Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines by Mervin Chávez-Castillo, Victoria Núñez, Manuel Nava, Ángel Ortega, Milagros Rojas, Valmore Bermúdez, Joselyn Rojas-Quintero

“…Currently available antidepressant drugs are notoriously problematic, with suboptimal remission rates and troubling side-effect profiles. Their mechanisms of action focus on the monoamine hypothesis for depression, which centers on the disruption of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain. …”
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Smart bus ticketing system through IoT enabled technology by Agyan Kumar, Antônio Clécio Fontelles Thomaz

“…As we advance toward a smart bus pass generation system, the trouble of keeping change in pockets will soon be a thing of the past. …”
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Ocular injuries by less-lethal weapon: a view from Switzerland by Anna Fierz

“…Dear Editor-in-chief: Thank you for focussing on this troubling subject in your issue 1/2024. It confirms that many of the difficulties involved are similar worldwide. …”
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Barotrauma and Successful Release of Fish Caught in Deep Water by Elizabeth A. Staugler, Holly Abeels, Angela Collins, Shelly Krueger, Kai Lorenzen

“…But deepwater fish can have trouble getting back where they came from without a little assist from the angler. …”
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Montaigne and the rise of modern cultural diplomacy [version 2; peer review: 2 approved, 1 approved with reservations, 3 not approved] by Gabriel Gherasim

“…In the troubling sixteenth century political and religious turmoil in Europe - and particularly in France - the cosmopolitan personality of Michel de Montaigne is not only indicative for acknowledging the more and more meddling resources of culture within the realm of politics, but is also explanatory for reforming and expanding the instruments of traditional diplomacy. …”
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Barotrauma and Successful Release of Fish Caught in Deep Water by Elizabeth A. Staugler, Holly Abeels, Angela Collins, Shelly Krueger, Kai Lorenzen

“…But deepwater fish can have trouble getting back where they came from without a little assist from the angler. …”
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Responsible innovation is not comfortable: a call for grounded, embodied reflexivity when doing RI by Karly Ann Burch, Susanna Finlay-Smits, Tara Roberson

“…Beginning with the premise that discomfort is inherent and valuable to practicing RI, we share three situated experiences of noticing and navigating discomfort in our research: embracing the discomfort of one’s compromised agency; developing relationships to hold discomfort; and staying with the trouble of colonialism. Through articulating our experiences, we encourage RI practitioners to reflect on their positionalities and response-abilities. …”
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How Does Nursing Staff Perceive the Use of Electronic Handover Reports? A Questionnaire-Based Study by Torbjørg Meum, Gro Wangensteen, Karen S. Soleng, Rolf Wynn

“…Staff that had a high level of trust in written reports believed these saved time, had little trouble finding time and a place to read the reports, and were more positive to the new handover routine.…”
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In Front of the Distorting Mirror of the Vortex: the Reception of Vorticism in the British Political Press (1913-1916) by Oriane MARRE

“…The Vorticist movement appeared in 1914, after a fight between the English avant-garde and Italian Futurism, just as England entered World War One, and when the country was facing an uneasy transition from an old and stable order to a new era of trouble reinforced by different strikes conducted by suffragettes, Unionists and workers. …”
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The impact of long-term exposure to NO2, O3, and their oxidative potential on adolescents’ mental health, and the protective role of school-based greenness by Jiajia Dang, Yaqi Wang, Ning Ma, Shan Cai, Jianhui Guo, Yunfei Liu, Haoyu Zhou, Xinyao Lian, Di Shi, Ziyue Chen, Yihang Zhang, Jiaxin Li, Tianyu Huang, Guangrong Zhu, Jing Li, Jun Ma, Yi Song

“…Each IQR (Interquartile Range) increase in OX was related to adverse mental health outcomes, with ORs of 1.17 (95 % CI: 1.06, 1.29) for being vulnerable, 1.20 (95 % CI: 1.12, 1.28) for being more symptomatic but content, and 1.15 (95 % CI: 1.07, 1.23) for being troubled. Similar findings emerged in relation to O3 exposure. …”
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Considering middle-classes in Latin America: An update of old debates by Isabel Díaz

