The Efficacy and Safety of the Chinese Herbal Formula, JTTZ, for the Treatment of Type 2 Diabetes with Obesity and Hyperlipidemia: A Multicenter Randomized, Positive-Controlled, Op... by Xiaotong Yu, Lipeng Xu, Qiang Zhou, Shengping Wu, Jiaxing Tian, Chunli Piao, Hailong Guo, Jun Zhang, Liping Li, Shentao Wu, Meizhen Guo, Yuzhi Hong, Weirong Pu, Xiyan Zhao, Yang Liu, Bing Pang, Zhiping Peng, Song Wang, Fengmei Lian, Xiaolin Tong

“…One group received JTTZ formula, and the other received metformin (MET) for 12 consecutive weeks. The primary efficacy outcomes were changes in HbA1c, TG, weight, and waist circumference. …”
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Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic live... by Nikolina Canová, Jana Šípková, Mahak Arora, Zuzana Pavlíková, Zuzana Pavlíková, Tomáš Kučera, Ondřej Šeda, Tijana Šopin, Tomáš Vacík, Ondřej Slanař

“…Therefore, this study aimed to investigate the effects of celastrol on the galaninergic system expression in the heart and liver of mice suffering from diet-induced obesity and metabolic dysfunction-associated steatotic liver disease and steatohepatitis (MASLD/MASH).MethodsThe male mice C57BL/6J were fed a Western-type high-fat diet for 16 and 20 weeks to induce obesity and MASLD/MASH. Celastrol was administered along with a specific diet for the last 4 weeks to evaluate its impact on the progression of these conditions. …”
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

“…We hypothesized that an adeno-associated virus (AAV-BR1) encoding the Npc2 gene could cure neurological symptoms in Npc2−/− mice through transduction of BECs, and possibly neurons via viral passage across the BBB. Methods Six weeks old Npc2−/− mice were intravenously injected with the AAV-BR1-NPC2 vector. …”
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Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery by Thomas Smytheman, Tiffany Pecor, Dana E. Miller, Debora Ferede, Suhavi Kaur, Matthew H. Harband, Hazem F. M. Abdelaal, Carlos A. Guerrero-Bustamante, Krista G. Freeman, Whitney E. Harrington, Lisa M. Frenkel, Graham F. Hatfull, Rhea N. Coler, Sasha E. Larsen

“…C57BL/6 mice were dosed weekly for 6 weeks by either route and serum and bronchoalveolar lavage fluid (BALf) were evaluated for anti-phage humoral responses by ELISA. …”
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Pharmacological modulation of Sigma-1 receptor ameliorates pathological neuroinflammation in rats with diabetic neuropathic pain via the AKT/GSK-3β/NF-κB pathway by Yuyu An, Shanshan Cao, Leilei Shi, Yuhan Zhang, Xin Wang, Shiyu Yuan, Yongheng Shi, Bin Wang, Jiping Liu, Chao-jun Han

“…The rats were divided into Control, Model, Sig-1R agonist PRE-084 (0.3, 0.6, 1 mg/kg), and metformin (Met, 20 mg/kg) groups, with seven rats per group, and their body weight, fasting blood glucose, mechanical withdrawal threshold and thermal withdrawal latency were tested weekly for two weeks. After treatment with PRE-084, the pain thresholds in the DNP rats were significantly improved, together with pathological changes in the dorsal root ganglion, reductions in the serum levels of TNF-α, IL-1β, IL-6, MOD, and prostaglandin E2 (PGE2), and the activity of superoxide dismutase was increased. …”
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Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in... by Imran Khan, Stephanie J. C. Taylor, Clare Robinson, Elisavet Moschopoulou, Paul McCrone, Liam Bourke, Mohamed Thaha, Kamaldeep Bhui, Derek Rosario, Damien Ridge, Sheila Donovan, Ania Korszun, Paul Little, Adrienne Morgan, Olivier Quentin, Rebecca Roylance, Peter White, Trudie Chalder

“…The intervention consists of up to eight sessions at weekly or fortnightly intervals using different modalities of delivery to suit individual needs, i.e. face-to-face sessions, over the phone or skype. …”
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Nowcasting to Monitor Real-Time Mpox Trends During the 2022 Outbreak in New York City: Evaluation Using Reportable Disease Data Stratified by Race or Ethnicity by Rebecca Rohrer, Allegra Wilson, Jennifer Baumgartner, Nicole Burton, Ray R Ortiz, Alan Dorsinville, Lucretia E Jones, Sharon K Greene

“…Performance was not improved by weekly aggregation. Hindcasts underestimated diagnoses in early August after the epidemic peaked, then overestimated diagnoses in late August as the epidemic waned. …”
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Cord Direct Antiglobulin Test for Predicting the Need for Phototherapy in Neonates with ABO Incompatibility: A Prospective Cohort Study by Ranjith Balan, Sakthipriya Balaji, Arun Kumar, Subash Sundar, Shrinidhi Krishnan, Ashok Chandrasekaran

