Astragalin and rutin restore gut microbiota dysbiosis, alleviate obesity and insulin resistance in high-fat diet-fed C57BL/6J mice by Muni Swamy Ganjayi, Karunakaran Reddy Sankaran, Balaji Meriga, Ruchika Bhatia, Shikha Sharma, Kanthi Kiran Kondepudi

“…Randomized male C57BL/6J mice were experimentally divided into 5 groups and fed either a normal diet or a high-fat diet (HFD) for 16 weeks. Compared to vehicle treated group (HFD group), CAR could substantially improve selected gut microbiota abundance (Akkermansia, Lactobacillus, Bifidobacteria, Roseburia, Prevotella), reversed the Firmicutes/Bacteroidetes proportions, and inhibited the growth of Escherichia coli, Salmonella, and Klebsiella in obese mice. …”
Get full text

Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure by Kengo Yoshida, Zhenqiu Liu, Yoshiko Kubo, Masahiko Miura, Mika Yamaoka, Hiroko Nagamura, Munechika Misumi, Yoichiro Kusunoki

“…This study investigated the naïve T-cell pool, thymic cellularity, and transcriptome in mice irradiated with 3.8 Gy at 5 weeks of age and treated 13 months later with 30 mM spermidine (SPD), a metabolism regulator. …”
Get full text

Functional Brain Correlates of Upper Limb Spasticity and Its Mitigation following Rehabilitation in Chronic Stroke Survivors by Svetlana Pundik, Adam D. Falchook, Jessica McCabe, Krisanne Litinas, Janis J. Daly

“…Methods. 23 stroke survivors (>6 months) were treated with an arm motor learning and spasticity therapy (5 d/wk for 12 weeks). Outcome measures included Modified Ashworth scale, sensory tests, and functional magnetic resonance imaging (fMRI) for wrist and hand movement. …”
Get full text

Achieving chronic hepatitis B functional cure: Factors and potential mechanisms by Jiarui Zheng, Zilong Wang, Linxiang Huang, Zixuan Qiu, Yandi Xie, Suzhen Jiang, Bo Feng

“…On the other hand, functional cure based on PegIFNα shows good long-term durability, but over 10 % of patients still experience relapse, mostly within 48 weeks after functional cure. Factors related to CHB functional cure with antiviral therapy are complex, including host factors, viral factors, environmental factors, etc. …”
Get full text

Elements of Success After Metatarsectomy Healing of Neuropathic Diabetic Foot Ulcers by Hossein Hemmati, Behrang Motamed, Sedighe Masoudi Taramsari, Mohammad Taghi Ashoobi, Mohaya Farzin, Habib Eslami Kenarsari, Rastin Hosseinzaeh Asli, Zahra Abbasi Ranjbar, Milad Sarafi

“…Patients were followed up for two weeks, one month, and three months after surgery and were evaluated for complete recovery, partial recovery, and no response. …”
Get full text

Scurvy as a Cause of Leg Pain and Limp in Pediatric and Adolescent Patients by Christopher J. DeFrancesco, MD, David Kell, BA, Sean Owens, BS, Matt Grady, MD, Naomi Brown, MD

“…Key Concepts: (1) Scurvy, the condition caused by vitamin C deficiency, is not a historical disease, with research suggesting that its incidence in the US is on the rise. (2) Scurvy can result in lower extremity pain and limping among children, who may present for orthopaedic evaluation. (3) An increased index of suspicion for vitamin C deficiency should be maintained for any child with a history of restrictive eating, especially those with a history of autism spectrum disorder. (4) Orthopaedic providers should know the specific MRI and x-ray findings characteristic of vitamin C deficiency. (5) Vitamin C levels can be repleted in weeks with proper supplementation, but children with scurvy due to restrictive eating generally require continued intervention from nutrition and/or feeding specialists.…”
Get full text

