Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Abstract Background Rare diseases (RDs) are a heterogeneous group of complex and low-prevalence conditions in which the time to establish a definitive diagnosis is often too long. …”
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Real-world experience with TTFields in glioma patients with emphasis on therapy usage by Claudius Jelgersma, Joan Alsolivany, Gülsüm Akkas, David Wasilewski, David Wasilewski, Bastian Gastl, Martin Misch, David Capper, David Capper, David Kaul, David Kaul, Lars Bullinger, Lars Bullinger, Peter Vajkoczy, Julia Onken, Julia Onken, Julia Onken

“…Linear regression found no predictors of usage, such as age, timing of therapy initiation, and duration or gender. 55% of patients continued TTFields beyond the first recurrence. …”
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Determinants of the Continuum of Maternal Healthcare Services in Northwest Ethiopia: Findings from the Primary Health Care Project by Asmamaw Atnafu, Adane Kebede, Bisrat Misganaw, Destaw Fetene Teshome, Gashaw Andargie Biks, Getu Debalkie Demissie, Haileab Fekadu Wolde, Kassahun Alemu Gelaye, Mezgebu Yitayal, Tadesse Awoke Ayele, Telake Azale, Terefe Derso, Tsegaye Gebremedhin, Endalkachew Dellie

“…Women who were able to read and write (AOR: 2.70, 95% CI: 1.22, 6.04), using car/motorcycle as a means of transportation to get the health facility (AOR: 5.59, 95% CI: 2.29, 9.50), travel time less than an hour to get the health facility (AOR: 4.98, 95% CI: 2.97, 8.38), being satisfied with the service delivery (AOR: 1.89, 95% CI: 1.15, 3.11), and getting health education on maternal healthcare services in the last 6 months (AOR: 2.77, 95% CI: 1.52, 5.05) were factors associated with the completion of the continuum of maternal healthcare services. …”
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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

“…Methods Mice were fed a choline-deficient L-amino acid-defined (CDAA) diet for ten weeks to induce MASH-associated liver fibrosis, or a CDAA diet or a high fat diet (HFD) for shorter periods of time to induce early steatosis-associated alterations. …”
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Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 by Andrew I Kim, William Bain, Alison Morris, Barbara Methe, Bryan J McVerry, Georgios D Kitsios, Daniel Kotok, Janet S Lee, Nameer Al-Yousif, Christine E Girard, Jana J Jacobs, Konstantin Golubykh, Hafiz Qurashi, Michael Lu, Saketram Komanduri, Anatoliy Korzhuk, Halimat O Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J Mitchell, Catherine M Dietz, Ellen K Hughes, Clara S Brandt, Georgia M Fitzgerald, Robin Joyce, Asmaa S Chaudhry, Jose D Rivera, Shruti Shettigar, Allen Lavina, Samantha R Gillenwater, Anas Hadeh, Faraaz A Shah, Matthew Bittner, Niall Prendergast, John Evankovich, Navitha Ramesh, Cathy Kessinger

“…In the discovery cohort, the required level of respiratory support at the time of CXR acquisition (supplemental oxygen or non-invasive ventilation (n=178); invasive-mechanical ventilation (n=234), extracorporeal membrane oxygenation (n=13)) was significantly associated with RALE scores (median (IQR): 20.0 (14.1–26.7), 26.0 (20.5–34.0) and 44.5 (34.5–48.0), respectively, p<0.0001). …”
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Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens by Zhihua Li, Md. Abul Kalam Azad, Chengwen Meng, Xiangfeng Kong, Jue Gui, Wenchao Lin, Yadong Cui, Wei Lan, Qinghua He

“…Chinese herbs have been widely used as medicine for a long time to prevent diseases and as nutrient supplements to improve the product quality. …”
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Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites by Mauricio Piñeiro, Mauricio Piñeiro, Sofía Manrique, Jessica Gómez, Jessica Gómez, Juan Manuel Rodriguez, Patricia Barrera, Duilio Caballero, Miguel A. Sosa, Gabriel Vargas-Arana, Gabriel Vargas-Arana, Alejandro Tapia, Beatriz Lima, Beatriz Lima, Mario J. Simirgiotis

“…The metabolite profiling was obtained using ultra-high-resolution liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QTOF-MS) system. …”
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Knowledge, attitude, and perception of Pakistani populations toward monkeypox: a cross-section study by Humayun Yousaf, Abdul Qadeer, Muhammad Sohail, Maqbool Khan, Muhammad Farooq, Zakir Khan, Dalia Fouad, Yu-Chia Liu, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen

