Efficacy and safety of everolimus for patients with focal cortical dysplasia type 2 by Se Hee Kim, Hoon‐Chul Kang, Yun Ho Roh, Jongsung Hahn, Kyung Lok Min, Seok‐Jin Lee, Donghwa Yang, Han Som Choi, Soyoung Park, Jeong Ho Lee, Sang‐Guk Lee, Se Hoon Kim, Min Jung Chang, Heung Dong Kim

“…The trial included a 4‐week baseline phase, two 12‐week core phases, and a 29‐week extension phase. …”
Get full text

Short- and long-term effects of transcutaneous spinal cord stimulation on autonomic cardiovascular control and arm-crank exercise capacity in individuals with a spinal cord injury... by Samuel J E Lucas, Tom E Nightingale, Jet J C S Veldhuijzen van Zanten, Shin-Yi Chiou, Alex J Wadley, Rebekah A I Lucas, Daniel D Hodgkiss, Shane J T Balthazaar, Joseph F Welch, Phoebe A Cox

“…All participants will perform 48 min of ACE twice per week (at workloads corresponding to 73–79% peak oxygen uptake), over a period of 8 weeks, either with (CV-TSCS) or without (SHAM-TSCS) cardiovascular-optimised stimulation. …”
Get full text

Risankizumab Versus Secukinumab: A Real-World Efficacy and Cost per Responder Comparison in Patients With Psoriasis in Italy by Federico Pirro, Giacomo Caldarola, Nicoletta Bernardini, Maria Grazia Celeste, Annunziata Dattola, Eleonora De Luca, Marco Galluzzo, Domenico Giordano, Chiara Izzi, Giulia Maretti, Lorenzo Marcelli, Roberto Ravasio, Antonio Giovanni Richetta, Nevena Skroza, Marina Talamonti, Arianna Zangrilli, Luca Bianchi, Giovanni Pellacani, Severino Persechino, Concetta Potenza, Ketty Peris, Clara De Simone

“…The cost per responder at week 16 and 52 was adopted as a cost-effectiveness indicator. …”
Get full text

Relationship of serum irisin levels, physical activity, and metabolic syndrome biomarkers in obese individuals with low-calorie intake and non-obese individuals with high-calorie i... by Jalal Hejazi, Bijan Ghobadian, Nasrin Ghasemi, Hossein Sadeh, Nasim Abedimanesh, Mehran Rahimlou

“…Participants in the obese group had lower physical activity compared to the non-obese group (3395.38 ± 2801 MET-min/week vs. 6015.18 ± 3178 MET-min/week; p < 0.001). …”
Get full text

Enhancing physical activity during pregnancy using a multi-theory model: a study protocol for a randomised controlled trial in China by Wei Zhang, Yu Shen, Le Zhang, Ying Jin, Ningning Liu, Suwen Feng, Xuesong Zhang

“…Data will be collected at baseline, 6 weeks of the intervention, 12 weeks of the intervention and within 1 week of delivery. …”
Get full text

Nerve regeneration using a Bio 3D conduit derived from umbilical cord-Derived mesenchymal stem cells in a rat sciatic nerve defect model. by Terunobu Iwai, Ryosuke Ikeguchi, Tomoki Aoyama, Takashi Noguchi, Koichi Yoshimoto, Daichi Sakamoto, Kazuaki Fujita, Yudai Miyazaki, Shizuka Akieda, Tokiko Nagamura-Inoue, Fumitaka Nagamura, Koichi Nakayama, Shuichi Matsuda

“…Based on macroscopic findings and histological findings (anti-human mitochondrial fluorescent immunostaining), UC-MSCs in the Bio 3D conduit disappeared gradually from week 1 to week 8.<h4>Conclusions</h4>The Bio 3D conduit prepared from UC-MSCs was superior to the silicone tube and achieved comparable nerve regeneration to the autologous (autograft) group. …”
Get full text

A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices by Ashley P. Barlow, Jane He, Cindy Tian, Peter Jeffery, Stephen C. Mason, Bao-Jun Tai, Han Jiang, Gareth D. Rees, Min Quan Du

“…Subjects (N=110), stratified into two groups (N=55), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. …”
Get full text

Effect of Conception Vessel Moxibustion of Different Duration on Urinary Function in Patients with Neurogenic Bladder after Suprasacral Spinal Cord Injury by Jun LENG, Wen GUO, Huimin LIU, Xiaoxue LENG, Xiaolei FANG, Chen ZHANG

