Effect of beetroot or beetroot plus vitamin C supplementation on cardiovascular function in patients with coronary artery disease: protocol for a double-blind, placebo-controlled,... by Hamed Tabesh, Mohsen Nematy, Leila Sadat Bahrami, Mohsen Mohebaty, Seyyed Mostafa Arabi, Reza Rezvani

“…Participants will be divided into three groups: (1) Those who receive 500 mg three times a day of beetroot capsules, (2) Those who receive 500 mg three times a day of beetroot plus vitamin C capsules, and (3) Those who receive placebo capsules three times a day for 4 weeks. Pulse wave velocity, Augmentation Index, heart rate, volume of oxygen (VO2) max/VO2 peak, peak heart rate, blood pressure, interleukin 6 (IL-6), high sensitivity C reactive protein, intercellular adhesion molecule, vascular cell adhesion molecule, lipid profile and anthropometry will be measured at the beginning and end of the intervention.Ethics and dissemination This study was approved by the Ethics Committee of Mashhad University of Medical Sciences (IR.MUMS.MEDICAL.REC.1399.717). …”
Get full text

Experience of Acceptance and Commitment Therapy for those with mild traumatic brain injury (ACTion mTBI): A qualitative descriptive study. by Josh W Faulkner, Jason Chua, Amabelle Voice-Powell, Deborah L Snell, Maree Roche, John Moffat, Suzanne Barker-Collo, Alice Theadom

“…After completing the ACTion mTBI sessions, 23/27 (85.2%) participants (mean time post-injury: 28.0 weeks) completed a semi-structured interview about their experience of the intervention. …”
Get full text

ANGPTL4 Attenuates Ang II-Induced Atrial Fibrillation and Fibrosis in Mice via PPAR Pathway by Xi Zhu, Xiaogang Zhang, Xinpeng Cong, Luoning Zhu, Zhongping Ning

“…Mice were infused with Ang II (2000 ng/kg/min) and were administrated with recombinant human ANGPTL4 (rhANGPTL4, 20 μg/kg/day) for 3 weeks. The fibrosis was evaluated with Masson’s trichrome staining in the atrial myocardium. mRNA levels of IL-1β, IL-6, collagen I, and collagen III were measured using real-time qRT-PCR. …”
Get full text

Seroprevalence of Avian Influenza in Guinea Fowls in Some Districts in the Upper East Region of Ghana by Albert Agyapong Tweneboah, Sherry Ama Mawuko Johnson, Patrick Mensah Amponsah, Derrick Adu Asare, Benjamin Obukowho Emikpe

“…Blood samples were collected from 397 guinea fowls that are over 4 weeks old, and seroprevalence was determined using ID Screen Influenza A Antibody Competition Enzyme‐linked immunosorbent assay (ELISA). …”
Get full text

Protective Effect of Exercise Preconditioning on Myocardial Ischemia-Reperfusion Injury in Rats Based on Autophagy by Qiang TANG, Jiyao ZHANG, Hongyu LI, Xue WANG, Xia YIN, Xuedong WANG, Zichen MU, Luwen ZHU

“…Before modeling the Sham group and MIRI group didn't receive intervention, and the EP group was given electric treadmill training for four weeks. The ultrastructure and autophagic bodies of rat cardiac myocytes were observed by transmission electron microscopy, the infarct size was measured by Evans blue-TTC double staining, and the expression ofPI3K-Akt-mTOR signal pathway related proteins was detected by Western blot.Results:In the Sham group, the nuclear membrane was intact and continuous, the myofibrillar bundles arranged orderly, the structure of mitochondria was intact and no edema, the morphology of myocardial cells was normal, and no autophagic bodies were found; in the MIRI group, the myofibrillar bundles were loose and disordered with interstitial edema, mitochondria and myocardial cells were damaged seriously, the structure of cells was disordered, and autophagy was observed in the field of vision; in the EP group, some of sarcoplasmic reticulum was edema and expanding, mitochondrial structure was more complete with slight edema, myocardial cell was less damaged, and autophagy was less. …”
Get full text

A Study on Coronavirus Disease-2019 Stigma Associated with Coronavirus Disease-2019 Warriors and an Insight into Community Perception by Madhavi GAJULA, Suwarna MADHUKUMAR

