Downregulation of the Proinflammatory State of Circulating Mononuclear Cells by Short-Term Treatment with Pioglitazone in Patients with Type 2 Diabetes Mellitus and Coronary Artery... by Andreas Pfützner, Alexander Weise, Elisabeth Pfützner-Riehn, Georg Lübben, Michael Morcos, Efstrathios Karagiannis, Matthias Weber, Thomas Forst

“…Sixty-three patients with well-controlled type 2 diabetes (52 males, 11 females, age (Mean ± SD): 66±7 yrs, disease duration: 6.6±9.6 yrs, HbA1c: 6.7±0.6%) were randomized to additional 45 mg of pioglitazone or placebo to their existing metformin and sulfonylurea therpay for four weeks in a double-blind study design. Protein risk marker levels (hsCRP, MMP-9, MCP-1, etc.) and the expression of NFκB subunits and NFκB-modulated cytokines from isolated peripheral monocyte/macrophages were determined at baseline and endpoint. …”
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Altered expression of miRNA profile in peripheral blood mononuclear cells following the third dose of inactivated COVID-19 vaccine by Guanguan Qiu, Ruoyang Zhang, Huifeng Qian, Ruoqiong Huang, Jie Xia, Ruoxi Zang, Zhenkai Le, Qiang Shu, Jianguo Xu, Guoping Zheng, Jiangmei Wang

“…Samples of peripheral blood mononuclear cells (PBMCs) were collected from healthcare volunteers both before and 1–2 weeks after the booster dose. miRNA microarray analysis in a discovery cohort of six volunteers identified 67 miRNAs with differential expression. …”
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Effects of Cholecalciferol on Key Components of Vitamin D-Endo/Para/Autocrine System in Experimental Type 1 Diabetes by Anna Mazanova, Ihor Shymanskyi, Olha Lisakovska, Lala Hajiyeva, Yulia Komisarenko, Mykola Veliky

“…T1D was induced in male Wistar rats by streptozotocin (55 mg/k b.w.). After 2 weeks of T1D, the animals were treated orally with or without vitamin D3 (cholecalciferol; 100 IU/rat, 30 days). …”
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Successful Management of Refractory Heart Failure and Multi-Organ Dysfunction in a Patient with CRT-D and Acute Pulmonary Edema: A Case Report by Marsela Goga, Saimir Kuci, Alfred Ibrahimi, Ermal Likaj, Alvi Cela, Romina Teliti, Ormir Shurdha, Erilda Selimi, Jacob Zeitani

“…The patient was admitted to the ICU with acute pulmonary edema, pneumonia, and multi-organ dysfunction syndrome, characterized by severe hypoxemia, hypotension, and metabolic acidosis. Over three weeks, the patient regained hemodynamic stability, renal function, and respiratory independence. …”
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Knights in shining armour and (M)others in life jackets: Women’s experiences of advocating for care alone when suffering recurrent early pregnancy loss during the SARS-CoV-2 pandem... by Flora E. Kent-Nye, Kayleigh S. Sheen, Karen Burgess, Munira Oza, Laura A. Magee, Davor Jurković, Sergio A. Silverio

“…A total of 16 women who had suffered two or more early pregnancy losses (≤ 14 weeks gestation) during the SARS-CoV-2 pandemic in the United Kingdom participated. …”
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Forecasting insect abundance using time series embedding and machine learning by Gabriel R. Palma, Rodrigo F. Mello, Wesley A.C. Godoy, Eduardo Engel, Douglas Lau, Charles Markham, Rafael A. Moral

“…We used two datasets containing a time series of aphids and climate data collected weekly in two municipalities in Southern Brazil for eight years. …”
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Effect and factors associated with reactivation after intravitreal conbercept or aflibercept in retinopathy of prematurity by Chunling Huang, Weikang Zou, Wenbei Ma, Jiali Li, Yichen Bai, Rong Wu, Qiqi Li, Qi Fang, Wenna Chen, Xiaohe Lu, Songfu Feng

