Effect of Orally Administrated Acriflavine to larval of Red Tilapia (Oreochromis sp.) on Their Sex Ratio by M. Zairin Junior, D. Nurlestiyoningrum, M. Raswin

“…In this study, acriflavine at dose of 0, 15, 25 and 35 mg/kg feed were fed to 10-day-old larvae for 6 weeks.  Feeding of larvae by diet containing 17a-methyltestosterone (MT) at dose of 50 mg/kg was also observed as a comparison of acriflavin treatment.  …”
Get full text

Efficacy of Esophageal Protector in Treating Gastroesophageal Reflux Disease with Extraesophageal Symptoms: a Multicenter, Open-Label, Observational Study by Yu. A. Kucheryavy, D. N. Andreyev, E. Yu. Eryomina, A. A. Gilmanov, O. V. Nazarova, Ye. A. Sidneva, Yu. G. Topalova

“…Visit 1 could be conducted on the same day as the screening visit, whereas visit 2 was conducted 4–5 weeks after visit 1 at the end of the course of treatment.Results. …”
Get full text

Real-Time Pharmacovigilance: Transforming Population-Based Monitoring of Post-Approval Vaccine Safety Through Rapid Cycle Analysis (RCA)—A Review of the Published Literature by Sampada Gandhi, Michelle R. Iannacone, Andrea Leapley, Li Wang, Mwedusasa Mtenga, Muhammad Younus, Joanne Wu

“…Over 80% conducted the RCA weekly or monthly and about 78% of the studies used a database-specific historical comparator group. …”
Get full text

Treatment of Vascular Dementia by Using Fuyuan Capsule Combined with "Xingnao Kaiqiao" Acupuncture by LI Hongmei, WANG Xiaoqin, GUO Yang, SHI Hongxing, GUO Xiao, WANG Xue

“…The control group received "Xingnao Kaiqiao" acupuncture treatment and the treatment group received oral administration of Fuyuan capsule in addition to the treatment of the control group for 12 weeks. The mini-mental state examination (MMSE) score, modified Hasegawa dementia scale (HDS-R) score, and modified Barthel index (MBI) score were compared between the two groups before and after treatment; the levels of serum superoxide dismutase (SOD) and malondialdehyde (MDA) of patients before and after treatment were measured and analyzed by colorimetry. …”
Get full text

Treatment and counselling preferences of postpartum women with and without symptoms of (childbirth-related) PTSD: findings of the cross-sectional study INVITE by Rosa Hannele Horstmann, Lara Seefeld, Julia Schellong, Susan Garthus-Niegel

“…Methods This study used data from the cross-sectional INVITE study, comprising telephone interviews with N = 3,874 women conducted six weeks to six months after childbirth. The City Birth Trauma Scale (City BiTS) was used to assess CB-PTSD, while the Primary Care Posttraumatic Stress Disorder Screen for DSM-5 (PC-PTSD-5) was used to assess gPTSD. …”
Get full text

A web-based pilot randomized controlled trial to test the efficacy of education and contact-based interventions in reducing public suicide stigma by Nathalie Oexle, Matthias Lühr, Daniele Valacchi, Nicolas Rüsch

“…Information about suicide stigma and suicide normalization were collected directly before (t0) and after intervention participation (t1) as well as about two weeks later (t2). To explore the attractiveness of the provided intervention material, we used Brown-Mood’s median test to compare the times participants spent with the provided intervention material in each group. …”
Get full text

Associations of macrosomia with sociodemographic, anthropometric, lifestyle factors and perinatal outcomes in Southwest Nigeria by Ikeola A. Adeoye, Joshua I. Fakorede, Mobolaji M. Salawu, Kofoworola I. Adediran

“…Maternal blood glucose and lipids were assessed between 24 and 28 weeks’ gestation. Bivariate and multiple logistic and Poisson regression analyses examined the associations at a 5% level of statistical significance. …”
Get full text

Residue depletion profile and withdrawal interval estimation of ivermectin in eggs following topical administration of injectable ivermectin to domestic chickens (Gallus domesticus... by Melissa A. Mercer, Jennifer L. Davis, Scott E. Wetzlich, Maaike O. Clapham, Lisa A. Tell

“…IntroductionTopical ivermectin is commonly prescribed extra-label for the control of mite infestations in backyard chicken flocks in the US.MethodsDomestic laying hens (n = 8; 78 weeks of age, weight 1.7–2.2 kg) were administered injectable ivermectin solution topically over the jugular vein (0.4 mg/kg every 7 days for 2 doses). …”
Get full text

Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-... by Joan Khoo, Christoph E Hagemeyer, Darren C Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong Teo

“…In type 2 diabetic adults, HbA1c decreased significantly (p = 0.002) by 0.3 ± 0.7% (4 ± 8 mmol/mol), with ELO water after 12 weeks of treatment but was unchanged with placebo.…”
Get full text

The Potential Impact of Dietary Fiber Supplementation on Hemoglobin and Reticulocyte Hemoglobin Equivalent (RET-He) Levels in Pregnant Women with Anemia Receiving Oral Iron Therapy... by Afifah A, Zuhairini Y, Ariyanto EF, Ghozali M, Fatimah SN, Pramatirta AY

“…The subjects were anemic pregnant women between 14 and 32 weeks of gestation. Fifteen control subjects received iron tablets and skim milk (placebo), while 25 intervention subjects received iron tablets and a fiber supplement containing 7.2 grams of dietary fiber. …”
Get full text

Effects of Iron and Vitamin C on Growth Performance, Iron Utilization, Antioxidant Capacity, Nonspecific Immunity, and Disease Resistance to Aeromonas hydrophila in Chinese Mitten... by Ying Song, Xinyu Cai, Xianyong Bu, Shubin Liu, Mingqi Song, Yiwen Yang, Xiaodan Wang, Qingchao Shi, Jianguang Qin, Liqiao Chen

“…Juvenile E. sinensis (1.14±0.01 g) were fed six diets supplemented with three levels of iron (41.40, 92.25, and 143.00 mg/kg), and each iron level supplemented either 4.33 mg/kg or 700.90 mg/kg of vitamin C for 8 weeks. Crabs fed 41.40 mg/kg of iron diet had the lowest weight gain (WG) and specific growth rate (SGR) and had the highest feed conversion rate (FCR) regardless of dietary vitamin C levels. …”
Get full text

Treatment outcomes of two surgical techniques in secondary reconstruction of unilateral cleft lip and ala nasi utilizing anthropometry assessment: a randomized controlled trial by Ebrahim Humadi, Mawia Karkoutly, Zafin Kara Beit

“…Immediately after surgery (t1). Two weeks after surgery (t2). Six months after surgery (t3). …”
Get full text

Factors Associated with Stunting in Children Under Five Years of Age: A Case of Buhara Sub County, Kabale District. by Namanya, Oliver

“…The study made the following findings in line with the objectives: low household income, child illness in the last few weeks incomplete child vaccination (p- Value = 0.005 < 0.05 and p- value = 0.001 < 0.05), the child’s guardian ethnicity with (p- value = 0.013 < 0.05 and 0.000), open defecation, indiscriminate waste disposal, 18(4.7%) 95 CI= 028311725 - .073831273) and use of unprotected water sources, were the major factors associated with stunting. …”
Get full text

Adherence to face mask use during the COVID-19 pandemic among women seeking antenatal care in Kinshasa, Democratic Republic of Congo: a facility-based cross-sectional study by Steven Anderson, Dalau Mukadi Nkamba, Patrick J Arena, Adva Gadoth, Nicole A Hoff, Camille Dzogang, David Kampilu, Michael Beya, Hui-Lee Wong, Didine Kaba, Anne W Rimoin

“…Objectives To describe face mask use among pregnant women seeking antenatal care (ANC) in Kinshasa, Democratic Republic of Congo and to identify factors associated with masking adherence in this population.Design Facility-based cross-sectional study nested within a prospective cohort study.Setting Random sample of 10 health facilities, including 5 primary health centers and 5 secondary facilities or hospitals.Participants A total of 934 pregnant women aged 18 years or above with a gestational age of at least 32 weeks were consecutively surveyed from 17 August 2020 to 31 January 2021.Primary and secondary outcome measures We estimated the proportions of pregnant women wearing a face mask and masking correctly (ie, over the mouth and nose), and assessed their knowledge regarding the COVID-19 pandemic. …”
Get full text

Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study by Umberto Simeoni, Antje Horsch, Arnaud Chiolero, Yvan Vial, Nicole Sekarski, Jardena J Puder, Pascal Bovet, Stefano Di Bernardo, Yvan Mivelaz, Adina Mihaela Epure, Sandrine Estoppey Younes, Bobby Stuijfzand, Leah Gilbert, Stefano Lanzi, Justine Gross, Stefano Di Bernardo, Dan Quansah, Jean-Benoît Rossel, Amar Arhab, Sandrine Estoppey Younes, Seyda Mayerat

