Subacute Toxicity Effects of the Aqueous Shoot Extract of Yushania alpina (K. Schum.) W.C.Lin in Sprague Dawley Rats: An Appraisal of Its Safety in Ethnomedicinal Usage by Joseph Ngugi Wanjiru, Timothy Elias Maitho, James Mucunu Mbaria, Gervason Apiri Moriasi

“…In this study, all the experimental rats treated orally with 40 mg/Kg BW, 200 mg/Kg BW, and 1000 mg/Kg BW of the aqueous shoot extract of Y. alpina remained normal, like the control group rats, and did not show any clinical signs of subacute toxicity, and no morbidity or mortality was recorded. Besides, the weekly body weight gains and the haematological and biochemical parameters of experimental rats orally administered with the studied plant extract at the tested doses and in the control group were comparable (P>0.05). …”
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Development and validation of the Women Autonomy Scale for measuring psychosocial freedom from conventional gender roles by Waqar Husain, Farrukh Ijaz, Muhammad Ahmad Husain, Achraf Ammar, Khaled Trabelsi, Haitham Jahrami

“…Test-retest reliability was 0.788 after two weeks of initial administration. EFA revealed a four-factor structure consisting of 18 items: personal freedom, freedom from conventional femininity, freedom from conventional masculinity, and freedom from shame. …”
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Coats-Like reaction post-vitreoretinal surgery for PDR managed with laser photocoagulation and adjunctive intravitreal steroids– a case report by Kanika Godani, Shruti Vidyasagar, Preksha Biradar, Vishma Prabhu, Prathiba Hande, Priyanka Gandhi, Rupal Kathare, Jay Chhablani, Ramesh Venkatesh

“…Results Silicone oil removal combined with targeted endolaser photocoagulation and intravitreal triamcinolone acetonide injection resulted in a complete resolution of the subretinal lipid exudation. Two weeks postoperatively, the retina remained well-attached, but best-corrected visual acuity declined to 6/60 due to posterior subcapsular cataract progression. …”
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Untreated exstrophy-epispadias complex: outcomes of Indiana pouch and primary abdominal wall closure by Niraj Kumar, Avishek Mandal, Sandeep Kumar, Siddharth Yadav, Somanath Karmungikar, Pawan Vasudeva

“…All patients underwent a standard evaluation and surgical procedure and were followed up at 6 weeks, 3, 6 and 12 months and then annually. At each visit, renal function test and ultrasonography were performed and a 3 day CIC diary was obtained. …”
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Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium- challenged rats by Ejike, Daniel Eze, Okpa, Precious Nwaka, Igbokwe, Ugochukwu Vincent, Moses, Dele Adams, Karimah, Mohammed Rabiu, Ayikobua, Emmanuel Tiyo

“…The administration of vehicle and extract was conducted orally for six weeks. Testicular activity of 17 beta- hydrosteroid dehydrogenase (17β-HSD) and serum testosterone, luteinizing and follicle stimulating hormone (LH, FSH) levels were evaluated. …”
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A descriptive-multivariate analysis of community knowledge, confidence, and trust in COVID-19 clinical trials amongst Ugandans working in healthcare settings. by Keneth Iceland, Kasozi, Lawrence Obado, Osuwat

“…Methods: A rapid exploratory survey with questions was conducted over 5 weeks at multiple health care centers across the country using an online platform. …”
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Trifluridine-tipiracil in previously treated patients with oestrogen receptor-positive, HER2-negative metastatic breast cancer (BOOG 2019-01 TIBET trial): a single-arm, multicentre... by Niels A.D. Guchelaar, Ron H.J. Mathijssen, Maaike de Boer, Marlies L. van Bekkum, Joan B. Heijns, Birgit E.P.J. Vriens, Mandy M. van Rosmalen, Lonneke W. Kessels, Lisanne Hamming, Karin J. Beelen, Peter Nieboer, Susan M. van den Berg, Esther Oomen-de Hoop, Rhodé M. Bijlsma, Monique E.M.M. Bos

“…The primary endpoint was the disease control rate (DCR) at 8 weeks, defined as the percentage of patients that had stable disease, partial response or complete response according to RECIST 1.1, in all patients that received at least one dose of trifluridine-tipiracil and met the key eligibility criteria defined a priori. …”
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Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…The pumps were implanted in mice, ensuring constant infusion of Ang II at a dose of 1.0 µg/kg per minute for 4 weeks. The mice were exposed to 0.4 W/cm2 intensity ultrasonic radiation for 15 min at 4 h post injection of sinoporphyrin sodium (DVDMS) (4 mg/kg) into the caudal vein was repeated weekly for 4 treatments. …”
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Pegilated interferon alpha 2b «Pegaltevir» chronic hepatitis C treatment (randomized clinical trial) by Marina V. Mayevskaya, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda, V. T. Ivashkin

“…Assessment of Pegaltevir® efficacy was carried out in 4 weeks (rapid virologic response, RVR) and 12 weeks of treatment (early virologic response, EVR) in groups 1 and 3 in comparison to corresponding scores in groups 2 and 4 (primary criteria of efficacy were estimated in all 140 patients enrolled in original study. …”
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Metabolomic and Transcriptomic Analysis of the Mechanism of the Apple Coloration Change After Uncovering Fruit Bag by Pengwei Duan, Xiaojian Ma, Haiqiang Shi, Lizhe Qin, Jizhuang Du, Sumiao Yang, Jianjun Zhang

