The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis by Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen

“…Female E3L.GK+/−, E3L, and GK+/− mice were fed fat- and cholesterol-containing diets for 37 weeks, and plasma parameters were measured throughout. …”
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Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

“…Lastly, the mTOR-S6K pathway was explored by detecting the protein expression of S6K and phosphorylated S6K.ResultsIn STZ-induced diabetic mice, administration of HU (20 mg/kg) in drinking water for 16 weeks resulted in significant reductions in creatinine and urea nitrogen levels, alongside mitigating histopathological damage. …”
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Implementation of the hidden curriculum in the formation of the religious character of students by Ulfa Fitria, Nur Khalimah

“…The hidden curriculum implemented includes congregational prayers, madrasah diniyah, istighosah, study sessions of the Ihya’ Ulumiddin book, Quran learning using the Yanbu’a method, monthly Ahad Legi gatherings, and weekly ro’an activities every Friday. This research contributes to uncovering the role of the hidden curriculum as an effective strategy for character development in Islamic boarding schools. …”
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The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…Acute toxicity assays were conducted in mice (75 and 150 mg/kg doses), and repeated-dose toxicity was evaluated over five doses, administered every 3 weeks in rats and cynomolgus monkeys. DX126-262 demonstrated significant and dose-dependent tumor growth inhibition across HER2-positive models, with superior antitumor efficacy compared to Kadcyla and comparable efficacy to Enhertu in vivo studies. …”
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No microorganism was detected in amniotic fluid of healthy pregnancies from the second trimester to the delivery by Yu Liu, Jingmei Ma, Xiang Li, Haijuan Zhao, Qubo Ai, Lanying Zhang, Yulong Tong, Lingzhen Meng, Huixia Yang

“…Methods AF samples were collected during the second trimester (19–21 gestational weeks) and at the time of delivery. Cohort 1 included 51 women who underwent the term and elective cesarean section, with both their second trimester and delivery AF samples (n = 55, respectively) analyzed. …”
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Effect of Traditional Chinese Medicine on Inflammatory Mediators in Pediatric Asthma by Hui Du, Yonghong Wang, Yumin Shi, Jian Yu, Wen Sun, Yiqun Zhang

“…Both groups received their respective treatment for 12 weeks. There were 35 patients in TCM group and 34 patients in SM group providing venous blood. …”
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Evaluating the effects of time-restricted eating on overweight and obese women with polycystic ovary syndrome: A randomized controlled trial study protocol. by Hui Liu, Fuliang Shangguan, Fen Liu, Yu Guo, Huixi Yu, Hanbing Li, Yinhua Su, Zhongyu Li

“…The primary outcomes, including changes in weight and body mass index (BMI), will be assessed weekly. Secondary outcomes, encompassing alterations in sex hormones, metabolic parameters, body composition, sleep quality, quality of life, anxiety, and depression, will be evaluated monthly. …”
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Combined Effects of Chrysin Supplementation and Exercise Training on Diabetes-Induced Oxidative Stress and Apoptosis in Rat Testicular Tissue by Shiva Cheraghi Abajlou, Asghar Tofighi, Javad Tolouei Azar, Amir Afshin Khaki, Mazdak Razi

“…Ratswere divided into control (received STZ solvent), DM-sole, Chrysin-sole (50 mg/kg, daily), moderate-intensityrunning exercise training (MIRET-sole, warm-up, 5 minutes at 30% of Smax1 (Maximum speed); Moderate intensityexercise, 60 minutes at 60% of Smax1, and recovery, 5 minutes to 30% of Smax1), DM+Chrysin, DM+MIRET,and DM+MIRET+Chrysin. Following 8 weeks, the histopathological changes (Johnson’s score, epithelial height,and tubular diameter), testicular malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase(GPX), and the mRNA levels of anti-apoptotic gene Bcl-2 and pro-apoptotic gene Bax was analyzed.Results: Chrysin solely and simultaneous with MIRET could remarkably (P=0.001) improve the DM-induced histopathologicaldamages, increase the testicular SOD and GPx levels, and decline the DM-increased MDA content.Moreover, our results showed that Chrysin solely and more simultaneously with MIRET could significantly (P=0.001)decrease the mRNA expression of Bax and improve the Bcl-2 expression and rebalance the Bax/Bcl-2 balance.Conclusion: Our findings showed that co-administration of Chrysin along with MIRET can significantly amelioratethe DM-induced histopathological, and biochemical impairments and reduce the pro-apoptotic impact of DMon testicular tissue.…”
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Cognitive improvement and prefrontal network interactions in individuals with remitted bipolar disorder after transcranial infrared laser stimulation by Douglas W. Barrett, Roger E. Davis, Jennifer E. Siegel-Ramsay, Amy Bichlmeier, Jorge R. C. Almeida, F. Gonzalez-Lima