“…Results: Of the participants, 46.1% were in the age group of 30-40 years, 47% were males, and 81% were doctors by profession and were engaged in a minimum of 6-12 h of duty for 2 weeks. Of the study population, 85.5% had anticipated stigma, whereas 72.2% had experienced stigma, 43.4% had internalized stigma, and 76.3% had disclosure concerns. …”
Get full text

A Quantitative Examination and Comparison of the Ability of Australian Gentamicin Dosing Guidelines to Achieve Target Therapeutic Concentrations in Neonates by Luke E. Grzeskowiak, Sheree Wynne, Michael J. Stark

“…We calculated the probability of target attainment (PTA) according to gestation at birth (22 to 40 weeks) and postnatal age (1–7, 8–14, 15–21, 22–28 days). …”
Get full text

Psychosocial and sociodemographic factors associated with gestational blood glucose levels in women attending public hospitals: Results from baseline of MAASTHI cohort. by Prafulla Shriyan, Srinidhi Koya, Eunice Lobo, Onno Cp van Schayck, Giridhara R Babu

“…A 2-hour 75 g oral glucose tolerance test (OGTT) was administered between 24-36 weeks of gestation. We examined the relation between psychosocial factors assessed at baseline and gestational blood glucose levels in second/third trimester using multivariate linear regression and explored association between serum cortisol and gestational blood glucose levels in subgroup samples.…”
Get full text

A prospective, randomized, single-center, two-arm, open-label study to evaluate the efficacy of biotherapi®, a two-strain bacillus probiotic blend, as an adjunctive therapy in the... by Arindam Nandy Roy, Yarram Ashok Kumar, Syeda Sana Fatima

“…Methods: In this prospective, randomized, single-center, two-arm, open-label study, patients were randomized (1:1) to receive twice-daily adjunctive Biotherapi® (n = 125) or standard of care alone (n = 125) for 12 weeks. The primary endpoint was the change from baseline to days 45 and 90 in the Disease Activity Score-28-erythrocyte sedimentation rate (DAS-28-ESR). …”
Get full text

Subacute Toxicity Effects of the Aqueous Shoot Extract of Yushania alpina (K. Schum.) W.C.Lin in Sprague Dawley Rats: An Appraisal of Its Safety in Ethnomedicinal Usage by Joseph Ngugi Wanjiru, Timothy Elias Maitho, James Mucunu Mbaria, Gervason Apiri Moriasi

“…In this study, all the experimental rats treated orally with 40 mg/Kg BW, 200 mg/Kg BW, and 1000 mg/Kg BW of the aqueous shoot extract of Y. alpina remained normal, like the control group rats, and did not show any clinical signs of subacute toxicity, and no morbidity or mortality was recorded. Besides, the weekly body weight gains and the haematological and biochemical parameters of experimental rats orally administered with the studied plant extract at the tested doses and in the control group were comparable (P>0.05). …”
Get full text

The effect of oil refinery by-products on reproductive and rearing performance in japanese quail by Süleyman Dere, Tahir Balevi, Şeref İnal, Varol Kurtoğlu, Alper Yılmaz

“…ln this study, the effect of oil industry by-products as energy source on daily feed intake, egg yield, feed conversion rate, fertility, hatchability, and live-weight in japanese quails (Coturnix coturnix japonica) 120 female and <\Q male quails with weeks old were used in this study. Quails were divided into lour main groups consisting 10 subgroups having 3 female quails in each of subgroups. …”
Get full text

Development and validation of the Women Autonomy Scale for measuring psychosocial freedom from conventional gender roles by Waqar Husain, Farrukh Ijaz, Muhammad Ahmad Husain, Achraf Ammar, Khaled Trabelsi, Haitham Jahrami

“…Test-retest reliability was 0.788 after two weeks of initial administration. EFA revealed a four-factor structure consisting of 18 items: personal freedom, freedom from conventional femininity, freedom from conventional masculinity, and freedom from shame. …”
Get full text

Coats-Like reaction post-vitreoretinal surgery for PDR managed with laser photocoagulation and adjunctive intravitreal steroids– a case report by Kanika Godani, Shruti Vidyasagar, Preksha Biradar, Vishma Prabhu, Prathiba Hande, Priyanka Gandhi, Rupal Kathare, Jay Chhablani, Ramesh Venkatesh

