Application of autogenous vaccine in bitches with transmissible venereal tumor by Sakine Ülküm Çizmeci, Ayşe Merve Köse, İbrahim Aydın, Dursun Ali Dinç, Mehmet Maden, Serkan İrfan Köse

“…The prepared vaccine was administered 4 times (SC) with an interval of 1 week. Dogs were followed up 3 months after 4th application and evaluations were performed for tumor regression.…”
Get full text

Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice by Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho

“…Eighteen 3-month-old male C57Bl/6 mice received a control or high-fat diet for 18 weeks. From the 15th to the 18th week, the animals received treatment—through orogastric gavage—with placebo or free capybara oil (5 g/kg). …”
Get full text

Altered mitochondrial unfolded protein response and FGF21 secretion in MASLD progression and the effect of exercise intervention by Xinmeng Yuan, Wen Sun, Ye Xu, Mengqi Xiang, Yaran Gao, Wanyu Feng, Hongjian Xiao, Liumei Zhang, Qiang Tang, Jiao Lu, Yuan Zhang

“…In this study, a total of 60 male C57BL/6J mice were maintained on a normal or amylin liver NASH (AMLN) diet for 6 or 10 weeks. Some of the mice were then subjected to voluntary wheel running, while the other mice were fed a normal or AMLN diet until 14 and 18 weeks. …”
Get full text

Improved Outcome of Biliary Atresia with Postoperative High-Dose Steroid by Rui Dong, Zai Song, Gong Chen, Shan Zheng, Xian-min Xiao

“…Intravenous prednisolone administration was started 1 week after surgery, followed by 8 to 12 weeks of oral prednisolone. …”
Get full text

The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review by Olga Theou, Liza Stathokostas, Kaitlyn P. Roland, Jennifer M. Jakobi, Christopher Patterson, Anthony A. Vandervoort, Gareth R. Jones

“…However, multicomponent training interventions, of long duration (≥5 months), performed three times per week, for 30–45 minutes per session, generally had superior outcomes than other exercise programs. …”
Get full text

Neuroprotective effects of curculigoside against Alzheimer’s disease via regulation oxidative stress mediated mitochondrial dysfunction in L-Glu-exposed HT22 cells and APP/PS1 mice... by Wenqi Wang, Yidi Qu, Siyu Li, Jinyu Chu, Hongxin Yang, Lirong Teng, Di Wang

“…Observably, CCG in L-Glu-damaged HT22 cells suppressed apoptosis, reduced the accumulation of reactive oxygen species, balanced the mitochondrial membrane potential and prevented the over-influx of calcium. In APP/PS1 mice, 4-week CCG administration significantly improved their memory and behavioral impairments, enhanced the function of cholinergic system, reduced the deposition of Aβ and neurofibrillary fiber tangles caused by tau phosphorylation, and suppressed the development and progression of oxidative stress in brains of APP/PS1 mice. …”
Get full text

The Effects of Parathyroid Hormone Applied at Different Regimes on the Trochanteric Region of the Femur in Ovariectomized Rat Model of Osteoporosis by M. Tezval, A. Banhardt, S. Sehmisch, L. Kolios, U. Schmelz, K. M. Stuermer, E. K. Stuermer

“…Three groups were ovariectomized, and 8 weeks later they were administered the following treatments (5 weeks): soy-free diet (OVX), subcutaneously injected PTH (0.040 mg/kg) 5 days a week (PTH 5x/w), subcutaneously injected PTH (0.040 mg/kg) every 2 days (PTH e2d), and a sham group. …”
Get full text

Evaluation of Three Adolescent Sexual Health Programs in Ha Noi and Khanh Hoa Province, Vietnam by Van Pham, Hoang Nguyen, Le Huu Tho, Truong Tan Minh, Porntip Lerdboon, Rosemary Riel, Mackenzie S. Green, Linda M. Kaljee

“…Programs were delivered over a ten-week period in the communities by locally trained facilitators. …”
Get full text

Impact of the COVID-19 lockdown in the United Kingdom on adolescent's time use (CONTRAST study). by Irina Pokhilenko, Emma Frew, Marie Murphy, Miranda Pallan

“…There was an overall decrease in the amount of time spent on school work, an increase in screen time, and an increase in sleep duration during the week. Descriptive analysis showed evidence of inequalities with changes in time use. …”
Get full text

Two Imported Malaria Cases with Delayed Response to Treatment in Hatay by Tuğba Kaya, Mehmet Çabalak, Gülnaz Çulha, Ceren Ünal

“…The patient was discharged after a 3-week follow-up. The study is presented to draw attention to the increasing cases of imported malaria in Hatay and the increase of malaria cases that respond late to treatment in recent years.…”
Get full text

Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy by Yiji Tu, Zenggan Chen, Feng Zhang, Zhenglin Di, Junhui Zhang, Li Cai

“…Microarray was performed on the sciatic nerve tissues from control rats and DPN rats at then6th week after diabetes induction, and differentially expressed genes (DEGs) between them were identified and applied for further bioinformatic analyses. …”
Get full text

Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling by Cheng-Hung Chuang, Yu-An Tai, Ting-Jing Wu, Ying-Jui Ho, Shu-Lan Yeh, Shu-Lan Yeh

