Features of development and progression of colorectal cancer on a background of ulcerative colitis by I. L. Khalif, V. N. Kashnikov, A. V. Gusev, O. V. Golovenko, K. V. Bolikhov, L. L. Kapuller, A. N. Kuznetsov, A. V. Vasilchenko

“…Combined effect of disease duration and UC intestinal extent increases probability of CRC development several times. Presence of two peaks of CRC development – at patients with 11 to 15 years of UC past history and from 26 to 30 years has been revealed.…”
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Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study by Peter P. Nghiem, Alexis M. Rutledge, Kyle Tehas, Corine Kaderli, Meredith Poling, Sidney Arnim, Vitaliy Dernov, Celine van Sas, Macie L. Mackey, Gabriella A. M. ten Have, Mariëlle P. K. J. Engelen, Nicolaas E. P. Deutz

“…In addition, a 6% reduction was found in rest time after HMB supplementation compared to placebo (23,857 [23,130, 24,584], versus 25,363 [24500, 26225]; p = 0.0122). …”
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Comparison of bullying victimization and depression symptoms among Chinese adolescents before and after the end of the dynamic zero-COVID-19 policy: a repeated cross-sectional stud... by Yong Yang, Yi Lin, Feng Wang, Si Jia Wang, Jing Hui Wang, Feng Tong, Qing Hai Gong

“…The odds ratio of experiencing depression (CES-D Score ≧ 16) and bullying victimization in school were 1.18 (95% CI, 1.10–1.28) and 1.86 (95% CI, 1.55–2.24) times higher, respectively, in 2023 than in 2022 (P < 0.01). …”
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An outbreak within an outbreak: The impact of Infection Prevention and Control strategies on hospital-acquired infections and the occurrence of multi-drug resistant organisms durin... by B Mashigo, A Parker, U Lalla, B W Allwood, M S Moolla, T Lovelock, C F N Koegelenberg

“…We observed a very significant rise in HAIs in the COVID-19 ICU during the third wave compared with the first, with almost three times as many patients developing HAIs. Unsurprisingly, it was associated with a longer mean stay in ICU and a higher mortality. …”
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Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study by Wan Yu, Runnian Huang, Shuning Sun, Li Bu, Xin Chen, Yunhua Di, Shuwu Lin, Qian Li, Yang Yang, Xingyue Ye, Wenxu Wang, Rui Ren, Linze Xi, Ru Zhang, Yi Li, Xin Li, Tianbo Hou, Zibo Ning, Yang Peng, Difei Wang

“…Patients aged ≥ 60 years, who were diagnosed with COVID-19 at the time of admission or during hospitalisation. The Barthel index was used to assess FI. …”
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Gastrointestinal symptoms and bowel habits in 53 046 healthy Danish blood donors: a nationwide cross-sectional study by Christian Erikstrup, Ole Birger Pedersen, Henrik Hjalgrim, Erik Sørensen, Jens Frederik Dahlerup, Klaus Rostgaard, Mikkel Steen Petersen, Sisse Rye Ostrowski, Susan Mikkelsen, Khoa Manh Dinh, Thorsten Brodersen, Janna Nissen, Anne Karmisholt Grosen, Jens Kjærgaard Boldsen, Simon Mark Dahl Baunwall, Mie Topholm Bruun, Bitten Aagaard, Christina Mikkelsen, Christian Lodberg Hvas

“…Half of the participants (50%) had a regular defaecation pattern (defined as generally the same stool consistency and stool frequency) consisting of Bristol Stool Form Scale 4 stools 1–3 times per day. Symptom phenotypes and their prevalence among 51 820 near-complete case participants were as follows: (1) no gastrointestinal symptoms (32%); (2) bloating and/or rumbling only (21%); (3) acid regurgitation and/or heartburn only (4%); (4) any other one or two symptoms (14%); (5) any three or four symptoms (18%); (6) any five or six symptoms (7%); (7) at least seven symptoms (3%). …”
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Evaluation of pulmonary tuberculosis disease burden in Shenyang, China, 2023 by Huijie Chen, Haiyan Bi, Peng Li, Zhixing Yang, Lihai Wen, Baijun Sun, Wei Sun

