Cross-cultural adaptation and validation of the Spanish version of the Prevent for Work questionnaire by Julia Blasco-Abadía, Pablo Bellosta-López, Víctor Doménech-García, Thorvaldur Skuli Palsson, Steffan Wittrup McPhee Christensen, Steffan Wittrup McPhee Christensen, Morten Hoegh, Pedro Berjano, Francesco Langella

“…Finally, 50 Spanish workers completed the P4Wq 2 weeks later to evaluate test–retest reliability and measurement error.ResultsMinor changes were made after the forward-and-backward translation process, which ensured that the Spanish versions was face-valid. …”
Get full text

Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery by Yinjie Zhang, Baibing Yang, Joy M. Davis, Madeline M. Drake, Mamoun Younes, Qiang Shen, Zhongming Zhao, Yanna Cao, Tien C. Ko

“…Pancreata were harvested from mice 4 days after the final injections (designated as CP and CON) or 4 weeks after the final injections (designated as CP recovery (CPR) and control recovery (CONR)). …”
Get full text

Scoping review of initiation criteria for inhaled nitric oxide in preterm infants (born by Hidehiko Nakanishi, Shin Kato, Erika Ota, Toshinori Nakashima, Katsuya Hirata, Sota Iwatani, Seiji Yoshimoto, Masayuki Ochiai, Daichi Suzuki, Fumihiko Namba, Yohei Minamitani, Miku Hosokawa, Atsushi Nakao, Takushi Hanita, Arata Oda, Masafumi Miyata

“…This study, therefore, aimed to identify the criteria for initiating iNO therapy, alongside the associated clinical and echocardiographic findings, in this population.Design We performed a scoping review using the population-concept-context framework following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews.Data sources PubMed, Embase and the Japanese database ‘Ichushi’ were systematically searched for relevant articles published between January 2003 and August 2023.Eligibility criteria This study included randomised controlled trials, prospective and retrospective cohort studies, case–control studies and case series on iNO therapy in the postacute phase for preterm infants born before 34 gestational weeks, written in English or Japanese.Data extraction and synthesis Data screening, extraction and charting were performed independently, with the characteristics and findings of the included studies subsequently summarised.Results We included 10 reports that analysed the data from 10 separate studies. …”
Get full text

Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition by Da Som Kim, Hong-Ki Min, Eun Kyung Kim, Seung Cheon Yang, Hyun Sik Na, Seon-Yeong Lee, Jeong-Won Choi, Kyung-Ah Jung, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho

“…Collagen-induced arthritis (CIA) mice were orally administered SAHA daily for 8 weeks and examined for their arthritis score and incidence of arthritis. …”
Get full text

Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study—INTERACT MESO by Job P van Kooten, Jacobus W A Burger, Cornelis Verhoef, Joachim G J V Aerts, Eva V E Madsen, Alexandra R M Brandt-Kerkhof, Stijn L W Koolen, Ron H J Mathijssen, Michelle V Dietz, Niels A D Guchelaar

“…Through this PAC, 8–16 weekly cycles of intraperitoneal chemotherapy will be administered.Ethics and dissemination The Central Committee on Research Involving Human Subjects (CCMO, The Hague, The Netherlands) and the Medical Research Ethics Committee (METC, Rotterdam, The Netherlands) have granted permission to carry out this study protocol. …”
Get full text

The necessity of gestational vitamin D supplementation depends on ambient temperature: concern for infant vitamin D status by Wanjun Yin, Wanjun Yin, Wanjun Yin, Wanjun Yin, Lei Zhang, Lei Zhang, Peng Zhu, Peng Zhu

“…Individual information on sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes was collected prospectively.ResultsThe best-fit relationship was observed in the regression model using a quadratic function to describe the association between the ambient temperature of the eighth gestational month (29–32 gestational weeks) and cord blood 25(OH)D concentrations (R2 = 0.358, p < 0.001). …”
Get full text

Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar by John Norrie, Julie Woodfield, David J Lowe, Paul M Brennan, Catriona Keerie, Julia Lawton, Matthew J Reed, Andrew Stoddart, Julia Boyd, Helen Eborall, Gina Cranswick, James Tomlinson, Polly L Black, Sadaquate Khan, Patrick Statham, Ellie Edlmann, Phillip Correia Copley, Angela Niven, Susan Deborah Shenkin

“…The primary outcome is quality of life measured using the EQ-5D-5L at 12 weeks. Secondary outcomes include pain scores, neck disability index, health and social care use and costs, and mortality.Ethics and dissemination Informed consent for participation will be sought from those able to provide it. …”
Get full text

Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial by Martin R Cowie, Stephen Morris, Gregory Lip, Richard J McManus, Stephen Sutton, Jonathan Mant, Simon J Griffin, Sarah Hoare, Jenni Burt, Rachel Johnson, Mark Lown, Alison Powell, Natalie Armstrong, FD Richard Hobbs, Trudie Lobban, Rakesh Narendra Modi, Ben Freedman, David A Fitzmaurice, Stephen Kaptoge, Jenny Lund, Duncan Edwards, Kate Williams, H Thom, Francesco Fusco, Michael J Sweeting, Andrew Dymond, The SAFER Authorship Group

“…Participants are asked to record four traces every day for 3 weeks on a hand-held single-lead ECG device. Cardiologists remotely confirm episodes of AF identified by the device algorithm, and general practitioners follow-up with anticoagulation as appropriate. …”
Get full text

Development of an easy non‐destructive particle isolation protocol for quality control of red blood cell concentrates by Marine Ghodsi, Anne‐Sophie Cloos, Anaïs Lotens, Marine De Bueger, Patrick Van Der Smissen, Patrick Henriet, Nicolas Cellier, Christophe E. Pierreux, Tomé Najdovski, Donatienne Tyteca

“…It was reproducible, could predict the number of extracellular vesicles obtained with the 20,000 × g protocol and better discriminated between the three vesiculation cohorts than haemolysis at the legal expiry date of 6 weeks. However, by decreasing red blood cell concentrate volumes to fit with the volume in the quality control tubing, particle yield was highly reduced. …”
Get full text

Almond snacking modestly improves diet quality and waist circumference but not psychosocial assessments and other cardiometabolic markers in overweight, middle-aged adults: A rando... by Vernon Uganiza Rayo, Lauren Okamoto, Maricarmen Cervantes, Mee Young Hong, Nathaniel Jason, Mark Kern, Changqi Liu, Elise North, Svitlana Storm, Oliver C. Witard, Shirin Hooshmand

“…We examined blood glucose homeostasis, lipid profile, anthropometrics, blood pressure, food cravings, and mood both pre- and post-feeding, using a randomized, crossover design with 26 healthy adults (37±6 y) consuming either ALMOND (57 g/d) or an isocaloric amount of pretzels (CONTROL) for 8 weeks. Almond supplementation was expected to improve all primary outcomes when compared to CONTROL. …”
Get full text

The Instant Effects of Continuous Transcutaneous Auricular Vagus Nerve Stimulation at Acupoints on the Functional Connectivity of Amygdala in Migraine without Aura: A Preliminary S... by Wenting Luo, Yue Zhang, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Yongsong Ye, Hui Li, Bo Liu

“…A significant positive correlation was observed between the FC of the left amygdala and right SMA and the frequency/total time of migraine attacks during the preceding four weeks. Conclusion. Continuous taVNS at acupoints can modulate the FC between the bilateral amygdalae and pain-related brain regions in MwoA, involving the limbic system, default mode network, and pain matrix, with obvious differences between the left amygdala and the right amygdala. …”
Get full text

Does tocilizumab eliminate inflammation in GCA? A cohort study on repeated temporal artery biopsies by Chiara Marvisi, Francesco Muratore, Carlo Salvarani, Pierluigi Macchioni, Pamela Mancuso, Luigi Boiardi, Stefania Croci, Paolo Giorgi Rossi, Alberto Cavazza, Annibale Versari, Rexhep Durmo, Caterina Ricordi, Martina Bonacini, Giuseppe Malchiodi

“…We aimed to evaluate the histological impact of adding tocilizumab (TCZ) to GCs.Methods We enrolled all consecutive GCA patients with an inflammed TAB at diagnosis who were treated with TCZ and GCs for ≥6 months and followed from December 2017 to December 2023. Within 2 weeks, all patients underwent a second TAB, positron emission 18-fluorodeoxyglucose tomography/CT (PET/CT) and vessel colour Doppler ultrasonography (CDUS). …”
Get full text

Cryptococcosis in wait-listed liver transplant candidates: Prevalence, manifestations, and risk factors by Wan-Ting Tsai, Aristine Cheng, Yu-Chung Chuang, Cheng-Maw Ho, Yao-Ming Wu, Ming-Chih Ho, Hsin-Yun Sun, Ray-Hung Hu, Yee-Chun Chen

“…Of the 87 candidates undergoing liver transplantation, one (1.2%) recipient developed cryptococcosis 14 days post-transplant with negative CrAg three weeks before transplantation. HBsAg-positive chronic HBV infection with HBV DNA loads <2000 IU/mL was significantly associated with cryptococcosis (odds ratio 4.4, 95% confidence interval 1.2–16.5, p = 0.03) after the adjustment of MELD-Na score. …”
Get full text

Potency of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin in Complete Freund’s Adjuvant-Induced Arthritic Rats: Roles of TNF-α, IL-10, iNOS, MMP-9, and TGF-β1 by Eman A. Ahmed, Osama M. Ahmed, Hanaa I. Fahim, Tarek M. Ali, Basem H. Elesawy, Mohamed B. Ashour