“…About 83.95% (2909) answered that during interaction with the Mpox patient, they’d dress in the appropriate personal protective clothing, like masks, gloves, and gowns. At the same time, 77.66% (2691) responded that they would perform hand hygiene after touching the patients’ surroundings, like beds, tables, doors, etc.ConclusionsMaximum research participants showed good attitudes and knowledge about Mpox. …”
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Deciphering hub genes and immune landscapes related to neutrophil extracellular traps in rheumatoid arthritis: insights from integrated bioinformatics analyses and experiments by Yang Li, Yang Li, Jian Liu, Jian Liu, Yue Sun, Yue Sun, Yuedi Hu, Yuedi Hu, Qiao Zhou, Qiao Zhou, Chengzhi Cong, Chengzhi Cong, Yiming Chen, Yiming Chen

“…We further investigated hub gene expression using immunohistochemistry (IHC) in an adjuvant-induced arthritis rat model and real-time quantitative polymerase chain reaction (RT-qPCR) in a clinical cohort.ResultsSeven cellular subpopulations were identified through downscaling and clustering, with neutrophils likely the most crucial cell clusters in RA. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…Histological and TUNEL detection in the liver demonstrated that the 14 °C and 7 °C cold stress caused severe morphological damage and cell apoptosis in a time-dependent manner. DEGs in the biosynthesis of fatty acids (<i>Acsbg2, Acsl3, Acsl4, Acsl5, Mcat,</i> and <i>Acacb</i>), as well as unsaturated fatty acids (<i>Hsd17b12</i>, <i>Elovl7</i>, <i>Scd</i>, and <i>Baat</i>), starch and sucrose metabolism (<i>Pgm1</i>, <i>Pgm2</i>, and <i>Treh</i>), and apoptosis (<i>Ddit3</i>, <i>Gadd45a</i>, <i>Lmnb1</i>, <i>Tuba1c</i>, <i>Tnf</i>, <i>Tnfsf10</i>, <i>Fos</i>, <i>Itpr1</i>, and <i>Ctso</i>) were discovered in the transcriptome under cold stress. …”
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Development and application of intelligent auxiliary diagnosis system in the Traditional Chinese Medicine nursing clinic (智能辅诊系统在中医护理门诊中的开发与应用)... by ZHANG Jing (张敬), TANG Ling (唐玲)

“…Medical staff can realize medical record management, differential nursing, treatment management and effect evaluation through the medical ports, and patients can make appointments for treatment time and beds, receive remote health guidance and view medical records through the patient ports. …”
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Therapeutic Efficacy of Moxibustion with Seed-Sized Moxa-Cone at Jing Acupoint on Limb Spasticity after Stroke： A Meta-Analysis by ZHANG Jinfei, JIANG Jiahui, TANG Jiqin

“…The randomized controlled trials (RCTs) of moxibustion with seed-sized moxa-cone at Jing acupoints for stroke patients with spastic hemiplegia were included, and the retrieval time was from inception to July 2022. The main outcome measures included the effective rate of spasticity improvement [number of cases (fully recovered + significant effect + some effect)/total number of cases]×100%], modified Ashworth scale (MAS) grading, clinical spasm index (CSI) score, Fugl-Meyer assessment scale (FMA) score, Barthel index (BI) score. …”
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HHO–LSSVM prediction model of blast casting muck pile morphology based on Gaussian distribution by Ning MA, Li MA, Yinda LI, Tianxiang LI, Sen YANG, Fuming LIU, You ZHOU, Xiaomin WANG, Qifeng ZHANG, Mengbo LI

“…And the Gaussian distribution model combined with the HHO–LSSVM algorithm was used to predict the shape of the blast casting muck pile, compare the accuracy of the LSSVM, Particle Swarm Optimization (PSO) optimized Least Squares Support Vector Machine, and Genetic Algorithm (GA) optimized BP neural network models, at the same time, compare the predicted blast casting muck pile morphology with the actual blasting muck pile morphology. …”
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Rapid inference of antibiotic susceptibility phenotype of uropathogens using metagenomic sequencing with neighbor typing by Amanda C. Carroll, Leanne Mortimer, Hiren Ghosh, Sandra Reuter, Hajo Grundmann, Karel Brinda, William P. Hanage, Angel Li, Aimee Paterson, Andrew Purssell, Ashley Rooney, Noelle R. Yee, Bryan Coburn, Shola Able-Thomas, Martin Antonio, Allison McGeer, Derek R. MacFadden

