Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…The KEYNOTE 158 trial supported United States Food and Drug Administration (FDA) approval of the Foundation Medicine test (FoundationOneCDx) at TMB≥10 mut/Mb as a companion diagnostic (CDx) for single-agent pembrolizumab in second+line. …”
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HANNAH ARENDT E A QUESTÃO NEGRA NA DESSEGREGAÇÃO DA ESCOLA DE LITTLE ROCK, 1957 by Danilo Arnaldo Briskievicz, Amauri Carlos Ferreira

“…The purpose of this article is to discuss the case of educational racial desegregation that took place in Arkansas, Little Rock, United States of America, on September 4, 1957. To illuminate the social and political context of the controversial case, we resume the controversial essay by Hannah Arendt published in 1959, entitled Reflections on Little Rock. …”
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A study of bacterial community structure of shrimp farms along the Ratnagiri coast, Maharashtra by Bhavesh Choudhary, Anil S. Pawase, Gajanan S. Ghode, Raju M. Tibile, Varsha R. Bhatkar, Divyashree Choudhary, Utkarsh Choudhary

“…The present study was conducted to identify the bacterial pathogens associated with the shrimp Penaeus vannamei farming systems along the Ratnagiri coast. In all, two farming units were selected: Varavade farm - a six-year-old farm, and Chinchkhari farm, a new virgin farm. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…The interrelated elements of the pedagogical theories and didactic principles, united by a common scientific-methodological objective, allowed the authors to create a methodological tool for gradual formation and consolidation of organisational and administrative competencies of young officers of the State Fire-Fighting Service. …”
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Alternative approaches for monitoring and evaluation of lymphatic filariasis following mass drug treatment with ivermectin, diethylcarbamazine and albendazole in East New Britain P... by Krufinta Bun, Benedict Mode, Melinda Susapu, Joyceline Salo, Catherine Bjerum, Michael Payne, Daniel Tisch, Makoto Sekihara, Emanuele Giorgi, Gary J Weil, Peter U Fischer, Leanne Robinson, Moses Laman, Christopher L King

“…Higher-prevalence areas will need additional MDA rounds, which could be targeted to smaller evaluation units to cut costs.<h4>Trial registration</h4>Clinicaltrials.gov NCT04124250.…”
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Is severe maternal morbidity a risk factor for postpartum hospitalization with mental health or substance use disorder diagnoses? Findings from a retrospective cohort study in Mary... by Carrie L Wolfson, Jessica Tsipe Angelson, Andreea A Creanga

“…Abstract Background Perinatal mental health conditions and substance use are leading causes, often co-occurring, of pregnancy-related and pregnancy-associated deaths in the United States. This study compares odds of hospitalization with a mental health condition or substance use disorder or both during the first year postpartum between patients with and without severe maternal morbidity (SMM) during delivery hospitalization. …”
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Eliciting Preferences for the Uptake of Smoking Cessation Apps: Discrete Choice Experiment by Dorothy Szinay, Rory A Cameron, Andy Jones, Jennifer A Whitty, Tim Chadborn, Jamie Brown, Felix Naughton

“…MethodsAdult smokers from the United Kingdom were invited to participate in a discrete choice experiment. …”
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SOIL TILLAGE VARIANTS AND SULPHUR FERTILIZATION AFFECT NODULATION, N2 FIXATION AND YIELD OF BAMBARA GROUNDNUT (Vigna subterreana) IN SOUTHEAST NIGERIA by M.A.N. Anikwe, Nnamnani D.E, Ikengannyia E.E, J.C. Eze, Obidike-Ugwu, E. O

“…Twenty-four experimental units were laid out in a Randomized Complete Block Design (RCBD). …”
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Patient-Generated Collections for Organizing Electronic Health Record Data to Elevate Personal Meaning, Improve Actionability, and Support Patient–Health Care Provider Communicatio... by Drashko Nakikj, David Kreda, Karan Luthria, Nils Gehlenborg

“… BackgroundThrough third party applications, patients in the United States have access to their electronic health record (EHR) data from multiple health care providers. …”
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Biofloc technology significantly reshapes water microbiome and improves survival rates in Japanese eel (Anguilla japonica) by Jiho Yang, Hyunjun Choi, Jun Seong Park, Yehyeon Cha, Ju-Ae Hwang, Seung-Yoon Oh

“…To identify the operational taxonomic units (OTUs) that directly influence the feed consumption rate of eels, closely linked to their growth rate, we first determined the differentially abundant residents and then highlighted the most informative OTUs. …”
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A Digital Parenting Intervention With Intimate Partner Violence Prevention Content: Quantitative Pre-Post Pilot Study by Moa Schafer, Jamie Lachman, Paula Zinser, Francisco Antonio Calderón Alfaro, Qing Han, Chiara Facciola, Lily Clements, Frances Gardner, Genevieve Haupt Ronnie, Ross Sheil