“…Results Silicone oil removal combined with targeted endolaser photocoagulation and intravitreal triamcinolone acetonide injection resulted in a complete resolution of the subretinal lipid exudation. Two weeks postoperatively, the retina remained well-attached, but best-corrected visual acuity declined to 6/60 due to posterior subcapsular cataract progression. …”
Get full text

Untreated exstrophy-epispadias complex: outcomes of Indiana pouch and primary abdominal wall closure by Niraj Kumar, Avishek Mandal, Sandeep Kumar, Siddharth Yadav, Somanath Karmungikar, Pawan Vasudeva

“…All patients underwent a standard evaluation and surgical procedure and were followed up at 6 weeks, 3, 6 and 12 months and then annually. At each visit, renal function test and ultrasonography were performed and a 3 day CIC diary was obtained. …”
Get full text

Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium- challenged rats by Ejike, Daniel Eze, Okpa, Precious Nwaka, Igbokwe, Ugochukwu Vincent, Moses, Dele Adams, Karimah, Mohammed Rabiu, Ayikobua, Emmanuel Tiyo

“…The administration of vehicle and extract was conducted orally for six weeks. Testicular activity of 17 beta- hydrosteroid dehydrogenase (17β-HSD) and serum testosterone, luteinizing and follicle stimulating hormone (LH, FSH) levels were evaluated. …”
Get full text

A descriptive-multivariate analysis of community knowledge, confidence, and trust in COVID-19 clinical trials amongst Ugandans working in healthcare settings. by Keneth Iceland, Kasozi, Lawrence Obado, Osuwat

“…Methods: A rapid exploratory survey with questions was conducted over 5 weeks at multiple health care centers across the country using an online platform. …”
Get full text

Trifluridine-tipiracil in previously treated patients with oestrogen receptor-positive, HER2-negative metastatic breast cancer (BOOG 2019-01 TIBET trial): a single-arm, multicentre... by Niels A.D. Guchelaar, Ron H.J. Mathijssen, Maaike de Boer, Marlies L. van Bekkum, Joan B. Heijns, Birgit E.P.J. Vriens, Mandy M. van Rosmalen, Lonneke W. Kessels, Lisanne Hamming, Karin J. Beelen, Peter Nieboer, Susan M. van den Berg, Esther Oomen-de Hoop, Rhodé M. Bijlsma, Monique E.M.M. Bos

“…The primary endpoint was the disease control rate (DCR) at 8 weeks, defined as the percentage of patients that had stable disease, partial response or complete response according to RECIST 1.1, in all patients that received at least one dose of trifluridine-tipiracil and met the key eligibility criteria defined a priori. …”
Get full text

Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…The pumps were implanted in mice, ensuring constant infusion of Ang II at a dose of 1.0 µg/kg per minute for 4 weeks. The mice were exposed to 0.4 W/cm2 intensity ultrasonic radiation for 15 min at 4 h post injection of sinoporphyrin sodium (DVDMS) (4 mg/kg) into the caudal vein was repeated weekly for 4 treatments. …”
Get full text

Pegilated interferon alpha 2b «Pegaltevir» chronic hepatitis C treatment (randomized clinical trial) by Marina V. Mayevskaya, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda, V. T. Ivashkin

“…Assessment of Pegaltevir® efficacy was carried out in 4 weeks (rapid virologic response, RVR) and 12 weeks of treatment (early virologic response, EVR) in groups 1 and 3 in comparison to corresponding scores in groups 2 and 4 (primary criteria of efficacy were estimated in all 140 patients enrolled in original study. …”
Get full text

STRUCTURAL AND FUNCTIONAL STATE OF THE MYOCARDIUM AND SYSTEMIC INFLAMMATION ACTIVITY IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE PRESENCE OF ARTERIAL H... by Rostyslav Kovalchuk, Uliana Bahan

“…In addition, the blood levels of natriuretic peptide (NT-proBNP) and C-reactive protein were determined, and an ultrasound examination of the heart was performed at the inpatient stage of treatment and after 6 weeks of follow-up. The results were evaluated using descriptive statistical analysis (arithmetic mean and its standard deviation; median and percentile, proportions and their 95 % confidence intervals calculated using the Wald and Fisher methods), unpaired Student's t-test, and Pearson correlation analysis. …”
Get full text