“…Finally, the article reflects on how to study the middle layers of society in troubled times, placing labor uncertainty at the forefront of academic discussion.…”
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Ecuador's Cantonal (Municipal) Planning System: The Need for Reform by Manuel Benabent-Fernández de Córdoba, Lorena Vivanco-Cruz

“…As a result, planning at the “cantonal” (municipal) level has become more complex and local administrations are having trouble in completing these documents. This article wants to figure out the causes of these difficulties and show that the current legislation is muddled by the uselessness of the required planning instruments and because of the mistaken conflation of short term development planning with long term territorial management. …”
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Rio de Janeiro residents’ perceptions of the 2016 Olympics in the pre-games period by Deborah Moraes Zouain, Paola Lohmann, Kaarina Virkki, Douglas Michele Turco, Gabriela De Laurentis Cardoso

“…The data indicated that the residents found the pre-game period troubling because of uncertainties regarding the city’s desired Olympic legacy. …”
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Mythologies of American violence in Alan Ball's True Blood series by Anne-Marie PAQUET-DEYRIS

“…All of them provide starkly original variations on the central notions of trouble and evil.The show addresses some the following key issues: which aesthetic, formal and ideological strategies are adopted to represent the different layers of reality? …”
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Development of Fatigue Test Bench for Gearbox Assembly of Crawler Combine Harvester by Zhu Ruiheng, Li Yaoming, Tang Zhong, Xu Lizhang, Ma Zheng

“…The field operation load is complex and variable, which leads to fatigue fracture and other accidents of gearboxes under the impact of variable loads and seriously affects the trouble-free working time of the whole machine. In order to solve the problem of high fault rate of gearboxes of crawler combine harvesters, the single HST hydro-mechanical differential steering gearbox developed by the team is taken as the test object, this study designs and builds the gearbox assembly fatigue test bench, and then carries out the fatigue test of differential steering gearboxes. …”
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The Effect of The CAMEL Method on Profitability in General Banking Listed on The Indonesian Stock Exchanges in 2020-2022 by Ainun Putri Rayhan, Dinda Permatasari, Ikah Afri Cahyani, Yasmin Fatihatul Azizah, Haidar Tri Putra, Rina Mudjiyanti

“…NIM affects ROA, so that interest income on productive assets managed by the bank increases so that the possibility of the bank being in trouble becomes smaller and the level of profitability can grow.…”
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The Socio-Economic Factors Affecting the Performance of Girl Child in Mathematics: A Case Study of Kanaba Sub-Count Kisoro District. by Munyabuntu, Reuben

“…The study findings show that there is influence in girl’s participation in mathematics compared to boys as they include; teachers hold the view that girls are not as trouble as boys in Mathematics as indicated by 20% respondents. beliefs lead to heavy cultural related support for males to be more successful than females as shown by 10% respondents. …”
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Design and Construction of an Electronic Mosquito Repellant. by Kwesiga, Isaac

“…Coils, mats can produce toxic fumes when heated and cause breathing trouble whereas liquid vaporizers can also produce fumes when heated. …”
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Make America Great Again as White Political Theology by S. Romi Mukherjee

“…Rather, resonating under Trumpism and the promise to Make America Great Again (MAGA) is a white political theology which is deployed in a new “spiritual war” for the soul of America and indeed, the soul of the West. More troubling is how this “spiritual war” articulates itself in the new culture wars and, for some, the inauguration of a geo-political apocalypse which finally resolves the clash of civilizations. …”
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Divided Memory: Dealing with the Past in the East German Town of Eisenhüttenstadt after the Upheaval of 1989–90 by Stanislav Serhiienko

“…Despite its being the most well-known “socialist town” in Eastern Bloc, no systematic research has been done into how the town dealt with its troubled past. By analyzing discussion and representation of the town’s past in the public space through the year 2010, this study investigates how a town like Eisenhüttenstadt, which has no pre-socialist history, dealt with its past as East Germany transitioned away from state socialism. …”
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