Ethanolic extract of Dayak onion (Eleutherine palmifolia) prevented sperm membran damage in mice exposed to monosodium glutamate by Syahraini Adhiya Lathifah, Aldin Akbar Rahmatullah, Boedi Setiawan, Chairul Anwar Nidom, Nove Hidajati, Sri Mulyati, Tri Wahyu Suprayogi

“…Twenty-five male mice, 8 weeks old with a body weight approximately 20g, were divided into five groups, C– (received 0.5% Na-CMC), C+ (received 4 mg/g bw MSG), and three treatment groups (T1, T2, T3) which were given 4 mg/g bw MSG accompanied by Dayak onion extract at doses of 30, 60, and 120 mg/kg bw respectively. …”
Get full text

Spinal arachnoid diverticula in cats: Clinical presentation, diagnostic imaging findings, treatment, and outcome by João Miguel De Frias, Sofie F. M. Bhatti, George Nye, Rita Gonçalves, Tom Harcourt‐Brown, Angela Fadda, Katia Marioni‐Henry, Hannah Padley, Steven De Decker

“…Results Most cats were Domestic Short Hair (67%), male (63%), and had a wide range of ages (18 weeks to 13 years old). Neuroanatomical localization was consistent with a T3‐L3 myelopathy in 18 cats (86%) and C1‐C5 myelopathy in 3 cats (14%). …”
Get full text

A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments by Ziyu Shu, Shuo Qing, Xu Yang, Ping Ma, Yang Wu, Baizhan Li, Fangxin Fang, Runming Yao

“…Male Balb/c mice were exposed to specific concentrations of CB-NPs (30–50 nm in diameter, 0.184 mg/(kg·day)) in a controlled environmental chamber mimicking cold (10°C/14°C) and humid (90 % RH) conditions over three weeks. The results indicate that exposure to CB-NPs alone increased lung function, oxidative stress (ROS, GSH, MDA), inflammation (IL-6, TNF-α, IL-1β), apoptosis (Caspase 3, Caspase 8, Caspase 9), and histopathological alterations in lung tissue. …”
Get full text

Sofosbuvir Based Regimens in the Treatment of Chronic Hepatitis C with Compensated Liver Cirrhosis in Community Care Setting by Vijay Gayam, Amrendra Kumar Mandal, Mazin Khalid, Osama Mukhtar, Arshpal Gill, Pavani Garlapati, Mowyad Khalid, Mohammed Mansour

“…Pretreatment baseline patient characteristics, treatment efficacy with the sustained virologic response at 12 weeks posttreatment (SVR12), and adverse reactions were assessed. …”
Get full text

From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes by Lorena Gallego, Kimberly Harvey, Marta Pevida, Luis García-Consuegra, Olivia García-Suárez, Álvaro Meana, María Alvarez-Viejo, Luis Junquera

“…The right-side defects were covered with the collagen membrane, while the left-side defects were left untreated as a control. Nine weeks post-surgery, clinical, radiological, and histological analyses demonstrated new bone formation in the treated areas, whereas the control sites showed no bone regeneration. …”
Get full text

Comparison of Concentration- and Homology-Dependent Effects of the Proinflammatory Cytokine Interleukin-1β (IL-1β) in a Bovine Chondrocyte Inflammation Model by Robert Ossendorff, Sarah Kurth, Su Wang, Max Jaenisch, Elio Assaf, Sebastian Scheidt, Kristian Welle, Christof Burger, Dieter C. Wirtz, Andreas C. Strauss, Frank A. Schildberg

“…Titration of IL-1β (100–0.1 ng/mL) was performed with both human and bovine recombinant protein in chondrocyte culture for 2 weeks. Gene expression of anabolic (collagen 2, aggrecan, cartilage oligomeric protein (COMP), proteoglycan-4 (PRG-4)), catabolic matrix metallo proteinases (MMP-3, MMP-13), dedifferentiation (collagen 1) markers and inflammatory cytokines IL-6 and IL-8 was determined. …”
Get full text

Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome by Pedro Perez, Wilson Sze, Daniel Lozeau, Dipa Avichal, Joshua Miller

