Metabolomic and Transcriptomic Analysis of the Mechanism of the Apple Coloration Change After Uncovering Fruit Bag by Pengwei Duan, Xiaojian Ma, Haiqiang Shi, Lizhe Qin, Jizhuang Du, Sumiao Yang, Jianjun Zhang

“…In this study, the pattern of metabolite accumulation and gene expression was profiled in the striped and blushed apple peels at three ripening periods to elucidate the color formation mechanism within two weeks after removing the bag. The phenotypes presented in the peel coloring process are different between SF (stripe red) and HM (blush red), which have different accumulated levels of metabolites and gene expression during the coloring process. …”
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Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in... by Rui-Ling Liu, Zhi-Lei Xu, Yu-Ling Hu, Xing-Yu Lv, Quan-Zi Yao, Jia-Liang He, Li-Juan Fu, Li-Hong Geng, Tong Wang, Zhao-Hui Zhong, Yi-Jian Zhu, Yu-Bin Ding

“…The distributed lag nonlinear model (DLNM) analysis revealed the lagged effects of PM2.5 component exposure, particularly during lag weeks 2–5, where exposure was significantly associated with the occurrence of POR. …”
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Effect of oral antibiotics after two-stage revision for periprosthetic joint infection on subsequent antibiotic resistance within a national cohort of United States veterans by J. Payne, J. Payne, J. D. Sutton, B. E. Blackburn, S. Bansod, S. Bansod, H. Imlay, H. Imlay, E. S. Spivak, E. S. Spivak, J. Pupaibool, J. Pupaibool, J. M. Gililland, J. M. Gililland, L. K. Certain, L. K. Certain, L. K. Certain

“…We compared those who received at least 2 weeks of oral antibiotics after Stage 2 reimplantation to those who did not. …”
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Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation by Ai-Li Xu, Zheng Shen, Shi-Hao Wang, Hai-Yun Luan, Yong Xu, Ze-Chun Kang, Zi-Qi Liao, Jie Liu, Xiao-Lei Duan, Wei-Hua Bian, Hui Sun, Xin Xie

“…Mice were intravenously administered DOX (5 mg/kg) for 4 weeks to establish a cardiac toxicity model. Heart function was determined using echocardiography, and cardiac tissue was assessed for protein expression, mRNA levels, fibrosis, and immunofluorescent staining. …”
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Genomic and phenotypic selection indices for decreased birth weight, shortening fattening period, and regulating total weight gain in beef cattle by Kenji Togashi, Atsushi Ogino, Toshio Watanabe, Masakazu Shinomiya, Masashi Kinukawa, Kazuhito Kurogi, Masanobu Nurimoto

“…One cycle of index-based selection made it possible to shorten the fattening period two weeks compared with that before selection while maintaining the same final fattening weight as before selection. …”
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Protocol for a prospective cohort study: Prevention of Transmissions by Effective Colonisation Tracking in Neonates (PROTECT-Neo) by Martin Wolkewitz, Roland Hentschel, Philipp Henneke, Daniel Jonas, Tim Götting, Sandra Reuter, Daniel Klotz, Simone Hock, Benjamin Blümel, Georg Häcker, Hajo Grundmann, Nico Mutters

“…Isolates will be obtained by routine weekly screening. Isogenicity will be determined by whole-genome sequencing. …”
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Factor structure and longitudinal measurement invariance of Edinburgh Postnatal Depression Scale during the whole perinatal period: a multicenter cohort study in China by Jichun Yang, Yu Jiang, Yimin Qu, Yongle Zhan, Haihui Ma, Xiaoxiu Li, Dongmei Man, Hongguo Wu, Ping Huang

“…Methods 4139 pregnant women from 24 hospitals in 15 provinces of China were measured using EPDS in the first, second, third trimesters and 6 weeks postpartum. Exploratory factor analysis and confirmatory factor analysis were used to explore the factor structure of EPDS at each time point. …”
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Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen by Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice

“…Healthy volunteers received either single or repeated (for 6 weeks) subcutaneous administrations of investigational drug or placebo. …”
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Effect of Intercropping Beans with Maize and Botanical Extract on Fall Armyworm (Spodoptera frugiperda) Infestation by Clovis Bessong Tanyi, Raymond Ndip Nkongho, Justin Nambangia Okolle, Aaron Suh Tening, Christopher Ngosong

“…FAW severity was assessed at three to seven weeks after planting (WAP), while maize infestation was assessed at seven WAP. …”
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Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim, Ji-eun Lee, Ho Kyoung Kim

“…IVE and AET were orally administered for four weeks. We investigated the effects of treatment on airway hyperresponsiveness, IgE production, pulmonary eosinophilic infiltration, immune cell phenotypes, Th2 cytokine production in bronchoalveolar lavage, Th1/Th2 cytokine production in splenocytes, forkhead box protein 3 (Foxp3) expression, and lung histology. …”
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Comparison of the conceive-design-implement-operate model and lecture-based learning in teaching the “healthcare-associated infections” course by Yu Chen, Rui Zhang, Zhenke Zhou, Min Hong, Zheng Huang, Heling Wen, Lei Peng

