Toll-like receptor upregulation in liver and peripheral blood mononuclear cells of patients with amoebic liver abscess by Sandhya Khunger, Abhishek Mewara, Upninder Kaur, Ajay Duseja, Pallab Ray, Naveen Kalra, Navneet Sharma, Rakesh Sehgal

“…Aim: We aimed to understand the host and microbe interactions at the time of infection and inflammatory response in amoebic liver abscess (ALA) patients based on toll-like receptor (TLR) expression (mRNA), cytokine and IgG subtypes levels. …”
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Hydrophobic deep eutectic solvents as novel, sustainable aids for intracellular protein release from Saccharomyces cerevisiae by Tjalling Gijsbert Tjalsma, Yannick Patrice Didion, Ziran Su, Magdalena Malankowska, Pablo Torres-Montero, José Luis Martínez, Manuel Pinelo

“…Here, the use of hydrophobic deep eutectic solvents (DESs) as cell wall permeabilization agents for intracellular protein release from Saccharomyces cerevisiae was studied for the first time. This study examines the relatively new type V DESs, which favors downstream methods because less solvent is needed and environmentally friendly substances can be used. …”
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Prevalence and sociodemographic characteristics of functional impairment in community-dwelling older adults in China: a cross-sectional study by Yun Li, Li Zhang, Zhe Tang, Lina Ma, Pan Liu, Xiaxia Li, Wenhua Yu, Yaxin Zhang

“…Objectives Functional impairment is an early stage of disability, and timely identification and intervention are critical for the health of older adults. …”
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Adapting the WHO Safe Childbirth Checklist: A collaborative study in West Africa by Kadidiatou R. Kourouma, Tieba Millogo, Aissatou Diallo, Wambi M.E. Yaméogo, Marie L. Agbré-Yacé, Mamadou D. Baldé, Issaka Tiembré, Alexandre Delamou, Séni Kouanda

“…The modified SCC implemented in each country consisted of 31 items, with variations observed in the timing of the monitoring signs when plotting the partograph. …”
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The Adaptation, Implementation, and Performance Evaluation of Intake24, a Digital 24-h Dietary Recall Tool for South Asian Populations: The South Asia Biobank by Divya Bhagtani, Birdem Amoutzopoulos, Toni Steer, David Collins, Suzanna Abraham, Bridget A Holmes, Baldeesh K Rai, Rajendra Pradeepa, Sara Mahmood, Abu Ahmed Shamim, Poorvee Mathur, Lathika Athauda, Laksara De Silva, Khadija I Khawaja, Vinitaa Jha, Anuradhani Kasturiratne, Prasad Katulanda, Malay K Mridha, Ranjit M Anjana, John C Chambers, Polly Page, Nita G Forouhi

“…Median recall completion time was 13 min. Quality control metrics showed 99% of recalls included >8 items and 8% had missing foods. …”
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Heterogeneous graph convolutional neural network for protein-ligand scoring by Kevin Crampon, Alexis Giorkallos, Xavier Vigouroux, Stephanie Baud, Luiz Angelo Steffenel

“…It is still an active area of research in both academic and industrial sectors with efforts on reducing time and cost. Computational simulations like molecular docking enable fast exploration of large databases of compounds and extract the most promising molecule candidates for further in vitro and in vivo tests. …”
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Enhancing the estimation of cadmium content in rice leaves by integrating vegetation indices and color indices using machine learning by Xiaoyun Huang, Shengxi Chen, Tianling Fu, Chengwu Fan, Hongxing Chen, Song Zhang, Hui Chen, Song Qin, Zhenran Gao

“…Excessive Cd levels can have detrimental effects on crop growth, development, and yield. Real-time, rapid, and nondestructive monitoring of Cd content in leaves (LCd) is essential for food security. …”
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PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

“…Results Here, we revealed that PTOV1 was highly expressed in human CRC tissues, especially at advanced stages, and associated with reduced survival time among CRC patients. The upregulated PTOV1 promoted cell proliferation, migration, invasion, tumor growth and metastasis of CRC cells in vitro and in vivo. …”
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Single-Institution Experience With Nononcologic Total Femoral Replacement by Ryan Ouillette, MD, Kevin Chen, BA, Matthew Dipane, BA, Alexander Christ, MD, Edward McPherson, MD, Alexandra Stavrakis, MD

“…Results: The average age at time of TFR was 65.7 years, with periprosthetic fracture (65.2%) and periprosthetic joint infection (34.8%) as predominant indications. …”
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Evaluation of enzymatic hydrolysis of palm kernel meal in largemouth bass (Micropterus salmoides) by Tao Ding, Hao Wang, Xiaofang Liang, Jie Yang, Yaping Zhu, Min Xue