Aggravating Effects of Psychological Stress on Ligature-Induced Periodontitis via the Involvement of Local Oxidative Damage and NF-κB Activation by Qiang Li, Yajuan Zhao, Daokun Deng, Jiuhui Yang, Yongjin Chen, Jia Liu, Min Zhang

“…Chronic unpredictable mild stress (CUMS) was used to establish psychological stress, and silk ligature was used to induce experimental periodontitis. Four weeks later, stressed rats showed altered behaviour, serum hormone levels, and sucrose preference. …”
Get full text

Case report: Pseudoprogression mimicking neoplastic recurrence three months after completion of proton beam therapy for an IDH-mutant astrocytoma CNS WHO grade 3 by Liv Cathrine Heggebø, Liv Cathrine Heggebø, Ida Maria Henriksen Borgen, Ida Maria Henriksen Borgen, Hanne Blakstad, Hanne Blakstad, Cathrine Saxhaug, Pål André Rønning, Pitt Frederik Niehusmann, Katja Werlenius, Malin Blomstrand, Malin Blomstrand, Petter Brandal, Petter Brandal

“…He was included in the PRO-GLIO trial and randomized to receive proton beam therapy to a total dose of 59.4 Gray (Gy) relative biological effectiveness (RBE). Four weeks after completion of radiotherapy, adjuvant temozolomide was commenced. …”
Get full text

Evaluation of the Effectiveness of Using STEAM Projects in Teaching Physics: Student Interest in the Field of Solar Energy by Amin Pattayev, Naci Genc, Sherzod Ramankulov, Serik Polatuly, Meirbek Tuiyebayev, Indira Usembayeva, Gulnara Rizakhojayeva

“…The educational process continued for 15 weeks. In this feature, pre- and post-participation calculations, especially surveys, and progress calculations are used to create a student score. …”
Get full text

Competencies developed by students while working in nutrition junior enterprises by Gabriela Gomes de Paiva, Daniele Cristina de Almeida, Letícia Clara Coelho, Simone Cardoso Lisboa Pereira, Bruna Vieira de Lima Costa

“…Thus, this study aimed to identify competencies perceived by students in nutrition junior enterprises in Brazil and compare them according to their profile (time of participation, number of positions and weekly workload). Methods: Cross-sectional study, carried out with a representative sample of students working in nutrition junior enterprises. …”
Get full text

Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats by Ilya Zavodnik, Tatsiana A. Kavalenia, Siarhei N. Kirko, Elena B. Belonovskaya, Irina A. Kuzmitskaya, Yulia V. Eroshenko, Elena A. Lapshina, Vyacheslav U. Buko

“…The naringin treatment (40 mg/kg of the body weight, 4 weeks) partially recovered impaired cardiac mitochondria respiration, decreased spontaneous and increased Ca2+-induced MPT pore opening, improved pancreatic islets morphology and dystrophic changes, lowered glycated hemoglobin and blood plasma urea, and decreased the oxidative stress level with glucose or insulin concentrations remaining unchanged in diabetic animals. …”
Get full text

Response to Statin Therapy in Obstructive Sleep Apnea Syndrome: A Multicenter Randomized Controlled Trial by Marie Joyeux-Faure, Renaud Tamisier, Jean-Philippe Baguet, Sonia Dias-Domingos, Stephen Perrig, Georges Leftheriotis, Jean-Paul Janssens, Wojciech Trzepizur, Sandrine H. Launois, Françoise Stanke-Labesque, Patrick A. Lévy, Frédéric Gagnadoux, Jean-Louis Pepin

“…This multicenter, randomized, double-blind study compared the effects of atorvastatin 40 mg/day versus placebo over 12 weeks on endothelial function (the primary endpoint) measured by peripheral arterial tone (PAT). …”
Get full text

Clarification of factors associated with post-artesunate delayed hemolysis (PADH): Analysis of 327 patients with severe imported Plasmodium falciparum malaria in France by Pierre-Louis Conan, Marc Thellier, Eric Kendjo, Sandrine Houzé, Rémonie Seng, Stéphane Jauréguiberry

