Enhanced Tolerance to Antifungals as a General Feature of Rho⁻ Mutants in Yeast Species: Implications to Positive Selection of Respiratory Deficiency by Zachary Johnson, Farhan Nadim, Mikhajlo K. Zubko

“…Nevertheless, a few research groups have reported that some petite mutants of <i>Candida glabrata</i> and <i>Saccharomyces cerevisiae</i> manifested higher levels of tolerance to the antifungal fluconazole than their wild-type (WT) counterparts. In this study, we show that elevated tolerance to two or three out of four tested antifungals is a generic feature of at least five petite-positive species of yeasts including <i>C. glabrata</i> (higher tolerance of petites to clotrimazole and miconazole), <i>S. bayanus</i> (tolerance to clotrimazole, fluconazole, and miconazole), <i>S. cerevisiae</i> (tolerance to clotrimazole and fluconazole), <i>S. paradoxus</i> (tolerance to clotrimazole, fluconazole, and miconazole), and <i>S. pastorianus</i> (tolerance to clotrimazole and fluconazole). …”
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Cytogenetic Identification and Molecular Marker Analysis of Two Wheat–<i>Thinopyrum ponticum</i> Translocations with Stripe Rust Resistance by Guotang Yang, Yi Han, Huihui Yin, Xingfeng Li, Honggang Wang, Yinguang Bao

“…<i>Thinopyrum ponticum</i>, a significant wild relative for wheat improvement, exhibits innate immunity to this disease. …”
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The diagnostic accuracy of circulating free DNA for the detection of KRAS mutation status in colorectal cancer: A meta‐analysis by Wenli Xie, Li Xie, Xianrang Song

“…We extracted true‐positive (TP), false‐positive (FP), false‐negative (FN), true‐negative (TN) values, survival rate of CRC patients with mutant and wild‐type KRAS and calculated pooled sensitivity and specificity, positive/negative likelihood ratios [PLRs/NLRs], diagnostic odds ratios [DORs], and corresponding 95% confidence intervals [95% CIs]. …”
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Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice by Xiaolong Fu, Linqing Zhang, Yecheng Jin, Xiaoyang Sun, Aizhen Zhang, Zongzhuang Wen, Yichen Zhou, Ming Xia, Jiangang Gao

“…More significant outer hair cell loss was observed in Myh14−/− mice than in wild type controls after acoustic trauma. Our findings suggest that Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA/CaJ mice.…”
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Evaluation of commercial traits in the accessions of the wheatgrass genus (<i>Agropyron</i> Gaertn.) under the conditions of Central Yakutia by A. A. Kochegina, V. M. Koryakina

“…‘Batyr’ (53.2 g/plant); for high seed yield, Siberian wheatgrass accession k-52440 (28.4 g/m2), wild crested wheatgrass k-51330 (25.2 g/m2) and k-52380 (19.4 g/m2), and Kerch wheatgrass k-48705 (17.3 g/m2). …”
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Second-line systemic treatment for metastatic colorectal cancer: A systematic review and Bayesian network meta-analysis based on RCT. by Chengyu Sun, Enguo Fan, Luqiao Huang, Zhengguo Zhang

“…Subgroup analyses showed that FOLFIRI + Bevacizumab + panitumumab ranked among the top in survival outcomes in the RAS-mutant population (OS SUCRA: 87.9%; PFS SUCRA: 70.2%); whereas in the RAS-wild-type population, FOLFIRI + Bevacizumab significantly improved survival outcomes (OS SUCRA: 73.2%; PFS SUCRA: 65.1%).…”
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Identification of the sex determination region and the development of a marker to distinguish males and females in megai abalone (Haliotis gigantea) by Taito Kina, Motoyuki Hara, Shotaro Hirase, Kiyoshi Kikuchi