“…The interval between injection and reactivation was significantly longer in the aflibercept group than in the conbercept group (15.50 ± 4.05 vs. 5.36 ± 0.50 weeks) (P < 0.001). The central retinal arteriolar equivalent (CRAE) of aggressive ROP was larger than that of type 1 prethreshold and threshold ROP before anti-VEGF therapy (P < 0.05). …”
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Effects of Chinese Herbal Medicines on Growth Performance, Antioxidant Capacity, and Liver and Intestinal Health of Hybrid Snakehead (<i>Channa maculata</i> ♀ × <i>Channa. argus</i... by Jiamin Kang, Shuzhan Fei, Junhao Zhang, Haiyang Liu, Qing Luo, Mi Ou, Langjun Cui, Tao Li, Jian Zhao

“…A total of 600 fish (mean weight: 15.85 ± 0.15 g) were randomly assigned to five groups, including the control group (CG), <i>I. radix</i> extract group (IRE), <i>F. suspensa</i> extract group (FSE), <i>S. chinensis</i> extract group (SCE), and the Chinese herbal medicine mixture group (CHMM; a mixture of extracts of <i>I. radix</i>, <i>F. suspensa</i>, and <i>S. chinensis</i> at the ratio of 1:1:1) for 6 weeks. The results show that the IRE-supplemented diet improved the survival rate (SR), feed efficiency ratio (FE), and condition factor (CF) compared to others. …”
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Sporadic Burkitt Lymphoma First Presenting as Painful Gingival Swellings and Tooth Hypermobility: A Life-Saving Referral by Erofili Papadopoulou, Maria Kouri, Dimitrios Velonis, Anastasia Andreou, Maria Georgaki, Spyridon Damaskos, Evangelia Piperi, Konstantina Delli, Ioannis K. Karoussis, Antonia Vlachou, Georgia Avgerinou, Antonis Kattamis, Nikolaos G. Nikitakis

“…A multi-chemotherapy regimen was initiated with the regression of oral lesions and symptoms within a few weeks and complete disease remission after nine chemotherapy cycles. …”
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Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation by Marianne Nuijsink, Wim C. J. Hop, Peter J. Sterk, Eric J. Duiverman, Johan C. De Jongste

“…At the same time points, we assessed symptom scores (2 weeks diary card), lung function (forced expiratory volume in one second (FEV1)), airway hyperresponsiveness (AHR), and percentage eosinophils in induced sputum (% eos). …”
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Biotransformation of organic wastes through composting using Trichoderma harzianum and its effects on cucumber ( Cucumis sativus L.) yield by Adeniyi Soretire, Cynthia A Ezema, Chukwuebuka E Awaogu, Chukwuagozie C Okafor, Abasiama S Umoren, Nurudeen O Adeyemi

“…The compost was thereafter incubated for 12 weeks. Results Total N, P and K contents were significantly (p < 0.05) highest in the mixture of solid organic wastes (22800 mg/kg), corn cobs (2600 mg/kg) and groundnut pods (2300 mg/kg), respectively. …”
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Ten-Day versus 14-Day Levofloxacin-Containing Triple Therapy for Second-Line Anti-Helicobacter pylori Eradication in Taiwan by Wei-Chen Tai, Chien-Hua Chiu, Chih-Ming Liang, Kuo-Chin Chang, Chung-Mou Kuo, Yi-Chun Chiu, Keng-Liang Wu, Ming-Luen Hu, Yeh-Pin Chou, Shue-Shian Chiou, King-Wah Chiu, Chung-Huang Kuo, Tsung-Hui Hu, Ming-Tsung Lin, Seng-Kee Chuah

“…Follow-up studies to assess treatment response were carried out 8 weeks later. Eradication rates attained by EAL-10 and EAL-14 were 75.6%; 95% –85.3% and 92.5%; 95% –98.1%, in the per protocol analysis and 68%; 95% –78.5% and 86%; 95% –93.4%, in the intention-to-treat analysis. …”
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Effects of Flash Glucose Monitoring on Dietary Variety, Physical Activity, and Self-Care Behaviors in Patients with Diabetes by Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Hujiwara, Hiroka Takahashi, Kazuya Murata

