Heart failure with mildly reduced ejection fraction: retrospective study of ejection fraction trajectory risk by Robert J.H. Miller, Majid Nabipoor, Erik Youngson, Gynter Kotrri, Nowell M. Fine, Jonathan G. Howlett, Ian D. Paterson, Justin Ezekowitz, Finlay A. McAlister

“…The primary outcome was all‐cause mortality or cardiovascular hospitalization after the second echocardiogram. Associations with time to first event were assessed with multivariable Cox analyses adjusted for age, co‐morbidities, and medications. …”
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PECULIARITIES OF CARBOHYDRATE METABOLISM INDICATORS, THE FUNCTIONAL STATE OF THE THYROID GLAND IN THE COURSE TREATMENT WITH TELMISARTAN AS PART OF THE COMPLEX THERAPY OF PATIENTS W... by Nataliya Chmyr, Roman Dutka, Halyna Svitlyk, Iryna Dronyk, Khrystyna Abrahamovych, Oksana Didenko, Nataliia Drobin'ska

“…In the patients of the experimental group, it was found that the level of Thyroid-stimulating hormone significantly decreased during treatment with Telmisartan as part of complex therapy, in contrast to the comparison group, taking Ramipril at the same time. The level of free Thyroxine in patients with experimental group increased a month after start of therapy, while it remained unchanged in patients with comparison group. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…Hepatic pro-inflammatory and metabolism-related gene expression and markers of nitrosative stress, were analyzed utilizing real-time polymerase chain reaction (RT-PCR) and correlated with behavioral and histological outcomes. …”
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Soybean oil, a linoleic acid source, in lamb diets: metabolic, feeding behavior, and ruminal parameters by V. G. O. Lima, L. O. da Silva, J. E. de Freitas Jr., H. D. R. Alba, V. M. Leite, W. P. Silva, D. D. S. Pina, L. C. Leite, C. S. Rodrigues, S. A. Santos, G. G. P. de Carvalho

“…The data were analyzed using linear and quadratic polynomial contrasts, except for the ruminal fermentation parameters and plasma glucose, which were analyzed using repeated measures over time. There was a linear reduction in DM (<span class="inline-formula"><i>P</i></span> <span class="inline-formula">=</span> 0.019) and crude protein (<span class="inline-formula"><i>P</i></span> <span class="inline-formula">=</span> 0.007) intake as well as a linear decrease in non-fibrous carbohydrate intake (<span class="inline-formula"><i>P</i></span> <span class="inline-formula">&lt;</span> 0.001) and digestibility (<span class="inline-formula"><i>P</i></span> <span class="inline-formula">=</span> 0.039) due to increased SO inclusion levels. …”
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Human Capital, Economic Growth and Environmental Quality with Special Emphasis on Public Education Expenditures: An Application of DSGE Models by Yahya Mohaghegh, hashem zare, Mehrzad Ebrahimi

“…For this reason, countries are trying to address environmental crises and economic growth at the same time. Basically, it is believed that the destruction of ecosystems in many countries is the result of human actions, including rapid industrialization, population growth, expansion of economic activities, urbanization, and widespread consumption of fossil fuels. …”
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Effect of lncRNA H19 on Rats with Chronic Heart Failure Based on TGF-β1/Smad3 Signaling Pathway by WANG Lingyan, CAO Guojun, MEI Yang, ZHANG Bin, ZHOU Shijing