“…Using an open-label design, 29 individuals with remitted BD received six weekly TILS treatments. Working memory and attention were assessed with trail-making and 2-back tasks sensitive to TILS cognitive effects in individuals with BD. …”
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Development and validation of a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for the screening of high-risk pregnant women for gestational diabetes mellitus in Pakistan by Romaina Iqbal, Iqbal Azam, Subhash Chandir, Rahat Qureshi, Ali Jaffar, Neelofur Babar, Sabahat Naz, Samreen Jamal, Aisha Syed Wali

“…Our study aimed to develop a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for GDM screening in Pakistani pregnant women based on risk factors reported in the literature.Methods Using a cross-sectional study design, we enrolled 500 pregnant women who attended antenatal clinics at one tertiary and two secondary care hospitals in Karachi between the 28th and 32nd weeks of gestation. We randomly divided data into derivation (n=404; 80%) and validation datasets (n=96; 20%). …”
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Exploring the association between pro-inflammatory diets and chronic liver diseases: evidence from the UK Biobank by Lili Pan, Lili Pan, Zhengrong Xu, Yining Li, Guoen Cai, Haibing Gao, Shenglong Lin

“…Cox proportional hazards models and Fine-Gray competing risk models were employed to evaluate the association between DII and CLD incidence, adjusting for potential confounders.ResultsOur analysis included 121,329 participants with a median follow-up of 604.43 weeks, during which 4,018 developed CLD. A higher DII, indicating a more inflammatory diet, was associated with a 16% increased risk of CLD [hazard ratio (HR) = 1.162, P = 0.001], with each unit increase in DII elevating the risk by 3.3% (HR: 1.033, P < 0.001). …”
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Effects of natural carotenoid (carrot and red bell pepper) on growth performance, digestive enzymes and antioxidant enzymes in koi, Cyprinus rubrofuscus by Abbas Zamani

“…The effect of prepared diets was evaluated on growth performance, digestive enzymes (trypsin and amylase) and antioxidant activity including superoxide dismutase (SOD) and catalase in koi (weight: 1.10 ± 0.20 g) for 8 weeks. Results and discussion: The results obtained from body weight gain, specific growth rate and condition factor showed that there was no significant difference among the experimental diets, although they were higher in D2, D3 and D4 compared to D1. …”
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Protection of the Peritoneal Membrane by Peritoneal Dialysis Effluent-Derived Mesenchymal Stromal Cells in a Rat Model of Chronic Peritoneal Dialysis by Lan Zhou, Ming Zong, Qiunong Guan, Gerald da Roza, Hao Wang, Hualin Qi, Caigan Du

“…Here, we showed that as compared to naive control, daily IP injection of the Dianeal PD solution for 6 weeks without pMSC treatment significantly reduced UF, which was associated with an increase in both PM thickness and blood vessel, while pMSC treatment prevented the UF loss and reduced PM injury and blood vessels. …”
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The Bile Acid Metabolism of Intestinal Microorganisms Mediates the Effect of Different Protein Sources on Muscle Protein Deposition in <i>Procambarus clarkii</i> by Xiaodi Xu, Xiaochuan Zheng, Qunlan Zhou, Cunxin Sun, Aimin Wang, Aimin Zhu, Yuanyuan Zhang, Bo Liu