“…The diets PKM and EPKM showed higher bulk density (BD) and hydration time (HT) compared to SBM. The three types of feed used for largemouth bass had no significant effect on their growth performance, body composition, or digestion. …”
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Impact of interventions on mpox transmission during the 2022 outbreak in Canada: a mathematical modeling study of three different cities by Fanyu Xiu, Carla M. Doyle, Jorge Luis Flores Anato, Jesse Knight, Linwei Wang, Joseph Cox, Daniel Grace, Trevor A. Hart, Terri Zhang, Shayna Skakoon-Sparling, Milada Dvorakova, Rita Shahin, Herveen Sachdeva, Nathan Lachowsky, Hind Sbihi, Darrell H.S. Tan, Michael A. Irvine, Sharmistha Mishra, Mathieu Maheu-Giroux

“…Vaccination's effect varied across cities due to the programs' timing and coverage, with 21%-39% mpox infections prevented. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…For an earlier version of the GRAIL test, the time to diagnostic resolution was shorter for those with a true positive result compared to false-positive results. …”
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Increased risk of Pneumocystis jirovecii colonization in rheumatoid arthritis patients on biologics and Janus kinase inhibitor by Ya-Chun Huang, Nan-Yao Lee, Meng-Yu Weng

“…We obtained oral-wash samples from asymptomatic RA patients treated with biologic disease-modifying antirheumatic drugs (bDMARDs) and JAKi. A real-time quantitative polymerase chain reaction assay focusing on the mitochondrial large subunit ribosomal ribonucleic acid gene of PJ was applied to detect colonization. …”
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A Nomogram for Predicting Overall Survival in Primary Central Nervous System Lymphoma: A Retrospective Study by Ling Y, Miao X, Zhou X, Ma J, Lin Z, Li Q, Zhang M, Ma Y, Chen B

“…The prognostic model demonstrated concordance Index (C-index) of 0.731 and 0.679 in the development and validation cohorts, respectively. In terms of the time dependent area under the curve (AUC) values for OS, the development cohort exhibited values of 0.765, 0.762, and 0.812 for 1-year, 3-year, and 5-year OS, respectively. …”
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Cobalt titanate nanocatalyst for enhanced photodegradation of atrazine: kinetics, degradation efficiency, and mechanistic analysis by Jeremiah Suleiman Nuhu, Femi Emmanuel Awe, Rajni Garg, Rishav Garg, Nnabuk Okon Eddy, Hazratullah Paktin

“…The efficiency was influenced by concentration (20–50 ppm), catalyst dosage (0.5–2.0 mg/L), pH (4.21–10.22), and irradiation time (0–120 min). The synthesized nanoparticles exhibited a surface area of 32.5 m2/g (DFT) and 828.03 m⁻1 (BET), a pore volume of 0.03925 m3/g, and a bandgap energy of 2.66 eV. …”
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Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction by Guihong Rong, Xiao Wang, Xinling Qin, Yanxia Wang, Meilian Quan, Chunfeng Xi

“…Background: Heart failure (HF) following acute myocardial infarction (AMI) is characterized by high mortality and disability rates, which highlights the need of timely and effective revascularization. Recent studies suggested the potential predictivity of biomarkers NT-proBNP, cTNT, PLR, NLR, and GDF-15 in cardiovascular events, but their value in HF patients post-AMI still require further verification. …”
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Detecting tropical freshly-opened swidden fields using a combined algorithm of continuous change detection and support vector machine by Ningsang Jiang, Peng Li, Zhiming Feng

“…The integration CCDC with SVM represents a novelty in combining time series analysis and machine learning techniques and helps monitor annual swidden agriculture in the tropics.…”
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Insecticidal effect of Essential Oils of Citrus limon, Cymbopogon citratus and Syzygium aromaticum and their Synergistic Combinations Against Anopheles Mosquitoes by Tunde Ayobami Owolabi, Philippine Chigozie Okubor, James Danga, Issa Onimisi

“…The insecticidal activity was tested using a susceptibility test to evaluate the knockdown, mortality rates and time against adult mosquitoes following standard protocols. …”
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Analgesic Efficacy of Transversus Abdominis Plane block vs Local Infiltration of Lignocaine and Bupivacaine in Post-operative Patients by Shabbir Ahmad, Muhammad Kareemullah, Saeed Mahmood, Muhammad Azhar Alam, Qasim Farooq, Muhammad Rashid

“…The results indicated that the TAP Block group consistently required fewer rescue analgesic doses than the local wound Infiltration group at all postoperative time points. At 6 hours, 23.63% of patients in the TAP Block group needed additional analgesia, compared to 38.18% in the Wound Infiltration group, though this difference was not statistically significant. …”
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