“…Before initiating flash glucose monitoring and 12 weeks after its initiation, blood glucose-related parameters were assessed and self-administered questionnaires were completed (Dietary Variety Score (DVS), the International Physical Activity Questionnaire (IPAQ), the Summary of Diabetes Self-Care Activities Measure (SDSCA), and the Diabetes Treatment Satisfaction Questionnaire (DTSQ)) and compared between the two time points. …”
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The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease... by Farzad Shidfar, Samaneh Sadat Bahrololumi, Saeid Doaei, Assieh Mohammadzadeh, Maryam Gholamalizadeh, Ali Mohammadimanesh

“…This clinical trial was carried out on 50 patients with nonalcoholic fatty liver (mean age of 45.91 ± 9.61 years, mean BMI of 29.7 ± 0.58 Kg/m2) and the subjects were randomly assigned to the olive oil group (receiving the equivalent of 20% of their total daily energy requirement from olive oil) or the control group (with normal consumption of oil) for 12 weeks. All the patients received a hypocaloric diet during the study. …”
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Performance, Carcass Traits and Meat Quality of Lambs Fed with Increasing Levels of High-Oleic Sunflower Cake by Daviane M. Costa, Tharcilla I. R. C. Alvarenga, Isabela J. dos Santos, Paulo C. G. Dias Junior, Flavio A. P. Alvarenga, Nadja G. Alves, Iraides F. Furusho-Garcia

“…The lambs were weighed weekly and slaughtered with 42.3 ± 0.18 kg body weight and 270 ± 10.8 days of old. …”
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The Stress and Adversity Inventory for Adults (Adult STRAIN) in Korean: Initial Validation and Associations with Psychiatric Disorders by Eun Soo Kim, Yun Tae Kim, Kang-Seob Oh, Young Chul Shin, Sang-Won Jeon, Dong-Won Shin, Sung Joon Cho, George M. Slavich, Junhyung Kim

“…Finally, the test–retest reliability for total lifetime stressor count and severity over four weeks was high. Conclusions: The Korean STRAIN is a practical, valid, and reliable instrument for researchers and clinicians to efficiently assess lifetime stressor exposure.…”
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BCI-Based Rehabilitation on the Stroke in Sequela Stage by Yangyang Miao, Shugeng Chen, Xinru Zhang, Jing Jin, Ren Xu, Ian Daly, Jie Jia, Xingyu Wang, Andrzej Cichocki, Tzyy-Ping Jung

“…All of them participated in rehabilitation training for four weeks and were assessed by the Fugl-Meyer Assessment (FMA) of motor function. …”
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Voluntary isometric contractions at maximal shortening as a new technique to achieve neuromuscular re-education in healthy subjects by Julio-Artemi Hernández-Trujillo, María-Dolores González-Rivera, Jorge M. González-Hernández

“…Methods: Sixty healthy, recreationally active participants (mean age: 46.4 ± 5.5), were randomly assigned to three groups (VICAMS, ballistic stretching, and control) who were trained for eight weeks. To assess chronic effects, active range of motion, maximal isometric strength, and countermovement jump height were determined before and after the intervention. …”
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Alternations of the gut microbiota and the Firmicutes/Bacteroidetes ratio after biologic treatment in inflammatory bowel disease by Yu-Chieh Tsai, Wei-Chen Tai, Chih-Ming Liang, Cheng-Kun Wu, Ming-Chao Tsai, Wan-Hsiang Hu, Pao-Yuan Huang, Chien-Hung Chen, Yuan-Hung Kuo, Chih-Chien Yao, Seng-Kee Chuah

“…Results: Biologic therapy led to significant clinical improvement in IBD disease activity after 48 weeks. About species richness, community alpha diversity was significant lower in active CD patients and enriched gradually after biologic therapy. …”
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A randomized double-blind clinical trial investigating the effects of ellagic acid on glycemic status, liver enzymes, and oxidative stress in patients with non-alcoholic fatty live... by Sara Mighani, Rasoul Samimi, Mohamadreza Rashidi Nooshabadi, Seyed Amir Farzam, Hossein Khadem Haghighian, Maryam Javadi

“…Methods In this clinical trial, 44 patients were selected based on including criteria and randomly received 180 mg of EA per day (n = 22) or placebo (n = 22) for 8 weeks. At the beginning and end of the study, glycemic indices, lipid profiles, liver enzymes, oxidative stress markers, and inflammatory factors were measured. …”
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