“…The disease burden showed a characteristic of increasing with age, and the PTB DALYs rate for males was higher than that for females, being equivalent to 4 times the female rate. The predominant disease burden of PTB was attributed to YLLs, accounting for as much as 71.38%, indicating that PTB primarily results in premature mortality rather than disability. …”
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Novel Procedures for Evaluating Autism Online in a Culturally Diverse Population of Children: Protocol for a Mixed Methods Pathway Development Study by Venus Mirzaei, Jeanne Wolstencroft, Georgia Lockwood Estrin, Eleanor Buckley, Shermina Sayani, Panos Katakis, Reena Anand, Tessa Squire, Eleanor Short, Paige Frankson, David Skuse, Michelle Heys

“…By addressing geographical and linguistic barriers, this pathway seeks to reduce service costs, shorten waiting times, and promote equity in autism diagnosis. The procedures developed are expected to be generalized to other populations nationwide. …”
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Characterization and comparative analysis of volatile organic compounds in four aromatic wild strawberry species using HS-SPME-GC-MS by Linlin Xu, Wan Liu, Zhiliang Pan, Fuhua Pang, Yongqi Zhang, Jiahui Liang, Qinglian Wang, Jing Wang, Mizhen Zhao, Yushan Qiao, Huazhao Yuan

“…Significant interspecies differences were found, with Fragaria mandshurica and F. nilgerrensis showing several times higher VOC levels than F. vesca and F. viridis, primarily due to high lactone content (up to 79.71 % of total VOCs). …”
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Migrasi Data Hasil Optimalisasi Pemuatan Kontainer Pada Legacy System ke SAP untuk Mempercepat Pembuatan Surat Jalan dengan Batch Data Communication (BDC) by Rehulina Tarigan, Ely Nuryani, Susy Katarina Sianturi, Nur Hidayanti, Widyawati Widyawati

“…The results of the research are in the form of synchronizing order data and delivery note data as well as accelerating the process of making delivery note documents to 3,775 times faster than before, thereby reducing customer complaints and speeding up the delivery process. …”
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Peningkatan Performa Pengelompokan Pola Berpikir Siswa dalam Belajar pada Media Pembelajaran Menggunakan Direct Batch Growing Self Organizing Map by Mochammad Izzuddin, Ahmad Afif Supianto, Tibyani Tibyani, Hilman Ferdinandus Pardede, Asri Rizki Yuliani, Ade Ramdan

“…Hal ini membuktikan bahwa penerapan DBGSOM mampu memberikan peningkatkan performa clustering yang signifikan dari SOM.   Abstract A few times, students have difficulty getting out of the deadlock in thinking while studying. …”
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Rapid aging of influenza epidemics in China from 2005/06 to 2016/17: A population-based study by Weibo Tang, Hao Lei, Nan Zhang, Yaojing Wang, Shimeng Cai, Shuyi Ji, Lei Yang, Mengya Yang, Can Chen, Shigui Yang, Dayan Wang, Yuelong Shu

“…Results: On average, the mean age of ILI cases and influenza-positive cases increased by 0.52 years and 0.60 years per year, respectively, which is approximately three times the annual increase in the mean age of the population. …”
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An efficient method for predicting the morphology of proppant packs based on a surrogate model by Tao ZHANG, Hangyu ZHOU, Yifan ZHANG, Jianchun GUO, Haoran GOU, Tang TANG

“…These methods are still confined by limited simulation scales, time-consuming computations, and high-cost operations. …”
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Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies by Touhidul Islam Tanim, Ayman M. Al-Qaaneh, Raihan Chowdhury, Md. Shimul Bhuia, Tabassum Islam, Md Showkoth Akbor, Md. Tahajul Islam, Md. Mohasin Miah, Ali Raza Ishaq, Mostafa A. Abdel-Maksoud, Mohamed A. El-Tayeb, Mohamed El-Shazly, Muhammad Torequl Islam, Heba A.S. El-Nashar