“…ABSTRACT Timely diagnostic tools are needed to improve antibiotic treatment. …”
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Noninferiority trial in veal calves on the efficacy of oxytetracycline and florfenicol treatment for pneumonia guided by quick thoracic ultrasound by Stan Jourquin, Florian Debruyne, Laurens Chantillon, Thomas Lowie, Randy Boone, Jade Bokma, Bart Pardon

“…After d 1, only calves with consolidations ≥1cm were given further treatment. On each time point, maximum consolidation depth was used to categorize calves into 4 qTUS categories: healthy (no consolidation), mild pneumonia (consolidation <1 cm), moderate pneumonia (consolidation 1–3 cm) and severe pneumonia (consolidation ≥3 cm). …”
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Effects of Hypoxia Stress on Biochemical Indices and Expression of Hypoxia-Related Genes in the Heart of Rainbow Trout (Oncorhynchus mykiss) by Jiuju MA, Jinqiang HUANG, Yongjuan LI, Shenji WU, Lu ZHAO, Yue ZENG

“…To elucidate the effects of hypoxic stress on the heart of rainbow trout, biochemical indices and hypoxia-related gene expression were measured during moderate (4.5±0.1 mg/L) and severe hypoxia (3.0±0.1 mg/L) stress for 4 h, 8 h, 12 h, and 24 h; moderate hypoxia for 1 month (TMM); severe hypoxia for 1 month (TMM); and reoxygenation (8.5±0.1 mg/L) for 12 h and 24 h using enzyme activity assays and quantitative real time polymerase chain reaction (RT-qPCR). The results showed that the pyruvate kinase (PK), total cholesterol (TC), lactic acid (LD), and glutamine aminotransferase (GPT) reactivates increased at 8 h, decreased at 24 h, and were significantly higher than the control levels after reoxygenation (P < 0.05) under moderate hypoxic stress. …”
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The Use of Zeolit and Activated Carbon on Packing System of Corydoras aenus by E. Supriyono, E. Supendi, K. Nirmala

“…Suitable and efficient packing technology is very needed to send live fish for long time transportation.  Two third of packing plastic volume was filled by oxygen, and Corydoras aenus 20 fish/pack.  …”
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GIS-based modeling and analytical approaches for groundwater quality suitability for different purposes in the Egyptian Nile Valley, a case study in Wadi Qena by Hanaa A. Megahed, Abd El-Hay A. Farrag, Amira A. Mohamed, Mahmoud H. Darwish, Mohamed A. E. AbdelRahman, Heba El-Bagoury, Paola D’Antonio, Antonio Scopa, Mansour A. A. Saad

“…Availability in Egypt is minimal due to a real restriction on the quantity and quality of acceptable water; it is also increasingly in demand, particularly since the reduction in the share in the Nile following the construction of the Renaissance Dam in Ethiopia. At the same time, the need for water increases due to population growth, industrial development and the cultivation of desert land. …”
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Pengembangan Aplikasi Sistem Informasi Pendataan Bangunan (SIPBANG) pada Dinas Pekerjaan Umum dan Penataan Ruang (DPUPR) Kota Malang Menggunakan Framework Scrum by Muhamad Rifky, Yusi Tyroni Mursityo, Bondan Sapta Prakoso

“…Scrum was used as the main method for system development because of three-month time limit from DPUPR. Besides, management project was used as the method that would ease the arrangement of general project planning from initialization, planning, implementation, evaluation, and closing. …”
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Development of the DO₃SE-Crop model to assess ozone effects on crop phenology, biomass, and yield by P. Pande, S. Bland, N. Booth, J. Cook, Z. Feng, L. Emberson

“…Here we extend the DO<span class="inline-formula">₃</span>SE model (designed to estimate total and stomatal O<span class="inline-formula">₃</span> deposition for risk assessment) to incorporate a coupled <span class="inline-formula"><i>A</i>_net</span>–<span class="inline-formula"><i>g</i>_sto</span> model to estimate O<span class="inline-formula">₃</span> uptake; an O<span class="inline-formula">₃</span> damage module (that impacts instantaneous <span class="inline-formula"><i>A</i>_net</span> and the timing and rate of senescence); and a crop phenology, carbon allocation, and growth model based on the JULES-crop model. …”
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