“…MethodsCaregivers of children aged between 0 and 18 years were recruited through convenience sampling by research assistants in Cape Town, South Africa, and by UNICEF (United Nations Children's Fund) Jamaica staff in 3 parishes of Jamaica. …”
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Antibiotic resistance genotype, phenotype, and clinical outcomes in patients with Gram-negative infections at Rabin Medical Center in Israel by Rachelle E. Koch, Jackson Barth, Andrew E. Clark, Dhara Desai, Jiwoong Kim, Christine A. Pybus, Xiaowei Zhan, Leonard Leibovici, Dafna Yahav, David E. Greenberg

“…This study focused on a hospitalized patient population in Israel with infections due to medically important bacterial pathogens as a way to build a framework that would unite clinical data with both bacterial antibiotic susceptibility and genomic data. …”
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Dietary β-Mannanase Affects the Growth, Antioxidant, and Immunes Responses of African Catfish, Clarias gariepinus, and Its Challenge Against Aeromonas hydrophila Infection by Ibrahim Adeshina, Bilal Ahamad Paray, Eijaz Ahmed Bhat, Shahid Sherzada, Olaolu O. Fawole, Dalhatu J. Bawa, Thais Pereira da Cruz, Lateef O. Tiamiyu

“…Five isonitrogenous diets were prepared to have 400 g/kg crude protein and supplemented with β-mannanase at 0, 1500, 3000, 4500, or 6000 thermostable endo, 1,4-β-mannanase units (TMUs)/kg diet and fed to 300 juveniles of the African catfish, C. gariepinus (mean weight 12.1 ± 0.1 g) for 12 weeks. …”
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Maternal prepregnancy overweight/obesity increase the risk of low Apgar scores in twins: a population-based cohort study in China by Zhoushan Feng, Zhoushan Feng, Xiaohong Wu, Xiaomei Tong, Zheng He, Chunxia Yang, Wei Shen, Yueqin Ding, Jin Liu, Qiong Meng, Aiqin Zhang, Hong Jiang, Wenkang Yan, Jianwu Qiu, Xian Wei, Yayu Zhang, Xiaobo Lin, Lijun Liu, Ya Jin, Youfen Wei, Xiufang Yang, Yitong Wang, Yangfan Cai, Xinzhu Lin, Qiliang Cui

“…Therefore, we conducted a nationwide, multicenter retrospective study to investigate the association between maternal prepregnancy weight and health outcomes in twins.Study designThis study collected data from 22 healthcare units across 12 regions in China between January 2018 and December 2020. …”
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ENTREPRENEURSHIP OF MEMORY IN PUBLIC SPACE AND SOCIAL COMMUNICATION: A POSTCOLONIAL APPROACH IN TIME OF WAR by Viktoriia Kovpak, Nataliia Lebid, Viktor Burenkov

“…An important part of the article is the description of interpretive approaches in the discourse of postcolonial studies in the interpretation of the concept of "memory entrepreneurship", which has its origin in the discourse of desegregation of the past in the United States and South Africa. Therefore, the conclusion of the scientific research includes theses on conceptual value approaches in the politics of memory that underlie the constructive or destructive use of organisational imprinting (the mechanism of persistent memorisation and subsequent remembering as a consequence of the systemic mechanism of broadcasting national and cultural memories and the construction of national identity) in entrepreneurial activity as a strategic practice of the impression economy model.…”
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Kidney disease among adults on tenofovir-based second-line antiretroviral therapy in Dar es Salaam, Tanzania by Sabina F. Mugusi, Grace A. Shayo, Philip G. Sasi, Lulu S. Fundikira, Eric A. Aris, Christopher R. Sudfeld, Ferdinand M. Mugusi

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The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review by Thiago Henrique Teodoro, Katerine Palharini Manfrin Costa, Jonato Prestes, José Campanholi, James Navalta, Guilherme Borges Pereira

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Loading rate, geometry, and damage state influence vertical extraction biomechanics in an ex vivo swine dental model by Timothy J. Gadzella, Karyne N. Rabey, Michael R. Doschak, Lindsey Westover, Owen Addison, Owen Addison, Dan L. Romanyk, Dan L. Romanyk

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Effects of isometric contraction training on hypertensive patients: A Systematic Review by Yuan Hao Dong

“…The same problem occurs not only in China, but also in the statistics of the Centers for Disease Control and Prevention in the United States. Nearly 47% of the American population has hypertension. …”
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Exploring Web-Based Support for Suicidal Ideation in the Scottish Population: Usability Study by Heather McClelland, Rory C O'Connor, Laura Gibson, Donald J MacIntyre

“… BackgroundSuicide is a global health concern. In the United Kingdom, Scotland has the highest suicide rate. …”
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