Pirfenidone Alleviates Choroidal Neovascular Fibrosis through TGF-β/Smad Signaling Pathway by Chuang Gao, Xin Cao, Lili Huang, Yueqi Bao, Tao Li, Yue Di, Liucheng Wu, Yu Song

“…C57BL/6J male mice (aged from 6 to 8 weeks) received intravitreal injections of phosphate-buffered saline (PBS)/PFD solution on 14 days after laser injury. …”
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Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway by Hua Wu, Lihua Feng, Huang Wu, Lihong Wang, Hengyi Xu, Fen Fu

“…In this study, polystyrene nanoplastics (PS-NPs) and/or cadmium (Cd) were exposed to 4-week-old female rats for 28 days, with the aim of exploring the potential effects of combined exposure to PS-NPs and Cd on the ovaries of adolescence rats. …”
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Acupuncture as prophylaxis for chronic migraine: a protocol for a single-blinded, double-dummy randomised controlled trial by Claire Shuiqing Zhang, Bin Li, Lin Zeng, Lu Liu, Luo-peng Zhao, Kelun Wang, Jingxia Zhao, Linpeng Wang, Xianghong Jing

“…All participants will receive a 12-week treatment and then be followed up for another 12 weeks. …”
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Exploring the Variability in Acute Glycemic Responses to Exercise in Type 2 Diabetes by Tasuku Terada, Alanna Friesen, Baljot S. Chahal, Gordon J. Bell, Linda J. McCargar, Normand G. Boulé

“…Fifteen individuals with T2D were randomly assigned to energy-matched high intensity interval exercise (HI-IE) and moderate intensity continuous exercise (MI-CE) interventions and performed a designated exercise protocol 5 days per week for 12 weeks. The duration of exercise progressed from 30 to 60 minutes. …”
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The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram, Obaid Ur Rehman, Eeshal Fatima, Zain Ali Nadeem, Omer Usman, Waqas Rasheed, Ramsha Ali, Khawaja Abdul Rehman, Abdulqadir J. Nashwan

“…Lubiprostone was associated with greater spontaneous bowel movements (SBM) per week (RR 1.454, 95% CI 1.193–1.771) and SBM within 24 h (RR 1.790, 95% CI 1.491–2.150) in patients with chronic idiopathic constipation (CIC). …”
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Risk factors of gallbladder cancer in Nepal: A case control study. by Chanda Thakur, Roshan Kumar Mahato, Sabina Marasini, Dinesh Timalsena, Krishna Sagar Sharma, Biraj Man Karmacharya

“…On multivariate analysis, the risk factors studied were; parity ≥3 (AOR = 2.80, 95% CI: 1.17-6.66, P value 0.020), being ethnic group of Terai/Madhesi (AOR = 7.88, 95% CI: 3.16-19.66, P value <0.001), being Janajati (AOR = 3.36, 95% CI: 1.17-6.61, P value <0.001), having gallbladder related disease (AOR = 2.00, 95% CI:1.00-4.02, P value 0.049), consuming alcohol ≥100ml/day (AOR = 3.44, 95% CI:1.11-10.63, P value 0.032), exposed with pesticides ≥2 times in a year (AOR = 4.04, 95% CI: 1.27-12.89, P value 0.018) and consuming less vegetables and fruits (<1 times per day in a week) (AOR = 2.69, 95% CI:1.34-5.40, P value 0.005).…”
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Preparation of recombinant myoglobin and investigation of the liquid antigen stability for quality control materials by Yu-Hui Wang, Xi-Feng Sun, Chun-Xin Xu, Feng-Qiang Sun, Rong-Rong Wang, Xiao-Kun Bian, Zhan-Zhao Wang, Qiang Wu

“…The long-term storage stability was investigated by the thermal acceleration experiment. At 37 °C for one week, Mb concentration decreased by less than 15 %, indicating that the Mb had good long-term storage stability. …”
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Effects of community family doctors-led intervention for self-management and medication adherence in type 2 diabetes mellitus patients: study protocol of a cluster randomised contr... by Yue Chen, Biqi Ren, Ningsheng Wang, Shuang Lei, Shuzhi Lin, Lianye Liu, Yufang Xiang, Bianling Feng

“…It will include five parts: usual care, a medication reminder, a 4-week plan, a weekly phone interview and a monthly interview. …”
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Effects of Functional Oligosaccharides Extracted from Straw on the Growth, Feeding, Physiology, Histology, Muscle Texture, and Gut Microbiota of Micropterus salmoides by Benli Wu, Long Huang, Cangcang Wu, Jing Chen, Xiajun Chen, Xiang Wang, Kai Cui, Zhigang Liu, Jixiang He

“…We conducted an 8-week feeding trial to investigate the effect of mixed functional oligosaccharides (chitosan oligosaccharide, fructooligosaccharide, and xylooligosaccharide) extracted from wheat straw on the growth, feeding, physiology, histology, muscle texture, and gut microbiota of Micropterus salmoides. …”
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Differences in central dopamine, but not serotonin, activity and welfare associated with age but not with preening cup use in commercial grow-out Pekin duck barns by M.M. Bergman, J.M. Schober, R. Novak, A. Grief, C. Plue, D. Frey, H. Parnin, G.S. Fraley

“…We visited 4 standard commercial barns that housed approximately 6000–9000 ducks (one preening cup per 1500 ducks) and collected samples on d21 prior to preening cup placement, d28 one week after preening cup placement, and d35 one day prior to processing. …”
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Interindividual Variability Response to Resistance and High-Intensity Interval Training on Blood Pressure Reduction in Hypertensive Older Adults by Johnattan Cano-Montoya, Nicolas Hurtado, Carolina Núñez Vergara, Sebastián Báez Vargas, Marcela Rojas-Vargas, Sergio Martínez-Huenchullán, Cristian Alvarez, Mikel Izquierdo