“…The effectiveness of these pedagogical approaches was evaluated by comparing pre-and post-training test scores, and we used the Course Experience Questionnaire (CEQ) to collect students’ feedback on the course and teaching.ResultsCompared to traditional LBL method, the CDIO model significantly improved the overall scores and practical application scores of nursing students in the HAI course, with these advantages still retained after 24 weeks. Additionally, preliminary results show that students in the CDIO model scored higher on CEQ categories such as good teaching, clear goals and standards, appropriate assessment, generic skills, and independence, but they also reported an increased workload.ConclusionOur research is the first to apply the CDIO framework to nursing education in HAI courses, enhancing nursing students’ practical application skills, particularly in the sustained retention in this area. …”
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Long-term Breast Shape Analysis After Short-scar Reduction Mammaplasty: A Critical View by Daniel Hilewitz, MD, Oren Ganor, MD, Neta Adler, MD, Asaf Olshinka, MD, Dafna Shilo Yaacobi, MD, Lior Har-Shai, MD, Tamir Shay, MD, Michael Icekson, MD, Dean Ad-El, MD, Sagit Meshulam-Derazon, MD

“…The mean sternal notch-to-nipple and upper breast-to-nipple distances decreased postoperatively by 22% and 43%, respectively, and remained stable over a mean time of 110.1 ± 65.58 weeks. The nipple-to-inframammary fold distance, which was intraoperatively shortened by an average of 63%, elongated back to 88% of its preoperative measurements. …”
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Podocyte-related biomarkers' role in evaluating renal toxic effects of silver nanoparticles with the possible ameliorative role of resveratrol in adult male albino rats by Eman El-Sayed Khayal, Mona G. Elhadidy, Sulaiman Mohammed Alnasser, Manal Mohammad Morsy, Azza I. Farag, Samah A. El-Nagdy

“…The treatments were given orally for 4 weeks. Ag NPs group displayed a reduction in kidney weight ( absolute and relative), excess in urinary levels of kidney injury molecule, neutrophil gelatinase-associated lipocalin, cystatin, and blood kidney biomarkers (creatinine, urea, and potassium), increases in oxidative stress markers with the reduction in antioxidant markers, and decreases in serum sirtuin 1(SIRT1) level. …”
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The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…Participants received KN046 5 mg/kg every 3 weeks and lenvatinib 12 or 8 mg once daily. The primary endpoints were safety, tolerability, dose-limiting toxicity (DLT), and objective response rate (ORR) according to RECIST v1.1. …”
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The effect of light-emitting diode-mediated photobiomodulation therapy on orthodontic tooth movement: A literature review by Rashin Bahrami, Nariman Nikparto, Fateme Gharibpour, Maryam Pourhajibagher, Abbas Bahador

“…Five studies were included in the review, comprising two animal studies (ages 10 and 12 weeks) and three human studies (ages ranging from 15 to 17 years). …”
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Determining the Nature of IC 10 X-2: A Comprehensive Study of the Optical/IR Emission from an Extragalactic BeHMXB by Jwaher Alnaqbi, Joseph D. Gelfand, Payaswini Saikia, Craig Heinke, M. C. Baglio, David M. Russell, Guobao Zhang, Antonios Manousakis, Ivan Yu. Katkov, Fraser Lewis

“…Our analysis of regular (daily and weekly) observations by both the Zwicky Transient Facility and Las Cumbres Observatory over a 5 yr period indicates both periodic flares and variations in the apparent magnitude and color with a period of ∼26.5 days—likely the orbital period of this binary system. …”
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Effect of a chemically-modified-curcumin on dental resin biodegradation by Qi Dai, Hsi-Ming Lee, Austin Giordano, Fu-Pen Chiang, Stephen G. Walker, Rafael Delgado-Ruiz, Francis Johnson, Lorne M. Golub, Ying Gu

“…This study is to investigate the inhibitory effects of a novel Chemically-Modified-Curcumin (CMC 2.24) on esterase activities and related dental material biodegradation.MethodsDental adhesive materials and composite resins were incubated in S. mutans suspension with CMC 2.24 and other compounds, including doxycycline, Chemically-Modified-Tetracycline (CMT-3), and curcumin for 4 weeks. The pre- and post-incubation surface roughness were evaluated by either laser diffraction pattern and/or a 3D laser scanning microscope. …”
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Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases by Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

“…Blood samples were collected before meals, between 8:30–9:00 am, daily for 10 weeks to evaluate the daily variation. At 4 days, blood was also collected before meals three times a day (at 8:30–9:00, 12:30–13:00, and 16:30–17:00) to evaluate circadian variation. …”
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Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors by Andreas Hermann, Jeong Beom Kim, Sumitra Srimasorn, Holm Zaehres, Peter Reinhardt, Hans R. Schöler, Alexander Storch

“…To prove whether this is also true for human cells, we compared the efficiency of neuronal differentiation of iPSC generated from fetal human neural stem cells with either one (OCT4; hiPSC1F-NSC) or two (OCT4, KLF4; hiPSC2F-NSC) reprogramming factors with iPSC produced from human fibroblasts using three (hiPSC3F-FIB) or four reprogramming factors (hiPSC4F-FIB). After four weeks of coculture with PA6 stromal cells, neuronal differentiation of hiPSC1F-NSC and hiPSC2F-NSC was as efficient as iPSC3F-FIB or iPSC4F-FIB. …”
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Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice by Zhuo Chen, Xiang Qian, Shasha Chen, Xiaoxuan Fu, Guanjun Ma, Aiqin Zhang

“…After treatment within 5 weeks, compared with the model group, the administered group improved the changes of tumor pathomorphology. …”
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