization and preservation of genetic sources of diversity of the cultivated pear varieties and their wild relatives is one of the main aspects of new cultivars breeding for modern intensive horticulture. …”
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2177
Successful domestication of Neonothopanus Hygrophanus (Mont.) De Kesel & Degreef and Lentinus Squarrosulus Mont., indigenous saprophytic edible mushrooms from Kibira National Park...
Published 2024-01-01“…This study was undertaken to explore opportunities for domestication of saprophytic wild edible mushrooms from the Kibira National Park (KNP) in Burundi. …”
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2178
Global demand for rice genetic resources
Published 2022-05-01“…Abstract Background The International Rice Research Institute (IRRI) holds in trust the world's largest collection of rice diversity, with more than 130,000 accessions of cultivated rice and wild species. Between 2012 and 2018, a total of 2174 requests for rice germplasm were received from more than 1000 unique requestors. …”
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2179
Evaluation of synthetic wheat lines (Triticum durum/Aegilops tausсhii) for vegetative period and resistance to diseases
Published 2017-05-01“…Increase of resistance to stress factors in the emerging varieties can be achieved by utilizing the diversity of the genetic resources of related wild species and genera in crosses. The results of a phenotypic evaluation of the synthetic hexaploid wheat lines of CIMMYT breeding created by crossing durum wheat varieties from Institute of Breeding and Genetics (Odessa, Ukraine) and variety Pandur from Romania (T. durum Desf., AB genome) with Aegilops (Ae. tausshii Coss., D genome), and also 15 synthetic wheat lines of Kyoto University breeding (Japan) created by crossing durum wheat variety Langdon with different ecological forms Aegilops are presented. …”
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2180
An experimental study of the effects of SNPs in the TATA boxes of the <i>GRIN1, ASCL3</i> and <i>NOS1</i> genes on interactions with the TATA-binding protein
Published 2022-06-01“…A comparison of experimental TBP–TATA affinity values (KD) of wild-type and minor alleles with predicted ones showed that the data correlate well (linear correlation coefficient r = 0.94, p < 0.01).…”
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