“…The patient originally presented to the emergency department with three days of fevers and a pruritic erythematous maculopapular rash that began two weeks prior. She had recently started an antibiotic course and had also been on a long-term antiepileptic drug regimen. …”
Get full text

Excessive copper induces lignin biosynthesis in the leaves and roots of two citrus species: Physiological, metabolomic and anatomical aspects by Xin Zhou, Xing Xiong, Fei Lu, Wenqing Shi, Yu Zhou, Ningwei Lai, Li-Song Chen, Zeng-Rong Huang

“…Osbeck, a more Cu-tolerant species] were treated with nutrient solution containing 0.5 (as Control), 100, 300 or 500 µM Cu for 15 weeks in sandy culture. By the end of treatments, citrus leaves and roots were sampled to investigate the biomass allocation, Cu distribution, the lignin biosynthesis and deposition. …”
Get full text

Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats by C. Gimenes, R. Gimenes, C. M. Rosa, N. P. Xavier, D. H. S. Campos, A. A. H. Fernandes, M. D. M. Cezar, G. N. Guirado, A. C. Cicogna, A. H. R. Takamoto, M. P. Okoshi, K. Okoshi

“…Diabetes was induced by intraperitoneal injection of streptozotocin. Rats exercised for 9 weeks in treadmill at 11 m/min, 18 min/day. Myocardial function was evaluated in left ventricular (LV) papillary muscles and oxidative stress in LV tissue. …”
Get full text

Overwintering temperature affects lipid and fatty acid metabolism in hepatopancreas and ovary of female mud crab Scylla paramamosain by Kaijia Yu, Hanying Xu, Ce Shi, Chunlin Wang, Changkao Mu, Yangfang Ye, Shujian Chen, Ronghua Li, Qingyang Wu

“…The influence of four overwintering temperatures, namely 8 ℃, 12 ℃, 16 ℃, and 20 ℃, on lipid metabolism and fatty acid profile in the hepatopancreas and ovary tissues of female mud crab Scylla paramamosain was investigated during eight weeks. According to the results, the hepatosomatic index (HSI) of the crabs after overwintering at 16 ℃ and 20 ℃ was significantly lower than that pre-overwintering (P < 0.05), however, overwintering did not affect the gonadosomatic index (GSI) (P > 0.05). …”
Get full text

Damoctocog Alfa Pegol, a PEGylated B-domain Deleted Recombinant Extended Half-life Factor VIII for the Treatment of Hemophilia A: A Product Review by Mark T. Reding, Shadan Lalezari, Gili Kenet, Giovanni Di Minno, Jonathan Ducore, Alexander Solms, Anita Shah, Pål André Holme, Lone H. Poulsen, Karina Meijer, Mindy Simpson, Maria Elisa Mancuso

“…Low bleeding rates were achieved across the studies, with twice weekly, every 5-day and every 7-day prophylaxis offering patients ≥ 12 years and their clinicians the chance to tailor treatment to individual needs and lifestyles, while maintaining long-term protection from bleeds and their consequences. …”
Get full text

Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece) by Dimitrios Rigopoulos, J. Katsantonis, O. Neofotistou, V. Chasapi, E. Lazaridou, A. V. Roussaki-Schulze, M. Papakonstantis, C. Angelakopoulos, P. Rigatos, P. Aronis, C. Zeglinas, A. Kyriakakis, T. Heatta-Speicher, A. Kollia, K. Antachopoulou, E. Papadavid

“…Eligible patients were consented adults (18–75 years old) on continuous treatment with any approved systemic therapy regimen for ≥24 weeks.Results 280 eligible patients were enrolled between 07APR2020 and 30NOV2020. …”
Get full text

Salinity affects the lipid metabolism and intestinal microbial composition of swimming crab Portunus trituberculatus by Meimei Liu, Tong Li, Hao Zhang, Zi Wang, Xugan Wu, Jie He, Zhiguo Dong