“…Background: Post-Artesunate delayed hemolysis (PADH) occurs in approximately 15 % of treated patients 2–3 weeks after artesunate administration. Identifying risk markers for PADH would help predict which patients are at higher risk. …”
Get full text

In Vivo Magic Angle Magnetic Resonance Imaging for Cell Tracking in Equine Low-Field MRI by Carolin Horstmeier, Annette B. Ahrberg, Dagmar Berner, Janina Burk, Claudia Gittel, Aline Hillmann, Julia Offhaus, Walter Brehm

“…Hypointense artefacts were observable in the cell-injected superficial digital flexor tendons over 24 weeks and artefact signal-to-noise ratio differed significantly from tendon signal-to-noise ratio in the magic angle images (P<0.001). …”
Get full text

Epidemiological and Clinical Profile of Dermatoses Observed in Chronic Hemodialysis Patients at the National Teaching Hospital (NTH-HKM) of Cotonou, Benin by Hugues Adégbidi, Fabrice Akpadjan, Odile Houngbo, Jacques Vigan, Bérénice Dégboé, Nadège Agbessi, Christiane Koudoukpo, Félix Atadokpèdé

“…Median age in hemodialysis was 36 months with two weekly sessions. The main dermatological manifestations were xerosis (48.3%), pruritus (34.5%), alopecia (14%), nail dystrophy (9.2%), equisegmented nails (8%), and melanoderma (8%). …”
Get full text

Fipronil prevents transmission of Lyme disease spirochetes by Radek Šíma, Adéla Palusová, Tereza Hatalová, Luise Robbertse, Petra Berková, Martin Moos, Petr Kopáček, Veronika Urbanová, Jan Perner, Ala Tabor

“…The I. ricinus nymphs infected with B. afzelii were topically treated with fipronil shortly after attachment to mice. Four weeks post-feeding, the skin and internal organs were examined for the presence of Borrelia. …”
Get full text

Assessment of the efficacy of on-demand tegoprazan therapy in gastroesophageal reflux disease through a randomized controlled trial by Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Sun Moon Kim, Ki Bae Kim, Seung Woo Lee, Young Sin Cho, Ki Bae Bang, Kyung Ho Song

“…Among the 69 participants who completed 8 weeks of on-demand therapy and rated patient satisfaction on a 5-point Likert scale, the tegoprazan and esomeprazole groups scored an average of 4.31 and 4.15 points, respectively, without any significant intergroup difference. …”
Get full text

The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional study by Nozomu Uchida, Mayumi Ishida, Izumi Sato, Akira Yoshioka, Takao Takahashi, Daisuke Furuya, Yasuhiro Ebihara, Hiroshi Ito, Hideki Onishi

“…Basic data (age, sex, height, weight, and BMI), dietary intake for the previous 3 weeks, degree of care (DOC), degree of independence in daily life for elderly with dementia (DIDLED), and comorbidities were analyzed using descriptive statistical methods. …”
Get full text

Spatiotemporal Variations in Chemical Composition of Wet Atmospheric Deposition in Mexico City by Elizabeth Vega, Ann Wellens, Ana Luisa Alarcón, Rodolfo Sosa, Monica Solano, Monica Jaimes-Palomera

“…Maximum concentrations of major ions were found in the northern and central part of the megacity, due to the impact of the Tula industrial corridor located north of the city. Weekly pH values varied from 3.6 to 9.4, being 27.1% of the values acidic. …”
Get full text

Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial by Hugh Taylor, Hao Huang, Lubna Pal, Heping Zhang, Howard J Li, Sandra Carson, Valerie Flores, Jared Robbins, Nanette F Santoro, James H Segars, David Seifer, Steven Young

“…A total of 814 patients with endometriosis undergoing fertility treatment will be enrolled and randomised 1:1 into two groups: elagolix 200 mg two times per day or placebo for 8 weeks, prior to undergoing IVF. All participants will then undergo IVF treatment per local protocols. …”
Get full text