“…By exploring Indel polymorphisms in the divergent region, we successfully developed a codominant PCR marker for sex identification that could be applied to wild individuals from geographically distant locations. …”
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Annotated review of the mammal fauna in the Chornobyl Biosphere Reserve as of 2023 by Sergii Gashchak

“…Additionally, feral domestic animals (cats, dogs, and cattle) have been included in the checklist as they have formed established wild populations. Only two species, the golden jackal and the European bison, arrived naturally in the Reserve for the first time. …”
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Genetic analysis of nucleotide sequences of neuraminidase gene of highly pathogenic avian influenza A/H5N8 virus isolates recovered in the Russian Federation in 2020 by P. B. Akshalova, N. G. Zinyakov, A. V. Andriyasov, P. D. Zhestkov, Z. B. Nikonova, S. N. Kolosov, I. A. Chvala

“…Currently, highly virulent influenza virus with N8 neur- aminidase subtype is quite often detected in populations of domestic and wild birds in various countries of the world. The article provides data on complete nucleotide sequences of the neuraminidase gene of highly pathogenic avian influenza virus isolates recovered in the second half of 2020 from pathological material received from four regions of the Russian Federation. …”
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Small-molecule-induced ERBB4 activation to treat heart failure by Julie M. T. Cools, Bo K. Goovaerts, Eline Feyen, Siel Van den Bogaert, Yile Fu, Céline Civati, Jens Van fraeyenhove, Michiel R. L. Tubeeckx, Jasper Ott, Long Nguyen, Eike M. Wülfers, Benji Van Berlo, Antoine A. F. De Vries, Nele Vandersickel, Daniël A. Pijnappels, Dominique Audenaert, H. Llewelyn Roderick, Hans De Winter, Gilles W. De Keulenaer, Vincent F. M. Segers

“…EF-1 reduces cell death and hypertrophy in cardiomyocytes and decreases collagen production in cardiac fibroblasts in an ERBB4-dependent manner. In wild-type mice, EF-1 inhibits angiotensin-II-induced fibrosis in males and females and reduces heart damage caused by doxorubicin and myocardial infarction in females, but not in Erbb4-null mice. …”
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IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy by Dylan Krajewski, Saurav Ranjitkar, Nathan Jordan, Sallie S. Schneider, Clinton B. Mathias

“…However, whether IL-33 is necessary for IL-10’s proinflammatory effects has not been examined.MethodsTo therefore determine the role of the IL-33/ST2 axis in this pathway, we assessed the effects of IL-10 on IgE-mediated MC activation and food allergy development in wild-type (WT) and ST2-/- mice.ResultsIL-10 stimulation significantly enhanced IL-33 gene expression, ST2 receptor expression, cytokine production, mMCP-1 secretion, and proliferation in IgE and antigen-activated bone marrow-derived MCs (BMMCs) from WT mice. …”
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Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome by Fabiana Boncimino, Ludovica D’Auria, Kristina Todorova, Sabina Y. van der Zanden, Jacques Neefjes, Anna Mandinova, Caterina Missero, Stefano Sol

“…By performing a high-throughput screening of epigenetic and FDA-approved compounds in a co-transfection model of wild-type and mutant p63, we found that two compounds, Doxorubicin and Epirubicin, alleviate protein aggregation and restore p63 transactivation function. …”
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Effect of Multiradiance Low-Level Laser Therapy and Topical Silver Sulfadiazine on Healing Characteristics of Dermal Wounds in Marine Toads (Rhinella marina) by Kate E. Archibald, Tara Harrison, Brigid Troan, Dustin Smith, Larry J. Minter

“…This pilot study evaluated the effects of repeated treatments of low-level laser therapy or topical SSD on second-intention healing characteristics of surgically induced full-thickness dermal wounds in 33 adult wild-caught marine toads. Toads were anesthetized, and a 6 mm cutaneous biopsy was performed over the right dorsum. …”
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Effect of Zbtb33 gene knockout and bacterial lipopolysaccharide on home cage behavior in mice by N. V. Khotskin, I. E. Sorokin, E. A. Kulikova, A. V.  Kulikov