“…The control group was given conception vessel moxibustion at conception vessel segment[Jiuwei (RN 15) to Zhongji (RN 3)], moxibustion for one hour each time, three times a week, continuous treatment for four weeks. The observation group moxibustion for two hours each time, and the other treatment procedures were the same as those in the control group, three times a week, continuous treatment for four weeks. …”
Get full text

Improvement of Fatigue in Patients with Ankylosing Spondylitis Receiving Tofacitinib: Analyses of a Phase 3 Randomized Controlled Trial by Laure Gossec, Jessica A. Walsh, Raj Sengupta, Andrew G. Bushmakin, Joseph C. Cappelleri, Arne Yndestad, Oluwaseyi Dina, David Cella

“…The rapidity of improvement was assessed by time-to-event analyses (nonparametric Kaplan–Meier models); initial improvement events (i.e., time to first week of FACIT-F improvement) and stable improvement events (i.e., time to first week of FACIT-F improvement, sustained to 16 weeks) were examined. …”
Get full text

Preliminary Clinical Study on Therapy of Lidocaine Local Block Combined with Acupuncture-rehabilitation in Treatment of Post-stroke Upper Limb Spasticity by Ji LI, Li ZHANG, Ying GUAN, Lu WANG, Guile XIN, Yanli XING, Qiang TANG

“…The control group was treated with conventional acupuncture-rehabilitation therapy, 6 times a week, for 4 weeks; the observation group was given Lidocaine local block therapy, 3 times a week, for 4 weeks. …”
Get full text

Effect of Visual Tracking Training combined with Six-character Formula on Motor Function and Quality of Life in Patients with Parkinson's Disease by Wanhong WANG, Hongyan BI, Zhengang QIU, Xihua LIU, He ZHUANG, Shijie HAO, Xin ZHANG, Wenyu SUN

“…Objective:To observe the effects of visual tracking training combined with six-character formula on motor function and quality of life in patients with Parkinson's disease.Methods:A total of 42 patients with Parkinson's disease treated in the affiliated hospital of Shandong university of traditional Chinese medicine were selected and divided into the control group and the observation group according to random number table method, with 21 cases in each group.The control group received routine rehabilitation training, mainly including core training, balance training, coordination training, gait training, and daily life ability training, twice a day, 45 minutes each time, five days a week, continuous training for six weeks.The observation group received visual tracking training combined with six-character formula training on the basis of the control group.Visual tracking training included thumb tracking, Whack-a-mole game, posture control, training eyeball moving as figure "8", each training for 20 minutes, once a day.Six-character formula of pronunciation training with blowing, shout, hippies, oh, boo, si breathing exercises, and cooperated with body guidance training, each training for 25 minutes, once a day.The above training for five days per week, continuous training for six weeks.The third part of the unified Parkinson's disease rating scale(UPDRS-Ⅲ)and the time up and go test(TUGT)were used to assess the patient's motor function; the balance stability limit test(AP-SD, ML-SD)was used to evaluate the patient's balance function;the Parkinson's questionnaire-39(PDQ-39)was used to evaluate the patient's quality of life.Results:Before treatment, there were no statistically significant difference in UPDRSⅢscore, AP-SD and ML-SD, TUGT time and PDQ-39 score between two groups(<italic>P</italic>&gt;0.05); Compared with before treatment, the UPDRSⅢ, AP-SD, ML-SD, TUGT and PDQ-39 scores of the two groups after treatment decreased significantly, the differences were statistically significant(<italic>P</italic>&lt;0.05); Compared with the control group, UPDRSⅢ, AP-SD, ML-SD, TUGT and PDQ-39 scores of the observation group after treatment were lower, the differences were statistically significant(<italic>P</italic>&lt;0.05).Conclusion:Visual tracking training combined with six-character formula can effectively improve the motor function and quality of life of patients with Parkinson's disease.…”
Get full text

Relationship between psychological empowerment, physical activity enjoyment, and response to a HIIT Program in physically inactive young women: a prospective multicentre study by Irene Ferrando-Terradez, Rodrigo Núñez-Cortés, Laura López-Bueno, Enrique Alcántara, Joaquín Calatayud, José Casaña, Ivana Parčina, Lirios Dueñas

“…Outcome measures included physical activity levels (MET-min/week), muscular endurance (plank test), and sleep quality through the Pittsburgh Sleep Quality Index (PSQI). …”
Get full text

Description and Classification of Training Drills, Based on Biomechanical and Physiological Load, in Elite Basketball by Carlos Sosa, Enrique Alonso-Pérez-Chao, Carlos Ribas, Xavier Schelling, Alberto Lorenzo