“…RT utilized elastic bands, and HIIT involved cycle ergometers, with three weekly 30 min sessions for 8 weeks. SBP and DBP were measured before intervention and at weeks 4 and 8, respectively. …”
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Influence of Melatonin on the Proliferative and Apoptotic Responses of the Prostate under Normal and Hyperglycemic Conditions by Marina G. Gobbo, Nishtman Dizeyi, Per-Anders Abrahamsson, Per-Anders Bertilsson, Viviane Sanches Masitéli, Eloisa Zanin Pytlowanciv, Sebastião R. Taboga, Rejane M. Góes

“…MLT was administered to Wistar rats from 5 weeks of age in the drinking water (10 μg/kg b.w.), and diabetes was induced at the 13th week by streptozotocin (4.5 mg/100g b.w., i.p.). …”
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Effects of photobiomodulation therapy in patients with chronic non-specific low back pain: protocol for a randomised placebo-controlled trial by Lucíola da Cunha Menezes Costa, Shaiane Silva Tomazoni, Leonardo Oliveira Pena Costa, Layana de Souza Guimarães, Amanda Costa Araujo, Dafne Port Nascimento, Flávia Cordeiro de Medeiros, Marina Athayde Avanzi

“…Treatment sessions will be provided three times a week for 4 weeks (totaling 12 sessions) with patients receiving either placebo or active PBMT. …”
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Development, implementation and evaluation of consultation case-based learning course to improve the interdisciplinary clinical reasoning ability-a pilot study from nephrology by Weiwei Kong, Ying Huang, Yingying Lu, Xiaoqi Shen, Chong Luo, Biyu Zhang, Yu Lin, Shaohua Chen, Xiayu Li, Fei Han, Jianghua Chen, Ying Xu

“…At the end of the course, summative evaluations were carried out to test the overall effects with the Kirkpatrick’s evaluation model. Results The ten-week interdisciplinary course were successfully implemented according to the planned training schedule. 26 residents from different majors were included, and 24 of the residents completed the modules and evaluation. …”
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Case report: Chemotherapy plus sintilimab for the treatment of gastroesophageal junction hepatoid adenocarcinoma with liver metastasis: a case study with literature review by Genlin Lu, Jiarui Tu, Jinming Tu, Renya Jiang

“…Chemotherapy (SOX or S-1) plus sintilimab was administered.ResultsA 65-year-old male patient with a history of hypertension was admitted to the hospital due to a one-week increase in serum AFP levels. There was a small intraluminal mass at the GEJ and a metastatic lesion in liver segment VIII, as well as enlarged perigastric and retroperitoneal lymph nodes. …”
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Longevity Recipe - Lifestyle Influences on the Quantity and Quality of Life by Katarzyna Piotrowicz, Hubert Piotrowicz, Jacek Kurzeja, Agnieszka Bajkacz, Wojciech Kraśnik, Olga Jankowska, Anna Rogala, Joanna Osmólska

“…The benefits of physical activity were discussed, including the amount of exercise necessary per week to reduce mortality risk, and the most efficacious sport disciplines for health promotion. …”
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Effects of probiotics and its fermented milk on constipation: a systematic review by Jiaming Yan, Meiling Wu, Wei Zhao, Lai-Yu Kwok, Wenyi Zhang

“…Administration of probiotics significantly increased stool frequency (MD: 1.15 times/week; 95 % CI: 0.59 to 1.70; P < 0.000 1), improved bloating (MD: –0.48; 95 % CI: –0.89 to –0.07; P = 0.02), reduced abdominal pain (MD: –0.71; 95 % CI: –1.25 to –0.16; P = 0.01), and improved quality of life (MD: –0.73; 95 % CI: –1.37 to –0.10; P = 0.02). …”
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Comparisons of risk factors and outcomes between abdominal aortic aneurysm and peripheral arterial disease: a case-control study by Ian Beeton, Jay Acharya, Bengisu Kesin Meric, James Hobden, Tahir Ali, Thang S. Han

“…Compared to patients with PAD, there were higher proportions of patients with AAA prescribed with cardiovascular medications, and developed post-operative complications in hospital: odds ratio = 7.34 (95% CI, 2.26-23.84, P < .001), and stayed in hospital >1week: odds ratio = 2.60 (95% CI, 1.15-5.85, P = .021). …”
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Considering Comorbidities and Individual Differences in Testing a Gaming Behavioral Activation App for Perinatal Depression and Anxiety: Open Trial Pilot Intervention Study by Gabriella E Hamlett, Chloe Schrader, Craig Ferguson, Lauren A Kobylski, Rosalind Picard, Joseph J Locascio, Richard J McNally, Lee S Cohen, Rachel Vanderkruik

“…MethodsPregnant adults with either CAD (n=10) or MDD (n=7) used a BA app for 10 weeks and completed biweekly symptom severity questionnaires for depression and anxiety. …”
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Administration of a Probiotic Mixture Ameliorates Cisplatin-Induced Mucositis and Pica by Regulating 5-HT in Rats by Yuanhang Wu, Jianlin Wu, Zhikun Lin, Qian Wang, Ying Li, Aman Wang, Xiu Shan, Jiwei Liu

“…In the probiotic+cisplatin group, predaily intragastric injection of the probiotic mixture (1×109 CFU/kg BW) was administrated for 1 week before cisplatin injection. This was then followed by further daily probiotic injections for 6 days. …”
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