“…SEL (25 and 50 mg/kg) showed dose-dependent elevation in latency (133.20 ± 2.19 and 293.00 ± 5.27 s) and diminishment in the retching number (16.40 ± 1.15 and 9.40 ± 1.04 times), compared to control. Additionally, SEL can antagonize the activity of ondansetron (OND; 5 mg/kg) and domperidone (DOM; 7 mg/kg), resulting in a decrease in latency (256.00 ± 9.59 and 253.00 ± 2.79 s) and enhancing the number of retches (11.80 ± 0.82 and 12.60 ± 1.04) in combination rather than OND and DOM alone. …”
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The effect of nursing care provided to coronary intensive care patients according to their circadian rhythms on sleep quality, pain, anxiety, and delirium: a randomised controlled... by Meryem Pelin, Havva Sert

“…Finally, the smartwatch data show no significant difference in sleep times between groups (p < 0.05), but the intervention group had more deep and total sleep, while the control group had less deep sleep. …”
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In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives by Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete

“…Cytotoxicity in B16–F10 and BMDMs cells was assessed using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT method. 1,2,4-oxadiazole derivative 2 exhibited antiproliferative effects on both cell lines, being 2.6 times more selective for B16–F10. Necrosis was identified as the active induced death pathway. …”
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SHoes for Adolescent PatEllofemoral pain: study protocol for the SHAPE Australian community-based, randomised clinical trial by Kim L Bennell, Kade L Paterson, Rana S Hinman, Jo-Anne Manski-Nankervis, Adam Bryant, Karen Elaine Lamb, Peixuan Li, Sam Shearer, Anurika P De Silva

“…They are advised to wear their study shoes for all planned sports and exercise-based activities over the subsequent 3 months and are also advised that they may wear them as much as desired at other times. The primary outcomes are the 3-month change in (1) severity of the worst knee pain experienced over the past week, measured using a Numerical Rating Scale, and (2) the function in sport and play subscale of the Knee Injury and Osteoarthritis Outcome Score for Children. …”
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Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format by Kalvaityte U, Bagdonas E, Kirdaite G, Kausaite-Minkstimiene A, Uzieliene I, Ramanaviciene A, Popov A, Butkiene G, Karabanovas V, Denkovskij J, Mobasheri A, Bernotiene E

“…The FL signal readouts from QD655 in the microvolume format were from 10 to 40 times stronger than those measured directly from a 96-well plate QLISAs. …”
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Early Postoperative Safety of Total Hip Arthroplasty in Systemic Lupus Erythematosus Patients by YANG Xingdong, YU Muyang, XU Yiming, ZHU Wei, HU Mingwei, WENG Xisheng, FENG Bin

“…After propensity score matching, 163 cases from SLE and control groups were included for analysis. (1) Regarding medical complications, compared with control group, SLE group showed significant differences in osteoporosis, respiratory system disorders, gastrointestinal diseases, urinary system disorders, hematologic abnormalities, and secondary or concomitant rheumatic diseases (all P < 0.05). (2) In terms of preoperative laboratory tests, SLE group had lower platelet counts, absolute lymphocyte counts, hemoglobin levels, hematocrit, albumin levels, blood glucose levels, and activated partial thromboplastin times than control group, while C-reactive protein, erythrocyte sedimentation rate, and D-dimer levels were higher (all P < 0.05). (3) Regarding surgical-related indicators, a higher proportion of patients in SLE group had an ASA grade > 2 (15.95% vs. 3.07%, P < 0.001), but intraoperative blood loss was significantly smaller [324.7 (200.0, 500.0) mL vs. 421.8 (200.0, 500.0) mL, P=0.005]. (4) In terms of complications, SLE group exhibited a significantly higher incidence of major complications than control group (8.59% vs. 1.23%, P=0.005), with a relative risk of 1.081 (95% CI: 1.028-1.136). …”
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Evolution of burnout syndrome in Spanish healthcare professionals during and after the COVID-19 pandemic: psychosocial variables involved by Fernanda Gil-Almagro, Fernanda Gil-Almagro, Fernanda Gil-Almagro, F. Javier Carmona-Monge, Fernando J. García-Hedrera, Cecilia Peñacoba-Puente

“…At the second time point, cognitive fusion and resilience were assessed. …”
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