“…We assessed whether GDM is associated with increased CIMT in the offspring at birth.Design and setting MySweetHeart Cohort is a prospective cohort study conducted in Switzerland.Participants, exposure and outcome measures This work included pregnant women with and without GDM at 24–32 weeks of gestation and their singleton live-born offspring with data on the primary outcome of CIMT. …”
Get full text

The Acute VertEbRal AugmentaTion (AVERT) study: protocol for a randomised controlled, feasibility trial of spinal medial branch nerve block in hospitalised older patients with vert... by Avril Drummond, Opinder Sahota, Simon Bishop, Dritan Pasku, Apostolos Fakis, Anastasios Bastounis, Chia Wei Tan, Maribel Cameron, Yuriy Arlachov, Michal Czernicki

“…We therefore propose a prospective feasibility randomised controlled trial (RCT) to compare the role of MBNB to VP, in hospitalised older patients.Method A parallel, two-arm RCT with participants allocated on a 1:1 ratio to either standard care-VP or MBNB in hospitalised patients aged over 70 with acute osteoporotic vertebral fractures. Follow-up will be at weeks 1, 4 and 8 post intervention. The primary objective is to determine the feasibility and design of a future trial, including specific outcomes of recruitment, adherence to randomisation and safety. …”
Get full text

Pilot implementation of two specific problem lists before and after solid organ transplantation into routine care by Sanna Higgen, Evamaria Müller, Markus J. Barten, Markus J. Barten, Doreen Eickhoff, Doreen Eickhoff, Florian Grahammer, Martin Härter, Sabine Bart, Martina R. Sterneck, Martina R. Sterneck, Angela Buchholz, Angela Buchholz

“…Even though regular screening is recommended to identify patients with high levels of distress, the implementation in routine care has been insufficient so far.MethodsTwo newly developed problem lists for patients before and after transplantations were pilot implemented for 8 weeks at the Medical Center Hamburg Eppendorf (UKE) to identify factors facilitating and impeding their implementation.ResultsHealth care professionals evaluated its appropriateness, feasibility, and the cooperation with the psychologists before (HCPs: n = 23) and after (HCPs: n = 19) the implementation. …”
Get full text

Multi-omics elucidates the kidney damage caused by aquatic Cu via the gut-kidney axis in ducks by Mingcai Duan, Jinyu Liu, Zhaoxia Cai, Li Chen, Yong Tian, Wenwu Xu, Tao Zeng, Tiantian Gu, Lizhi Lu

“…The ducks were gavaged with different doses of CuSO4 (0, 100, and 200 mg/kg body weight) for 4 weeks. Results indicate that Cu exposure causes pathological damage to the kidney, with a significant increase in the levels of TNFα, IL-6, and IL-1β in both serum and renal tissue. 16S rDNA analysis revealed that the relative abundances of Candidatus_Saccharimonas and Bacteroides were significantly reduced in the Cu-induced group. …”
Get full text

RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice by Shireen Mohammad, Sura Al Zoubi, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Nadine Krieg, Bianka Wissuwa, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Gareth S. D. Purvis, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Andrea Baragetti, Andrea Baragetti, Alberico Luigi Catapano, Alberico Luigi Catapano, Alberico Luigi Catapano, Egle Solito, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Lukas Martin, Christoph Thiemermann

“…In a reverse-translational approach, we have investigated the effects of the AMP, peptide 19-2.5, in a murine model of high-fat diet (HFD)-induced insulin-resistance, steatohepatitis and T2DM. HFD-fed mice for 12 weeks caused obesity, an impairment in glycemic regulations, hypercholesterolemia, microalbuminuria and steatohepatitis, all of which were attenuated by Peptide 19-2.5. …”
Get full text

Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation by Chrissa Petersen, Adhini Kuppuswamy Satheesh Babu, Ceres Mattos Della Lucia, Henry A. Paz, Lisard Iglesias-Carres, Ying Zhong, Thunder Jalili, J David Symons, Kartik Shankar, Andrew P. Neilson, Umesh D. Wankhade, Pon Velayutham Anandh Babu

“…C57BL/6J mice were fed a standard diet [C]; strawberry-supplemented diet (~2 human servings) [CS]; strawberry-supplemented diet and treated with antibiotics (to deplete gut microbes) [CSA]; high-fat diet (HFD) [HF]; strawberry-supplemented HFD [HS]; and strawberry-supplemented HFD and treated with antibiotics [HSA] for 12 weeks. First, antibiotic treatment suppressed the production of selected metabolites (CSA vs. …”
Get full text