“…The main objective of the present study was to investigate whether quercetin regulates the hypothalamic-pituitary-adrenal (HPA) axis and chemoattractant protein-1 (MCP-1) signaling, two factors contributing to CRF in mice exposed to cisplatin.MethodsMale BALB/c mice were randomly assigned to the following five groups for 15 weeks: Control, CDDP, CDDP+TAK779 (an antagonist of MCP-1 receptor, human CC chemokine receptor R2 (CCR2)), CDDP+OQ (a diet containing 1% quercetin) and CDDP+IQ (quercetin given by ip, 10 mg/kg, 3 times/week).ResultsThe results first showed that OQ and IQ significantly increased grip strength and locomotor activity, decreased plasma cortisol/corticosterone levels, and decreased the corticotropin releasing hormone (CRH) mRNA level in the brain tissues in mice exposed to CDDP. …”
Get full text

Maternal Serum Uric Acid as an Index of Perinatal Outcomes in Severe Preeclampsia by Rozhan Yassin Khalil, Awat Saber Muhammed

“…Preeclampsia is a multisystem disorder characterized by gestational hypertension after the 20th week of gestation with proteinuria, is common and dangerous adverse event of pregnancy. …”
Get full text

Effect of a Selective Progesterone Receptor Modulator on Induction of Apoptosis in Uterine Fibroids In Vivo by Petr Horak, Michal Mara, Pavel Dundr, Kristyna Kubinova, David Kuzel, Robert Hudecek, Roman Chmel

“…Immunohistochemical examination of fibroid tissue, using avidin-biotin complex and cleaved caspase-3 antibody for detecting apoptosis, was performed in premenopausal women who underwent 12-week treatment with oral SPRM (6 patients with 5 mg and 5 patients with 10 mg of ulipristal acetate per day) or gonadoliberin agonist (GnRHa, 17 patients) and subsequent myomectomy or hysterectomy for symptomatic uterine fibroids. …”
Get full text

Incorporating specific sambo exercises into distance learning for high school students aged 15-16 by Valeriia Zakharevich, Georgiy Korobeynikov, Olena Nesen, Abdulaziz Xamidjonov

“…The experiment lasted for 8 weeks (with sessions three times a week), during which specific sambo exercises were applied in a remote format during physical education lessons. …”
Get full text

Investigation of the Protective Effect of Probiotic Lactobacillus plantarum Ep-M17 on the Hepatopancreas of Penaeus vannamei by Xiaoman Hu, Wenlong Xu, Hao Li, Bowen Lu, Yang Du, Jiong Chen

“…To address this knowledge gap, our present study investigated the histological changes, enzyme activity, gene transcription, and metabolite levels in the hepatopancreas of shrimp after a 4-week diet supplemented with Ep-M17. The results revealed that incorporating Ep-M17 into the shrimp’s diet alleviated the damage by V. parahaemolyticus E1 infection in hepatopancreatic cells. …”
Get full text

Efficacy and Safety of Immunotherapy with Interferon-Gamma in the Management of Chronic Sulfur Mustard-Induced Cutaneous Complications: Comparison with Topical Betamethasone 1% by Yunes Panahi, Amirhossein Sahebkar, Seyyed Masoud Davoudi, Mojtaba Amiri, Fatemeh Beiraghdar

“…Forty subjects who were suffering from chronic skin complications of SM and were diagnosed to have severe atopic dermatitis, were assigned to IFN-γ (50 μg/m2) subcutaneously three times per week (n=20) or betamethasone valerate topical cream 0.1% (n=20) every night for 30 days. …”
Get full text

Lower serum magnesium level is an important risk factor for erythropoiesis-stimulating agents hypo-responsiveness in hemodialysis patients by Hayam Hebah, Shaimaa Abdelmegied, Dina Osman, Lina Khedr

“…ERI mean values were (13.63 ± 3.17 Vs 10.52 ± 2.74 IU/week/kg) which was also found to be a significant p-value < 0.001. …”
Get full text

Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses by Carrie Down, Amit Mehta, Gayle Salama, Erika Hissong, Russell Rosenblatt, Michael Cantor, David Helfgott, Kristen Marks

“…We describe an immunocompetent 67-year-old male who presented with one week of fever and abdominal pain. Computed tomography (CT) scan and magnetic resonance imaging (MRI) of the abdomen showed multiple bilobar hepatic lesions, some with rim enhancement, compatible with liver abscesses. …”
Get full text

Negative Influence of a Long-Term High-Fat Diet on Murine Bone Architecture by Hinrich Fehrendt, Thomas Linn, Sonja Hartmann, Gabor Szalay, Christian Heiss, Reinhard Schnettler, Katrin Susanne Lips

“…Thus, the aim of the present study was to investigate the influence of diet-induced mild obesity (11% increased body weight compared to control) on bone microstructure in mice. Four-week-old male C57BL/6J mice received a high-fat diet (HFD, 60% kcal from fat) and were analyzed by means of dual X-ray absorptiometry, histological methods, real-time RT-PCR, and transmission electron microscopy in comparison to control animals (10% kcal from fat). …”
Get full text