“…This study established an all-animal protein source (AP) and an all-plant protein source group (PP), with a feeding period of 8 weeks (four replicates per group, 45 individuals per replicate). …”
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Prevalence and risk factors of gestational diabetes mellitus among pregnant women in northern Vietnam: a cross-sectional study by Hieu Minh Le, Thi Ai Nguyen, Dang Kien Nguyen, Ditte Søndergaard Linde, Ib Christian Bygbjerg, Jens Søndergaard, Thanh Duc Nguyen, Bay Quang Nguyen, Ngoc-Anh Thi Dang, Xuan Bai Nguyen, Dan W. Meyrowitsch, Christina A. Vinter, Tine M. Gammeltoft, Vibeke Rasch

“…A 2-hour 75 g oral glucose tolerance test was conducted at 24–28 weeks of gestation. GDM was diagnosed according to the World Health Organization 2013 criteria. …”
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The Effect of Drinking Ionized Water on the Productive Performance, Physiological Status, and Carcass Characteristics of Broiler Chicks by Abdullah Mohamed, Mohamed Khalil, Farid Soliman, Karim El-Sabrout

“…Productive traits, such as weekly body weight, feed intake, and water intake, were recorded. …”
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Differences in Physical and Psychological Parameters in Sub-Elite, Male, Youth Soccer Players with Jumper's Knee Following Physical Therapy Compared to Healthy Controls: A Longitud... by Marc Niering, Thomas Muehlbauer

“… # Methods All subjects were tested four times (start of the season \[T1\], 6 \[T2\], 16 \[T3\], and 20 \[T4\] weeks after the start of the season). Outcome measures included muscle power (drop jump, jump-and-reach), change of direction speed \[CODS\] (acyclic sprint), speed (tapping, 30-m linear sprint), endurance (Yo-Yo intermittent recovery test level 1), the Achievement Motives Scale (AMS) Sport, and injury-/pain-related data. …”
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20(S)-Ginsenoside Rg3 Protects Kidney from Diabetic Kidney Disease via Renal Inflammation Depression in Diabetic Rats by Tong Zhou, Lin Sun, Shuo Yang, You Lv, Yue Cao, Xiaokun Gang, Guixia Wang

“…In order to detect the protective effect of 20(S)-Rg3 on diabetic kidney disease (DKD), diabetic rat models which were established by administering high-sugar, high-fat diet combined with intraperitoneal injection of streptozotocin (STZ), and age-matched wild-type (WT) rat were given 20(S)-Rg3 for 12 weeks, with three groups: control group (normal adult rats with saline), diabetic group (diabetic rats with saline), and 20(S)-Rg3 treatment group (diabetic rats with 20(S)-Rg3 (10 mg/kg body weight/day)). …”
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Effects of Tannic Acid Supplementation of a High-Carbohydrate Diet on the Growth, Serum Biochemical Parameters, Antioxidant Capacity, Digestive Enzyme Activity, and Liver and Intes... by Yi Wang, Jianjun Wu, Luoxin Li, Yuanfeng Yao, Chiqing Chen, Yucong Hong, Yi Chai, Wei Liu

“…Five diets were prepared, including a positive control (dietary carbohydrate level, 16%, LC0), a negative control (dietary carbohydrate level, 21%, HC0), and three TA-supplementation diets based on the negative control diet with TA addition at 200, 400, and 800 mg/kg, respectively. After 8 weeks of feeding, the results showed that compared with the LC0 diet, 400–800 mg/kg dietary TA significantly improved the survival rate of largemouth bass (P<0.05) while significantly reducing its weight-gain rate and specific growth rate (P<0.05). …”
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A novel approach for managing the incisions of tibial plateau fractures with soft tissue swelling by Yang Zhang, Yangyang Zhao, Shuanggong Liu, Zihan Yao, Zikang Jin, Wanli Ma

“…The VAS and WOMAC scores were reduced in both groups (P < 0.05); Group A had lower VAS scores two weeks after surgery. There was no statistically significant difference in the WOMAC score between the groups. …”
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