“…Two days after the last injection, color Doppler ultrasound was used to detect cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic dimension (LVEDD)]; Masson staining was used to detect myocardial fibrosis and collagen volume fraction (CVF); real-time fluorescence quantitative PCR was used to detect the transcription level of lncRNA H19 and miRNA-200a in myocardial tissue of rats; Western blot method was used to detect the protein expression level of TGF-β1 and Smad3 in myocardial tissue of rats.ResultsCompared with sham surgery group, the protein expression level of LVEDD, LVESD, TGF-β1, Smad3 and transcription level of miRNA-200a in the other four groups significantly increased, while the protein expression level of LVFS, LVEF and transcription level of lncRNA H19 significantly decreased (<italic>P</italic>&lt;0.05); compared with the heart failure group and the negative control group, the protein expression level of LVEDD, LVESD, TGF-β1, Smad3 and transcription level of miRNA-200a in the overexpression group and the combined overexpression group significantly decreased, while the protein expression level of LVFS, LVEF and transcription level of lncRNA H19 significantly increased (<italic>P</italic>&lt;0.05); compared with the overexpression group, the protein expression level of LVEDD, LVESD, TGF-β1, Smad3 and transcription level of miRNA-200a in the combined overexpression group significantly increased, while LVFS and LVEF significantly decreased (<italic>P</italic>&lt;0.05), and the transcription level of lncRNA H19 was not statistically different (<italic>P</italic>&gt;0.05). …”
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Jiangu Granules Regulates Endoplasmic Reticulum Stress-Induced Apoptosis in UMR-106 Cells by Modulating the PERK/eIF2α/ATF4/CHOP Pathway by CHEN Sainan, ZHOU Fen, HUANG Yunmei, LIN Yanping

“…Intracellular ROS content was detected using DCFH-DA. The real-time dynamic changes of intracellular calcium ions were observed using laser confocal microscopy to determine whether the ROS/ERS model was constructed. …”
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The practice and exploration of SPOC-based online-offline mixed teaching mode in Traditional Chinese Medicine nursing teaching (基于SPOC的线上-线下混合式教学模式在中医护理教学中的实践与探索)... by WANG Li (王黎), MA Xueling (马雪玲), WANG Zhen (王臻), CHEN Hong (陈宏), WENG Zhiwen (翁志文), WANG Junxiang (王俊翔)

“…However, there are still some problems in the implementation of this teaching model, such as teachers and students being unable to communicate in time and relying too much on students' autonomy, which need to be further improved. …”
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Effect of Transcranial Direct Current Stimulation in the Treatment of Aphasia after Stroke：A Meta-Analysis by CUI Ying, LI Bo, TIAN Guang

“…The randomized controlled trials (RCTs) of tDCS in the treatment of aphasia after stroke were included, and the retrieval time for each database was from inception to August 2021. …”
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Household transmission of SARS-CoV-2 in a rural area in South Africa by G Maimela, C E Martin, M Chersich, B Bello, J Mauti, T Bäernighausen, S Kohler, A Almuedo-Riera, S Luchters, S Sawry

“…We found a high SARS‐CoV‐2 infection rate among HCs in a rural setting, with 48% of households having a co‐primary case at the time of enrolment. Households with co‐primary cases were associated with a higher seroprevalence and incidence of SARS‐CoV‐2. …”
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FTO rs17817449 Variant Increases the Risk of Severe Obesity in a Brazilian Cohort: A Case-Control Study by Salum KCR, Assis ISS, Kopke ÚA, Palhinha L, Abreu GM, Gouvêa LW, Teixeira MR, Mattos FCC, Nogueira Neto JF, Felício RFM, Rosado EL, Zembrzuski VM, Campos Junior M, Maya-Monteiro CM, Cabello PH, Carneiro JRI, Bozza PT, Kohlrausch FB, da Fonseca ACP

“…We collected demographic, body composition, biochemical, and genotyping data by real-time PCR, and performed logistic and linear regression analyses to investigate the association of polymorphisms with severe obesity status and obesity-related quantitative parameters.Results: Individuals with severe obesity had significantly higher anthropometric measures, blood pressure, and biochemical levels. …”
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Efficacy and Safety of High-dose versus Standard-dose Prazosin in Paediatric Scorpion Envenomation: A Single-blinded Randomised Controlled Study by Apoorva Gayatri Abbadi, Hidaytullah R Bijapure, Chandrika R Doddihal, Bhavana B Lakhkar, Y Rohith, VJ Prakash, Kumar BM Prasanna, Mallanagouda Patil

“…After the patient was haemodynamically stable for 24 hours shifted to a high-dependency unit. The time interval between sting and treatment, various vital parameters, duration of the PICU stay and hospital stay were noted. …”
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Efek Pengurangan Durasi Tidur terhadap Jumlah dan Hitung Jenis Leukosit pada Tikus Wistar by Wahyu Tri Novriansyah, Ellyza Nasrul, Rosfita Rasyid