“…Understanding the distinct demands of different drills can help coaches structure training sessions more effectively to optimize player load and performance development throughout the week.…”
Get full text

Special Education Combined with Sensory Integration Training for Children with Autism Spectrum Disorder by Ya SHAN, Min ZHU

“…For the children with positive reinforcement, we would choose effective reinforcement and gradually depart from the reinforcement process, after education, family members of the children should be guided to intervene at home according to the given intervention operations, which were synchronized with treatment, 40 minutes each time, 6 times a week, 3 months as a course of treatment. The special sensation group was given sensory integration training on the basis of the special education intervention, the personalized sensory integration training program was developed according to the condition, social ability and development of ASD children, which was included the training of tactile, vestibular and proprioceptive sensory, 2 hours each time, 3 times a week, 3 months as a course of treatment. …”
Get full text

The impact of universal mental health screening on stigma in primary schools by Annabel Songco, Deanna A. Francis, Emma A. McDermott, Chloe Y. S. Lim, Abigail Allsop, Joseph Croguennec, Gemma Sicouri, Andrew Mackinnon, Jennifer L. Hudson

“…A sample of 798 children (8 to 13 years; Mage = 10.29) completed assessments at baseline, 6-week, and 12-week follow-ups. Results Significant time-by-group interaction effects were present, indicating differing changes in mental health stigma between groups. …”
Get full text

Valerenic acid ameliorates amphetamine-related neurotoxicity by improving hypothalamus tyrosine hydroxylase and histamine-N-methyl transferase enzymes by Khaled M.M. Koriem, Ammar H.A. Naiem

“…METH-treated, VA (5 mg/kg) prior to METH-treated, and VA (10 mg/kg) before METH-treated groups: normal rats were oral administrated with METH (2.5 mg/kg), 3 days/week for 3 weeks, where the last two groups were oral administrated daily during four weeks at 5 mg/kg and 10 mg/kg VA, starting one week prior to METH administration. …”
Get full text

High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI): an open, randomised controlled trial by Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Angelika Terbuch, Barbara Obermayer-Pietsch, Erika Richtig, Stefan Pilz

“…This is the first randomised study to evaluate whether hormonal recovery differs in patients treated with high-dose glucocorticoids versus glucocorticoid replacement therapy.Design/Methods In this single-centre, open, randomised controlled study, patients with ICI associated hypophysitis were randomised 1:1 to high-dose glucocorticoid treatment (1 mg/kg of prednisolone for two weeks, followed by tapering until week 7 and a switch to hydrocortisone 20 mg total daily dose in week 8) or glucocorticoid replacement therapy (hydrocortisone 20 mg total daily dose) over 8 weeks. …”
Get full text

Association of vaginal oestradiol and the rate of breast cancer in Denmark: registry based, case-control study, nested in a nationwide cohort by Christian Torp-Pedersen, Lina Steinrud Mørch, Nelsan Pourhadi, Amani Meaidi, Ellen Christine Løkkegaard

“…Results were similar in women who had long term use (≥four years) and with high intensity of use (&gt;50-70 micrograms per week) with an adjusted hazard ratio 0.93 (95% confidence interval 0.81 to 1.08).Conclusions Use of vaginal oestradiol tablets was not associated with increased breast cancer rate compared with never-use. …”
Get full text

The Effect of Zinc Supplementation on Glycemic, Weight, and Blood Pressure Control in Patients With Type 2 Diabetes Mellitus: A Double‐Blind Randomized Controlled Trial by Mehrab Sayadi, Sara Javadpour Nowbandegani, Fatemeh Balaghi Inalou, Bahman Nazemzadegan, Shirzad Javidi Alsaadi, Mohammadreza Eskandari, Matin Sepehrinia

“…Results After 12 weeks of follow‐up, 72 patients completed the study. …”
Get full text

Comparison of dairy production based on feed of Pennisetum sp., Pennisetum purpureum and CIAT 36087 by Noel Ernesto Blanco–Roa, Hernaldo Ramón Novoa–Novoa, Eveling Cristina Berríos, Omar Alfredo Soto–Gutiérrez, Carlos Alberto Zúniga–González, Silvio Javier Sáenz–Rojas, José de Jesús Nuñez–Rodriguez

“…Daily milk production for each cow was monitored and recorded over the six–week period. Highly significant differences (P<0.01) were observed among the three studied groups from the second week onward. …”
Get full text