“…In this study, the pattern of metabolite accumulation and gene expression was profiled in the striped and blushed apple peels at three ripening periods to elucidate the color formation mechanism within two weeks after removing the bag. The phenotypes presented in the peel coloring process are different between SF (stripe red) and HM (blush red), which have different accumulated levels of metabolites and gene expression during the coloring process. …”
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Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in... by Rui-Ling Liu, Zhi-Lei Xu, Yu-Ling Hu, Xing-Yu Lv, Quan-Zi Yao, Jia-Liang He, Li-Juan Fu, Li-Hong Geng, Tong Wang, Zhao-Hui Zhong, Yi-Jian Zhu, Yu-Bin Ding

“…The distributed lag nonlinear model (DLNM) analysis revealed the lagged effects of PM2.5 component exposure, particularly during lag weeks 2–5, where exposure was significantly associated with the occurrence of POR. …”
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Effect of oral antibiotics after two-stage revision for periprosthetic joint infection on subsequent antibiotic resistance within a national cohort of United States veterans by J. Payne, J. Payne, J. D. Sutton, B. E. Blackburn, S. Bansod, S. Bansod, H. Imlay, H. Imlay, E. S. Spivak, E. S. Spivak, J. Pupaibool, J. Pupaibool, J. M. Gililland, J. M. Gililland, L. K. Certain, L. K. Certain, L. K. Certain

“…We compared those who received at least 2 weeks of oral antibiotics after Stage 2 reimplantation to those who did not. …”
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Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation by Ai-Li Xu, Zheng Shen, Shi-Hao Wang, Hai-Yun Luan, Yong Xu, Ze-Chun Kang, Zi-Qi Liao, Jie Liu, Xiao-Lei Duan, Wei-Hua Bian, Hui Sun, Xin Xie

“…Mice were intravenously administered DOX (5 mg/kg) for 4 weeks to establish a cardiac toxicity model. Heart function was determined using echocardiography, and cardiac tissue was assessed for protein expression, mRNA levels, fibrosis, and immunofluorescent staining. …”
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Factor structure and longitudinal measurement invariance of Edinburgh Postnatal Depression Scale during the whole perinatal period: a multicenter cohort study in China by Jichun Yang, Yu Jiang, Yimin Qu, Yongle Zhan, Haihui Ma, Xiaoxiu Li, Dongmei Man, Hongguo Wu, Ping Huang

“…Methods 4139 pregnant women from 24 hospitals in 15 provinces of China were measured using EPDS in the first, second, third trimesters and 6 weeks postpartum. Exploratory factor analysis and confirmatory factor analysis were used to explore the factor structure of EPDS at each time point. …”
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Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen by Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice

“…Healthy volunteers received either single or repeated (for 6 weeks) subcutaneous administrations of investigational drug or placebo. …”
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Effect of Intercropping Beans with Maize and Botanical Extract on Fall Armyworm (Spodoptera frugiperda) Infestation by Clovis Bessong Tanyi, Raymond Ndip Nkongho, Justin Nambangia Okolle, Aaron Suh Tening, Christopher Ngosong

“…FAW severity was assessed at three to seven weeks after planting (WAP), while maize infestation was assessed at seven WAP. …”
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Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim, Ji-eun Lee, Ho Kyoung Kim

“…IVE and AET were orally administered for four weeks. We investigated the effects of treatment on airway hyperresponsiveness, IgE production, pulmonary eosinophilic infiltration, immune cell phenotypes, Th2 cytokine production in bronchoalveolar lavage, Th1/Th2 cytokine production in splenocytes, forkhead box protein 3 (Foxp3) expression, and lung histology. …”
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Comparison of the conceive-design-implement-operate model and lecture-based learning in teaching the “healthcare-associated infections” course by Yu Chen, Rui Zhang, Zhenke Zhou, Min Hong, Zheng Huang, Heling Wen, Lei Peng

“…The effectiveness of these pedagogical approaches was evaluated by comparing pre-and post-training test scores, and we used the Course Experience Questionnaire (CEQ) to collect students’ feedback on the course and teaching.ResultsCompared to traditional LBL method, the CDIO model significantly improved the overall scores and practical application scores of nursing students in the HAI course, with these advantages still retained after 24 weeks. Additionally, preliminary results show that students in the CDIO model scored higher on CEQ categories such as good teaching, clear goals and standards, appropriate assessment, generic skills, and independence, but they also reported an increased workload.ConclusionOur research is the first to apply the CDIO framework to nursing education in HAI courses, enhancing nursing students’ practical application skills, particularly in the sustained retention in this area. …”
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Long-term Breast Shape Analysis After Short-scar Reduction Mammaplasty: A Critical View by Daniel Hilewitz, MD, Oren Ganor, MD, Neta Adler, MD, Asaf Olshinka, MD, Dafna Shilo Yaacobi, MD, Lior Har-Shai, MD, Tamir Shay, MD, Michael Icekson, MD, Dean Ad-El, MD, Sagit Meshulam-Derazon, MD

“…The mean sternal notch-to-nipple and upper breast-to-nipple distances decreased postoperatively by 22% and 43%, respectively, and remained stable over a mean time of 110.1 ± 65.58 weeks. The nipple-to-inframammary fold distance, which was intraoperatively shortened by an average of 63%, elongated back to 88% of its preoperative measurements. …”
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The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…Participants received KN046 5 mg/kg every 3 weeks and lenvatinib 12 or 8 mg once daily. The primary endpoints were safety, tolerability, dose-limiting toxicity (DLT), and objective response rate (ORR) according to RECIST v1.1. …”
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