Early tolerance and late persistence as alternative drug responses in cancer by Simona Punzi, Davide Cittaro, Guido Gatti, Gemma Crupi, Oronza A. Botrugno, Antonino Alex Cartalemi, Alon Gutfreund, Caterina Oneto, Valentina Giansanti, Chiara Battistini, Giovanni Santacatterina, Lucrezia Patruno, Ilaria Villanti, Martina Palumbo, Daniel J. Laverty, Francesca Giannese, Alex Graudenzi, Giulio Caravagna, Marco Antoniotti, Zachary Nagel, Ugo Cavallaro, Luisa Lanfrancone, Timothy A. Yap, Giulio Draetta, Nathalie Balaban, Giovanni Tonon

Get full text

Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model by José Sereno, Belmiro Parada, Flávio Reis, Fernanda X. Cunha, Edite Teixeira-Lemos, Patrícia Garrido, Rui Pinto, Petronila Rocha-Pereira, Paula Neto, José Ruivo, Paulo Rodrigues-Santos, Sara Nunes, Alfredo Mota, Arnaldo Figueiredo, Frederico Teixeira

Get full text

Vegetal and Animal Food Proteins Have a Different Impact in the First Postprandial Hour of Impedance-pH Analysis in Patients with Heartburn by Irene Martinucci, Giada Guidi, Edoardo V. Savarino, Marzio Frazzoni, Salvatore Tolone, Leonardo Frazzoni, Lorenzo Fuccio, Lorenzo Bertani, Giorgia Bodini, Linda Ceccarelli, Vincenzo Savarino, Santino Marchi, Nicola de Bortoli

Get full text

CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

Get full text

Instantaneous self-recovery and ultra-low detection limit hydrogel electronic sensor for temporomandibular disorders intelligent diagnosis by Yujie Yan, Lixia Yu, Xuefeng Zhang, Qi Han, Zhixin Yang, Xingyuan Lu, Jiongke Wang, Hao Xu, Qianming Chen, Hang Zhao

Get full text

Booster Vaccination against Yellow Fever in Gambian children-(BoVY) -a Phase 3 clinical trial to establish safety and immunogenicity of repeated YF vaccination in healthy Gambian c... by David Jeffries, Caitlin Pley, Beate Kampmann, Mam Nabou Leigh, Julia Strandmark, Ed Clarke, Peter Ndow, Ebrima Kanteh, Amadou Faal, Elishia Roberts

“…All children were vaccinated with the 17D YF vaccine at 9–10 months of age as part of clinical trials run by the Medical Research Council (MRC) Unit The Gambia, and are thus well-characterised, including basic clinical, anthropometric, and post-primary immunogenicity data. …”
Get full text

Larval Cytotoxic and Subacute Toxicity of Gardenia ternifolia, Rourea coccinea, and Cassytha filiformis Used in Traditional Medicine of Benin (West Africa) by E. Agbodjento, J. R. Klotoé, T. I. Sacramento, T. V. Dougnon, E. Déguenon, J. Agbankpé, K. Fabiyi, P. Assogba, M.-P. Hounkanrin, R. Akotegnon, T. J. Dougnon, J.-M. Atègbo

Get full text

CLN6‐related continuum phenotype caused by aberrant splicing by Federica Invernizzi, Barbara Castellotti, Chiara Reale, Celeste Panteghini, Isabel Colangelo, Roberta Solazzi, Francesca Ragona, Lucio Giordano, Jessica Galli, Davide Rossi Sebastiano, Gianluca Marucci, Valeria Cuccarini, Giuseppe Didato, Cinzia Gellera, Barbara Garavaglia, Tiziana Granata, Laura Canafoglia

Get full text

IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells by Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge

Get full text

Prehospital scale to differentiate intracerebral hemorrhage from large-vessel occlusion patients: a prospective cohort study by A. Freixa-Cruz, G. Jimenez-Jimenez, G. Mauri-Capdevila, Y. Gallego-Sánchez, A. García-Díaz, R. Mitjana-Penella, M. Paul-Arias, C. Pereira-Priego, E. Ruiz-Fernández, S. Salvany-Montserrat, A. Sancho-Saldaña, E. San-Pedro-Murillo, E. Saureu, D. Vázquez-Justes, Francisco Purroy

Get full text

On-demand and efficient scheduling scheme for cryptographic service resource by Wenlong KOU, Yuyang ZHANG, Fenghua LI, Xiaogang CAO, Jiamin LI, Zhu WANG, Kui GENG