“…</p><p>                            <strong>Kata kunci:</strong> <em>sleep deprivation</em>, leukosit, eosinofil, neutrofil, limfosit, monosit</p><p><strong><em> </em></strong></p><p><strong><em>Abstract</em></strong></p><p><em>Sleep Deprivation (SD) is a complete loss of sleep for a certain period or a shorter sleep duration than the</em><em> </em><em>optimal time required. Sleep deprivation affects the immune system as well as the disruption of circadian rhythms. …”
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Kontrol Level Kecepatan Kipas Melalui Deteksi Gestur Jari Tangan Menggunakan MediaPipe dan Faster-RCNN by Muhammad Aldi Fakhruddin, Heri Pratikno, Musayyanah, Weny Indah Kusumawati

“…In this study, an interaction control system was applied between the user and the computer to adjust the fan speed level automatically and in real time based on computer vision technology for deep learning through the detection of the shape of the right hand finger gesture and the left hand finger gesture using a webcam. …”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…The trials’ assessment time points were between 6 and 16 weeks after randomisation. …”
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Early and high-volume administration of sodium bicarbonate in sepsis-associated acute kidney injury in patients with malignancies, during continuous renal replacement therapy by Lamei Ouyang, Yin Pan, Ya-Fei Wu, Qiang Tang, Dao-Feng Wang, Ning Lou

“…Based on the initiation time of CRRT and the volume of sodium bicarbonate infusion, patients were divided into four groups: the early high-volume group, early low-volume group, late high-volume group, and late low-volume group.Results The results of this study showed that in the 28-day mortality model, established using the Cox proportional hazards method, early CRRT (HR 0.473; 95% CI 0.245–0.915, p = 0.026) and high-volume sodium bicarbonate infusion (HR 0.173; 95% CI 0.078–0.383, p < 0.001) were identified as two independent protective factors. …”
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Development and validation of a model to predict cognitive impairment in traumatic brain injury patients: a prospective observational studyResearch in context by Xiaofang Yuan, Qingrong Xu, Fengxia Du, Xiaoxia Gao, Jing Guo, Jianan Zhang, Yehuan Wu, Zhongkai Zhou, Youjia Yu, Yi Zhang

“…We aimed to develop and validate a predictive model for cognitive impairment in TBI patients, with the goal of early identification and support for those at risk of developing cognitive impairment at the time of hospital admission. Methods: The training cohort included 234 TBI patients, all of whom were admitted to the Department of Neurosurgery at the Third Affiliated Hospital of Soochow University from May 2017 to April 2020. …”
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A Prospective, Crossover, Randomized, Double-Blind Clinical Study Comparing the Effectiveness and Ocular Comfort of 0.1% Hyaluronic Acid and 0.3% Hyaluronic Acid in Patients With D... by Kim SJ, Yoo WS, Kwon LH, Kim RB, Yoon HJ, Yoon KC

“…Patients aged > 19 years with DED level 2 or higher, corneal staining score > 1, and tear break-up time (TBUT) < 10s were included. Sixty patients were randomly assigned to two groups. …”
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Prognostic value of intraductal carcinoma subtypes and postoperative radiotherapy for localized prostate cancer by Fang Cao, Qing Li, Tianyu Xiong, Yingjie Zheng, Tian Zhang, Mulan Jin, Liming Song, Nianzeng Xing, Yinong Niu

“…Screening cases with pathological results of intraductal carcinoma, subtyping was completed by a pathologist, grouped by intraductal carcinoma (+/-; pattern 1/ 2) and treatment regimen (RP + PORT / RP only), Kaplan-Meier curves were plotted based on the time to biochemical recurrence-free and overall survival of the patients, and Cox regression analyses were performed. …”
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Combined Effects of Humic Acid-Modified Magnetic Biochar and AMF on the Properties of Saline-Alkali Soil and Photosynthetic Parameters of Muskmelon by ZHANG Yating, LOU Xueyi, WU Jiarui, LIU Hongyuan, YE Binyu, XIAO Jiamin, LI Jiameng, MIAO Yining, CHEN Xinyan, LIU Yilin, TAN Yuyu, WANG Zhichao, LIU Peng

“…[Conclusion] HA-MBC prepared with a biochar to humic acid ratio of 6∶1 and cross-linking time of 72 h, using 0.04 mmol/L FeCl3 and FeSO4 reagents, is suitable for combined application with AMF. …”
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