“…Aim: To evaluate the diagnostic ability of routine cord blood DAT in neonates ≥35 weeks of gestation with ABO incompatibility in predicting the requirement for phototherapy. …”
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The effects of contralateral limb cross-education training on post-surgical rehabilitation outcomes in patients with anterior cruciate ligament reconstruction: a randomized control... by Chao Liu, ShiJia Li, JianPing Li, HongHao Zhang, GuQiang Li, XiangZhan Jiang

“…Methods Forty anterior cruciate ligament reconstruction (ACLR) patients, 5–6 weeks postoperatively, were included and randomly assigned to either an experimental group (n = 20) or a control group (n = 20). …”
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Comparison of analgesic efficacy of diclofenac suppository with intramuscular diclofenac sodium in post-operative pain relief after cesarean delivery in the first 24 hours by Sidra Khan, Noreen Majeed, Ruqya, Mehreen Mehdi, Faiza Safdar, Saana Bibj

“…Mean gestational age was 37.82 weeks with STD of 1.79. In group B; mean age was 25.3 years with STD of 3.47. …”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke (RHOMBUS II): protocol of a feasibility randomised controlled trial by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Outcomes assessed at baseline and 7 weeks include gross level of disability, arm function, spasticity, pain, fatigue and quality of life (QoL). …”
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Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics by Yujia Shu, Xuanfu Wu, Dongxu Zhang, Shuxia Jiang, Wenqiang Ma

“…In this study, 16 male SD rats aged 6 to 7 weeks were randomly assigned to either a control group (CON) or an iron overload group (IO). …”
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Effect of Whole Wheat Noodles on Biochemical Indexes and Histopathology of Type 2 Diabetic Rats by Li WU, Yuan ZHANG, Chunhong TANG, Huan YOU, Haijun CHANG, Shuai ZHANG

“…Methods: SD rats were fed continuously for 8 weeks and then randomly divided into normal and high-fat groups. …”
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Effect of JumpstartMD, a Commercial Low-Calorie Low-Carbohydrate Physician-Supervised Weight Loss Program, on 22,407 Adults by Sean Bourke, John Magaña Morton, Paul Williams

“…A one-on-one medically supervised program that emphasized real low-carbohydrate foods produced effective weight loss, particularly in those attending ≥75% of their weekly appointments.…”
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Utilization of Blood Flow Restriction Therapy with a Former Triathlete After Total Knee Arthroplasty: A Case Report by Christopher Keating, Stephanie Muth, Cameron Hui, Lisa T Hoglund

“…Despite participating in supervised PT, she had persistent pain, ROM deficits, and muscle weakness 16 weeks following TKA. BFR was incorporated into her home program, 16-weeks postoperatively. …”
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Susceptibility profile and associated factors of urinary tract infections among women with established preterm labor delivering at a tertiary teaching hospital in Eastern Uganda: a... by Abdirizak Ahmed Ifrah, Marie Pascaline Sabine Ishimwe, Carlos Antonio Batista Cedeño, Eilu Emmanuel, Theoneste Hakizimana

“…Primary or no formal education, monthly income ≤ 500,000Ugandan shillings, history of urinary tract infections, gestational age ≥ 26 weeks and diabetes were significantly associated with urinary tract infection.…”
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The effect of single and dual task training on the intracortical inhibition in young and old adults by Michael Wälchli, Craig Tokuno, Benedikt Lauber, Wolfgang Taube

“…Young groups had 6 and old groups 9 balance training sessions within 3 weeks, the DT training consisted of cognitive and motor secondary tasks. …”
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Common mental disorders and associated factors among adult patients admitted in non-psychiatric wards of public hospitals in Harari regional State, Eastern Ethiopia by Hirko Assefa, Tilahun Ali, Ibsa Mussa, Tadesse Misgana, Dawit Abdi, Abinet Zewudie, Abdi Temesgen

“…Age 41–51 years (AOR = 1.732, 95% CI: 1.030, 2.913), age 51 and above (AOR = 2.429, 95% CI: 1.515, 3.894), staying at hospital for 1–2 weeks (AOR = 1.743, 95% CI: 1.065, 2.853), staying at hospital for more than 4 weeks (AOR = 2.12, 95% CI: 1.77, 3.29), history of mental illness (AOR = 5.841, 95% CI: 2.274, 15.004), stressful life events (AOR = 1.876, 95% CI: 1.206, 2.9196), current substance use (AOR = 1.688, 95% CI: 1.75, 2.650), and poor social support (AOR = 2.562, 95% CI:1.166, 5.629) were factors significantly associated with common mental disorders. …”
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A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus by Jessica Parrott, Mitch Tener, Katie Dennis, Matthew Sharpe, Cecily Clark-Ganheart

“…Case. A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. …”
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Quantification of Eosinophilic Granule Protein Deposition in Biopsies of Inflammatory Skin Diseases by Automated Image Analysis of Highly Sensitive Immunostaining by Peter Kiehl, Katrin Falkenberg, Markus Vogelbruch, Alexander Kapp

“…Using strictly standardized protocols, the assay was proven to be specific and accurate concerning segmentation in 8916 fields of 520 sections, well reproducible in repeated measurements and reliable over 16 weeks observation time. The method may be valuable for the cell‐independent segmentation of immunostaining in other applications as well.…”
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