“…This study investigated the hepatopancreatic index, hepatopancreatic lipid metabolism, physiological and biochemical indicators and gut microbiota of P. trituberculatus cultured at salinity 28 ‰, 25 ‰, 22 ‰ and 19 ‰ for 8 weeks. The results showed that the highest expression level of SREBP1, FAS, LPR1, ACOX and FABP was found in 19 ‰ group compared to the 28 ‰ group, along with the enzyme activities of CPT1 and FAS. …”
Get full text

A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure contr... by Philip Düsing, Stephan H. Schirmer, Sebastian Schäfer, Alexander Krogmann, Jan-Malte Sinning, Nikos Werner, Florian Bönner, Alexander Sedaghat, Cornelius Müller, Irina Eckardt, Georg Nickenig, Andreas Zietzer

“…From the original cohort, subgroups of patients with systolic BP ≥140 mmHg (n = 44), ≥130 mmHg (n = 89) and diastolic BP ≥90 mmHg (n = 28) were analyzed for BP reduction after 12 weeks.ResultsIn patients with systolic BP ≥140 mmHg, the intervention group showed a reduction in systolic BP by 15.5 mmHg (± 16.7 mmHg, p = 0.0001), which was greater compared to the control group (6.0 ± 13.0 mmHg, p = 0.058). …”
Get full text

Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants by Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad, Ingrid Meulenbelt

“…Osteochondral explants were isolated from macroscopically preserved and lesioned areas of the joint and were kept in culture for two weeks, with or without exposure to 200ng/ml hrIL11. …”
Get full text

Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model by Tu Zhilan, Zhang Zengyu, Jin Pengpeng, Yang Hualan, Li Chao, Xi Yan, Guo Zimin, Hou Shuangxing, Li Weiwei

“…Subsequently, the MRI, pathomorphism, as well as Morriss water maze test were conducted to determine CSVD-related indicators. 8 weeks post-surgery, animals were randomly administered SAL, DAPT, ATN161 or saline.The aim was to explore the protective effects of SAL in CSVD as well as its possible mechanism. …”
Get full text

Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice by Tianchan Peng, Jian Xiang, Yun Tian, Xiaogen Tang, Lina Wang, Lijuan Gao, Oscar Junhong Luo, Li’an Huang, Guobing Chen

“…Methods: Mice were subcutaneously injected with D-galactose (500 mg/kg/day) for 12 weeks to induce aging, while LbGp was orally administered (100 mg/kg/day) throughout the study. …”
Get full text

Passive hyperthermia alters the resting-state functional connectivity of mouse brain by Yang Ruan, Kai Liu, Bo Li, Shaowen Qian, Hongxia Lei, Yao Xing, Gang Sun

“…Purpose To investigate how passive hyperthermia affect the resting-state functional brain activity based on an acute mouse model after heat stress exposure.Materials and methods Twenty-eight rs-fMRI data of C57BL/6J male mice which weighing about 24 ∼ 29 g and aged 12 ∼ 16 weeks were collected. The mice in the hyperthermia group (HT, 40 °C ± 0.5 °C, 40 min) were subjected to passive hyperthermia before the anesthesia preparation for scanning. …”
Get full text

Hypercholesterolemia triggers innate immune imbalance and transforms brain infarcts after ischemic stroke by Ali Ata Tuz, Nils Hoerenbaum, Özgür Ulusoy, Adel Ahmadi, Alana Gerlach, Alexander Beer, Andreas Kraus, Anja Hasenberg, Nina Hagemann, Dirk M. Hermann, Matthias Gunzer, Matthias Gunzer, Vikramjeet Singh

“…Mice were fed with HFD or normal diet (ND) for six weeks and then induced stroke by transient occlusion of the middle cerebral artery. …”
Get full text

Robot-assisted ureteral reconstruction for managing kidney transplant patients with ureteric complications by Dongho Shin, San Kang, Seung Ah Rhew, Chang Eil Yoon, Hyong Woo Moon, Yong Hyun Park, Hyuk Jin Cho

“…The urethral catheter was removed after 15.1±5.4 days, and the ureteral catheter was removed after 4.9±1.5 weeks. The mean follow-up period was 23.9±6.8 months, with no additional interventions required after surgery. …”
Get full text