“…Experiments were performed on adult male mice with Zbtb33 gene knockout (KO) and animals of the C57BL/6 line (wild type, WT). All animals were 11 weeks old, weighed 26 ± 1 g and had SPF (specific pathogen free) status throughout the experiment. …”
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Traditional Processing, Physicochemical Property, Phytochemical Content, and Microbiological and Sensory Quality of the Yellow “Téa Lémi” Wine Made in the Far-North of Cameroon... by James Ronald Bayoï, Yonas Vandi, Bruno Yaya Foundikou, Francois-Xavier Etoa

“…This can be seen by the uncontrolled addition of some ingredients such as sugar, extract of banana, and honey and a significant fermentation step started by wild, unselected yeasts. The physicochemical analyses revealed that the wine had an acid pH of around 3.84, with a total acidity between 7.72 g/L and 8.79 g/L. …”
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Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats by Yuka Toyoshima, Katsuyuki Nakamura, Yusuke Taguchi, Reiko Tokita, Shiho Takeuchi, Hayato Osawa, Naomi Teramoto, Hidetoshi Sugihara, Fumiaki Yoshizawa, Keitaro Yamanouchi, Shiro Minami

“…The body weight of IRS-1 KO rats at birth was lower than that of wild-type (WT) littermates, and postnatal growth of IRS-1 KO rats was severely impaired. …”
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Salvage pathway of vitamin B12 absorption in chickens with mutant tumor virus a receptor by Yun Ji Shin, Jin-Kyoo Kim, Seung Je Woo, Byung Chul Park, Jae Yong Han

“…We found four TVA variants comprising the wild type (TVAWT), a single nucleotide polymorphism variant (TVASNP), and two partial deletions in the splicing branch point region (TVAR). …”
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Climate-smart livestock nutrition in semi-arid Southern African agricultural systems by Felix Fushai, Teedzai Chitura, Oyegunle Emmanuel Oke

“…The keystone potential climate-smart alternative feedstuffs are identified to be the small cereal grains, such as sorghum (Sorghum bicolor) and pearl millet (Pennisetum glaucum) as dietary energy sources, the native legumes, such as the cowpea (Vigna unguiculata) and the marama bean (Tylosema esculentum) as protein sources, wild browse Fabaceae trees such as Vachellia spp. and Colophospermum mopane, which provide dry season and drought supplementary protein, minerals, and antioxidants, the non-fabaceous tree species such as the marula tree (Sclerocarya birrea), from which animals consume the energy and electrolyte-rich fresh fruit or processed pulp. …”
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Analysis of Feature Extraction and Anti-Interference of Face Image under Deep Reconstruction Network Algorithm by Jin Yang, Yuxuan Zhao, Shihao Yang, Xinxin Kang, Xinyan Cao, Xixin Cao

“…To explore the anti-interference performance of convolutional neural network (CNN) reconstructed by deep learning (DL) framework in face image feature extraction (FE) and recognition, in the paper, first, the inception structure in the GoogleNet network and the residual error in the ResNet network structure are combined to construct a new deep reconstruction network algorithm, with the random gradient descent (SGD) and triplet loss functions as the model optimizer and classifier, respectively, and it is applied to the face recognition in Labeled Faces in the Wild (LFW) face database. Then, the portrait pyramid segmentation and local feature point segmentation are applied to extract the features of face images, and the matching of face feature points is achieved using Euclidean distance and joint Bayesian method. …”
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Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice by Qing-Qing Yang, Pui Kit Suen, Chang-Quan Zhang, Wan Sheung Mak, Ming-Hong Gu, Qiao-Quan Liu, Samuel Sai-Ming Sun

“…In this study, a 70-day rat feeding study was conducted to assess the nutritional value of two transgenic lines as compared with either their wild type (WT) or the WT rice supplemented with different concentrations of L-lysine. …”
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