“…Therefore, our target of this study was to explore and compare the effect of BM-MSCs (1×106 cells/rat at the 1st, 6th, 12th, and 18th days) and IMC (2 mg/kg b.w./day for 3 weeks) either alone or in combination on arthritic rats. …”
Get full text

Global disparities in cancer supportive care: An international survey by Alexandre Chan, Lawson Eng, Changchuan Jiang, Mary Dagsi, Yu Ke, Mary Tanay, Cristiane Bergerot, Niharika Dixit, Ana Cardeña Gutiérrez, Ana I. Velazquez, Farhad Islami, Enrique Soto‐Perez‐de‐Celis

“…The survey, available for 3 weeks, comprised sections covering (1) sociodemographic information; (2) clinical service/practice‐related disparities in their region/nation; (3) population groups facing disparities within their region or country. …”
Get full text

Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo by Wieslawa H. Dragowska, Jagbir Singh, Mohamed Wehbe, Malathi Anantha, Katarina Edwards, Sharon M. Gorski, Marcel B. Bally, Ada W. Y. Leung

“…Autophagy markers in tumor tissue harvested after four weeks of treatment were assessed by Western blot. …”
Get full text

Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways by Jemma J. Taitz, Jemma J. Taitz, Jian Tan, Jian Tan, Duan Ni, Duan Ni, Camille Potier-Villette, Camille Potier-Villette, Georges Grau, Georges Grau, Ralph Nanan, Ralph Nanan, Ralph Nanan, Laurence Macia, Laurence Macia, Laurence Macia

“…While the impact of specific metabolites or taxa on host cells is well-documented, the broader impact of a disrupted microbiota on immune homeostasis is less understood, which is particularly important in the context of the increasing overuse of antibiotics.MethodsFemale C57BL/6 mice were gavaged twice daily for four weeks with Vancomycin, Polymyxin B, or PBS (control). …”
Get full text

A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda by Keneth Iceland, Kasozi, Anne, Laudisoit, Lawrence Obado, Osuwat, Gaber El-Saber, Batiha, Naif E. Al, Omairi, Eric, Aigbogun, Herbert Izo, Ninsiima, Ibe Michael, Usman, Lisa M., DeTora, Ewan Thomas, MacLeod, Halima, Nalugo, Francis P., Crawley, Barbara E., Bierer, Daniel Chans, Mwandah, Charles Drago, Kato, Kenedy, Kiyimba, Emmanuel Tiyo, Ayikobua, Linda, Lillian, Kevin, Matama, Shui Ching, Nelly Mak, David, Onanyang, Theophilus, Pius, Linda, Lillian, Kevin, Matama, Shui Ching, Nelly Mak, David, Onanyang, Theophilus, Pius, David Paul, Nalumenya, Robinson, Ssebuufu, Nina Olivia, Rugambwa, Grace Henry, Musoke, Kevin, Bardosh, Juma John, Ochieng, Fred, Ssempijja, Patrick, Kyamanywa, Gabriel, Tumwine, Khalid J., Alzahrani, Susan Christina, Welburn

“…Methods—a rapid exploratory survey was conducted over 5 weeks among 260 respondents (66% male) from healthcare centers across the country using an online questionnaire. …”
Get full text

Management modes and effects analysis of strengthening the volunteer’s normalized nucleic acid sampling (加强志愿者常态化核酸采样的管理方法与效果) by HAN Chunying (韩春英), YOU Chenggang (尤诚刚), PAN Meili (潘美丽), JIANG Yuting (蒋玉婷), XU Yiwen (徐伊雯), LU Weijie (陆玮婕), XIA Hui (夏卉), CHEN Haiyan (陈海燕), HUANG Ying (黄莹), GU Yuanlu (顾元露), CHEN Huiying (陈慧颖), ZHANG Qi (张琪), LI Xu (李旭), WU Weina (吴维娜), SHEN Xiaojie (沈晓洁), ZHOU Yi (周毅), ZHANG Xian (张宪), LI Qin (李琴)

“…The normalized nucleic acid sampling was applied in the control group, and the theoretical knowledge and professional skills training were applied in the test group weekly. The weekly examination performances were evaluated through the questionnaires and interviews. …”
Get full text

Temporal relationship between symptom cluster and quality of life in rectal cancer patients after laparoscopic anus-preserving surgery by Chaoxiang You, Guiqiong Xie, Shun Lin, Shuang Li, Mengying Jia, Xiufei Wu, Xiaoxuan Zhang, Yi Zhou, Hongyan Kou

“…The present study aimed to investigate longitudinal causal relationships between symptom clusters and quality of life. 128 patients with rectal cancer from Nanchong City, Sichuan Province who underwent laparoscopic anus-preserving surgery completed 4 follow-up visits, and the survey time point are 2 weeks after surgery (T1), 1 month after surgery (T2), 3 months after surgery (T3), and 6 months after surgery (T4). …”
Get full text