“…However, with the increase of the number of cryptographic service requests, the number of service requests per unit time of the three scheduling algorithms reaches the peak.Because the on-demand scheduling algorithm realizes the cryptographic job migration and the dynamic configuration of FPGA computing units, the number of service requests per unit time is higher than the other two scheduling algorithms.Fig. 9 shows that under the premise of minimizing the migration of cryptographic operations and the reconstruction of FPGA computing units, the on-demand scheduling algorithm prioritizes the cryptographic operations to the same FPGA computing unit.Therefore,only one FPGA computing unit has load when the number of cryptographic service requests is small, and with the increase of the number of cryptographic service requests, the number of FPGA computing units working also increases. …”
Get full text

Clinical Images: Osteomyelitis complicating uncommon tophaceous gout: a case study with genetic findings by Matteo Colina, Maria Giulia Salomoni, Antonio Poerio

Get full text

Plasma exchange alone versus combination with intravenous immunoglobulin/methylprednisolone pulse therapy in severe systemic rheumatic diseases: a retrospective study by Jing Guo, Jing Guo, Jing Guo, Shuiwen Li, Shuiwen Li, Shuiwen Li, Hao Xu, Hao Xu, Hao Xu, Xinxin Wang, Xinxin Wang, Xinxin Wang, Weiyuan Luo, Weiyuan Luo, Weiyuan Luo, Jie Sun, Jie Sun, Jie Sun, Jianhua Li, Jianhua Li, Jianhua Li, Zhu Chen, Zhu Chen, Zhu Chen, Guiyang Lu, Guiyang Lu, Guiyang Lu, Xiaolong Huang, Xiaolong Huang, Xiaolong Huang, Shiju Chen, Shiju Chen, Yaogui Ning, Yaogui Ning, Yaogui Ning

“…However, the necessity of this combination treatment strategy in SRDs remains uncertain.ObjectiveThis retrospective study aimed to evaluate the effectiveness of TPE alone versus TPE combined with IVIG/IVMP in treating severe SRDs.MethodsPatients with severe SRDs treated with TPE who were admitted to the department of intensive care unit (ICU) from January 2011 to December 2019 were included. …”
Get full text

CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer by Lorenzo Castagnoli, Alma Franceschini, Valeria Cancila, Matteo Dugo, Martina Bigliardi, Claudia Chiodoni, Paolo Toneguzzo, Viola Regondi, Paola A. Corsetto, Filippo Pietrantonio, Serena Mazzucchelli, Fabio Corsi, Antonio Belfiore, Antonio Vingiani, Giancarlo Pruneri, Francesca Ligorio, Mario P. Colombo, Elda Tagliabue, Claudio Tripodo, Claudio Vernieri, Tiziana Triulzi, Serenella M. Pupa

Get full text

Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis by Esther Álvarez-Sánchez, Álvaro Carbayo, Natalia Valle-Tamayo, Laia Muñoz, Joaquim Aumatell, Soraya Torres, Sara Rubio-Guerra, Jesús García-Castro, Judit Selma-González, Daniel Alcolea, Janina Turon-Sans, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Ricard Rojas-García, Oriol Dols-Icardo

Get full text

Necrotizing Fasciitis of the Chest in a Neonate in Southern Nigeria by Oluwafemi Olasupo Awe, Emeka B. Kesieme, Babatunde Kayode-Adedeji, Quinzy O. Aigbonoga

Get full text

Aspiration in the Context of Upper Gastrointestinal Endoscopy by A Thomson, J Tye-Din, S Tonga, J Scott, C Mclaren, P Pavli, F Lomas

Get full text

Chaos and Dynamics Induced by the Amplitude of Load Torque: Analysis and Control by Arnaud Ngonting Topy, Justin Roger Mboupda Pone, Alex Stephane Kemnang Tsafack, Romanic Kengne

Get full text

Diffuse Large B Cell Lymphoma Mimicking Granulomatosis with Polyangiitis by Mohammad E. Naffaa, Alexander P. Rozin, Netanel Horowitz, Ofer Ben-Itzhak, Yolanda Braun-Moscovici, Alexandra Balbir-Gurman

Get full text

Correction: Are socio-economic inequalities related to cardiovascular disease risk? A systematic review and meta-analysis of prospective studies by Ololade J. Baruwa, Federica Alberti, Sunday Onagbiye, Annalisa Guddemi, Anna Odone, Hannah Ricci, Maddalena Gaeta, Schmid Daniela, Cristian Ricci

Get full text